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The map label for this gene is lysC [H]

Identifier: 78357091

GI number: 78357091

Start: 2090049

End: 2091278

Strand: Direct

Name: lysC [H]

Synonym: Dde_2048

Alternate gene names: 78357091

Gene position: 2090049-2091278 (Clockwise)

Preceding gene: 78357090

Following gene: 78357092

Centisome position: 56.03

GC content: 54.07

Gene sequence:

>1230_bases
ATGCGTATTCTGGTTCAGAAGTTCGGTGGAACTTCAGTCGCAAATCTGGAATGCATGCAGCAGGTCAAGCAGAAAGTGCT
GCACGCCCGAGAAAACGGTTACAAAGTAATAGCCGTTCTTTCCGCCATGTCCGGAGAAACCAACCGGCTGCTCAACATGG
CCGGCCAGTGGTCGCAATGCCCCGACGAGGCGGAAGTGGATGCGCTCATCTCCACGGGCGAGCAGGTCTCGGTATCGCTT
TTTGCCATGCTGCTGCAGAACGAAGGCATCAAGGCCCGCTCGGTGCTTGGTTTTCAGATTCCGCTGAAAACCAATACGGC
GTACAGCCGTGCCCGCATTCTTGATATCCGCAAAGACACCCTGGTCGAACTGCTTGAAGCGCACGATGTGCTGGCCGTTG
CCGGCTTTCAGGGCATAAACGATGATAACCGCATAACCACGCTCGGTCGCGGCGGCTCCGATACTTCTGCCGTGGCGCTG
GCGGCGGCTCTGGGCTGTGAATGCGAAATTTATACTGATGTGGACGGCGTATACACGACAGACCCCAATATGTGTTCCGC
AGCCCGTAAACTGGACCGCATTTCCTATGACGAAATGCTTGAGATGGCCAGCATGGGAGCAAAGGTTCTGCAGATACGTT
CTGTGGAATTTGCAAAAAAATACAAGGTGCCTGTCCGCGTTCGCTCAACTTTTACCAATGATTCAGGAACATTGCTTACT
CAGGAGGACTCTCAGATGGAAGCCGTCATGGTATCCGGCATTGCATATGACAAGGATCAGGCACGAATTACCCTACGCGG
TGTGCCGGACACGCCCGGCGTGGCCGCGTCGCTGTTCTGTCCCCTTGCCGATGCCGGCATAGTGGTGGACATGATAGTCC
AGAACCCGAGTCTGGACGGCGTCACAGACATGACGTTCACCGTTCCCCGCAAAGACCTGACGAGAGCGCTTGAACTGGTG
GAAAAAACCAGAGCAGAAGTGGGCGCCAAGGAAGTGCTGCACGACCTCAATGTTTGCAAAGTTTCGGCAATCGGCGTCGG
CATGCGCAATCATTCGGGCGTTGCCAGCAAAACTTTTGCCACGCTGCGCAGAGAAAACATCAATATTCTGATGATCAGCA
CTTCTGAAATCAAAATAACCTGTCTGATAGAAGAAAAATACACAGAACTGGCCGTCCGCACACTGCATGATGCCTTCGGC
CTCGACAAAGATCAGTCACAGGCGGGCTGA

Upstream 100 bases:

>100_bases
GAAAATGTACTTGCCTGTCTGACCCCGCAGACGGCCGGGTTCACTGCATAAGCACAACACGGCGCCCTTTGAAACTACGC
TAAACGATTAGGATTACGGT

Downstream 100 bases:

>100_bases
CACACAATGCCATGAAGCACATAGAAATATACGACACCACGCTGCGTGACGGCACTCAGGCCGAGGATATAAACCTCAGC
ACCGAAGATAAAATCAAGAT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRILVQKFGGTSVANLECMQQVKQKVLHARENGYKVIAVLSAMSGETNRLLNMAGQWSQCPDEAEVDALISTGEQVSVSL
FAMLLQNEGIKARSVLGFQIPLKTNTAYSRARILDIRKDTLVELLEAHDVLAVAGFQGINDDNRITTLGRGGSDTSAVAL
AAALGCECEIYTDVDGVYTTDPNMCSAARKLDRISYDEMLEMASMGAKVLQIRSVEFAKKYKVPVRVRSTFTNDSGTLLT
QEDSQMEAVMVSGIAYDKDQARITLRGVPDTPGVAASLFCPLADAGIVVDMIVQNPSLDGVTDMTFTVPRKDLTRALELV
EKTRAEVGAKEVLHDLNVCKVSAIGVGMRNHSGVASKTFATLRRENINILMISTSEIKITCLIEEKYTELAVRTLHDAFG
LDKDQSQAG

Sequences:

>Translated_409_residues
MRILVQKFGGTSVANLECMQQVKQKVLHARENGYKVIAVLSAMSGETNRLLNMAGQWSQCPDEAEVDALISTGEQVSVSL
FAMLLQNEGIKARSVLGFQIPLKTNTAYSRARILDIRKDTLVELLEAHDVLAVAGFQGINDDNRITTLGRGGSDTSAVAL
AAALGCECEIYTDVDGVYTTDPNMCSAARKLDRISYDEMLEMASMGAKVLQIRSVEFAKKYKVPVRVRSTFTNDSGTLLT
QEDSQMEAVMVSGIAYDKDQARITLRGVPDTPGVAASLFCPLADAGIVVDMIVQNPSLDGVTDMTFTVPRKDLTRALELV
EKTRAEVGAKEVLHDLNVCKVSAIGVGMRNHSGVASKTFATLRRENINILMISTSEIKITCLIEEKYTELAVRTLHDAFG
LDKDQSQAG
>Mature_409_residues
MRILVQKFGGTSVANLECMQQVKQKVLHARENGYKVIAVLSAMSGETNRLLNMAGQWSQCPDEAEVDALISTGEQVSVSL
FAMLLQNEGIKARSVLGFQIPLKTNTAYSRARILDIRKDTLVELLEAHDVLAVAGFQGINDDNRITTLGRGGSDTSAVAL
AAALGCECEIYTDVDGVYTTDPNMCSAARKLDRISYDEMLEMASMGAKVLQIRSVEFAKKYKVPVRVRSTFTNDSGTLLT
QEDSQMEAVMVSGIAYDKDQARITLRGVPDTPGVAASLFCPLADAGIVVDMIVQNPSLDGVTDMTFTVPRKDLTRALELV
EKTRAEVGAKEVLHDLNVCKVSAIGVGMRNHSGVASKTFATLRRENINILMISTSEIKITCLIEEKYTELAVRTLHDAFG
LDKDQSQAG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=360, Percent_Identity=31.6666666666667, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790455, Length=454, Percent_Identity=27.9735682819383, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790376, Length=302, Percent_Identity=26.8211920529801, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=366, Percent_Identity=25.9562841530055, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44464; Mature: 44464

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVQKFGGTSVANLECMQQVKQKVLHARENGYKVIAVLSAMSGETNRLLNMAGQWSQC
CEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCHHHHHHHCCCCCCC
PDEAEVDALISTGEQVSVSLFAMLLQNEGIKARSVLGFQIPLKTNTAYSRARILDIRKDT
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHEEEECCHHH
LVELLEAHDVLAVAGFQGINDDNRITTLGRGGSDTSAVALAAALGCECEIYTDVDGVYTT
HHHHHHHCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCEEEC
DPNMCSAARKLDRISYDEMLEMASMGAKVLQIRSVEFAKKYKVPVRVRSTFTNDSGTLLT
CCHHHHHHHHHHCCCHHHHHHHHHCCHHEEEEHHHHHHHHCCCCEEEEEEEECCCCCEEE
QEDSQMEAVMVSGIAYDKDQARITLRGVPDTPGVAASLFCPLADAGIVVDMIVQNPSLDG
CCCCCHHHEEEECEEECCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCC
VTDMTFTVPRKDLTRALELVEKTRAEVGAKEVLHDLNVCKVSAIGVGMRNHSGVASKTFA
CCCCEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHH
TLRRENINILMISTSEIKITCLIEEKYTELAVRTLHDAFGLDKDQSQAG
HHHHCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRILVQKFGGTSVANLECMQQVKQKVLHARENGYKVIAVLSAMSGETNRLLNMAGQWSQC
CEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCHHHHHHHCCCCCCC
PDEAEVDALISTGEQVSVSLFAMLLQNEGIKARSVLGFQIPLKTNTAYSRARILDIRKDT
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHEEEECCHHH
LVELLEAHDVLAVAGFQGINDDNRITTLGRGGSDTSAVALAAALGCECEIYTDVDGVYTT
HHHHHHHCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCEEEC
DPNMCSAARKLDRISYDEMLEMASMGAKVLQIRSVEFAKKYKVPVRVRSTFTNDSGTLLT
CCHHHHHHHHHHCCCHHHHHHHHHCCHHEEEEHHHHHHHHCCCCEEEEEEEECCCCCEEE
QEDSQMEAVMVSGIAYDKDQARITLRGVPDTPGVAASLFCPLADAGIVVDMIVQNPSLDG
CCCCCHHHEEEECEEECCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCC
VTDMTFTVPRKDLTRALELVEKTRAEVGAKEVLHDLNVCKVSAIGVGMRNHSGVASKTFA
CCCCEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHH
TLRRENINILMISTSEIKITCLIEEKYTELAVRTLHDAFGLDKDQSQAG
HHHHCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]