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The map label for this gene is qacE [H]

Identifier: 78357393

GI number: 78357393

Start: 2369957

End: 2370301

Strand: Direct

Name: qacE [H]

Synonym: Dde_2350

Alternate gene names: 78357393

Gene position: 2369957-2370301 (Clockwise)

Preceding gene: 78357392

Following gene: 78357395

Centisome position: 63.53

GC content: 56.52

Gene sequence:

>345_bases
ATGAATCCTACAGTAACATCATACGCGGCACTGGCTCTGGCCATCGTGGTTGAGGTCATCGCCACGTCTGTGCTGCCGCA
CACAAGAGAATTCACCCGCCCGTGGCCCACGCTACTGGTGGCAGTGCTGTACGCCACGGCGTTCTATCTGCTGACCATTG
TCACCCGTGCCGTGCCCATAGGCATTGCCTATGCTCTCTGGAGCGGCTTCGGCATCGTACTCATTGCCGCGGTCAACTGG
CTCATATTCCGGCAGCGTCTCGACACGCCTGCCATCATAGGACTGGGACTGCTCATATCAGGCATCGTGGTCATCAACGT
TTTTTCTAAAACCGTCTCTCACTGA

Upstream 100 bases:

>100_bases
TCTGGCTGGAAGACCTGATGCTGGGCAAAAAGCGTTCAGCCGGTGAAACAGCCAGACTGCAGAAACAGCTGCTGGCGCTC
ATAGACAGGAAACAGGAAGC

Downstream 100 bases:

>100_bases
CAACGCGCGCCAGACAGCCGGCCGGTGCTCCCAAAGGCACTCCGCACTGCTACACTCCATCCATCCGGCACAAGGCGTCC
CCCCGGCACCGGCATCTGCT

Product: putative methyl viologen/ethidium resistance transmembrane protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 114; Mature: 114

Protein sequence:

>114_residues
MNPTVTSYAALALAIVVEVIATSVLPHTREFTRPWPTLLVAVLYATAFYLLTIVTRAVPIGIAYALWSGFGIVLIAAVNW
LIFRQRLDTPAIIGLGLLISGIVVINVFSKTVSH

Sequences:

>Translated_114_residues
MNPTVTSYAALALAIVVEVIATSVLPHTREFTRPWPTLLVAVLYATAFYLLTIVTRAVPIGIAYALWSGFGIVLIAAVNW
LIFRQRLDTPAIIGLGLLISGIVVINVFSKTVSH
>Mature_114_residues
MNPTVTSYAALALAIVVEVIATSVLPHTREFTRPWPTLLVAVLYATAFYLLTIVTRAVPIGIAYALWSGFGIVLIAAVNW
LIFRQRLDTPAIIGLGLLISGIVVINVFSKTVSH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=114, Percent_Identity=44.7368421052632, Blast_Score=102, Evalue=4e-24,
Organism=Escherichia coli, GI1787883, Length=99, Percent_Identity=38.3838383838384, Blast_Score=66, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12334; Mature: 12334

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTVTSYAALALAIVVEVIATSVLPHTREFTRPWPTLLVAVLYATAFYLLTIVTRAVPI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAYALWSGFGIVLIAAVNWLIFRQRLDTPAIIGLGLLISGIVVINVFSKTVSH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPTVTSYAALALAIVVEVIATSVLPHTREFTRPWPTLLVAVLYATAFYLLTIVTRAVPI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAYALWSGFGIVLIAAVNWLIFRQRLDTPAIIGLGLLISGIVVINVFSKTVSH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]