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The map label for this gene is purM

Identifier: 78356715

GI number: 78356715

Start: 1724540

End: 1725595

Strand: Direct

Name: purM

Synonym: Dde_1672

Alternate gene names: 78356715

Gene position: 1724540-1725595 (Clockwise)

Preceding gene: 78356710

Following gene: 78356720

Centisome position: 46.23

GC content: 55.11

Gene sequence:

>1056_bases
ATGCCTGAGGATCGTGCAAAAGCGTACACCGAGGCGGGGGTTGATATCAATGCCGGCAACGCTCTTGTCTCGCGAATCAA
GTCCATGGTCGCAAGCACCCACACCAAGGGTGTGATCTCCGACATCGGAGGTTTCGGCGGCCTTTTCAAACCTGATCTGG
GAGGCATGGAAGACCCTGTACTCGTTTCGTCCACCGACGGCGTGGGTACTAAGCTTAAGCTTGCATTCATGTTTGACAAG
CATGATACCGTGGGTATCGATCTTGTGGCAATGAGTGTCAACGATGTGCTGGTTCAGGGTGCAAAGCCCCTTTTCTTTCT
GGATTATTTTGCAACCGGCAAGCTGGACGTGGAAGCTGCCGCACAGGTTGTCTCCGGCGTGGCAGAAGGCTGCCGCCAGG
CACAGTGTGCCCTGCTGGGCGGAGAAACTGCCGAGATGCCCGACATGTATGCCCCGGGAGAATATGATCTGGCCGGATTC
TGCGTAGGCATTGCCGACAATGCCCGCATCGTGGACGGTTCGGATATCCGCGTGGGTGATGTGATTATCGGTCTGGGAGC
AAGTGGTGTCCATTCAAACGGATACACCCTTGTCCGGAAGCTCTTTGAAAAGAGCGGGCTGGGTGCCGATGATATTATGC
CCGGCACCGACGCCTCCGTGCGTGACGTACTGATGACTCCCACCAGAATTTATGTGGAAACCATCCGTAACCTGATGCGG
GATTTTCAGATAAAAGGGATGGTGCATGTGACGGGCGGTGGTTTTTACGACAACATTCCCCGTGTGCTGCCTGCTTCTGT
AGATGCCCGCATAGCCTTTGGCGCGTGGGATATTCTGCCTGTTTTCCACTGGCTGCGTGATCTGGGTGAGCTTAGCTGGC
CTGAGATGCTGCAGATATTCAACTGTGGTATCGGCTATGTGGTGATTGTGGGGCAGGAAGAAGCAGACGATGTGCTGGGC
AGGCTTGCTGCGCTTGATCAGCCCGCATGGGCCATCGGCACTGTAGAAAGACGCCGCGAAGAAAGCGAAGAACAGGTATA
TGTGGATTTCGGCTGA

Upstream 100 bases:

>100_bases
GAAAAAATGACTGTCCGCATAGGCTACCCCTTGCGCTTGAGACCCTAAAAGCCTATGAATGCCTTCCGAATTTTGACGCA
ACCTGTAAGGAGCAGATTAC

Downstream 100 bases:

>100_bases
TCGGGCCGGATACTTTATGACCCGTCCTAAAATGAGTTGACGTTTTTTAGATTGTTCAAGTTTGGGCTGTGAGGGCAACC
TCACAGCCCATTTTATGTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MPEDRAKAYTEAGVDINAGNALVSRIKSMVASTHTKGVISDIGGFGGLFKPDLGGMEDPVLVSSTDGVGTKLKLAFMFDK
HDTVGIDLVAMSVNDVLVQGAKPLFFLDYFATGKLDVEAAAQVVSGVAEGCRQAQCALLGGETAEMPDMYAPGEYDLAGF
CVGIADNARIVDGSDIRVGDVIIGLGASGVHSNGYTLVRKLFEKSGLGADDIMPGTDASVRDVLMTPTRIYVETIRNLMR
DFQIKGMVHVTGGGFYDNIPRVLPASVDARIAFGAWDILPVFHWLRDLGELSWPEMLQIFNCGIGYVVIVGQEEADDVLG
RLAALDQPAWAIGTVERRREESEEQVYVDFG

Sequences:

>Translated_351_residues
MPEDRAKAYTEAGVDINAGNALVSRIKSMVASTHTKGVISDIGGFGGLFKPDLGGMEDPVLVSSTDGVGTKLKLAFMFDK
HDTVGIDLVAMSVNDVLVQGAKPLFFLDYFATGKLDVEAAAQVVSGVAEGCRQAQCALLGGETAEMPDMYAPGEYDLAGF
CVGIADNARIVDGSDIRVGDVIIGLGASGVHSNGYTLVRKLFEKSGLGADDIMPGTDASVRDVLMTPTRIYVETIRNLMR
DFQIKGMVHVTGGGFYDNIPRVLPASVDARIAFGAWDILPVFHWLRDLGELSWPEMLQIFNCGIGYVVIVGQEEADDVLG
RLAALDQPAWAIGTVERRREESEEQVYVDFG
>Mature_350_residues
PEDRAKAYTEAGVDINAGNALVSRIKSMVASTHTKGVISDIGGFGGLFKPDLGGMEDPVLVSSTDGVGTKLKLAFMFDKH
DTVGIDLVAMSVNDVLVQGAKPLFFLDYFATGKLDVEAAAQVVSGVAEGCRQAQCALLGGETAEMPDMYAPGEYDLAGFC
VGIADNARIVDGSDIRVGDVIIGLGASGVHSNGYTLVRKLFEKSGLGADDIMPGTDASVRDVLMTPTRIYVETIRNLMRD
FQIKGMVHVTGGGFYDNIPRVLPASVDARIAFGAWDILPVFHWLRDLGELSWPEMLQIFNCGIGYVVIVGQEEADDVLGR
LAALDQPAWAIGTVERRREESEEQVYVDFG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=48.695652173913, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=48.695652173913, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=48.695652173913, Blast_Score=341, Evalue=7e-94,
Organism=Escherichia coli, GI1788845, Length=351, Percent_Identity=49.8575498575499, Blast_Score=338, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17567511, Length=338, Percent_Identity=37.8698224852071, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=45.3216374269006, Blast_Score=293, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24582400, Length=296, Percent_Identity=42.9054054054054, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_DESDG (Q311C7)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388164.1
- ProteinModelPortal:   Q311C7
- SMR:   Q311C7
- STRING:   Q311C7
- GeneID:   3756670
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1672
- NMPDR:   fig|207559.3.peg.1465
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   DDES207559:DDE_1672-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37632; Mature: 37501

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEDRAKAYTEAGVDINAGNALVSRIKSMVASTHTKGVISDIGGFGGLFKPDLGGMEDPV
CCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCE
LVSSTDGVGTKLKLAFMFDKHDTVGIDLVAMSVNDVLVQGAKPLFFLDYFATGKLDVEAA
EEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCEEEEEECCCCCCCHHHH
AQVVSGVAEGCRQAQCALLGGETAEMPDMYAPGEYDLAGFCVGIADNARIVDGSDIRVGD
HHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCEEEEE
VIIGLGASGVHSNGYTLVRKLFEKSGLGADDIMPGTDASVRDVLMTPTRIYVETIRNLMR
EEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
DFQIKGMVHVTGGGFYDNIPRVLPASVDARIAFGAWDILPVFHWLRDLGELSWPEMLQIF
HHEECEEEEEECCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHH
NCGIGYVVIVGQEEADDVLGRLAALDQPAWAIGTVERRREESEEQVYVDFG
CCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
PEDRAKAYTEAGVDINAGNALVSRIKSMVASTHTKGVISDIGGFGGLFKPDLGGMEDPV
CCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCE
LVSSTDGVGTKLKLAFMFDKHDTVGIDLVAMSVNDVLVQGAKPLFFLDYFATGKLDVEAA
EEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCEEEEEECCCCCCCHHHH
AQVVSGVAEGCRQAQCALLGGETAEMPDMYAPGEYDLAGFCVGIADNARIVDGSDIRVGD
HHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCEEEEE
VIIGLGASGVHSNGYTLVRKLFEKSGLGADDIMPGTDASVRDVLMTPTRIYVETIRNLMR
EEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
DFQIKGMVHVTGGGFYDNIPRVLPASVDARIAFGAWDILPVFHWLRDLGELSWPEMLQIF
HHEECEEEEEECCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHH
NCGIGYVVIVGQEEADDVLGRLAALDQPAWAIGTVERRREESEEQVYVDFG
CCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA