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The map label for this gene is trxB [H]

Identifier: 78357194

GI number: 78357194

Start: 2196462

End: 2197355

Strand: Direct

Name: trxB [H]

Synonym: Dde_2151

Alternate gene names: 78357194

Gene position: 2196462-2197355 (Clockwise)

Preceding gene: 78357193

Following gene: 78357195

Centisome position: 58.88

GC content: 50.45

Gene sequence:

>894_bases
ATGCATACCCCCCTAGTCATCATCGGTTCCGGCCCTGCCGGACTGTCTTCCGCCATCTACACCTGCAGATCCGGCATTGA
TACAATCGTATTCGGCTCAAAGCCCAAAGTTGCCGGAGATTATGAGATAGACAACTATTTCGGATTTGAAGAAACAATTT
CCGGCAAAGAACTGCTGGAAAAAGGGCGGGCGCAGGCCGAGCGCTTCGGTGCCCGCTTTAAAGAAGACAGGGTGCTCTCT
GTACATCATAACGAAAGCGGAGGCTTTCATATAAAAACTGAGCACGAAGAATTTGACGCATGCGCGGTAATTCTGGCCAC
CGGCGTGGGCAGAGTCCGTCCGGGCATAAGCAACCTGAAAGATTACGAGGGCAAAGGAGTATCCTACTGCGTAAGTTGTG
ACGGTTTTTTTTATAAAAACCGAAAAGTTATCGTAGTCGGAGAAGGCATCTACGCCGCCAATCAGGCTCTTGAACTCTTG
TCGTATACGCCCCACGTAACCATAATCACGCAAGGGAAAAAATCGTCCATCACTCCGGAATTCCAGCAACGCCTTAGTGC
TGCCGGCATAACCGTTTCAGAACAAAAAATCGAAACCCTTTCCGGCTCTCCGGCACTGTCATCCGTTACCTTGTCGGACG
GGACAAGCCTTGAGGCCGAAGGTATTTTCATTGCCATGGGCGAAGCTTCTTCACTTGATTTTGCTTATACTCTGGGGCTG
GAACGCAGCGGCGTCTTTCTGGTGGCAGACAAAGAACAAAAAACCAACATTCCCGGAATATACGCTGCAGGCGACTGCAC
AGGCGGTTTTTTGCAAATTGCAGTAGCAGTTGGCGAAGGAGCCACTGCTGCACGCTCGGCCATTGCCCACATCAAAGAAA
ATTGCAAAGGCTGA

Upstream 100 bases:

>100_bases
CCGCCCCCCACGGCTTTTAAATTTTACCCTTGCCAGCCACAGATATGATTCCCATATTAGATAATGTGTTTTTTCCAACC
CTCACACGGAGGCTGTGATC

Downstream 100 bases:

>100_bases
AAGCAAACAGGCACCATAACATATTGACACCCCTCGTGGCTGGTGATATCTAGCTCAGCTCGTTGGACGCAAAAGGGCCT
ATAGCTCAGTTGGCAGAGCC

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MHTPLVIIGSGPAGLSSAIYTCRSGIDTIVFGSKPKVAGDYEIDNYFGFEETISGKELLEKGRAQAERFGARFKEDRVLS
VHHNESGGFHIKTEHEEFDACAVILATGVGRVRPGISNLKDYEGKGVSYCVSCDGFFYKNRKVIVVGEGIYAANQALELL
SYTPHVTIITQGKKSSITPEFQQRLSAAGITVSEQKIETLSGSPALSSVTLSDGTSLEAEGIFIAMGEASSLDFAYTLGL
ERSGVFLVADKEQKTNIPGIYAAGDCTGGFLQIAVAVGEGATAARSAIAHIKENCKG

Sequences:

>Translated_297_residues
MHTPLVIIGSGPAGLSSAIYTCRSGIDTIVFGSKPKVAGDYEIDNYFGFEETISGKELLEKGRAQAERFGARFKEDRVLS
VHHNESGGFHIKTEHEEFDACAVILATGVGRVRPGISNLKDYEGKGVSYCVSCDGFFYKNRKVIVVGEGIYAANQALELL
SYTPHVTIITQGKKSSITPEFQQRLSAAGITVSEQKIETLSGSPALSSVTLSDGTSLEAEGIFIAMGEASSLDFAYTLGL
ERSGVFLVADKEQKTNIPGIYAAGDCTGGFLQIAVAVGEGATAARSAIAHIKENCKG
>Mature_297_residues
MHTPLVIIGSGPAGLSSAIYTCRSGIDTIVFGSKPKVAGDYEIDNYFGFEETISGKELLEKGRAQAERFGARFKEDRVLS
VHHNESGGFHIKTEHEEFDACAVILATGVGRVRPGISNLKDYEGKGVSYCVSCDGFFYKNRKVIVVGEGIYAANQALELL
SYTPHVTIITQGKKSSITPEFQQRLSAAGITVSEQKIETLSGSPALSSVTLSDGTSLEAEGIFIAMGEASSLDFAYTLGL
ERSGVFLVADKEQKTNIPGIYAAGDCTGGFLQIAVAVGEGATAARSAIAHIKENCKG

Specific function: Component of the thioredoxin-thioredoxin reductase system which may be involved in biosynthesis of penicillins and cephalosporins and may be important in determining the thiol- disulfide redox balance [H]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=306, Percent_Identity=27.4509803921569, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI87081763, Length=289, Percent_Identity=26.643598615917, Blast_Score=88, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321898, Length=311, Percent_Identity=27.0096463022508, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320560, Length=317, Percent_Identity=27.1293375394322, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 31518; Mature: 31518

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTPLVIIGSGPAGLSSAIYTCRSGIDTIVFGSKPKVAGDYEIDNYFGFEETISGKELLE
CCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHCCCHHHHHH
KGRAQAERFGARFKEDRVLSVHHNESGGFHIKTEHEEFDACAVILATGVGRVRPGISNLK
HHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHH
DYEGKGVSYCVSCDGFFYKNRKVIVVGEGIYAANQALELLSYTPHVTIITQGKKSSITPE
HCCCCCEEEEEECCCEEEECCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
FQQRLSAAGITVSEQKIETLSGSPALSSVTLSDGTSLEAEGIFIAMGEASSLDFAYTLGL
HHHHHHHCCCEECHHHHHHCCCCCCCEEEEECCCCCEEECEEEEEECCCCCCCEEEEECC
ERSGVFLVADKEQKTNIPGIYAAGDCTGGFLQIAVAVGEGATAARSAIAHIKENCKG
CCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHTPLVIIGSGPAGLSSAIYTCRSGIDTIVFGSKPKVAGDYEIDNYFGFEETISGKELLE
CCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHCCCHHHHHH
KGRAQAERFGARFKEDRVLSVHHNESGGFHIKTEHEEFDACAVILATGVGRVRPGISNLK
HHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHH
DYEGKGVSYCVSCDGFFYKNRKVIVVGEGIYAANQALELLSYTPHVTIITQGKKSSITPE
HCCCCCEEEEEECCCEEEECCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
FQQRLSAAGITVSEQKIETLSGSPALSSVTLSDGTSLEAEGIFIAMGEASSLDFAYTLGL
HHHHHHHCCCEECHHHHHHCCCCCCCEEEEECCCCCEEECEEEEEECCCCCCCEEEEECC
ERSGVFLVADKEQKTNIPGIYAAGDCTGGFLQIAVAVGEGATAARSAIAHIKENCKG
CCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8349555; 8423136 [H]