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The map label for this gene is lpxB [H]

Identifier: 78357228

GI number: 78357228

Start: 2225536

End: 2226666

Strand: Direct

Name: lpxB [H]

Synonym: Dde_2185

Alternate gene names: 78357228

Gene position: 2225536-2226666 (Clockwise)

Preceding gene: 78357227

Following gene: 78357229

Centisome position: 59.66

GC content: 58.44

Gene sequence:

>1131_bases
ATGACACAGAAGCACAAAAACATCTGGATAAGCGCCGGAGAAATGTCTGGCGACATGCATGCAGCCAATCTGATACGGGC
CCTGCAAACTCAGGATTGCGGCATAACATGCTCGGGCGTGGGCGGTCCCGACATGCGCAGTGCCGGCTTCAACGCCCTGT
TCAGGGTGGAAGATCTGTCCGTCATGGGCATAACCGAGGTTCTCGGACACCTGCCGCGGATACTCTCCATGCTGCGCTCC
ATCCGGCGCACCCTGCGGCAGATGCGCCCCGACGCCGTGGTTCTTGTTGACGCCCCCTCCTTCAACTTCCGCATAGCCCG
CTATGCCAGAGAACTGGGTATTCCCGTCTTTTATTATATAAGCCCCAAAATATGGGCATGGCGCACAGGCAGAATCCGGT
TCATACGCAGTCATGTGCATAAGGTCATCAGCATTCTGCCATTCGAAGTGGATTTTTATCGCAGCCACGGCATGGAAATA
GAGTATGTGGGCAACCCGCTGGTGGATATGGTGAACTGGGACGAAATAGACGCCATGACTCCTCTGCCGCAGCGCATAGG
GTTGCTGCCCGGCAGCCGGAAAAAAGAAATCACCTCGCTGATGCCGCAGTTTGCCGTTGCCGCAGAAATAATGCACCGAC
GTCTGCCCGGACTTGAATTCCACTGCGTACGCGCCCCGGGCATAACCGAAGATGCACTGCGCAGGCTGTGGCAAACCGAT
GTGCCGCTGCACATGCATGCCCCCGACAACCGGTACAGCTTCATGCGCAGTTGCAACATGCTCATTGCGGCATCAGGCAC
TGTCACACTGGAATCAGCGCTGCTGGGCACCCCCACGCTGGTGACATACAAAGTTTCGCCCCTGTCGTTTGCCGTGGGCA
AGCGTCTGGTCAGGGTTCCTTATGTAAGTCTGCCCAATCTTGTAATGCAGCGGGAAGTCTTTCCTGAACTGCTGCAGGAA
AACGCCGACGGCGCGGTACTGGCGCGCCACGCGCTGGCATGGCTGGAACACCCGGAACAGATGTCCGCCGTACGCGCGCA
GCTTGCCACATTGCGCACCATGCTGGGAGCCCCCGGAGCCCCTGCCCGCGCTGCCGGTATTATTCTGAAAGCACTGGGCA
CCGCCGCCTGA

Upstream 100 bases:

>100_bases
TTCGCTGCTGGCCGTGGCCCTGCTGGCCCGCCTGTACGCCCGTTTTGTCCCTTCTGCACCGCAGACCGGTGCAGGTAACC
CGCAAAAAGCCTGATTTTTG

Downstream 100 bases:

>100_bases
AATTCTCGCCGCGCGGCATAACACCGCACGGCTGCGGCCAAAGCCCGTGCAGACGCGCCTGCGGTGTACCGCCTTTTCTG
TCCTGCGGCACACAGCATGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTQKHKNIWISAGEMSGDMHAANLIRALQTQDCGITCSGVGGPDMRSAGFNALFRVEDLSVMGITEVLGHLPRILSMLRS
IRRTLRQMRPDAVVLVDAPSFNFRIARYARELGIPVFYYISPKIWAWRTGRIRFIRSHVHKVISILPFEVDFYRSHGMEI
EYVGNPLVDMVNWDEIDAMTPLPQRIGLLPGSRKKEITSLMPQFAVAAEIMHRRLPGLEFHCVRAPGITEDALRRLWQTD
VPLHMHAPDNRYSFMRSCNMLIAASGTVTLESALLGTPTLVTYKVSPLSFAVGKRLVRVPYVSLPNLVMQREVFPELLQE
NADGAVLARHALAWLEHPEQMSAVRAQLATLRTMLGAPGAPARAAGIILKALGTAA

Sequences:

>Translated_376_residues
MTQKHKNIWISAGEMSGDMHAANLIRALQTQDCGITCSGVGGPDMRSAGFNALFRVEDLSVMGITEVLGHLPRILSMLRS
IRRTLRQMRPDAVVLVDAPSFNFRIARYARELGIPVFYYISPKIWAWRTGRIRFIRSHVHKVISILPFEVDFYRSHGMEI
EYVGNPLVDMVNWDEIDAMTPLPQRIGLLPGSRKKEITSLMPQFAVAAEIMHRRLPGLEFHCVRAPGITEDALRRLWQTD
VPLHMHAPDNRYSFMRSCNMLIAASGTVTLESALLGTPTLVTYKVSPLSFAVGKRLVRVPYVSLPNLVMQREVFPELLQE
NADGAVLARHALAWLEHPEQMSAVRAQLATLRTMLGAPGAPARAAGIILKALGTAA
>Mature_375_residues
TQKHKNIWISAGEMSGDMHAANLIRALQTQDCGITCSGVGGPDMRSAGFNALFRVEDLSVMGITEVLGHLPRILSMLRSI
RRTLRQMRPDAVVLVDAPSFNFRIARYARELGIPVFYYISPKIWAWRTGRIRFIRSHVHKVISILPFEVDFYRSHGMEIE
YVGNPLVDMVNWDEIDAMTPLPQRIGLLPGSRKKEITSLMPQFAVAAEIMHRRLPGLEFHCVRAPGITEDALRRLWQTDV
PLHMHAPDNRYSFMRSCNMLIAASGTVTLESALLGTPTLVTYKVSPLSFAVGKRLVRVPYVSLPNLVMQREVFPELLQEN
ADGAVLARHALAWLEHPEQMSAVRAQLATLRTMLGAPGAPARAAGIILKALGTAA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=331, Percent_Identity=33.8368580060423, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41893; Mature: 41762

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKHKNIWISAGEMSGDMHAANLIRALQTQDCGITCSGVGGPDMRSAGFNALFRVEDLS
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCH
VMGITEVLGHLPRILSMLRSIRRTLRQMRPDAVVLVDAPSFNFRIARYARELGIPVFYYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEE
SPKIWAWRTGRIRFIRSHVHKVISILPFEVDFYRSHGMEIEYVGNPLVDMVNWDEIDAMT
CCEEEEEECCHHHHHHHHHHHHHHHCCCEEEHHHHCCCEEEECCCCHHHHCCCCHHCCCC
PLPQRIGLLPGSRKKEITSLMPQFAVAAEIMHRRLPGLEFHCVRAPGITEDALRRLWQTD
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCC
VPLHMHAPDNRYSFMRSCNMLIAASGTVTLESALLGTPTLVTYKVSPLSFAVGKRLVRVP
CCEEEECCCCHHHHHHHCCEEEEECCCEEEHHHHCCCCEEEEEEECCHHHHHHHHHHHCC
YVSLPNLVMQREVFPELLQENADGAVLARHALAWLEHPEQMSAVRAQLATLRTMLGAPGA
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
PARAAGIILKALGTAA
CHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQKHKNIWISAGEMSGDMHAANLIRALQTQDCGITCSGVGGPDMRSAGFNALFRVEDLS
CCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCH
VMGITEVLGHLPRILSMLRSIRRTLRQMRPDAVVLVDAPSFNFRIARYARELGIPVFYYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEE
SPKIWAWRTGRIRFIRSHVHKVISILPFEVDFYRSHGMEIEYVGNPLVDMVNWDEIDAMT
CCEEEEEECCHHHHHHHHHHHHHHHCCCEEEHHHHCCCEEEECCCCHHHHCCCCHHCCCC
PLPQRIGLLPGSRKKEITSLMPQFAVAAEIMHRRLPGLEFHCVRAPGITEDALRRLWQTD
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCC
VPLHMHAPDNRYSFMRSCNMLIAASGTVTLESALLGTPTLVTYKVSPLSFAVGKRLVRVP
CCEEEECCCCHHHHHHHCCEEEEECCCEEEHHHHCCCCEEEEEEECCHHHHHHHHHHHCC
YVSLPNLVMQREVFPELLQENADGAVLARHALAWLEHPEQMSAVRAQLATLRTMLGAPGA
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
PARAAGIILKALGTAA
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA