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The map label for this gene is proA

Identifier: 78356676

GI number: 78356676

Start: 1684510

End: 1685769

Strand: Reverse

Name: proA

Synonym: Dde_1633

Alternate gene names: 78356676

Gene position: 1685769-1684510 (Counterclockwise)

Preceding gene: 78356679

Following gene: 78356675

Centisome position: 45.19

GC content: 58.57

Gene sequence:

>1260_bases
ATGGATATACAGGAAACAATCAACCAGATGGGTAAAAAAGCAGCCGCAGCCGCCCGTGCCATGCGCGCTGCATCCCCTTC
TGCAAAAACAAGCGCCCTGCTCAGTCTGGCACAGCTTATCCGTCAGGAAAACAAAGCCATCACCGAAGCCAATGCCAGGG
ATCTGGCCGCAGCGGCAGACCGGGGTCTTGATGCTCCGCGCATGGACAGGCTGCGCCTGACCGATGCTGTTATCGAAGAA
ATGGCCCGCGCCTGCGAATTTGTCGCCGGACTGCCCGACCCCATCGGGGCCACCGAAAAACAGTGGCAAAGGCCCAATGG
ACTGCTGGTGGGCAAAATGCGCATCCCGCTCGGCGTCATATCCATGATCTATGAATCACGTCCCAACGTCACGGTGGACT
CGGGCATTCTGTGCCTGAAGGCCGGCAACGCAGTGATACTGCGCGGCGGCTCGGAAGCTTTTCATTCCAATATGATGCTG
GCCTCGCTTATCCACAGGGCACTTATACTCGCCGGGCTGCCGCAAGACGCCGTGCAGGTGGTTCCCTCAACCGACCGCGG
CGCCATCAAGGCCCTGTGTGAACTGGAAGAATATATTGATGTCATAATACCCCGCGGTGGTGAAACACTGATCCGCACTG
TGGTGGCCGATGCGCGCATGCCCGTGCTCAAGCACTACAAAGGCGTTTGCCACGCCTATGTCGATGAAGGCGCCGACCTT
GAGCAGGCCTGCGAAATCATCTTTAACGCCAAAGTACAGCGGCCCGGAGTGTGCAATGCTCTTGAAGGTCTGCTGGTACA
CCGCTCCGAAGCTCATACGCTGCTGCCCGCCGTAGCGCAAAAACTCGGCGACGCCGGGGTCAGTTTTCGTGCCTGCCCCC
GCGCCCTGCCCCTGCTGGCACCCCATGGCGTGCCTATGGCAGAGACCGATCCCGGCACGGAATTTCATGATCTGGTGATG
GTCGTGAAGGTGGTGGACAGTCAGGACGAAGCGCAGGACTACATTGCACAGCACGGCTCGAACCATACGGAAATTATCTG
CACCCGCAATCATCAGAACGCCATGCGCTTTGTGCGTGAGGTGGACGCTTCAATGGTTGCCGTGAATGCCTCTTCCCGCT
TCAATGACGGCGGGCAGCTGGGGCTCGGGGCCGAAATAGGCATCAGCACCTCAAAGCTGCACTCATACGGCCCCATGGGA
GTTGAAGAGCTGACCACGACAAAATTCGTGGTGCTCGGAAACGGTCAGATTCGTCAGTAG

Upstream 100 bases:

>100_bases
GGAATTAAGCGATGTAACCGTCAGGACGGTGTATTGCCACTTAGTGCAGAAACGGATAATTTGCCAGATTCATAATGCGG
TTATCAAGCTAGGAGGCATC

Downstream 100 bases:

>100_bases
CCTTTTCACCTGCCGGCAGGGCATCATACCGCCCTGCCGGCAGATACTCCGGTACCTCAATGCATACTAAAGCGCTGTTC
GGCGGCACATTCAACCCGCC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MDIQETINQMGKKAAAAARAMRAASPSAKTSALLSLAQLIRQENKAITEANARDLAAAADRGLDAPRMDRLRLTDAVIEE
MARACEFVAGLPDPIGATEKQWQRPNGLLVGKMRIPLGVISMIYESRPNVTVDSGILCLKAGNAVILRGGSEAFHSNMML
ASLIHRALILAGLPQDAVQVVPSTDRGAIKALCELEEYIDVIIPRGGETLIRTVVADARMPVLKHYKGVCHAYVDEGADL
EQACEIIFNAKVQRPGVCNALEGLLVHRSEAHTLLPAVAQKLGDAGVSFRACPRALPLLAPHGVPMAETDPGTEFHDLVM
VVKVVDSQDEAQDYIAQHGSNHTEIICTRNHQNAMRFVREVDASMVAVNASSRFNDGGQLGLGAEIGISTSKLHSYGPMG
VEELTTTKFVVLGNGQIRQ

Sequences:

>Translated_419_residues
MDIQETINQMGKKAAAAARAMRAASPSAKTSALLSLAQLIRQENKAITEANARDLAAAADRGLDAPRMDRLRLTDAVIEE
MARACEFVAGLPDPIGATEKQWQRPNGLLVGKMRIPLGVISMIYESRPNVTVDSGILCLKAGNAVILRGGSEAFHSNMML
ASLIHRALILAGLPQDAVQVVPSTDRGAIKALCELEEYIDVIIPRGGETLIRTVVADARMPVLKHYKGVCHAYVDEGADL
EQACEIIFNAKVQRPGVCNALEGLLVHRSEAHTLLPAVAQKLGDAGVSFRACPRALPLLAPHGVPMAETDPGTEFHDLVM
VVKVVDSQDEAQDYIAQHGSNHTEIICTRNHQNAMRFVREVDASMVAVNASSRFNDGGQLGLGAEIGISTSKLHSYGPMG
VEELTTTKFVVLGNGQIRQ
>Mature_419_residues
MDIQETINQMGKKAAAAARAMRAASPSAKTSALLSLAQLIRQENKAITEANARDLAAAADRGLDAPRMDRLRLTDAVIEE
MARACEFVAGLPDPIGATEKQWQRPNGLLVGKMRIPLGVISMIYESRPNVTVDSGILCLKAGNAVILRGGSEAFHSNMML
ASLIHRALILAGLPQDAVQVVPSTDRGAIKALCELEEYIDVIIPRGGETLIRTVVADARMPVLKHYKGVCHAYVDEGADL
EQACEIIFNAKVQRPGVCNALEGLLVHRSEAHTLLPAVAQKLGDAGVSFRACPRALPLLAPHGVPMAETDPGTEFHDLVM
VVKVVDSQDEAQDYIAQHGSNHTEIICTRNHQNAMRFVREVDASMVAVNASSRFNDGGQLGLGAEIGISTSKLHSYGPMG
VEELTTTKFVVLGNGQIRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=415, Percent_Identity=35.1807228915663, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI62912457, Length=415, Percent_Identity=35.1807228915663, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=42.1686746987952, Blast_Score=315, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=35.9712230215827, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=35.9712230215827, Blast_Score=241, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=33.4883720930233, Blast_Score=230, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=38.0835380835381, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_DESDG (Q311G6)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388125.1
- ProteinModelPortal:   Q311G6
- SMR:   Q311G6
- STRING:   Q311G6
- GeneID:   3756630
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1633
- NMPDR:   fig|207559.3.peg.1426
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- ProtClustDB:   PRK00197
- BioCyc:   DDES207559:DDE_1633-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44971; Mature: 44971

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQETINQMGKKAAAAARAMRAASPSAKTSALLSLAQLIRQENKAITEANARDLAAAAD
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RGLDAPRMDRLRLTDAVIEEMARACEFVAGLPDPIGATEKQWQRPNGLLVGKMRIPLGVI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCHHHH
SMIYESRPNVTVDSGILCLKAGNAVILRGGSEAFHSNMMLASLIHRALILAGLPQDAVQV
HHHHHCCCCEEECCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
VPSTDRGAIKALCELEEYIDVIIPRGGETLIRTVVADARMPVLKHYKGVCHAYVDEGADL
CCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCH
EQACEIIFNAKVQRPGVCNALEGLLVHRSEAHTLLPAVAQKLGDAGVSFRACPRALPLLA
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
PHGVPMAETDPGTEFHDLVMVVKVVDSQDEAQDYIAQHGSNHTEIICTRNHQNAMRFVRE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
VDASMVAVNASSRFNDGGQLGLGAEIGISTSKLHSYGPMGVEELTTTKFVVLGNGQIRQ
HHHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC
>Mature Secondary Structure
MDIQETINQMGKKAAAAARAMRAASPSAKTSALLSLAQLIRQENKAITEANARDLAAAAD
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RGLDAPRMDRLRLTDAVIEEMARACEFVAGLPDPIGATEKQWQRPNGLLVGKMRIPLGVI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCHHHH
SMIYESRPNVTVDSGILCLKAGNAVILRGGSEAFHSNMMLASLIHRALILAGLPQDAVQV
HHHHHCCCCEEECCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
VPSTDRGAIKALCELEEYIDVIIPRGGETLIRTVVADARMPVLKHYKGVCHAYVDEGADL
CCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCH
EQACEIIFNAKVQRPGVCNALEGLLVHRSEAHTLLPAVAQKLGDAGVSFRACPRALPLLA
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
PHGVPMAETDPGTEFHDLVMVVKVVDSQDEAQDYIAQHGSNHTEIICTRNHQNAMRFVRE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
VDASMVAVNASSRFNDGGQLGLGAEIGISTSKLHSYGPMGVEELTTTKFVVLGNGQIRQ
HHHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA