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The map label for this gene is fusA

Identifier: 78357106

GI number: 78357106

Start: 2106035

End: 2108077

Strand: Reverse

Name: fusA

Synonym: Dde_2063

Alternate gene names: 78357106

Gene position: 2108077-2106035 (Counterclockwise)

Preceding gene: 78357107

Following gene: 78357105

Centisome position: 56.51

GC content: 55.9

Gene sequence:

>2043_bases
ATGACAGCCAAATCTCATTCTGATGAGTACATGAAGTCTTTGCGCAATATCGGGGTCATTGCCCATATCGATGCGGGAAA
AACTACTCTTACTGAACGTTTTTTGTATTATTCAGAAAAGATACACAGAATGGGAGAGGTGCATGACGGCACTGCCACCA
TGGATTACCTGCCCGAAGAGCAGGAACGCGGAATCACCATTACGTCAGCTTGTACTACCTGCCGTTGGAAAGACCACGAT
ATTAACATCATAGACACCCCGGGGCATGTCGATTTCACCATTGAGGTGGAACGCTCGTTGCGCGTTCTTGACGGCGCGGT
GGGCGTTTTCTGCGCCGTTGGCGGCGTTGAACCGCAGTCGGAGACCGTCTGGCGGCAGTCTCAGCGTTTCAACGTGCCCA
AGCTGGCATTTATTAACAAAATGGACAGAGTCGGCGCGGATTTTGAGCGCGTGCTGGGCGATATCCGTTCCAGACTCAAA
GCCAACGCCGTGGCAGTGCAGATTCCCGTAGGACAGGGAGAAACGTTTGAGGCCGTCATTGATCTTGTACACATGCGGCG
CATCGATTTTGATGCTTCTGATTACGGAAAAACATATTCTTTTTCAGATCTTTCAGAGCAGGAACTGTCGCTTGCAGAAT
CATGGCGCGAGCGTCTGATCGAGGCGTTGGCAGATTTTGACGACGGGCTTCTTGCGGCGTATCTCTCCGGAGAGGCTGTT
TGTGCAGACCAGCTTGAAGCACACCTGCGCACGGCTACGCTGGAGCATGGTCTGGTTCCTGTTTTTGCCGGCTCTGCCCT
GCGTAATGTGGGTGTCCAGCCTGTGATGGATGCTGTGTGCAGGTACCTTCCGGGACCTGCTGATGTGCCCGCTCCGGCCG
GAGTAACTGAAAACGGAAACATTCAGCTGGCCATTACTCCTGATGCTCCGCTTGCCGCACTGGTTTTTAAGGTCATCATG
GAAGGGTCGCGCGCTGTTGCGCTTATACGGCTGTATTCCGGTGTGCTGCACGAAGGGACCGCGTGCTGGAACAGCAGCCG
TCAGTGTTTTGAAAAGGCTGCCCAGCTTTTCCGGCTGCATGCGGGGCGCAGAGAGCGTATGGAACAGGCGCGTGCCGGGG
AAATTGTAGGCGTTGTGGGGTTTAAGCAGGCCCGCACCGGCGATACGCTGACGGATAAAGGCTCGCCGGTCGTGCTCGAA
AACATCCAGCAGTACCGCCCTGTTATTTCATTGGCTCTGGAACCCCGTAATGCTGAAGAAGCTGAAAAGCTGGACGATGT
GCTTTCGCGCGTGCTGGTGGAAGACCCCACCCTTACACTTGAACATGACGAAGACTCCGGACAGCGGGTGCTTTCGGGCA
TGGGCGAACTGCATCTGGAGGTGGTGCTCGAGCGGTTGCGCCGCGAATATGGTGTGTCTCCCCGTTCCGGAAATCCTCAG
GTTGTCTATCAGGAAACGGTACGCATGACCGCGGAAGCGGAAGCTGAATTTGACCGTGAACTGGGTGATACCCGTCTGTA
CGGGCACGTGGCGGTACGTCTAGAACCGCTGGAACGGGATGCCGGTGTGGATGTGCAGACGGCGGTAGATGACGAGACAA
TTCCTGAAAGCTGGATAGCCGAAGCTGTGCAGGGAGTGAAGGACTGTCTGTTGAGCGGAGTGGTCAAAGGCTTTCCCGTA
CAGGATGTCAGGGTGACAGTTACGGCTCTGTACCGCACAGACGGGGTCTCTTCCGCCGCCGGGTACCGCATGGCTGCCGT
GGCTGCCGTGAAGGCGGCGCTGGAAAAAGCCGGTCCGGTTCTTCTTGAGCCCATAATGACAGTGGAAATTTCTGTACCCG
CAGAGTTTGTCGGCGAAGCCATCAGCCTGATGGGTGCCAAAGGGGGGCGTGTGGAAGAAATGCTTGACCAGAGCGGCGTT
AAAATCGTGCGCGGCATAGCCCCCATGCGGATGCTTTTCGGTTTCACCACGCAGTTGCGCAGCGCGACACAGGGGCGTGC
GGCCCTTGTGCTCACCTTTAACCGTTTTGACATGCTGCAGTAA

Upstream 100 bases:

>100_bases
GCTTTCCCGCGCTTTTTTTACTGAGCAATCTGTTTCTTTCACCGGGTAATGTTCTGTCTCTTTTTCCATCGCATGATTAA
CAGCAGGTCTGGTACCGAGT

Downstream 100 bases:

>100_bases
CCGTTGGTGTGTATATCACTTTGCGGAGGAAAAAAGATCCGTGCATTGGTGGGCTTCTTTCAGGCGCCTGTTGCGTTTTC
AATACCTCAGGCTGCTGCGC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G 2 [H]

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTAKSHSDEYMKSLRNIGVIAHIDAGKTTLTERFLYYSEKIHRMGEVHDGTATMDYLPEEQERGITITSACTTCRWKDHD
INIIDTPGHVDFTIEVERSLRVLDGAVGVFCAVGGVEPQSETVWRQSQRFNVPKLAFINKMDRVGADFERVLGDIRSRLK
ANAVAVQIPVGQGETFEAVIDLVHMRRIDFDASDYGKTYSFSDLSEQELSLAESWRERLIEALADFDDGLLAAYLSGEAV
CADQLEAHLRTATLEHGLVPVFAGSALRNVGVQPVMDAVCRYLPGPADVPAPAGVTENGNIQLAITPDAPLAALVFKVIM
EGSRAVALIRLYSGVLHEGTACWNSSRQCFEKAAQLFRLHAGRRERMEQARAGEIVGVVGFKQARTGDTLTDKGSPVVLE
NIQQYRPVISLALEPRNAEEAEKLDDVLSRVLVEDPTLTLEHDEDSGQRVLSGMGELHLEVVLERLRREYGVSPRSGNPQ
VVYQETVRMTAEAEAEFDRELGDTRLYGHVAVRLEPLERDAGVDVQTAVDDETIPESWIAEAVQGVKDCLLSGVVKGFPV
QDVRVTVTALYRTDGVSSAAGYRMAAVAAVKAALEKAGPVLLEPIMTVEISVPAEFVGEAISLMGAKGGRVEEMLDQSGV
KIVRGIAPMRMLFGFTTQLRSATQGRAALVLTFNRFDMLQ

Sequences:

>Translated_680_residues
MTAKSHSDEYMKSLRNIGVIAHIDAGKTTLTERFLYYSEKIHRMGEVHDGTATMDYLPEEQERGITITSACTTCRWKDHD
INIIDTPGHVDFTIEVERSLRVLDGAVGVFCAVGGVEPQSETVWRQSQRFNVPKLAFINKMDRVGADFERVLGDIRSRLK
ANAVAVQIPVGQGETFEAVIDLVHMRRIDFDASDYGKTYSFSDLSEQELSLAESWRERLIEALADFDDGLLAAYLSGEAV
CADQLEAHLRTATLEHGLVPVFAGSALRNVGVQPVMDAVCRYLPGPADVPAPAGVTENGNIQLAITPDAPLAALVFKVIM
EGSRAVALIRLYSGVLHEGTACWNSSRQCFEKAAQLFRLHAGRRERMEQARAGEIVGVVGFKQARTGDTLTDKGSPVVLE
NIQQYRPVISLALEPRNAEEAEKLDDVLSRVLVEDPTLTLEHDEDSGQRVLSGMGELHLEVVLERLRREYGVSPRSGNPQ
VVYQETVRMTAEAEAEFDRELGDTRLYGHVAVRLEPLERDAGVDVQTAVDDETIPESWIAEAVQGVKDCLLSGVVKGFPV
QDVRVTVTALYRTDGVSSAAGYRMAAVAAVKAALEKAGPVLLEPIMTVEISVPAEFVGEAISLMGAKGGRVEEMLDQSGV
KIVRGIAPMRMLFGFTTQLRSATQGRAALVLTFNRFDMLQ
>Mature_679_residues
TAKSHSDEYMKSLRNIGVIAHIDAGKTTLTERFLYYSEKIHRMGEVHDGTATMDYLPEEQERGITITSACTTCRWKDHDI
NIIDTPGHVDFTIEVERSLRVLDGAVGVFCAVGGVEPQSETVWRQSQRFNVPKLAFINKMDRVGADFERVLGDIRSRLKA
NAVAVQIPVGQGETFEAVIDLVHMRRIDFDASDYGKTYSFSDLSEQELSLAESWRERLIEALADFDDGLLAAYLSGEAVC
ADQLEAHLRTATLEHGLVPVFAGSALRNVGVQPVMDAVCRYLPGPADVPAPAGVTENGNIQLAITPDAPLAALVFKVIME
GSRAVALIRLYSGVLHEGTACWNSSRQCFEKAAQLFRLHAGRRERMEQARAGEIVGVVGFKQARTGDTLTDKGSPVVLEN
IQQYRPVISLALEPRNAEEAEKLDDVLSRVLVEDPTLTLEHDEDSGQRVLSGMGELHLEVVLERLRREYGVSPRSGNPQV
VYQETVRMTAEAEAEFDRELGDTRLYGHVAVRLEPLERDAGVDVQTAVDDETIPESWIAEAVQGVKDCLLSGVVKGFPVQ
DVRVTVTALYRTDGVSSAAGYRMAAVAAVKAALEKAGPVLLEPIMTVEISVPAEFVGEAISLMGAKGGRVEEMLDQSGVK
IVRGIAPMRMLFGFTTQLRSATQGRAALVLTFNRFDMLQ

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=686, Percent_Identity=38.9212827988338, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI19923640, Length=709, Percent_Identity=35.4019746121298, Blast_Score=411, Evalue=1e-114,
Organism=Homo sapiens, GI25306287, Length=708, Percent_Identity=33.4745762711864, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI25306283, Length=391, Percent_Identity=41.1764705882353, Blast_Score=280, Evalue=4e-75,
Organism=Homo sapiens, GI4503483, Length=464, Percent_Identity=25.8620689655172, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI94966754, Length=152, Percent_Identity=36.8421052631579, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI157426893, Length=149, Percent_Identity=34.8993288590604, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI310132016, Length=119, Percent_Identity=38.655462184874, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI310110807, Length=119, Percent_Identity=38.655462184874, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI310123363, Length=119, Percent_Identity=38.655462184874, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789738, Length=679, Percent_Identity=42.5625920471281, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1790835, Length=495, Percent_Identity=25.2525252525253, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI48994988, Length=177, Percent_Identity=35.5932203389831, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788922, Length=153, Percent_Identity=39.2156862745098, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1789737, Length=135, Percent_Identity=31.8518518518519, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI1790412, Length=135, Percent_Identity=31.8518518518519, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17533571, Length=683, Percent_Identity=34.8462664714495, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17556745, Length=632, Percent_Identity=30.5379746835443, Blast_Score=281, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI17557151, Length=178, Percent_Identity=35.3932584269663, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=438, Percent_Identity=26.2557077625571, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988819, Length=138, Percent_Identity=34.0579710144928, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988811, Length=138, Percent_Identity=34.0579710144928, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323098, Length=675, Percent_Identity=37.037037037037, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322359, Length=777, Percent_Identity=29.98712998713, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324707, Length=437, Percent_Identity=25.4004576659039, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320593, Length=437, Percent_Identity=25.4004576659039, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323320, Length=151, Percent_Identity=32.4503311258278, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324166, Length=147, Percent_Identity=34.0136054421769, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324761, Length=135, Percent_Identity=31.8518518518519, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24582462, Length=688, Percent_Identity=35.1744186046512, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI221458488, Length=704, Percent_Identity=32.1022727272727, Blast_Score=331, Evalue=9e-91,
Organism=Drosophila melanogaster, GI24585711, Length=438, Percent_Identity=26.2557077625571, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585713, Length=438, Percent_Identity=26.2557077625571, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585709, Length=438, Percent_Identity=26.2557077625571, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI78706572, Length=192, Percent_Identity=33.8541666666667, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574573, Length=143, Percent_Identity=36.3636363636364, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 74529; Mature: 74398

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKSHSDEYMKSLRNIGVIAHIDAGKTTLTERFLYYSEKIHRMGEVHDGTATMDYLPEE
CCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCH
QERGITITSACTTCRWKDHDINIIDTPGHVDFTIEVERSLRVLDGAVGVFCAVGGVEPQS
HHCCEEEEECCCCCEECCCCCEEEECCCCEEEEEEECHHHHHHHHHHHHHHEECCCCCCH
ETVWRQSQRFNVPKLAFINKMDRVGADFERVLGDIRSRLKANAVAVQIPVGQGETFEAVI
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHH
DLVHMRRIDFDASDYGKTYSFSDLSEQELSLAESWRERLIEALADFDDGLLAAYLSGEAV
HHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCCHH
CADQLEAHLRTATLEHGLVPVFAGSALRNVGVQPVMDAVCRYLPGPADVPAPAGVTENGN
HHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
IQLAITPDAPLAALVFKVIMEGSRAVALIRLYSGVLHEGTACWNSSRQCFEKAAQLFRLH
EEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHH
AGRRERMEQARAGEIVGVVGFKQARTGDTLTDKGSPVVLENIQQYRPVISLALEPRNAEE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCHHHEEEECCCCCHH
AEKLDDVLSRVLVEDPTLTLEHDEDSGQRVLSGMGELHLEVVLERLRREYGVSPRSGNPQ
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VVYQETVRMTAEAEAEFDRELGDTRLYGHVAVRLEPLERDAGVDVQTAVDDETIPESWIA
EEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCEEECCCCCCCCHHHHH
EAVQGVKDCLLSGVVKGFPVQDVRVTVTALYRTDGVSSAAGYRMAAVAAVKAALEKAGPV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCE
LLEPIMTVEISVPAEFVGEAISLMGAKGGRVEEMLDQSGVKIVRGIAPMRMLFGFTTQLR
EECCEEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SATQGRAALVLTFNRFDMLQ
HCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
TAKSHSDEYMKSLRNIGVIAHIDAGKTTLTERFLYYSEKIHRMGEVHDGTATMDYLPEE
CCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCH
QERGITITSACTTCRWKDHDINIIDTPGHVDFTIEVERSLRVLDGAVGVFCAVGGVEPQS
HHCCEEEEECCCCCEECCCCCEEEECCCCEEEEEEECHHHHHHHHHHHHHHEECCCCCCH
ETVWRQSQRFNVPKLAFINKMDRVGADFERVLGDIRSRLKANAVAVQIPVGQGETFEAVI
HHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHH
DLVHMRRIDFDASDYGKTYSFSDLSEQELSLAESWRERLIEALADFDDGLLAAYLSGEAV
HHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCCHH
CADQLEAHLRTATLEHGLVPVFAGSALRNVGVQPVMDAVCRYLPGPADVPAPAGVTENGN
HHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
IQLAITPDAPLAALVFKVIMEGSRAVALIRLYSGVLHEGTACWNSSRQCFEKAAQLFRLH
EEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHH
AGRRERMEQARAGEIVGVVGFKQARTGDTLTDKGSPVVLENIQQYRPVISLALEPRNAEE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCHHHEEEECCCCCHH
AEKLDDVLSRVLVEDPTLTLEHDEDSGQRVLSGMGELHLEVVLERLRREYGVSPRSGNPQ
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VVYQETVRMTAEAEAEFDRELGDTRLYGHVAVRLEPLERDAGVDVQTAVDDETIPESWIA
EEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCEEECCCCCCCCHHHHH
EAVQGVKDCLLSGVVKGFPVQDVRVTVTALYRTDGVSSAAGYRMAAVAAVKAALEKAGPV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCE
LLEPIMTVEISVPAEFVGEAISLMGAKGGRVEEMLDQSGVKIVRGIAPMRMLFGFTTQLR
EECCEEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SATQGRAALVLTFNRFDMLQ
HCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA