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The map label for this gene is tpx [H]

Identifier: 78357356

GI number: 78357356

Start: 2330431

End: 2330946

Strand: Direct

Name: tpx [H]

Synonym: Dde_2313

Alternate gene names: 78357356

Gene position: 2330431-2330946 (Clockwise)

Preceding gene: 78357355

Following gene: 78357357

Centisome position: 62.47

GC content: 56.59

Gene sequence:

>516_bases
ATGAACGAACGTACCGGAATCATCACGTTTAAAGGCAACGGCCTCACCCTGCAGGGAACCCCTGTGGAAAAAGGCGGCAA
AGCCCCCGACTTTACAGTGCTTGCCAATGATCTTTCGCCCCGCACACTGGCAGACTATAAAGGAAAGGTACTTATCCTCA
GTTCGGTGCCTTCGCTCGACACCCCCGTATGCGATGTGGAAACCCGCAGGTTCAATCAGGAGGCAGCCAACCTCGGCGAT
GACGTGAAGGTGCTGACGGTGAGCGCCGACCTGCCCTTTGCGCAGGCCCGCTGGTGCGGCGCCGCCGGCATTGATGCCGT
GGAAACGCTTTCCGACCACAAAGATCTTGCTTTCGGTAATGCATACGGCGTGGTCATAAAAGAACTGCGCCTGCTGGCAA
GAGCAGTTTTCGTCGTCAACCGCGATGGCGTCATCACCTATCAGCAGATAGTGCCTGAAGTCACTTCGGAACCCGACTAC
GAAGCTGCCATTGCAGCCGCCAAAGCGGCATTGTAA

Upstream 100 bases:

>100_bases
CGAGGTAAGTTTTTTGTCTGCGCCCATTCCCATAGCAGCACTCGTGTGTTATGAGAGTAGTTCCTAATAATTCAAGACCT
CTCTCCAAAGGAGATCCGCT

Downstream 100 bases:

>100_bases
CCGGACCATGAAAGGGCGGCCTGCAGGCCGCCCTTTTTTTTCAATACGTCCACACCTGACATTTGTCGCCTCAGAACCCA
TGCCACCACGGTATGCCCCG

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Superoxide-inducible protein 8; SOI8 [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MNERTGIITFKGNGLTLQGTPVEKGGKAPDFTVLANDLSPRTLADYKGKVLILSSVPSLDTPVCDVETRRFNQEAANLGD
DVKVLTVSADLPFAQARWCGAAGIDAVETLSDHKDLAFGNAYGVVIKELRLLARAVFVVNRDGVITYQQIVPEVTSEPDY
EAAIAAAKAAL

Sequences:

>Translated_171_residues
MNERTGIITFKGNGLTLQGTPVEKGGKAPDFTVLANDLSPRTLADYKGKVLILSSVPSLDTPVCDVETRRFNQEAANLGD
DVKVLTVSADLPFAQARWCGAAGIDAVETLSDHKDLAFGNAYGVVIKELRLLARAVFVVNRDGVITYQQIVPEVTSEPDY
EAAIAAAKAAL
>Mature_171_residues
MNERTGIITFKGNGLTLQGTPVEKGGKAPDFTVLANDLSPRTLADYKGKVLILSSVPSLDTPVCDVETRRFNQEAANLGD
DVKVLTVSADLPFAQARWCGAAGIDAVETLSDHKDLAFGNAYGVVIKELRLLARAVFVVNRDGVITYQQIVPEVTSEPDY
EAAIAAAKAAL

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=165, Percent_Identity=46.0606060606061, Blast_Score=140, Evalue=7e-35,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18234; Mature: 18234

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERTGIITFKGNGLTLQGTPVEKGGKAPDFTVLANDLSPRTLADYKGKVLILSSVPSLD
CCCCCEEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCCCCHHCCCCCEEEEECCCCCC
TPVCDVETRRFNQEAANLGDDVKVLTVSADLPFAQARWCGAAGIDAVETLSDHKDLAFGN
CCCCCCHHHHCCHHHHCCCCCEEEEEEECCCCHHHHHHCCCCCCHHHHHHHCCCCCCCCC
AYGVVIKELRLLARAVFVVNRDGVITYQQIVPEVTSEPDYEAAIAAAKAAL
HHHHHHHHHHHHHHHHEEECCCCEEEHHHHCCHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNERTGIITFKGNGLTLQGTPVEKGGKAPDFTVLANDLSPRTLADYKGKVLILSSVPSLD
CCCCCEEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCCCCHHCCCCCEEEEECCCCCC
TPVCDVETRRFNQEAANLGDDVKVLTVSADLPFAQARWCGAAGIDAVETLSDHKDLAFGN
CCCCCCHHHHCCHHHHCCCCCEEEEEEECCCCHHHHHHCCCCCCHHHHHHHCCCCCCCCC
AYGVVIKELRLLARAVFVVNRDGVITYQQIVPEVTSEPDYEAAIAAAKAAL
HHHHHHHHHHHHHHHHEEECCCCEEEHHHHCCHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 9298659 [H]