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The map label for this gene is mtaD [H]

Identifier: 78356855

GI number: 78356855

Start: 1861778

End: 1863100

Strand: Reverse

Name: mtaD [H]

Synonym: Dde_1812

Alternate gene names: 78356855

Gene position: 1863100-1861778 (Counterclockwise)

Preceding gene: 78356863

Following gene: 78356854

Centisome position: 49.95

GC content: 58.13

Gene sequence:

>1323_bases
ATGAAGCAACATTGTGACCGGATTATCAGAGCCGGTGTTCTTGTCACTCAGGACGAGCAGCGCCGTGTGCTTGGTGATGC
GGCTGTGGCCGTGACCGGAGACACCATAGCCGCCGTCGACCATGCTGATGTGATAGTCGCGGAATGGAGCACCGACGCTG
TAAGCGACCTTTCGGGCATGCTCGTCATGCCGGGGCTGGTCAATGCCCACACCCATGTGGCGATGACTTTTCTGCGCGGG
CTTGCCGACGATTTGCCGCTAATGCAGTGGCTCACCGAGCATATTTTTCCGGTTGAAAAGCATCTGAGTGCCGAGATAGT
CGAAGTCAGCGCTCTGCTGGGCTGCGCCGAAATGGCTGCCACGGGCACTACCACCCTGTGCGACATGTACCTTATCGAAG
ATGCCACATTCAAGGCCGTTGACCGTGCGGGGCTGCGCATGCAGGGCGGAGAAGGCCTTTTCGCCTTTCCTTCGCCGGCA
TATGCCTGCATTGAAGATGCCTTTGAACTAGTACGCCGGCAGCATGACAGGTATTCCTCTCACAGCCGCATACGTCATGC
GGTCATGCCTCACGCCGTATACACCAGCAACCCTGAAATGCTGGCCCGCTGCGCCGCGCTGGCCGGAGAACTCGGTTGCG
GGCTGCATATCCATCTGGCCGAAACCGCAGCCGAAACCGCGCAGTGCCTTGCGAGCTTCGGCAAACGCCCCATCCCTTAC
TGCCGTGATCTGGGCGTACTTTCGCCGCGTACCACTGTGGCGCATGCGGTGGATGTAACCGATGACGAGCTGGAGATACT
GCGCGAATCCGGGATTTGCGTGGCACACAACCCGGTAAGCAATATGAAGCTTGCATCAGGTGCCGCACGTGTTCCGGAAA
TGCTTGCCGCAGGTATCTGCGTAGGCATTGGTACTGACGGTGCGGCCAGTAACAACGGGCTTAATATGTTTACGGAAATG
AAAACATGCGCCCTGCTGCACAAGTTGCGCTATGCCGACCCGACCTGCGTGCCTGCGGCAACGGTGCTGGACATGGCAAC
CACGGGGGGTGCGAAGTGCGCCGGCTGGCCGGAAACCGGTGCGCTGGTGCCGGGAGCCAAGGCAGATCTCATTGCACTGG
ATTTGTCAGCCCCGAATCTGCAGCCTCTGTATTCTGCGGTTTCTCATATTGTTTATGCCGCCACAGGGCACGAAGTTACC
CACACCATGGTCGGCGGTGAATTTGTATATGAAAACGGACGACACACCAGATTTGATTATCCGGCCTTGCTGCGGGAAGT
GGCCTCTATCCGCAGGTGGGTGCAGAAAAAAATCACGGGATGA

Upstream 100 bases:

>100_bases
ACATCCCCATTTCATTTTTCACTCCTGAGTTGTTAGTTATTGCCTGACAGACGATGTCTTTATACCATATGTGATTACGC
CTGTCGCAAAGGAGACCTGA

Downstream 100 bases:

>100_bases
TCCGGCTTTCTGGCCTGTTGAAACGCTTTTATGTTGACATTTGCCGCAATCCGTATCATGGATTCCTGCTTTCAAGACAA
CAATACCGCGCAGCCTGCGC

Product: Atrazine chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKQHCDRIIRAGVLVTQDEQRRVLGDAAVAVTGDTIAAVDHADVIVAEWSTDAVSDLSGMLVMPGLVNAHTHVAMTFLRG
LADDLPLMQWLTEHIFPVEKHLSAEIVEVSALLGCAEMAATGTTTLCDMYLIEDATFKAVDRAGLRMQGGEGLFAFPSPA
YACIEDAFELVRRQHDRYSSHSRIRHAVMPHAVYTSNPEMLARCAALAGELGCGLHIHLAETAAETAQCLASFGKRPIPY
CRDLGVLSPRTTVAHAVDVTDDELEILRESGICVAHNPVSNMKLASGAARVPEMLAAGICVGIGTDGAASNNGLNMFTEM
KTCALLHKLRYADPTCVPAATVLDMATTGGAKCAGWPETGALVPGAKADLIALDLSAPNLQPLYSAVSHIVYAATGHEVT
HTMVGGEFVYENGRHTRFDYPALLREVASIRRWVQKKITG

Sequences:

>Translated_440_residues
MKQHCDRIIRAGVLVTQDEQRRVLGDAAVAVTGDTIAAVDHADVIVAEWSTDAVSDLSGMLVMPGLVNAHTHVAMTFLRG
LADDLPLMQWLTEHIFPVEKHLSAEIVEVSALLGCAEMAATGTTTLCDMYLIEDATFKAVDRAGLRMQGGEGLFAFPSPA
YACIEDAFELVRRQHDRYSSHSRIRHAVMPHAVYTSNPEMLARCAALAGELGCGLHIHLAETAAETAQCLASFGKRPIPY
CRDLGVLSPRTTVAHAVDVTDDELEILRESGICVAHNPVSNMKLASGAARVPEMLAAGICVGIGTDGAASNNGLNMFTEM
KTCALLHKLRYADPTCVPAATVLDMATTGGAKCAGWPETGALVPGAKADLIALDLSAPNLQPLYSAVSHIVYAATGHEVT
HTMVGGEFVYENGRHTRFDYPALLREVASIRRWVQKKITG
>Mature_440_residues
MKQHCDRIIRAGVLVTQDEQRRVLGDAAVAVTGDTIAAVDHADVIVAEWSTDAVSDLSGMLVMPGLVNAHTHVAMTFLRG
LADDLPLMQWLTEHIFPVEKHLSAEIVEVSALLGCAEMAATGTTTLCDMYLIEDATFKAVDRAGLRMQGGEGLFAFPSPA
YACIEDAFELVRRQHDRYSSHSRIRHAVMPHAVYTSNPEMLARCAALAGELGCGLHIHLAETAAETAQCLASFGKRPIPY
CRDLGVLSPRTTVAHAVDVTDDELEILRESGICVAHNPVSNMKLASGAARVPEMLAAGICVGIGTDGAASNNGLNMFTEM
KTCALLHKLRYADPTCVPAATVLDMATTGGAKCAGWPETGALVPGAKADLIALDLSAPNLQPLYSAVSHIVYAATGHEVT
HTMVGGEFVYENGRHTRFDYPALLREVASIRRWVQKKITG

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=377, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789249, Length=378, Percent_Identity=26.4550264550265, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082177, Length=436, Percent_Identity=24.0825688073394, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319963, Length=343, Percent_Identity=26.2390670553936, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24643849, Length=387, Percent_Identity=24.8062015503876, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47108; Mature: 47108

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHCDRIIRAGVLVTQDEQRRVLGDAAVAVTGDTIAAVDHADVIVAEWSTDAVSDLSGM
CCHHHHHHHHCCEEEECCHHHHHHCCEEEEEECCEEEEECCCCEEEEECCCHHHHHCCCC
LVMPGLVNAHTHVAMTFLRGLADDLPLMQWLTEHIFPVEKHLSAEIVEVSALLGCAEMAA
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TGTTTLCDMYLIEDATFKAVDRAGLRMQGGEGLFAFPSPAYACIEDAFELVRRQHDRYSS
CCCHHHHHHHHHCCCHHHHHHHCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
HSRIRHAVMPHAVYTSNPEMLARCAALAGELGCGLHIHLAETAAETAQCLASFGKRPIPY
HHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCH
CRDLGVLSPRTTVAHAVDVTDDELEILRESGICVAHNPVSNMKLASGAARVPEMLAAGIC
HHHCCCCCCCCHHHEEECCCCHHHHHHHHCCCEEEECCCCCCEECCCHHHHHHHHHCCCE
VGIGTDGAASNNGLNMFTEMKTCALLHKLRYADPTCVPAATVLDMATTGGAKCAGWPETG
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
ALVPGAKADLIALDLSAPNLQPLYSAVSHIVYAATGHEVTHTMVGGEFVYENGRHTRFDY
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHEEEECCCCEEHEEECCEEEEECCCCCCCCH
PALLREVASIRRWVQKKITG
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQHCDRIIRAGVLVTQDEQRRVLGDAAVAVTGDTIAAVDHADVIVAEWSTDAVSDLSGM
CCHHHHHHHHCCEEEECCHHHHHHCCEEEEEECCEEEEECCCCEEEEECCCHHHHHCCCC
LVMPGLVNAHTHVAMTFLRGLADDLPLMQWLTEHIFPVEKHLSAEIVEVSALLGCAEMAA
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TGTTTLCDMYLIEDATFKAVDRAGLRMQGGEGLFAFPSPAYACIEDAFELVRRQHDRYSS
CCCHHHHHHHHHCCCHHHHHHHCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
HSRIRHAVMPHAVYTSNPEMLARCAALAGELGCGLHIHLAETAAETAQCLASFGKRPIPY
HHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCH
CRDLGVLSPRTTVAHAVDVTDDELEILRESGICVAHNPVSNMKLASGAARVPEMLAAGIC
HHHCCCCCCCCHHHEEECCCCHHHHHHHHCCCEEEECCCCCCEECCCHHHHHHHHHCCCE
VGIGTDGAASNNGLNMFTEMKTCALLHKLRYADPTCVPAATVLDMATTGGAKCAGWPETG
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
ALVPGAKADLIALDLSAPNLQPLYSAVSHIVYAATGHEVTHTMVGGEFVYENGRHTRFDY
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHEEEECCCCEEHEEECCEEEEECCCCCCCCH
PALLREVASIRRWVQKKITG
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA