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The map label for this gene is mutS2 [H]

Identifier: 78357097

GI number: 78357097

Start: 2098386

End: 2100701

Strand: Reverse

Name: mutS2 [H]

Synonym: Dde_2054

Alternate gene names: 78357097

Gene position: 2100701-2098386 (Counterclockwise)

Preceding gene: 78357098

Following gene: 78357096

Centisome position: 56.32

GC content: 57.56

Gene sequence:

>2316_bases
ATGCAGTCCAGAAGCGCGCACGTACTGGAATTTGATAAGGTGCTCCGGCACCTTGCCGGATATGCTGTATCCGAAGCCGG
GGCACAGGCCTGCCTTTTGCTGGCGCCCGCCGCTGACTGTGACAGCGCCAGAATGCGCTGCGCTTTTTTCCGTCAGGGAC
AGCTGTGGGCGGAACGGACAGGGTTCTCTCTTGCTCCGTTTCCTGATCTTTCAGGAGTGTTCCGTTTTCTGGAATCACCG
GCGGCTGTGCTGGATATTGACGCCCTGTGGGCCGTGCGGCAGGTGCTTGCGCAATCACGCGAGCTGGCCGTTGCCATAGG
GAGTGGCAATACGGCGGAAAACTGGCCGCTTCTGGCGCAGATGCTGGAACGTTACCGCATGCCTGAAAAGGCTCTTTCCG
GACTGATGCGTTGCCTTGGCGAAGACGGGTTGCTGCGTGATGAAAGTTCACCGGAGCTGCTGCTGGTCCGGGAAGAAATA
CGCCGTATTCACCGGCTCTGCACACGCAAGGTGAAAGAGCTGGCCAATACTTACAATCTCAGCCATTACATGCAGGATGA
GTTCCTGACGCTTTCCTCTGACAGATATGTGCTTCCTTTGAAGGCAAACTTCAAAGGCCGGCTGCAGGGAATAATTCACG
AATACTCCCAGACCGGTGAAACCTGCTATTTCGAACCCATGTTTCTTGTGGAGATCAACAACGATCTTCAGAATCTGAAA
CGGCAGGAACGCGCGGAAGAGCGCAAGATTTTTGAATATCTCACGGGTCTGCTTCGCGCAGAGATGGAAGGCGTGAACGC
GTGCTGGAACCTGCTTGTGGAAGCGGATGTGCTGCTGGCGCGGTGCGCTCTGGCCGGTGCGTTTGGCGGCATCGCCATAG
ATTTTGACGACACAAGACCCTTTTCTCTGCGCGGGGTGAAGCATCCGCTGCTGGCACTGTCTTCTGCGGATACGCATCCG
GTGGACCTTGAATTGCTGGAAGGACAGAACTGCCTGATCATCAGCGGGGGTAATGCCGGCGGCAAGACGGTAAGCCTGAA
GACCATAGGTCTTGTGGCGCTGATGGCCGCTGCCGGGCTGCCCGTGCCTGCTGCTGAAGGCAGCACCCTGCCGTGCTGGC
GTGCAGTTCATGCTTTTATCGGCGACGAACAGAGCCTTGAGGGCAATGTCAGTACGTTCACGGCTCAGATACGCAACCTT
AGTGATATCTGGCAGGAAGTCGGTAGCGGTTCGCTTGTTATTCTTGACGAATTCGGTGCGGGAACGGACCCCGCGCAGGG
CGCCGCGCTGGCTCAGGCTGTGGTTGACGAGCTTATGGAAAAGAATGTCACCGTGTGTGTGGCTACTCATTTTCCGGCTC
TCAAAGCCTATGCCCTGAGCAGGGAAGGTGTCCGCGCTGCTTCGGTGCTTTTTGATCCCGGTACCAAGAGACCTCTGTAC
CGTCTTGCCTATGATCAGGTTGGGGCCAGTCAGGCTCTGGATGTTGCCCGTGAACATGGCATGCCCGATGCTGTGCTCAG
GCGTGCGCATAACTATCTGCTGCTGGACGGAGAAGATTCAGCTGCGCTTATTGAACGTCTTAATGCCCTTGCAGTATCCA
GAGAACAGGAACTGGATGATCTTGAACGCGAAAAGCTGCGACTGAAGAGCAAGCGGGACAAGCTTGAAGCCAGATTTGAA
AAGGAGCGGCTCCGTCTTTTTGAAAGTGTGCAGGCTCAGGCGCAGGACGTGCTGCGTGACTGGAAACAGGGTAAGCGCAG
CCATAAGCAGGCGTTGAAAGACCTTGCGGCGGTGCGTCAGCGTCTTGTCAGCGAGCAGGCCGCGGCGCAGCAGGGACAGG
CCGCCCCGGTGGAAGCACTTTGCGCAGGCATGACTGTCCGTTATATTCCCTGGGGAAAAAAGGCTGTCATTGAAGAGGTT
GACGCACGCAAAGAGCGCCTTAAAGTTGACTTGAACGGTGTGTCTTTGTGGGTTTCTTGCAAGGATGTGGCCGCGTCGGT
ACCGCCTGCCGCGCCGAAGACCGTACGGCGTGAGTCGGTGGTGGCGGAAGATAACGTGCAGGAACCTGCCGGTCCGCCCA
TGCGCGCAGATCTGCGCGGGATGAGAGCCGATGTGGCCGTGGCAGAGCTTGCGGCTGTGCTTGATAACGCACTGCTTGCC
GGTACCCGCGAGGTGGAAGTGGTCCATGGCCGGGGTACAGGTGCGCTGCGGAAGGAAGTTCACGCTTTTTTGCGGAGTTT
TGCTGCGGTCGATGCTTTCCGCCTTGCACCCGAAGGGCGCGGCGGCGACGGCATGACCATTGTCGAATTGAAGTAG

Upstream 100 bases:

>100_bases
AGGTGATGAACGCCATCATGGCGGACTACAAGGGACGTGTGGACGGCAAGGCTCTCAGCGGGATGGTGCGCACCAAGCTG
CAGGCTCAGTCCAGTTAGAT

Downstream 100 bases:

>100_bases
CCTTGCATTTGCGGAGATTGTGCCATTATGTCGGGTCACGATAATTCGGCTGTACAGGCCATCAAGTCCAGACTGAATCT
TGCCGAGCTGGCGCGGCGAT

Product: DNA mismatch repair protein MutS-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 771

Protein sequence:

>771_residues
MQSRSAHVLEFDKVLRHLAGYAVSEAGAQACLLLAPAADCDSARMRCAFFRQGQLWAERTGFSLAPFPDLSGVFRFLESP
AAVLDIDALWAVRQVLAQSRELAVAIGSGNTAENWPLLAQMLERYRMPEKALSGLMRCLGEDGLLRDESSPELLLVREEI
RRIHRLCTRKVKELANTYNLSHYMQDEFLTLSSDRYVLPLKANFKGRLQGIIHEYSQTGETCYFEPMFLVEINNDLQNLK
RQERAEERKIFEYLTGLLRAEMEGVNACWNLLVEADVLLARCALAGAFGGIAIDFDDTRPFSLRGVKHPLLALSSADTHP
VDLELLEGQNCLIISGGNAGGKTVSLKTIGLVALMAAAGLPVPAAEGSTLPCWRAVHAFIGDEQSLEGNVSTFTAQIRNL
SDIWQEVGSGSLVILDEFGAGTDPAQGAALAQAVVDELMEKNVTVCVATHFPALKAYALSREGVRAASVLFDPGTKRPLY
RLAYDQVGASQALDVAREHGMPDAVLRRAHNYLLLDGEDSAALIERLNALAVSREQELDDLEREKLRLKSKRDKLEARFE
KERLRLFESVQAQAQDVLRDWKQGKRSHKQALKDLAAVRQRLVSEQAAAQQGQAAPVEALCAGMTVRYIPWGKKAVIEEV
DARKERLKVDLNGVSLWVSCKDVAASVPPAAPKTVRRESVVAEDNVQEPAGPPMRADLRGMRADVAVAELAAVLDNALLA
GTREVEVVHGRGTGALRKEVHAFLRSFAAVDAFRLAPEGRGGDGMTIVELK

Sequences:

>Translated_771_residues
MQSRSAHVLEFDKVLRHLAGYAVSEAGAQACLLLAPAADCDSARMRCAFFRQGQLWAERTGFSLAPFPDLSGVFRFLESP
AAVLDIDALWAVRQVLAQSRELAVAIGSGNTAENWPLLAQMLERYRMPEKALSGLMRCLGEDGLLRDESSPELLLVREEI
RRIHRLCTRKVKELANTYNLSHYMQDEFLTLSSDRYVLPLKANFKGRLQGIIHEYSQTGETCYFEPMFLVEINNDLQNLK
RQERAEERKIFEYLTGLLRAEMEGVNACWNLLVEADVLLARCALAGAFGGIAIDFDDTRPFSLRGVKHPLLALSSADTHP
VDLELLEGQNCLIISGGNAGGKTVSLKTIGLVALMAAAGLPVPAAEGSTLPCWRAVHAFIGDEQSLEGNVSTFTAQIRNL
SDIWQEVGSGSLVILDEFGAGTDPAQGAALAQAVVDELMEKNVTVCVATHFPALKAYALSREGVRAASVLFDPGTKRPLY
RLAYDQVGASQALDVAREHGMPDAVLRRAHNYLLLDGEDSAALIERLNALAVSREQELDDLEREKLRLKSKRDKLEARFE
KERLRLFESVQAQAQDVLRDWKQGKRSHKQALKDLAAVRQRLVSEQAAAQQGQAAPVEALCAGMTVRYIPWGKKAVIEEV
DARKERLKVDLNGVSLWVSCKDVAASVPPAAPKTVRRESVVAEDNVQEPAGPPMRADLRGMRADVAVAELAAVLDNALLA
GTREVEVVHGRGTGALRKEVHAFLRSFAAVDAFRLAPEGRGGDGMTIVELK
>Mature_771_residues
MQSRSAHVLEFDKVLRHLAGYAVSEAGAQACLLLAPAADCDSARMRCAFFRQGQLWAERTGFSLAPFPDLSGVFRFLESP
AAVLDIDALWAVRQVLAQSRELAVAIGSGNTAENWPLLAQMLERYRMPEKALSGLMRCLGEDGLLRDESSPELLLVREEI
RRIHRLCTRKVKELANTYNLSHYMQDEFLTLSSDRYVLPLKANFKGRLQGIIHEYSQTGETCYFEPMFLVEINNDLQNLK
RQERAEERKIFEYLTGLLRAEMEGVNACWNLLVEADVLLARCALAGAFGGIAIDFDDTRPFSLRGVKHPLLALSSADTHP
VDLELLEGQNCLIISGGNAGGKTVSLKTIGLVALMAAAGLPVPAAEGSTLPCWRAVHAFIGDEQSLEGNVSTFTAQIRNL
SDIWQEVGSGSLVILDEFGAGTDPAQGAALAQAVVDELMEKNVTVCVATHFPALKAYALSREGVRAASVLFDPGTKRPLY
RLAYDQVGASQALDVAREHGMPDAVLRRAHNYLLLDGEDSAALIERLNALAVSREQELDDLEREKLRLKSKRDKLEARFE
KERLRLFESVQAQAQDVLRDWKQGKRSHKQALKDLAAVRQRLVSEQAAAQQGQAAPVEALCAGMTVRYIPWGKKAVIEEV
DARKERLKVDLNGVSLWVSCKDVAASVPPAAPKTVRRESVVAEDNVQEPAGPPMRADLRGMRADVAVAELAAVLDNALLA
GTREVEVVHGRGTGALRKEVHAFLRSFAAVDAFRLAPEGRGGDGMTIVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=224, Percent_Identity=29.4642857142857, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI4504191, Length=357, Percent_Identity=28.2913165266106, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284813531, Length=362, Percent_Identity=24.8618784530387, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI26638666, Length=295, Percent_Identity=27.1186440677966, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4505253, Length=295, Percent_Identity=27.1186440677966, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4557761, Length=129, Percent_Identity=39.5348837209302, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI26638664, Length=296, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1789089, Length=291, Percent_Identity=28.1786941580756, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539736, Length=191, Percent_Identity=31.9371727748691, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534743, Length=314, Percent_Identity=26.1146496815287, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=309, Percent_Identity=23.6245954692557, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321109, Length=241, Percent_Identity=26.1410788381743, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324482, Length=180, Percent_Identity=31.1111111111111, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=245, Percent_Identity=24.0816326530612, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320302, Length=217, Percent_Identity=26.2672811059908, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24584320, Length=218, Percent_Identity=27.9816513761468, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664545, Length=313, Percent_Identity=24.2811501597444, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 84543; Mature: 84543

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSRSAHVLEFDKVLRHLAGYAVSEAGAQACLLLAPAADCDSARMRCAFFRQGQLWAERT
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHC
GFSLAPFPDLSGVFRFLESPAAVLDIDALWAVRQVLAQSRELAVAIGSGNTAENWPLLAQ
CCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
MLERYRMPEKALSGLMRCLGEDGLLRDESSPELLLVREEIRRIHRLCTRKVKELANTYNL
HHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
SHYMQDEFLTLSSDRYVLPLKANFKGRLQGIIHEYSQTGETCYFEPMFLVEINNDLQNLK
HHHHCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCEEEEEECCHHHHHH
RQERAEERKIFEYLTGLLRAEMEGVNACWNLLVEADVLLARCALAGAFGGIAIDFDDTRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
FSLRGVKHPLLALSSADTHPVDLELLEGQNCLIISGGNAGGKTVSLKTIGLVALMAAAGL
CEECCCCCHHHEECCCCCCCCEEEEECCCCEEEEECCCCCCCEEEHHHHHHHHHHHHCCC
PVPAAEGSTLPCWRAVHAFIGDEQSLEGNVSTFTAQIRNLSDIWQEVGSGSLVILDEFGA
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GTDPAQGAALAQAVVDELMEKNVTVCVATHFPALKAYALSREGVRAASVLFDPGTKRPLY
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCEEHEEECCCCCCCHH
RLAYDQVGASQALDVAREHGMPDAVLRRAHNYLLLDGEDSAALIERLNALAVSREQELDD
HHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHH
LEREKLRLKSKRDKLEARFEKERLRLFESVQAQAQDVLRDWKQGKRSHKQALKDLAAVRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLVSEQAAAQQGQAAPVEALCAGMTVRYIPWGKKAVIEEVDARKERLKVDLNGVSLWVSC
HHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHEEEEECCEEEEEEE
KDVAASVPPAAPKTVRRESVVAEDNVQEPAGPPMRADLRGMRADVAVAELAAVLDNALLA
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GTREVEVVHGRGTGALRKEVHAFLRSFAAVDAFRLAPEGRGGDGMTIVELK
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MQSRSAHVLEFDKVLRHLAGYAVSEAGAQACLLLAPAADCDSARMRCAFFRQGQLWAERT
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHC
GFSLAPFPDLSGVFRFLESPAAVLDIDALWAVRQVLAQSRELAVAIGSGNTAENWPLLAQ
CCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
MLERYRMPEKALSGLMRCLGEDGLLRDESSPELLLVREEIRRIHRLCTRKVKELANTYNL
HHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
SHYMQDEFLTLSSDRYVLPLKANFKGRLQGIIHEYSQTGETCYFEPMFLVEINNDLQNLK
HHHHCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCEEEEEECCHHHHHH
RQERAEERKIFEYLTGLLRAEMEGVNACWNLLVEADVLLARCALAGAFGGIAIDFDDTRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
FSLRGVKHPLLALSSADTHPVDLELLEGQNCLIISGGNAGGKTVSLKTIGLVALMAAAGL
CEECCCCCHHHEECCCCCCCCEEEEECCCCEEEEECCCCCCCEEEHHHHHHHHHHHHCCC
PVPAAEGSTLPCWRAVHAFIGDEQSLEGNVSTFTAQIRNLSDIWQEVGSGSLVILDEFGA
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GTDPAQGAALAQAVVDELMEKNVTVCVATHFPALKAYALSREGVRAASVLFDPGTKRPLY
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCEEHEEECCCCCCCHH
RLAYDQVGASQALDVAREHGMPDAVLRRAHNYLLLDGEDSAALIERLNALAVSREQELDD
HHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHH
LEREKLRLKSKRDKLEARFEKERLRLFESVQAQAQDVLRDWKQGKRSHKQALKDLAAVRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLVSEQAAAQQGQAAPVEALCAGMTVRYIPWGKKAVIEEVDARKERLKVDLNGVSLWVSC
HHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHEEEEECCEEEEEEE
KDVAASVPPAAPKTVRRESVVAEDNVQEPAGPPMRADLRGMRADVAVAELAAVLDNALLA
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GTREVEVVHGRGTGALRKEVHAFLRSFAAVDAFRLAPEGRGGDGMTIVELK
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA