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The map label for this gene is panC

Identifier: 78356543

GI number: 78356543

Start: 1518215

End: 1519060

Strand: Reverse

Name: panC

Synonym: Dde_1498

Alternate gene names: 78356543

Gene position: 1519060-1518215 (Counterclockwise)

Preceding gene: 78356545

Following gene: 78356542

Centisome position: 40.72

GC content: 60.99

Gene sequence:

>846_bases
ATGCAGATAATCACATCTCCCGAAGAGCTTCAGCGGCTTTGCCTTGACTGGCGCTGCGGCGGTGTCAAAACCGCGCTGGT
TCCGACCATGGGTTACTACCATGCAGGGCACGAAAGCCTTATGGCCTATGCCCGCGAACGTGCGGACAAGGTTGTGGTGA
GCCTTTTTGTCAACCCCGCGCAGTTTGCTCCCGGAGAAGATCTGGCAGCCTACCCCCGCGACCTTTCCGGCGATGCCGAG
GTTGCCCAGCGGGCCGGTGCCGATGTGCTGTTCACCCCGCAGCCGGAAGCCATGTACCCGCAGGGATTCGACACATGGGT
GGAAATTCCCGGACTGTCTTCCGGCCTGTGCGGCGCCGACCGTCCCGGTCATTTCCGCGGGGTGTGCACCGTGGTCATGA
AGCTGATGCTGCTCACCCTGCCCCGTCTTGCCGTTTTCGGCGAAAAAGACTGGCAGCAGCTGGCAGTGCTCAGACGCATG
GCAAAAGACATGCATCTGCCCGTAACCATAGACGGTTGCCCCATTGTACGCGAAACAGACGGTCTGGCCATGAGTTCACG
CAATGTGTATCTGACTCCGGAAGAGCGCAGACAGGCACCTGCCCTGTACCAGGGGCTGATCCGTGCACGCGACATGGTGG
CCGGCGGAGAGCGCGACACGGCCGTTCTGCGGGCTGCGGTTAAAGAATACTGGAAGCAGCACCTGCCGGAAGGCAGGGAA
GATTATCTGGAAATCGTTCACCCCGACACGCTGCAGCCGCTGGAACGTGTGGGGGGCATGGCCACATGCGCAGCCGCCGT
ACGTCTGGGCAGAGCACGCCTGATTGACAATCTGGCTCTGATATGA

Upstream 100 bases:

>100_bases
CTGCGACGCCCTACGCGGCACAGTATGTTCCGGATTTTGCTTTACAACAAGGGCCACTAAGTTTACAACCAGAACAACAA
CTATATGCGGATACATTGAT

Downstream 100 bases:

>100_bases
ACGGCAGGCACGGATAATGACCGCTCAGGATTCTTCAGGCGGCTTTATGGCGTTGCTGCGCCGGTTCATCAAGGCAAACC
TGTTTGCCGGCATACTGGTG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQIITSPEELQRLCLDWRCGGVKTALVPTMGYYHAGHESLMAYARERADKVVVSLFVNPAQFAPGEDLAAYPRDLSGDAE
VAQRAGADVLFTPQPEAMYPQGFDTWVEIPGLSSGLCGADRPGHFRGVCTVVMKLMLLTLPRLAVFGEKDWQQLAVLRRM
AKDMHLPVTIDGCPIVRETDGLAMSSRNVYLTPEERRQAPALYQGLIRARDMVAGGERDTAVLRAAVKEYWKQHLPEGRE
DYLEIVHPDTLQPLERVGGMATCAAAVRLGRARLIDNLALI

Sequences:

>Translated_281_residues
MQIITSPEELQRLCLDWRCGGVKTALVPTMGYYHAGHESLMAYARERADKVVVSLFVNPAQFAPGEDLAAYPRDLSGDAE
VAQRAGADVLFTPQPEAMYPQGFDTWVEIPGLSSGLCGADRPGHFRGVCTVVMKLMLLTLPRLAVFGEKDWQQLAVLRRM
AKDMHLPVTIDGCPIVRETDGLAMSSRNVYLTPEERRQAPALYQGLIRARDMVAGGERDTAVLRAAVKEYWKQHLPEGRE
DYLEIVHPDTLQPLERVGGMATCAAAVRLGRARLIDNLALI
>Mature_281_residues
MQIITSPEELQRLCLDWRCGGVKTALVPTMGYYHAGHESLMAYARERADKVVVSLFVNPAQFAPGEDLAAYPRDLSGDAE
VAQRAGADVLFTPQPEAMYPQGFDTWVEIPGLSSGLCGADRPGHFRGVCTVVMKLMLLTLPRLAVFGEKDWQQLAVLRRM
AKDMHLPVTIDGCPIVRETDGLAMSSRNVYLTPEERRQAPALYQGLIRARDMVAGGERDTAVLRAAVKEYWKQHLPEGRE
DYLEIVHPDTLQPLERVGGMATCAAAVRLGRARLIDNLALI

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=280, Percent_Identity=46.4285714285714, Blast_Score=228, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6322046, Length=313, Percent_Identity=35.4632587859425, Blast_Score=175, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_DESDG (Q311U9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387992.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q311U9
- SMR:   Q311U9
- STRING:   Q311U9
- GeneID:   3756051
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1498
- NMPDR:   fig|207559.3.peg.705
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   DDES207559:DDE_1498-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31071; Mature: 31071

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIITSPEELQRLCLDWRCGGVKTALVPTMGYYHAGHESLMAYARERADKVVVSLFVNPA
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCH
QFAPGEDLAAYPRDLSGDAEVAQRAGADVLFTPQPEAMYPQGFDTWVEIPGLSSGLCGAD
HCCCCCCHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCCCCC
RPGHFRGVCTVVMKLMLLTLPRLAVFGEKDWQQLAVLRRMAKDMHLPVTIDGCPIVRETD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCEECCC
GLAMSSRNVYLTPEERRQAPALYQGLIRARDMVAGGERDTAVLRAAVKEYWKQHLPEGRE
CCEECCCCEEECCHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCH
DYLEIVHPDTLQPLERVGGMATCAAAVRLGRARLIDNLALI
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIITSPEELQRLCLDWRCGGVKTALVPTMGYYHAGHESLMAYARERADKVVVSLFVNPA
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCH
QFAPGEDLAAYPRDLSGDAEVAQRAGADVLFTPQPEAMYPQGFDTWVEIPGLSSGLCGAD
HCCCCCCHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCCCCC
RPGHFRGVCTVVMKLMLLTLPRLAVFGEKDWQQLAVLRRMAKDMHLPVTIDGCPIVRETD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCEECCC
GLAMSSRNVYLTPEERRQAPALYQGLIRARDMVAGGERDTAVLRAAVKEYWKQHLPEGRE
CCEECCCCEEECCHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCH
DYLEIVHPDTLQPLERVGGMATCAAAVRLGRARLIDNLALI
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA