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The map label for this gene is gcvT [H]

Identifier: 78357039

GI number: 78357039

Start: 2039186

End: 2040289

Strand: Direct

Name: gcvT [H]

Synonym: Dde_1996

Alternate gene names: 78357039

Gene position: 2039186-2040289 (Clockwise)

Preceding gene: 78357038

Following gene: 78357040

Centisome position: 54.67

GC content: 56.7

Gene sequence:

>1104_bases
ATGACCGCAAGGAGAAATGCCTTGGCCCAACTGCACACCACCCCGCTTACAGCATGGCACCGCGCACACGGCGCTAAAAT
GGCCCCCTTTGCCGGCTGGGATATGCCCATCCAGTATTCCGGCATCATTGCCGAACACCAGCACACCCGCAATGGCGCAT
CGGTTTTCGATATCTGCCATATGGGCGAATTTCTTCTGAAAGGCGAAGGAGCCCGCGAAGCGTTGTCACAGGTGGTCACC
CACAATCTGGCCACCCTTGCACCGGGCAAGTGCCGGTACGGCTTTCTGCTCAACGAACAAGGTGGCATTCTTGACGACCT
GATCGTCTACTGCCTGAACACCGACGAGTACATGCTGGTGGTCAACGGTGCCTGCACTGAAAGCGATTTCGAGTGGATAC
AGTCCCACATGCCCGCAACTGCCGTGCTGGACGACGTTTCCTCCGCCACGGCAAAAATAGACCTTCAGGGCCCTGAGTCC
TTGAATGTACTGGAAAAATGCTTTGCCCGCGATTTCCGCTCACTGGGCTATTTCGGATTTGAACAGGTGACACTGGACGG
TGCCTGCGTCATTGTAAGCCGGACCGGATACACAGGCGAACTCGGGTATGAGTTTTATCTGCCCTGGACAAAAGCCCTGA
TGCTCTGGGAACTCCTGCTGCAGGACAGCCGTGTGCAGCCCGCCGGTCTCGGGGCCCGCGACACGCTGCGGCTGGAAGTT
GGCCTGCCTCTTTACGGTCAGGATCTTGATGCCGCGCACACCCCTGCCGAGGCGGGATACGGCATGATGCTGAAATCAGA
AGCGGCTTACATAGGCAAAGGAAAAGATACTCAAATCAGAGAGCAGCTCATTCCCCTTATTATCCGCGGAAGGCGCAGCG
CCCGTCACAATGATATAGTCACCCTGCCCGACGGCCGGGAAGTGGGCGTTGTCACCAGCGGCTCTTTTGCACCATCTGTG
GGCAGCGCTGTGGCTCTGGCGTATATCAACGCAGAATATGCAGACAGGCAGAAATTCCTTGTGCAGGCAGCCCGTACGGC
GCTTGAAGCTGAAAAAGCCGACCTGCCTTTTTATAAAAAAGGCACAGCGCGCATCAAGCTGTAA

Upstream 100 bases:

>100_bases
GCAAACTGGTGGCGCTCATTGACGAGTTCAGAGCCATACGCCGCTCGCGCCGGGAATAACCGTCCGCCTACCTCACACCA
CTCCTGCGGCGCAAGCCGCA

Downstream 100 bases:

>100_bases
CCACAGAATTCCGAAGGCTCCACCTTTTACAGGCACGGCTTTCCGTGCCTTTTTTCATAGAGCTTATGAGAACGTTTTTT
CTTTCACCGGACGAATGGGA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTARRNALAQLHTTPLTAWHRAHGAKMAPFAGWDMPIQYSGIIAEHQHTRNGASVFDICHMGEFLLKGEGAREALSQVVT
HNLATLAPGKCRYGFLLNEQGGILDDLIVYCLNTDEYMLVVNGACTESDFEWIQSHMPATAVLDDVSSATAKIDLQGPES
LNVLEKCFARDFRSLGYFGFEQVTLDGACVIVSRTGYTGELGYEFYLPWTKALMLWELLLQDSRVQPAGLGARDTLRLEV
GLPLYGQDLDAAHTPAEAGYGMMLKSEAAYIGKGKDTQIREQLIPLIIRGRRSARHNDIVTLPDGREVGVVTSGSFAPSV
GSAVALAYINAEYADRQKFLVQAARTALEAEKADLPFYKKGTARIKL

Sequences:

>Translated_367_residues
MTARRNALAQLHTTPLTAWHRAHGAKMAPFAGWDMPIQYSGIIAEHQHTRNGASVFDICHMGEFLLKGEGAREALSQVVT
HNLATLAPGKCRYGFLLNEQGGILDDLIVYCLNTDEYMLVVNGACTESDFEWIQSHMPATAVLDDVSSATAKIDLQGPES
LNVLEKCFARDFRSLGYFGFEQVTLDGACVIVSRTGYTGELGYEFYLPWTKALMLWELLLQDSRVQPAGLGARDTLRLEV
GLPLYGQDLDAAHTPAEAGYGMMLKSEAAYIGKGKDTQIREQLIPLIIRGRRSARHNDIVTLPDGREVGVVTSGSFAPSV
GSAVALAYINAEYADRQKFLVQAARTALEAEKADLPFYKKGTARIKL
>Mature_366_residues
TARRNALAQLHTTPLTAWHRAHGAKMAPFAGWDMPIQYSGIIAEHQHTRNGASVFDICHMGEFLLKGEGAREALSQVVTH
NLATLAPGKCRYGFLLNEQGGILDDLIVYCLNTDEYMLVVNGACTESDFEWIQSHMPATAVLDDVSSATAKIDLQGPESL
NVLEKCFARDFRSLGYFGFEQVTLDGACVIVSRTGYTGELGYEFYLPWTKALMLWELLLQDSRVQPAGLGARDTLRLEVG
LPLYGQDLDAAHTPAEAGYGMMLKSEAAYIGKGKDTQIREQLIPLIIRGRRSARHNDIVTLPDGREVGVVTSGSFAPSVG
SAVALAYINAEYADRQKFLVQAARTALEAEKADLPFYKKGTARIKL

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=33.695652173913, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI257796258, Length=344, Percent_Identity=34.3023255813954, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI257796254, Length=359, Percent_Identity=30.3621169916435, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI257796256, Length=303, Percent_Identity=32.013201320132, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI24797151, Length=315, Percent_Identity=23.4920634920635, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI197927446, Length=325, Percent_Identity=25.2307692307692, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI21361378, Length=325, Percent_Identity=25.2307692307692, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789272, Length=332, Percent_Identity=36.4457831325301, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32563613, Length=325, Percent_Identity=23.6923076923077, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994045, Length=373, Percent_Identity=22.5201072386059, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994052, Length=373, Percent_Identity=22.5201072386059, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=381, Percent_Identity=33.0708661417323, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=31.2997347480106, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28571104, Length=262, Percent_Identity=26.7175572519084, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20130091, Length=322, Percent_Identity=24.5341614906832, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40245; Mature: 40114

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARRNALAQLHTTPLTAWHRAHGAKMAPFAGWDMPIQYSGIIAEHQHTRNGASVFDICH
CCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEECCEEECCCCCCCCCHHHHHHH
MGEFLLKGEGAREALSQVVTHNLATLAPGKCRYGFLLNEQGGILDDLIVYCLNTDEYMLV
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHEEEECCCCEEEE
VNGACTESDFEWIQSHMPATAVLDDVSSATAKIDLQGPESLNVLEKCFARDFRSLGYFGF
EECCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
EQVTLDGACVIVSRTGYTGELGYEFYLPWTKALMLWELLLQDSRVQPAGLGARDTLRLEV
EEEEECCEEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
GLPLYGQDLDAAHTPAEAGYGMMLKSEAAYIGKGKDTQIREQLIPLIIRGRRSARHNDIV
CCCCCCCCCCCCCCCCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCEE
TLPDGREVGVVTSGSFAPSVGSAVALAYINAEYADRQKFLVQAARTALEAEKADLPFYKK
ECCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
GTARIKL
CCEEEEC
>Mature Secondary Structure 
TARRNALAQLHTTPLTAWHRAHGAKMAPFAGWDMPIQYSGIIAEHQHTRNGASVFDICH
CCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEECCEEECCCCCCCCCHHHHHHH
MGEFLLKGEGAREALSQVVTHNLATLAPGKCRYGFLLNEQGGILDDLIVYCLNTDEYMLV
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHEEEECCCCEEEE
VNGACTESDFEWIQSHMPATAVLDDVSSATAKIDLQGPESLNVLEKCFARDFRSLGYFGF
EECCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
EQVTLDGACVIVSRTGYTGELGYEFYLPWTKALMLWELLLQDSRVQPAGLGARDTLRLEV
EEEEECCEEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEE
GLPLYGQDLDAAHTPAEAGYGMMLKSEAAYIGKGKDTQIREQLIPLIIRGRRSARHNDIV
CCCCCCCCCCCCCCCCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCEE
TLPDGREVGVVTSGSFAPSVGSAVALAYINAEYADRQKFLVQAARTALEAEKADLPFYKK
ECCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
GTARIKL
CCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA