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The map label for this gene is rnc

Identifier: 78356751

GI number: 78356751

Start: 1765073

End: 1765762

Strand: Direct

Name: rnc

Synonym: Dde_1708

Alternate gene names: 78356751

Gene position: 1765073-1765762 (Clockwise)

Preceding gene: 78356750

Following gene: 78356753

Centisome position: 47.32

GC content: 57.68

Gene sequence:

>690_bases
ATGTTTGAAAAATTGCAGGATGTGCTGTGTTACCGTTTTGCAGATGTACGTCTGCTGGAAACGGCGCTGACGCATAGTTC
CTACGCTAACGAGCGCGGTACGGAGATAGAGCATAACGAACGGCTGGAATATCTGGGCGATGCAGTTCTGGAACTGACAG
TTTCCGAGCAGCTGTTCACACGCTTTCCCGAAGCCAGAGAAGGGCAGCTGACCCGCATGCGGGCACGGCTGGTGAGCAAG
CCTTCGCTGGCCGAACTGGCACGTGAGCTGAAGCTGGATACCTATCTGCTGTTGGGCAAAGGTGAAGAAAGTCAGGGGGG
CAGAACCCGCAGCTCTGTACTCAGCGATGCCTTTGAGGCGATCCTCGGGGCGATTTTTCTGGACGGCGGCTATGCCGCGG
CCGGCAAGACGGTGCTGCATGTTTTCAGCTCGCGCTGGCCGCAGGGGGCCGAGGCAGCCCGCACCAAAGATGCCAAAAGC
ACATTGCAGGAGCTTACCCAGCGTCTGTTTAAGGAACGGCCGGTGTATACGCTGCTTGGCAGCAGCGGGCCGGAGCATGA
AAAAATTTTTAAGGTCAGGCTGCTGCTGCCGGACGGCAGAGCGCTGGAAACAGAAGGGCAAAGCGTCAAAAGAGCCGAGC
AGAAGGCTGCCGGACTTGCTCTTGAACTGCTGGAAGGCGAAAGCGCCTGA

Upstream 100 bases:

>100_bases
ATCCGGCTTTTCTGGCGACGGATGTTTTTTCAAGGTTGCGCTATCGCAATGGGCCGGTAAACGAAGACGTTCCGGCTTTT
TTATATGGAGAATTCTGAAA

Downstream 100 bases:

>100_bases
TTGCGGATGAACATCGGTAAAATGACCGGGGAGGGGGAGCTCCCCGGTCATTCTGTCTTTGGTCACCCGAAAACCGATGT
GGAGCGGTGCTAGTGTTGCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MFEKLQDVLCYRFADVRLLETALTHSSYANERGTEIEHNERLEYLGDAVLELTVSEQLFTRFPEAREGQLTRMRARLVSK
PSLAELARELKLDTYLLLGKGEESQGGRTRSSVLSDAFEAILGAIFLDGGYAAAGKTVLHVFSSRWPQGAEAARTKDAKS
TLQELTQRLFKERPVYTLLGSSGPEHEKIFKVRLLLPDGRALETEGQSVKRAEQKAAGLALELLEGESA

Sequences:

>Translated_229_residues
MFEKLQDVLCYRFADVRLLETALTHSSYANERGTEIEHNERLEYLGDAVLELTVSEQLFTRFPEAREGQLTRMRARLVSK
PSLAELARELKLDTYLLLGKGEESQGGRTRSSVLSDAFEAILGAIFLDGGYAAAGKTVLHVFSSRWPQGAEAARTKDAKS
TLQELTQRLFKERPVYTLLGSSGPEHEKIFKVRLLLPDGRALETEGQSVKRAEQKAAGLALELLEGESA
>Mature_229_residues
MFEKLQDVLCYRFADVRLLETALTHSSYANERGTEIEHNERLEYLGDAVLELTVSEQLFTRFPEAREGQLTRMRARLVSK
PSLAELARELKLDTYLLLGKGEESQGGRTRSSVLSDAFEAILGAIFLDGGYAAAGKTVLHVFSSRWPQGAEAARTKDAKS
TLQELTQRLFKERPVYTLLGSSGPEHEKIFKVRLLLPDGRALETEGQSVKRAEQKAAGLALELLEGESA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=215, Percent_Identity=30.2325581395349, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI155030236, Length=215, Percent_Identity=30.2325581395349, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1788920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17506883, Length=233, Percent_Identity=31.3304721030043, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193202651, Length=233, Percent_Identity=31.3304721030043, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137682, Length=234, Percent_Identity=31.1965811965812, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_DESDG (Q310Z1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388200.1
- ProteinModelPortal:   Q310Z1
- SMR:   Q310Z1
- STRING:   Q310Z1
- GeneID:   3756706
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1708
- NMPDR:   fig|207559.3.peg.1501
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   VECRIDD
- ProtClustDB:   PRK00102
- BioCyc:   DDES207559:DDE_1708-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25457; Mature: 25457

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKLQDVLCYRFADVRLLETALTHSSYANERGTEIEHNERLEYLGDAVLELTVSEQLFT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RFPEAREGQLTRMRARLVSKPSLAELARELKLDTYLLLGKGEESQGGRTRSSVLSDAFEA
HCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHH
ILGAIFLDGGYAAAGKTVLHVFSSRWPQGAEAARTKDAKSTLQELTQRLFKERPVYTLLG
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
SSGPEHEKIFKVRLLLPDGRALETEGQSVKRAEQKAAGLALELLEGESA
CCCCCHHHEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFEKLQDVLCYRFADVRLLETALTHSSYANERGTEIEHNERLEYLGDAVLELTVSEQLFT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RFPEAREGQLTRMRARLVSKPSLAELARELKLDTYLLLGKGEESQGGRTRSSVLSDAFEA
HCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHH
ILGAIFLDGGYAAAGKTVLHVFSSRWPQGAEAARTKDAKSTLQELTQRLFKERPVYTLLG
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
SSGPEHEKIFKVRLLLPDGRALETEGQSVKRAEQKAAGLALELLEGESA
CCCCCHHHEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA