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The map label for this gene is mscS [H]

Identifier: 78356899

GI number: 78356899

Start: 1905555

End: 1906400

Strand: Reverse

Name: mscS [H]

Synonym: Dde_1856

Alternate gene names: 78356899

Gene position: 1906400-1905555 (Counterclockwise)

Preceding gene: 78356900

Following gene: 78356898

Centisome position: 51.11

GC content: 52.6

Gene sequence:

>846_bases
ATGATCGTTGAGTTTTGGAGTTCGCATTCGGAGAGCATTATCGGTATCGGGTACAACGCCCTGTTGTGCCTTATCATTCT
TTTTGCCAGCACTATTGTCGCCAAAGGTGTCAGGCGTTCGATCAGAAAGGCAAAGGATCGCTTTGAAAAGCTTGACGCCA
CTCTGGTGCCCATCCTCTGCGCGACGGCTACCTATGTGATTTACATCATTGGCGGCGTGTTCATTCTTGATATTTTCGGT
GTGAATACGGCGAGCATCATTGCCTTGCTGGGTGCTGCCGGCATCGCCGTCGGCCTGGCGCTCAAGGACACTTTAAGCAA
TATCGCGGCCGGGATCATGCTGCTGTTTCTGCGCCCATTCCGGACCGGTGATTTTGTCGAGATCGGTTCTGTCATGGGGT
CCGTCAAAGAGATCAATCTTTTCACCACCATTCTGGAGACATTCGACGGCCTTTACATCGCCTCGCCCAACAGCGTGATC
TGGGGAAGTAGCATTAAAAATTACACGCGCAACGGCAAACGCCGCATGGATATCGTGATTGGAATCGCCTACTCCGATTC
CATAGATGCCGGACTAGACGTCTTGAAAAAAATTGCACGGGAAGAACCGCGTTTTTTGAATGACCCGGCTCCGGAGACGA
TGGTTGTTTCCATGGCGGAAAGTTGCGTAAATCTCCAGCTCCGGGGATGGGCGGCAATTGACGACTATTGGCCAACCTAC
TGGGACCTGAACAAGCGCGTCAAAGAGGAAATCGAGAAGGCCGGACTGACCATTCCATTTCCGCAACGAAGCGTCCATGT
GGTCACAGGTCCTGGAACCATCGATGTGGCGGAGGCTGGCGCATGA

Upstream 100 bases:

>100_bases
GATGTTGTCAATACAACACAGATGAGAGCAAAGCAGCAAATCGAAATAGTCGTAATTTTGAAGGCATCCATGCCGTATAG
GAGAAAATAAAGGGATGGAA

Downstream 100 bases:

>100_bases
TGCTCGCCTTTGCCAATGTTGCATCAAGCAATGCCCTTCGGGTTTGGCGCGAAAGCCTTCTTCCTCTTTTGCTGGCGACC
GGGCTGGCCGTGCTTCTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MIVEFWSSHSESIIGIGYNALLCLIILFASTIVAKGVRRSIRKAKDRFEKLDATLVPILCATATYVIYIIGGVFILDIFG
VNTASIIALLGAAGIAVGLALKDTLSNIAAGIMLLFLRPFRTGDFVEIGSVMGSVKEINLFTTILETFDGLYIASPNSVI
WGSSIKNYTRNGKRRMDIVIGIAYSDSIDAGLDVLKKIAREEPRFLNDPAPETMVVSMAESCVNLQLRGWAAIDDYWPTY
WDLNKRVKEEIEKAGLTIPFPQRSVHVVTGPGTIDVAEAGA

Sequences:

>Translated_281_residues
MIVEFWSSHSESIIGIGYNALLCLIILFASTIVAKGVRRSIRKAKDRFEKLDATLVPILCATATYVIYIIGGVFILDIFG
VNTASIIALLGAAGIAVGLALKDTLSNIAAGIMLLFLRPFRTGDFVEIGSVMGSVKEINLFTTILETFDGLYIASPNSVI
WGSSIKNYTRNGKRRMDIVIGIAYSDSIDAGLDVLKKIAREEPRFLNDPAPETMVVSMAESCVNLQLRGWAAIDDYWPTY
WDLNKRVKEEIEKAGLTIPFPQRSVHVVTGPGTIDVAEAGA
>Mature_281_residues
MIVEFWSSHSESIIGIGYNALLCLIILFASTIVAKGVRRSIRKAKDRFEKLDATLVPILCATATYVIYIIGGVFILDIFG
VNTASIIALLGAAGIAVGLALKDTLSNIAAGIMLLFLRPFRTGDFVEIGSVMGSVKEINLFTTILETFDGLYIASPNSVI
WGSSIKNYTRNGKRRMDIVIGIAYSDSIDAGLDVLKKIAREEPRFLNDPAPETMVVSMAESCVNLQLRGWAAIDDYWPTY
WDLNKRVKEEIEKAGLTIPFPQRSVHVVTGPGTIDVAEAGA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=251, Percent_Identity=38.2470119521912, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786670, Length=205, Percent_Identity=28.2926829268293, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787591, Length=206, Percent_Identity=29.6116504854369, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI2367355, Length=199, Percent_Identity=25.1256281407035, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 30621; Mature: 30621

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVEFWSSHSESIIGIGYNALLCLIILFASTIVAKGVRRSIRKAKDRFEKLDATLVPILC
CEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATATYVIYIIGGVFILDIFGVNTASIIALLGAAGIAVGLALKDTLSNIAAGIMLLFLRPF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTGDFVEIGSVMGSVKEINLFTTILETFDGLYIASPNSVIWGSSIKNYTRNGKRRMDIVI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEECCHHHHHHHCCCEEEEEEE
GIAYSDSIDAGLDVLKKIAREEPRFLNDPAPETMVVSMAESCVNLQLRGWAAIDDYWPTY
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEEECCEEEECCCCCCH
WDLNKRVKEEIEKAGLTIPFPQRSVHVVTGPGTIDVAEAGA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEECCCCCC
>Mature Secondary Structure
MIVEFWSSHSESIIGIGYNALLCLIILFASTIVAKGVRRSIRKAKDRFEKLDATLVPILC
CEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATATYVIYIIGGVFILDIFGVNTASIIALLGAAGIAVGLALKDTLSNIAAGIMLLFLRPF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTGDFVEIGSVMGSVKEINLFTTILETFDGLYIASPNSVIWGSSIKNYTRNGKRRMDIVI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEECCHHHHHHHCCCEEEEEEE
GIAYSDSIDAGLDVLKKIAREEPRFLNDPAPETMVVSMAESCVNLQLRGWAAIDDYWPTY
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEEECCEEEECCCCCCH
WDLNKRVKEEIEKAGLTIPFPQRSVHVVTGPGTIDVAEAGA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]