Click here to switch to the map view.

The map label for this gene is siaP [H]

Identifier: 78357259

GI number: 78357259

Start: 2256015

End: 2257016

Strand: Reverse

Name: siaP [H]

Synonym: Dde_2216

Alternate gene names: 78357259

Gene position: 2257016-2256015 (Counterclockwise)

Preceding gene: 78357260

Following gene: 78357258

Centisome position: 60.51

GC content: 59.18

Gene sequence:

>1002_bases
ATGTTACTGGCCGTATGTGCGGTCTTGCTTGGAGTGTCCGGCTTTGCTTCTGTATGTCTGGGGCAGACGTACAGGCTGAC
ATACAGCAGCTTTTTTCCGCCCTCGCATGTGCAGTCCGTACTGGCGGAAGAGTGGGCGCGGGAAGTTGAAAAAAGAACAG
CAGGCGCTGTCGTCATTGATTTTTATCCTGCCGGAACCCTGACAGGGGCAAGGCAGGCCTACGACGGCGTGGTGCAGGGG
ATTTCTGACATCGGGCTCTCCGCGCTGGCGTATTCCAGAGGACGTTTTCCGCTTATGGAAGCCGTGGACCTGCCGCTGGG
GTATACCAGCGGGGCGCAGGCCACACGGGTTGCAAACAGCGTGTACAGTCACTTTGTGCCGCGCGAACTGCAGGACGTGC
ATGTGCTGTATTTTCATGCCCATGGTCCCGGGCTGCTGCATACGCGGCAAAAGGCGGTGCGCTCGCTGGAAGATATGCAG
GGCTTGAAGCTGCGTGCCACAGGAAATTCCGCCAGTGTGGTCAAAGCACTGGGCGGGACGCCCGTGGCCATGTCGATGCC
TGAATCGTATCAGTCCATCCAGCGCGGCGTGGTTGACGGCGGCATGTATCCCGCCGAAACAAACAAAGGCTGGAAAATGG
CGGAAGTTGTTGATTACTGCACGGAGGCCGTGCCCGTGGCGTATACGACAACGTTTTTTGTGGTGATGAATAAAGACCGG
TGGGAATCTCTGCCCGGTGAGGTGCAGGAGACCATCACCTGGATAAGCCGCGAGTGGGCACCGCGCCATGGTGCGGCGTG
GGACGAGAGCGACGCAGAAGGCAGGGCGTTTTTTGCAGCGCAGGGCAACAGCTTCATCACGCTGGAAGAGGCCGAGATGG
CACGCTGGAAACAGGCTGTCGAGCCGGTGGTTCAGGAGTATGTGCGGCAGGCCGCAAAGCGTGGTGTGGATGCAGAGGGC
GTGGTGGAGTTTATCCGCAATGAGCTTGCAAGCGGCCGTTGA

Upstream 100 bases:

>100_bases
CTGGCGGCGCGGGCTCTGGCCCTGGCGCTTAAGGACGGTTCTGAACAGGAACCGGCAACCGCGACAGAAAGCAGTTCGGG
AGGGTAGTGTGAAACGTCTG

Downstream 100 bases:

>100_bases
AGCCGGTGTCTTGCTTGAACAGTGATTACAGGCACGGGATATCCCGTGCCTGTTTGTCCGTAAGGGGAAACAGAAGTGAA
ATGGCTTGATGGTATGCTGT

Product: extracellular solute-binding protein

Products: NA

Alternate protein names: Extracytoplasmic solute receptor protein siaP; N-acetylneuraminic-binding protein; Neu5Ac-binding protein [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MLLAVCAVLLGVSGFASVCLGQTYRLTYSSFFPPSHVQSVLAEEWAREVEKRTAGAVVIDFYPAGTLTGARQAYDGVVQG
ISDIGLSALAYSRGRFPLMEAVDLPLGYTSGAQATRVANSVYSHFVPRELQDVHVLYFHAHGPGLLHTRQKAVRSLEDMQ
GLKLRATGNSASVVKALGGTPVAMSMPESYQSIQRGVVDGGMYPAETNKGWKMAEVVDYCTEAVPVAYTTTFFVVMNKDR
WESLPGEVQETITWISREWAPRHGAAWDESDAEGRAFFAAQGNSFITLEEAEMARWKQAVEPVVQEYVRQAAKRGVDAEG
VVEFIRNELASGR

Sequences:

>Translated_333_residues
MLLAVCAVLLGVSGFASVCLGQTYRLTYSSFFPPSHVQSVLAEEWAREVEKRTAGAVVIDFYPAGTLTGARQAYDGVVQG
ISDIGLSALAYSRGRFPLMEAVDLPLGYTSGAQATRVANSVYSHFVPRELQDVHVLYFHAHGPGLLHTRQKAVRSLEDMQ
GLKLRATGNSASVVKALGGTPVAMSMPESYQSIQRGVVDGGMYPAETNKGWKMAEVVDYCTEAVPVAYTTTFFVVMNKDR
WESLPGEVQETITWISREWAPRHGAAWDESDAEGRAFFAAQGNSFITLEEAEMARWKQAVEPVVQEYVRQAAKRGVDAEG
VVEFIRNELASGR
>Mature_333_residues
MLLAVCAVLLGVSGFASVCLGQTYRLTYSSFFPPSHVQSVLAEEWAREVEKRTAGAVVIDFYPAGTLTGARQAYDGVVQG
ISDIGLSALAYSRGRFPLMEAVDLPLGYTSGAQATRVANSVYSHFVPRELQDVHVLYFHAHGPGLLHTRQKAVRSLEDMQ
GLKLRATGNSASVVKALGGTPVAMSMPESYQSIQRGVVDGGMYPAETNKGWKMAEVVDYCTEAVPVAYTTTFFVVMNKDR
WESLPGEVQETITWISREWAPRHGAAWDESDAEGRAFFAAQGNSFITLEEAEMARWKQAVEPVVQEYVRQAAKRGVDAEG
VVEFIRNELASGR

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid. This protein specifically binds sialic acid [H]

COG id: COG1638

COG function: function code G; TRAP-type C4-dicarboxylate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 7 family [H]

Homologues:

Organism=Escherichia coli, GI1790004, Length=253, Percent_Identity=22.9249011857708, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018389
- InterPro:   IPR004682 [H]

Pfam domain/function: PF03480 SBP_bac_7 [H]

EC number: NA

Molecular weight: Translated: 36425; Mature: 36425

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAVCAVLLGVSGFASVCLGQTYRLTYSSFFPPSHVQSVLAEEWAREVEKRTAGAVVID
CHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEE
FYPAGTLTGARQAYDGVVQGISDIGLSALAYSRGRFPLMEAVDLPLGYTSGAQATRVANS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHH
VYSHFVPRELQDVHVLYFHAHGPGLLHTRQKAVRSLEDMQGLKLRATGNSASVVKALGGT
HHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCC
PVAMSMPESYQSIQRGVVDGGMYPAETNKGWKMAEVVDYCTEAVPVAYTTTFFVVMNKDR
CEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCH
WESLPGEVQETITWISREWAPRHGAAWDESDAEGRAFFAAQGNSFITLEEAEMARWKQAV
HHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEHHHHHHHHHHH
EPVVQEYVRQAAKRGVDAEGVVEFIRNELASGR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLAVCAVLLGVSGFASVCLGQTYRLTYSSFFPPSHVQSVLAEEWAREVEKRTAGAVVID
CHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEE
FYPAGTLTGARQAYDGVVQGISDIGLSALAYSRGRFPLMEAVDLPLGYTSGAQATRVANS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHH
VYSHFVPRELQDVHVLYFHAHGPGLLHTRQKAVRSLEDMQGLKLRATGNSASVVKALGGT
HHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCC
PVAMSMPESYQSIQRGVVDGGMYPAETNKGWKMAEVVDYCTEAVPVAYTTTFFVVMNKDR
CEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCH
WESLPGEVQETITWISREWAPRHGAAWDESDAEGRAFFAAQGNSFITLEEAEMARWKQAV
HHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEHHHHHHHHHHH
EPVVQEYVRQAAKRGVDAEGVVEFIRNELASGR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA