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The map label for this gene is ywrD [H]

Identifier: 78356684

GI number: 78356684

Start: 1692011

End: 1693639

Strand: Direct

Name: ywrD [H]

Synonym: Dde_1641

Alternate gene names: 78356684

Gene position: 1692011-1693639 (Clockwise)

Preceding gene: 78356678

Following gene: 78356688

Centisome position: 45.36

GC content: 60.16

Gene sequence:

>1629_bases
GTGAAAAGTTCCTTGCCTGTTTTTGAGTTCGCATCACGTCGTTCACCTGTTTATGCACCGGAGGTCATGGTTGCTGCGTC
ACAGCCTCTGGCTGTCAGCGCCGGTCTGGGCATTGCTGCCCGTGGCGGCAGCGCCGCCGATATGGCCGTGGCCGTGGCGG
CCGTGCTTGCCGTTGTCGAGCCGTGCAGCACCGGTCTGGGAGGTGATGCGTTTGCTCTGTACTACGATTCAGCCACACAG
CATGTGGCGGCGCTGAACGGTTCGGGAAAAAGCGGAGGCGGCCATACCCCCGAAGCTGTTTTTTCCGCCGGGTATGACGC
AGTGCCGGCAAGGCACGGGCTGGCAGTAACTGTGCCGGGGGCATGTGCCGCATGGTGTGAACTGCATAGAAAATACGGCC
GGCTGGATCTTGCCGAGGTATTGGCTCCTGCAGTGCGCCTTGCCCGTGACGGCTTTGCCGTCGGACCCGTTACCGCGCGG
TTATGGGCAACCGAAGAAGCGCTGCTGCGTGGCAGCGAAGGTGGAAAAAGTCTGCTGGTCCGCGGAAGGGCTCCCCGTGC
GGGCGAACGTATCCGCAACCATGCGCTTGCCCGTCTTTTGAAAAATATAGCTCGCAAGGGAGCTGCAGCATTGTACGAAG
GGGCTGCTGCCGCGGCTCTGGCCGATGCGGTTCAGGCTGCAGGCGGCGTGCTGACCGCGGATGACATGAGCCGGTGCAGG
GCGCAGTGGCAGACACCGGCCAGTACCGTGTACGGCGGTGTACGCGTGCATGAATGCCCGCCCAACGGTCAGGGGCTGGT
GGCTCTGAGTGCGCTCAACATACTTGCTGCCTTGAGTGATAAGATAAAAGGTGCCCCTGTGTCCGCAGAACGTCTGCACT
GTATGATAGAGTCTCTGCGGCTCGGTTTCGCTGACGGAGCAGCGTATATTGCAGACCCTGATTTTTCGGCCGTTCCTGCG
GATGGATTGCTTTCCGGGGAATATGCGGCCGCACGGGCTGCATTGATAGACTCCGGCAGGGCTTTGCCGCAGGCCGTGTG
CGGTGTTCCCCAGTCTTCTTCCGATACTGTACAGTTCTGCGTGACCGACAGAGACGGTAATGCCTGTTCCATGGTGAACA
GCATATACATGACGTTCGGCAGCGGAGTAGTTGTGCCTTCTTTGGGACTGGCTCTGCAGAACAGGGGGCACAACTTTGTG
TTGCGGCAGGATCATCCCAACTGCCTTGCGCCGTATAAACGACCTTACCATACGATAATTCCGTGCCTGACAACGCACGA
AAACGGTGAACTGCACGGAGTTATGGGAGTTATGGGCGGATTTATGCAGCCACAGGGGCATGTGCAGATTCTCAGTGCTC
TGCTGGATGATGGATGCAATCCTCAGCAGGCTCTGGACAGGCTCCGCTTCTGCATTCAGCCTGACGGTGCAGCCAGTGTT
GTGGCGCTGGAAGAGGGCATGGATGCGGGGCTGGCGGACAGCCTGAAGGCCAGAGGTCATGATGTCCGGCCAGTCAGCGG
ATACGCCCGCGACCTGTTCGGACGCGGGCAGATTATCCTGCGGCAGCCCAACGGATTCTGGGAAGCCGGCAGTGACGGGC
GCGCAGACGGACTTGCGCTGGGTTTCTGA

Upstream 100 bases:

>100_bases
CTTATTGTTAAACCAGCTTGTAATGCTGCGCAAGGTTAAATCCGTTATTTGTGGTAGTTGAGTCTTCAGTCAGCAGAAAA
TACGTCAGGAGTGCCGTATC

Downstream 100 bases:

>100_bases
TCACAGAGATATGTTGGTGAACAGCCCGCGCAGCATTTCCTGTGATACAGTGGGCATGGGTGTCTGTATCCGTGTAGGGT
ACTGCTCGCTTACTTTCAGC

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MKSSLPVFEFASRRSPVYAPEVMVAASQPLAVSAGLGIAARGGSAADMAVAVAAVLAVVEPCSTGLGGDAFALYYDSATQ
HVAALNGSGKSGGGHTPEAVFSAGYDAVPARHGLAVTVPGACAAWCELHRKYGRLDLAEVLAPAVRLARDGFAVGPVTAR
LWATEEALLRGSEGGKSLLVRGRAPRAGERIRNHALARLLKNIARKGAAALYEGAAAAALADAVQAAGGVLTADDMSRCR
AQWQTPASTVYGGVRVHECPPNGQGLVALSALNILAALSDKIKGAPVSAERLHCMIESLRLGFADGAAYIADPDFSAVPA
DGLLSGEYAAARAALIDSGRALPQAVCGVPQSSSDTVQFCVTDRDGNACSMVNSIYMTFGSGVVVPSLGLALQNRGHNFV
LRQDHPNCLAPYKRPYHTIIPCLTTHENGELHGVMGVMGGFMQPQGHVQILSALLDDGCNPQQALDRLRFCIQPDGAASV
VALEEGMDAGLADSLKARGHDVRPVSGYARDLFGRGQIILRQPNGFWEAGSDGRADGLALGF

Sequences:

>Translated_542_residues
MKSSLPVFEFASRRSPVYAPEVMVAASQPLAVSAGLGIAARGGSAADMAVAVAAVLAVVEPCSTGLGGDAFALYYDSATQ
HVAALNGSGKSGGGHTPEAVFSAGYDAVPARHGLAVTVPGACAAWCELHRKYGRLDLAEVLAPAVRLARDGFAVGPVTAR
LWATEEALLRGSEGGKSLLVRGRAPRAGERIRNHALARLLKNIARKGAAALYEGAAAAALADAVQAAGGVLTADDMSRCR
AQWQTPASTVYGGVRVHECPPNGQGLVALSALNILAALSDKIKGAPVSAERLHCMIESLRLGFADGAAYIADPDFSAVPA
DGLLSGEYAAARAALIDSGRALPQAVCGVPQSSSDTVQFCVTDRDGNACSMVNSIYMTFGSGVVVPSLGLALQNRGHNFV
LRQDHPNCLAPYKRPYHTIIPCLTTHENGELHGVMGVMGGFMQPQGHVQILSALLDDGCNPQQALDRLRFCIQPDGAASV
VALEEGMDAGLADSLKARGHDVRPVSGYARDLFGRGQIILRQPNGFWEAGSDGRADGLALGF
>Mature_542_residues
MKSSLPVFEFASRRSPVYAPEVMVAASQPLAVSAGLGIAARGGSAADMAVAVAAVLAVVEPCSTGLGGDAFALYYDSATQ
HVAALNGSGKSGGGHTPEAVFSAGYDAVPARHGLAVTVPGACAAWCELHRKYGRLDLAEVLAPAVRLARDGFAVGPVTAR
LWATEEALLRGSEGGKSLLVRGRAPRAGERIRNHALARLLKNIARKGAAALYEGAAAAALADAVQAAGGVLTADDMSRCR
AQWQTPASTVYGGVRVHECPPNGQGLVALSALNILAALSDKIKGAPVSAERLHCMIESLRLGFADGAAYIADPDFSAVPA
DGLLSGEYAAARAALIDSGRALPQAVCGVPQSSSDTVQFCVTDRDGNACSMVNSIYMTFGSGVVVPSLGLALQNRGHNFV
LRQDHPNCLAPYKRPYHTIIPCLTTHENGELHGVMGVMGGFMQPQGHVQILSALLDDGCNPQQALDRLRFCIQPDGAASV
VALEEGMDAGLADSLKARGHDVRPVSGYARDLFGRGQIILRQPNGFWEAGSDGRADGLALGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=524, Percent_Identity=25.9541984732824, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI73915090, Length=524, Percent_Identity=25.9541984732824, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI73915096, Length=524, Percent_Identity=25.9541984732824, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI73915094, Length=524, Percent_Identity=25.9541984732824, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI113429324, Length=524, Percent_Identity=25.1908396946565, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI113429326, Length=529, Percent_Identity=24.7637051039698, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI109148539, Length=491, Percent_Identity=29.5315682281059, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI153266885, Length=378, Percent_Identity=25.6613756613757, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI153266901, Length=376, Percent_Identity=26.063829787234, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI153266907, Length=377, Percent_Identity=24.1379310344828, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789856, Length=552, Percent_Identity=29.7101449275362, Blast_Score=196, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17506189, Length=516, Percent_Identity=24.031007751938, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17542894, Length=431, Percent_Identity=24.8259860788863, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212646519, Length=453, Percent_Identity=22.5165562913907, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI72000294, Length=453, Percent_Identity=22.5165562913907, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI193208247, Length=579, Percent_Identity=21.4162348877375, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193208245, Length=579, Percent_Identity=21.4162348877375, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24642670, Length=500, Percent_Identity=25.6, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642666, Length=500, Percent_Identity=25.6, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077878, Length=500, Percent_Identity=25.4, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551474, Length=500, Percent_Identity=25.6, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077880, Length=500, Percent_Identity=25.4, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859893, Length=543, Percent_Identity=24.3093922651934, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI18859741, Length=528, Percent_Identity=23.2954545454545, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI161077496, Length=420, Percent_Identity=23.8095238095238, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56136; Mature: 56136

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSLPVFEFASRRSPVYAPEVMVAASQPLAVSAGLGIAARGGSAADMAVAVAAVLAVVE
CCCCCCHHHHHHCCCCCCCCCEEEECCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHH
PCSTGLGGDAFALYYDSATQHVAALNGSGKSGGGHTPEAVFSAGYDAVPARHGLAVTVPG
HHCCCCCCCEEEEEECCCHHEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCC
ACAAWCELHRKYGRLDLAEVLAPAVRLARDGFAVGPVTARLWATEEALLRGSEGGKSLLV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHCCCCCCCEEEE
RGRAPRAGERIRNHALARLLKNIARKGAAALYEGAAAAALADAVQAAGGVLTADDMSRCR
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
AQWQTPASTVYGGVRVHECPPNGQGLVALSALNILAALSDKIKGAPVSAERLHCMIESLR
HHCCCCHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LGFADGAAYIADPDFSAVPADGLLSGEYAAARAALIDSGRALPQAVCGVPQSSSDTVQFC
CCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEE
VTDRDGNACSMVNSIYMTFGSGVVVPSLGLALQNRGHNFVLRQDHPNCLAPYKRPYHTII
EECCCCCHHHHHHHHHHHHCCCEEHHCCCHHHHCCCCEEEEECCCCCCCCCCCCCCHHHC
PCLTTHENGELHGVMGVMGGFMQPQGHVQILSALLDDGCNPQQALDRLRFCIQPDGAASV
CEEEECCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCEE
VALEEGMDAGLADSLKARGHDVRPVSGYARDLFGRGQIILRQPNGFWEAGSDGRADGLAL
EEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEE
GF
CC
>Mature Secondary Structure
MKSSLPVFEFASRRSPVYAPEVMVAASQPLAVSAGLGIAARGGSAADMAVAVAAVLAVVE
CCCCCCHHHHHHCCCCCCCCCEEEECCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHH
PCSTGLGGDAFALYYDSATQHVAALNGSGKSGGGHTPEAVFSAGYDAVPARHGLAVTVPG
HHCCCCCCCEEEEEECCCHHEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCC
ACAAWCELHRKYGRLDLAEVLAPAVRLARDGFAVGPVTARLWATEEALLRGSEGGKSLLV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHCCCCCCCEEEE
RGRAPRAGERIRNHALARLLKNIARKGAAALYEGAAAAALADAVQAAGGVLTADDMSRCR
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
AQWQTPASTVYGGVRVHECPPNGQGLVALSALNILAALSDKIKGAPVSAERLHCMIESLR
HHCCCCHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LGFADGAAYIADPDFSAVPADGLLSGEYAAARAALIDSGRALPQAVCGVPQSSSDTVQFC
CCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEE
VTDRDGNACSMVNSIYMTFGSGVVVPSLGLALQNRGHNFVLRQDHPNCLAPYKRPYHTII
EECCCCCHHHHHHHHHHHHCCCEEHHCCCHHHHCCCCEEEEECCCCCCCCCCCCCCHHHC
PCLTTHENGELHGVMGVMGGFMQPQGHVQILSALLDDGCNPQQALDRLRFCIQPDGAASV
CEEEECCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCEE
VALEEGMDAGLADSLKARGHDVRPVSGYARDLFGRGQIILRQPNGFWEAGSDGRADGLAL
EEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEE
GF
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]