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The map label for this gene is hpt [H]

Identifier: 78357155

GI number: 78357155

Start: 2161387

End: 2161917

Strand: Reverse

Name: hpt [H]

Synonym: Dde_2112

Alternate gene names: 78357155

Gene position: 2161917-2161387 (Counterclockwise)

Preceding gene: 78357156

Following gene: 78357154

Centisome position: 57.96

GC content: 54.05

Gene sequence:

>531_bases
ATGACCGTAACCGGAATGGATGTTGTATATACCGCCGAGCAGGTGCAGGAGCGTGTGCGCGAACTGGCTGTTCAGATCAA
TGCTGAGTATGAAGACAAACCGCTGGTCGTGGTGTGCGTGCTCAAAGGCGCTTTCATGTTTTTTTCCGACCTGCTCAAGC
ATTTGACAGTCCGGCCGGAAATTGATTTCGTAAGGGTAGCAAGTTACGGTAACTCGACAACCCGTTCCAGAAACATTTCC
TTTACCAAGGATCTGGAAGTGTCCATAGACGGCAAGCATGTGCTGGTGGTCGAAGACATCGTGGATACCGGCCATACCGT
GGACTTTCTGTACCGTCAGCTTGCAGCGCGCGGTGCCGCCAGCATCCGGCTGTGCGCTATAGTGGACAAGGCCGAGCGCC
GCGAGGTGGACGTGACCGTGGACTTCCCCGGATTTGCGTTGGATAAAGGGTACATTATCGGGTACGGGATGGATTACGCC
GAACAGTACAGGGAGCTTGACGCCATTTACGACGCTCATGTCGCAAACTAG

Upstream 100 bases:

>100_bases
GCAGAAGGTGTGGGCGGACTGCATCAATTGTCCGCGCTTTCCCGACTGCGATGAAGTGGCTATGATGATTGAATTGTAAC
GCAACAAAGGGCAGAAAAAG

Downstream 100 bases:

>100_bases
CCTCAGGGCATATACTTGTAACAGGATAAACGATGCACGTTACCTGCCCGAACTGCAAGACAGTATACAATCTTGCGGAA
GAACTGGTCAGACCGGGAGC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MTVTGMDVVYTAEQVQERVRELAVQINAEYEDKPLVVVCVLKGAFMFFSDLLKHLTVRPEIDFVRVASYGNSTTRSRNIS
FTKDLEVSIDGKHVLVVEDIVDTGHTVDFLYRQLAARGAASIRLCAIVDKAERREVDVTVDFPGFALDKGYIIGYGMDYA
EQYRELDAIYDAHVAN

Sequences:

>Translated_176_residues
MTVTGMDVVYTAEQVQERVRELAVQINAEYEDKPLVVVCVLKGAFMFFSDLLKHLTVRPEIDFVRVASYGNSTTRSRNIS
FTKDLEVSIDGKHVLVVEDIVDTGHTVDFLYRQLAARGAASIRLCAIVDKAERREVDVTVDFPGFALDKGYIIGYGMDYA
EQYRELDAIYDAHVAN
>Mature_175_residues
TVTGMDVVYTAEQVQERVRELAVQINAEYEDKPLVVVCVLKGAFMFFSDLLKHLTVRPEIDFVRVASYGNSTTRSRNISF
TKDLEVSIDGKHVLVVEDIVDTGHTVDFLYRQLAARGAASIRLCAIVDKAERREVDVTVDFPGFALDKGYIIGYGMDYAE
QYRELDAIYDAHVAN

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=164, Percent_Identity=29.8780487804878, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI9910262, Length=164, Percent_Identity=29.8780487804878, Blast_Score=85, Evalue=4e-17,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=39.1566265060241, Blast_Score=137, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=170, Percent_Identity=38.8235294117647, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19805; Mature: 19674

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTGMDVVYTAEQVQERVRELAVQINAEYEDKPLVVVCVLKGAFMFFSDLLKHLTVRPE
CEECCCHHEEEHHHHHHHHHHHHEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCC
IDFVRVASYGNSTTRSRNISFTKDLEVSIDGKHVLVVEDIVDTGHTVDFLYRQLAARGAA
CCEEEEEECCCCCCCCCCCEEEECEEEEECCCEEEEEEEHHCCCCHHHHHHHHHHHCCCC
SIRLCAIVDKAERREVDVTVDFPGFALDKGYIIGYGMDYAEQYRELDAIYDAHVAN
CEEEEEEECCCCCCEEEEEEECCCEEECCCEEEEECCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVTGMDVVYTAEQVQERVRELAVQINAEYEDKPLVVVCVLKGAFMFFSDLLKHLTVRPE
EECCCHHEEEHHHHHHHHHHHHEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCC
IDFVRVASYGNSTTRSRNISFTKDLEVSIDGKHVLVVEDIVDTGHTVDFLYRQLAARGAA
CCEEEEEECCCCCCCCCCCEEEECEEEEECCCEEEEEEEHHCCCCHHHHHHHHHHHCCCC
SIRLCAIVDKAERREVDVTVDFPGFALDKGYIIGYGMDYAEQYRELDAIYDAHVAN
CEEEEEEECCCCCCEEEEEEECCCEEECCCEEEEECCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]