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The map label for this gene is map [H]

Identifier: 78357279

GI number: 78357279

Start: 2271971

End: 2272735

Strand: Reverse

Name: map [H]

Synonym: Dde_2236

Alternate gene names: 78357279

Gene position: 2272735-2271971 (Counterclockwise)

Preceding gene: 78357280

Following gene: 78357278

Centisome position: 60.93

GC content: 53.59

Gene sequence:

>765_bases
GTGAAAAAGTATCGCGGTATCTTTCTCAAAAACGAGAAAGAGATAGGCTTCATGCGTGAAGCCAACCGGATTGTGGCTAC
AATTCTTGATGTCCTGGGCGAGAATGTTCGCCCAGGCGTCAAGACTTTGTATTTTGAAGAGCTTGCTCAGGACCTGTGCC
GTAAGCACAATGTCCGTCCTGCATTTCAGGGGTACGGGGGCTTTCCCTTTGCTCTTTGCTGCTCGGTCAACGAAGAGGTC
GTTCACGGCTTTCCTTCCGAGCGGGTATTGAAAGAAGGCGATATTGTCAGCTTTGACATGGGTGTCATTTACGAAGGCTT
CTACGGAGATTCGGCCAGAACGTATGCCGTAGGCGAGGTTCCGGACGAAACGGCCCGTCTTCTCAAGGTGACTCAGGAGT
CGCTGATGAAAGGCATTGAAAAGGCCTTGTCGGGTAACAACCTGTACGACATTTCCGCCGCTGTTCAGCAGCATGTGGAA
AATGCCGGTTTTCAGGTGGTCCGGCGCTTTGTAGGGCACGGAATTGGACGCAAGCTGCATGAAAAGCCCGAAATTCCGAA
CTTTGTACCGTTCGGCCTTCCCGGCGTACCTTTGCGCCCCGGCATGGTGCTTGCTATCGAGCCCATGGTGACGGCGGGAA
CGTATGAAGTGGAGGTGCTGTCCGACAACTGGACAGCGGTGACAAAGGACAGGAAGCTTTCGGCGCATTTCGAGCATAGC
GTTGCCATTACCTCCGACGGCCCGGTAATCCTGAGTCAGGCGTAA

Upstream 100 bases:

>100_bases
GGGTTGCCATGGACTTCATGTCCCAGGTGGAATCCCATCTGATCTCCCGACAGTACGAAGGCCTCATGAACAAGGCCCGT
ATCAAGGGAAGGCGCTGACG

Downstream 100 bases:

>100_bases
CCGGATACGTTTGTAAGTATAAGGGTTGACTCAGACAGGACGCAGTGATACTTAACCGCGTTCTGGGTCTGTTTTTACCC
AGGCACGTTGTTGCACTAAA

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKKYRGIFLKNEKEIGFMREANRIVATILDVLGENVRPGVKTLYFEELAQDLCRKHNVRPAFQGYGGFPFALCCSVNEEV
VHGFPSERVLKEGDIVSFDMGVIYEGFYGDSARTYAVGEVPDETARLLKVTQESLMKGIEKALSGNNLYDISAAVQQHVE
NAGFQVVRRFVGHGIGRKLHEKPEIPNFVPFGLPGVPLRPGMVLAIEPMVTAGTYEVEVLSDNWTAVTKDRKLSAHFEHS
VAITSDGPVILSQA

Sequences:

>Translated_254_residues
MKKYRGIFLKNEKEIGFMREANRIVATILDVLGENVRPGVKTLYFEELAQDLCRKHNVRPAFQGYGGFPFALCCSVNEEV
VHGFPSERVLKEGDIVSFDMGVIYEGFYGDSARTYAVGEVPDETARLLKVTQESLMKGIEKALSGNNLYDISAAVQQHVE
NAGFQVVRRFVGHGIGRKLHEKPEIPNFVPFGLPGVPLRPGMVLAIEPMVTAGTYEVEVLSDNWTAVTKDRKLSAHFEHS
VAITSDGPVILSQA
>Mature_254_residues
MKKYRGIFLKNEKEIGFMREANRIVATILDVLGENVRPGVKTLYFEELAQDLCRKHNVRPAFQGYGGFPFALCCSVNEEV
VHGFPSERVLKEGDIVSFDMGVIYEGFYGDSARTYAVGEVPDETARLLKVTQESLMKGIEKALSGNNLYDISAAVQQHVE
NAGFQVVRRFVGHGIGRKLHEKPEIPNFVPFGLPGVPLRPGMVLAIEPMVTAGTYEVEVLSDNWTAVTKDRKLSAHFEHS
VAITSDGPVILSQA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=253, Percent_Identity=36.7588932806324, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=36.0323886639676, Blast_Score=166, Evalue=1e-41,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=40.9638554216867, Blast_Score=198, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71996291, Length=253, Percent_Identity=34.7826086956522, Blast_Score=158, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=35.4581673306773, Blast_Score=176, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=36.2549800796813, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=32.6530612244898, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28115; Mature: 28115

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYRGIFLKNEKEIGFMREANRIVATILDVLGENVRPGVKTLYFEELAQDLCRKHNVRP
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
AFQGYGGFPFALCCSVNEEVVHGFPSERVLKEGDIVSFDMGVIYEGFYGDSARTYAVGEV
CCCCCCCCCEEEEECCCHHHHCCCCCHHHHCCCCEEEEEHHHEEECEECCCCCEEEECCC
PDETARLLKVTQESLMKGIEKALSGNNLYDISAAVQQHVENAGFQVVRRFVGHGIGRKLH
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
EKPEIPNFVPFGLPGVPLRPGMVLAIEPMVTAGTYEVEVLSDNWTAVTKDRKLSAHFEHS
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEECCCEEEEEECCCCEEEECCCCCCEECCCE
VAITSDGPVILSQA
EEEECCCCEEEECC
>Mature Secondary Structure
MKKYRGIFLKNEKEIGFMREANRIVATILDVLGENVRPGVKTLYFEELAQDLCRKHNVRP
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
AFQGYGGFPFALCCSVNEEVVHGFPSERVLKEGDIVSFDMGVIYEGFYGDSARTYAVGEV
CCCCCCCCCEEEEECCCHHHHCCCCCHHHHCCCCEEEEEHHHEEECEECCCCCEEEECCC
PDETARLLKVTQESLMKGIEKALSGNNLYDISAAVQQHVENAGFQVVRRFVGHGIGRKLH
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
EKPEIPNFVPFGLPGVPLRPGMVLAIEPMVTAGTYEVEVLSDNWTAVTKDRKLSAHFEHS
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEECCCEEEEEECCCCEEEECCCCCCEECCCE
VAITSDGPVILSQA
EEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]