Click here to switch to the map view.

The map label for this gene is ald [H]

Identifier: 78356596

GI number: 78356596

Start: 1572670

End: 1573782

Strand: Direct

Name: ald [H]

Synonym: Dde_1553

Alternate gene names: 78356596

Gene position: 1572670-1573782 (Clockwise)

Preceding gene: 78356595

Following gene: 78356597

Centisome position: 42.16

GC content: 55.62

Gene sequence:

>1113_bases
ATGATCGTAGGCATTCTCAAAGAAATAAAGTCCGAAGAGAACCGGGTGTCCATGACGCCTGCCGGTGCGGAAGTGATGGT
GCATCATGGACATACCGTGCTGGTGGAGAAAAATGCGGGGACGGGCAGCGGATTTCTGGACGAGGCCTACACCAGAGCCG
GAGCGGAAATTGTAGAGACTCCTGCAGAGATTTATGCCCGCGCTGATATGGTTATGCACGTCAAAGAACCTCTGCCTTCT
GAATACGGCCTTATCCGTGAAGGACAGATTGTGTTCACCTATCTGCACCTTGCCGCAGATGAAAAGCTTACCAGGGCTCT
GGTGGACAGCAAGGCGGTATGCATCGCGTATGAAACCATTCAGAAGCCGGACGGAAGCCTGCCGCTGCTTACTCCCATGA
GCGAAGTGGCCGGGCGGATGGCCATTCAGCAGGGTGCCAAATATCTGGAGATGACACAGGGCGGGCACGGCGTGCTGCTG
GGCGGCGTTCCCGGGGTTGATCCGGGTACAGTTGTAGTCATAGGCGGCGGAGTGGTGGGTACCAATGCCGCCAAGATGGC
ATGCGGTCTGGGCGCAAAGGTGTACATTCTTGATATGAATCTTGACCGGCTGCGTCACCTCAGCGATATCATGCCGGCCA
ACTGCTTTCCTCTGATGTCTTCTCCCGCCACGCTGCGCAAGCTGGTACGCGAGGCTGACGTGGTGGTGGGTGCCGTACTG
GTTGCTGGCGCCAAGGCTCCGCGTCTTGTAACACGTGAGATGATAAAAACCATGAAGCGCGGATCCGTACTGGTGGATGT
GGCCATTGATCAGGGCGGATGTTTTGAAACTTCTCATCCCACAACACACAAGGATCCCACGTTTGTGGTGGACGATGTGG
TGCATTACTGCGTGGCCAACATGCCCGGCGCCGTGGCAAAAACCTCCACACTGGCTCTGACCAATGCCACGTTGCCCTAT
GCCGTGACTCTGGCGGATAAAGGGTGGAAAAAAGCCATGCAGGACAGCCGTGAAATTGCGCTGGGTGCCAACGTGATCGA
TGGCGAAATCACATATAAAGGTGTGGCTGAAGCATTTGATATGCCCTACGCCGGAGTGGAAAAGTTTCTGTAG

Upstream 100 bases:

>100_bases
TTTTTTAGCTCCGCATTCTGGCAAGGTGTTTGCTTTCTTATGAAAAGGGCGCAGGCATGGTGTCTGCTGCTTTGCATATT
TCAGCGTGGAGGAAAGCAAT

Downstream 100 bases:

>100_bases
AAACAGGCAGATGATCCTGACAGCGTGTCGGGTGCCTGTAGCCGTGAGCAAAAGTCGCACCGGCCGGAAGACTCCGGCCG
GTGCTTTTTTTACAAATAAG

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIVGILKEIKSEENRVSMTPAGAEVMVHHGHTVLVEKNAGTGSGFLDEAYTRAGAEIVETPAEIYARADMVMHVKEPLPS
EYGLIREGQIVFTYLHLAADEKLTRALVDSKAVCIAYETIQKPDGSLPLLTPMSEVAGRMAIQQGAKYLEMTQGGHGVLL
GGVPGVDPGTVVVIGGGVVGTNAAKMACGLGAKVYILDMNLDRLRHLSDIMPANCFPLMSSPATLRKLVREADVVVGAVL
VAGAKAPRLVTREMIKTMKRGSVLVDVAIDQGGCFETSHPTTHKDPTFVVDDVVHYCVANMPGAVAKTSTLALTNATLPY
AVTLADKGWKKAMQDSREIALGANVIDGEITYKGVAEAFDMPYAGVEKFL

Sequences:

>Translated_370_residues
MIVGILKEIKSEENRVSMTPAGAEVMVHHGHTVLVEKNAGTGSGFLDEAYTRAGAEIVETPAEIYARADMVMHVKEPLPS
EYGLIREGQIVFTYLHLAADEKLTRALVDSKAVCIAYETIQKPDGSLPLLTPMSEVAGRMAIQQGAKYLEMTQGGHGVLL
GGVPGVDPGTVVVIGGGVVGTNAAKMACGLGAKVYILDMNLDRLRHLSDIMPANCFPLMSSPATLRKLVREADVVVGAVL
VAGAKAPRLVTREMIKTMKRGSVLVDVAIDQGGCFETSHPTTHKDPTFVVDDVVHYCVANMPGAVAKTSTLALTNATLPY
AVTLADKGWKKAMQDSREIALGANVIDGEITYKGVAEAFDMPYAGVEKFL
>Mature_370_residues
MIVGILKEIKSEENRVSMTPAGAEVMVHHGHTVLVEKNAGTGSGFLDEAYTRAGAEIVETPAEIYARADMVMHVKEPLPS
EYGLIREGQIVFTYLHLAADEKLTRALVDSKAVCIAYETIQKPDGSLPLLTPMSEVAGRMAIQQGAKYLEMTQGGHGVLL
GGVPGVDPGTVVVIGGGVVGTNAAKMACGLGAKVYILDMNLDRLRHLSDIMPANCFPLMSSPATLRKLVREADVVVGAVL
VAGAKAPRLVTREMIKTMKRGSVLVDVAIDQGGCFETSHPTTHKDPTFVVDDVVHYCVANMPGAVAKTSTLALTNATLPY
AVTLADKGWKKAMQDSREIALGANVIDGEITYKGVAEAFDMPYAGVEKFL

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=395, Percent_Identity=27.3417721518987, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI122939153, Length=395, Percent_Identity=27.3417721518987, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1787887, Length=308, Percent_Identity=30.8441558441558, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17550456, Length=374, Percent_Identity=27.2727272727273, Blast_Score=126, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39347; Mature: 39347

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGILKEIKSEENRVSMTPAGAEVMVHHGHTVLVEKNAGTGSGFLDEAYTRAGAEIVET
CCCHHHHHHCCCCCEEEECCCCCEEEEECCEEEEEECCCCCCCCHHHHHHHHCCHHHHHC
PAEIYARADMVMHVKEPLPSEYGLIREGQIVFTYLHLAADEKLTRALVDSKAVCIAYETI
HHHHHHHHHHEEEECCCCCCCCCCEECCCEEEEEEEHHHHHHHHHHHHCCCEEEEEEEHH
QKPDGSLPLLTPMSEVAGRMAIQQGAKYLEMTQGGHGVLLGGVPGVDPGTVVVIGGGVVG
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCEEEEECCCEEC
TNAAKMACGLGAKVYILDMNLDRLRHLSDIMPANCFPLMSSPATLRKLVREADVVVGAVL
CCHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VAGAKAPRLVTREMIKTMKRGSVLVDVAIDQGGCFETSHPTTHKDPTFVVDDVVHYCVAN
HHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
MPGAVAKTSTLALTNATLPYAVTLADKGWKKAMQDSREIALGANVIDGEITYKGVAEAFD
CCCCHHCCCEEEEECCCCCEEEEECCCHHHHHHHCCCEEEECCEEECCCEEHHHHHHHHC
MPYAGVEKFL
CCHHHHHHCC
>Mature Secondary Structure
MIVGILKEIKSEENRVSMTPAGAEVMVHHGHTVLVEKNAGTGSGFLDEAYTRAGAEIVET
CCCHHHHHHCCCCCEEEECCCCCEEEEECCEEEEEECCCCCCCCHHHHHHHHCCHHHHHC
PAEIYARADMVMHVKEPLPSEYGLIREGQIVFTYLHLAADEKLTRALVDSKAVCIAYETI
HHHHHHHHHHEEEECCCCCCCCCCEECCCEEEEEEEHHHHHHHHHHHHCCCEEEEEEEHH
QKPDGSLPLLTPMSEVAGRMAIQQGAKYLEMTQGGHGVLLGGVPGVDPGTVVVIGGGVVG
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCEEEEECCCEEC
TNAAKMACGLGAKVYILDMNLDRLRHLSDIMPANCFPLMSSPATLRKLVREADVVVGAVL
CCHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VAGAKAPRLVTREMIKTMKRGSVLVDVAIDQGGCFETSHPTTHKDPTFVVDDVVHYCVAN
HHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
MPGAVAKTSTLALTNATLPYAVTLADKGWKKAMQDSREIALGANVIDGEITYKGVAEAFD
CCCCHHCCCEEEEECCCCCEEEEECCCHHHHHHHCCCEEEECCEEECCCEEHHHHHHHHC
MPYAGVEKFL
CCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA