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The map label for this gene is cdd [H]

Identifier: 78356504

GI number: 78356504

Start: 1480835

End: 1482025

Strand: Direct

Name: cdd [H]

Synonym: Dde_1459

Alternate gene names: 78356504

Gene position: 1480835-1482025 (Clockwise)

Preceding gene: 78356502

Following gene: 78356505

Centisome position: 39.7

GC content: 56.17

Gene sequence:

>1191_bases
ATGCCGAAATCTGTTATTGCCGCCATACCGCGTCCGTCGCACATGGTGCGTTTTTGTGCGCTGTTCTGCACTGTGTGGCT
GTTCTGCTGGCTGTTTGCTTTTCCGTTGCAGGCGGCACCGCTTAAAGTGATATACGGTTTTGACAGAGAGTTTCCGCCGT
TTTCCTTTGAAGAAGCGCAGGGCATTCCCACGGGGTTTGATGTGGACCTGCTTAAAGCTGTCCTCCGGGATAAGCCGGTG
AAGCTGATCATGCGTCCGCTTTCGTGGGATCAGGTGCTGGTGGAACTTTCCGCCGGAAATATCACGGTGACATCCGGCAT
GGCCAAGACAGCTCAGCGTGAGTTGTTGTACCGCTTCACAGAACGTCCCACCCTGCCTGCGCGGGTTATGCTGTTTACCA
AAAATCATAACCGCGTGGGCAATGTGCGCCTGTTGCGCGGGCAGACTGTTTCTGTGGAAAAAGGGTCGTTTCAGCAGCGT
GTGCTGGAAGGCTTCGGCGGGCTTAACGTCAAGCTGTTCAATACCAAGGTGGATGCCCTGCGGGCCCTGTACAGGGACGA
GGTTGTGGCATACGGCGGGCCGGAGCGCACGGCGTACTATTATATAGAAAAGCTGAAGCTGGGCGGGATAACCACCGTCG
GCACTCCGCTGCGTGTCACCGACGTTTTTTATGCGGTGAACCGCGAAGAGCCTGAACTGCTCAAGTTAATCAACGACGGC
ATGCTGGAAGTTATGCGCAACGGTGAGTATGACCGCATTTACCGTAAATGGTTTGTGCCGGAACTGTTGCCCGAAGAGCG
TGCCGAACTGATAAAACAGGCCACGGCAGCGGCTATCAATGCCTATGCGCCGTATTCCAGAGTGCCGGTGGGCGCTGCGG
TGCTTACCCGCTCCGGAAAAATCTTCACAGGCTGCAATGTGGAGAATCCCATGCTCAACCTTACGGGTACGGCACTGCGT
ACGGCCACGCTTAAAGCCGTGTCGGAGGGCGACATAGGCATCCGTGCAGTGGTGTCAGTGGGACCGGACGGACGCCTTTT
ATCACCTTCCGCTTCTGACAGACAGTTCCTCTACGAGTTCGGACGTGGTATACTGGCCCTGATAGAGCCTGAAAAAGGCG
TCTACGAAGAGCGCATGCTCTCTGAGCTGCTGCCGGAACCGTATGTCCAGCGTCCGGAGTGGCAGGAGTAG

Upstream 100 bases:

>100_bases
CTCCCTGCCGTATCTGCCGAATAGAACAGGTGAACCGGTGCACGCTGCCGGTGGCCGGATTATTGTTATAGTGCTGTCTA
CTCAACTACGGGGTTTGTTC

Downstream 100 bases:

>100_bases
TCTGTTTTTCCGGAGGTCGTGATTTATGGATGATCGTCGCAGAAGGTTGCGTGTGCCCGCACGGTATGCCGTGCATCTGG
AATACGGCGGAAGCAGAAAC

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MPKSVIAAIPRPSHMVRFCALFCTVWLFCWLFAFPLQAAPLKVIYGFDREFPPFSFEEAQGIPTGFDVDLLKAVLRDKPV
KLIMRPLSWDQVLVELSAGNITVTSGMAKTAQRELLYRFTERPTLPARVMLFTKNHNRVGNVRLLRGQTVSVEKGSFQQR
VLEGFGGLNVKLFNTKVDALRALYRDEVVAYGGPERTAYYYIEKLKLGGITTVGTPLRVTDVFYAVNREEPELLKLINDG
MLEVMRNGEYDRIYRKWFVPELLPEERAELIKQATAAAINAYAPYSRVPVGAAVLTRSGKIFTGCNVENPMLNLTGTALR
TATLKAVSEGDIGIRAVVSVGPDGRLLSPSASDRQFLYEFGRGILALIEPEKGVYEERMLSELLPEPYVQRPEWQE

Sequences:

>Translated_396_residues
MPKSVIAAIPRPSHMVRFCALFCTVWLFCWLFAFPLQAAPLKVIYGFDREFPPFSFEEAQGIPTGFDVDLLKAVLRDKPV
KLIMRPLSWDQVLVELSAGNITVTSGMAKTAQRELLYRFTERPTLPARVMLFTKNHNRVGNVRLLRGQTVSVEKGSFQQR
VLEGFGGLNVKLFNTKVDALRALYRDEVVAYGGPERTAYYYIEKLKLGGITTVGTPLRVTDVFYAVNREEPELLKLINDG
MLEVMRNGEYDRIYRKWFVPELLPEERAELIKQATAAAINAYAPYSRVPVGAAVLTRSGKIFTGCNVENPMLNLTGTALR
TATLKAVSEGDIGIRAVVSVGPDGRLLSPSASDRQFLYEFGRGILALIEPEKGVYEERMLSELLPEPYVQRPEWQE
>Mature_395_residues
PKSVIAAIPRPSHMVRFCALFCTVWLFCWLFAFPLQAAPLKVIYGFDREFPPFSFEEAQGIPTGFDVDLLKAVLRDKPVK
LIMRPLSWDQVLVELSAGNITVTSGMAKTAQRELLYRFTERPTLPARVMLFTKNHNRVGNVRLLRGQTVSVEKGSFQQRV
LEGFGGLNVKLFNTKVDALRALYRDEVVAYGGPERTAYYYIEKLKLGGITTVGTPLRVTDVFYAVNREEPELLKLINDGM
LEVMRNGEYDRIYRKWFVPELLPEERAELIKQATAAAINAYAPYSRVPVGAAVLTRSGKIFTGCNVENPMLNLTGTALRT
ATLKAVSEGDIGIRAVVSVGPDGRLLSPSASDRQFLYEFGRGILALIEPEKGVYEERMLSELLPEPYVQRPEWQE

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=128, Percent_Identity=39.84375, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787031, Length=243, Percent_Identity=24.6913580246914, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788228, Length=226, Percent_Identity=23.4513274336283, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17540514, Length=101, Percent_Identity=46.5346534653465, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24582741, Length=125, Percent_Identity=40.8, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24582744, Length=98, Percent_Identity=41.8367346938776, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: 1440 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 460 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 44518; Mature: 44387

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSVIAAIPRPSHMVRFCALFCTVWLFCWLFAFPLQAAPLKVIYGFDREFPPFSFEEAQ
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHC
GIPTGFDVDLLKAVLRDKPVKLIMRPLSWDQVLVELSAGNITVTSGMAKTAQRELLYRFT
CCCCCCCHHHHHHHHCCCCCEEHCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHH
ERPTLPARVMLFTKNHNRVGNVRLLRGQTVSVEKGSFQQRVLEGFGGLNVKLFNTKVDAL
CCCCCCEEEEEEECCCCCCCCEEEEECCEEEECCCHHHHHHHHHCCCCEEEEECCHHHHH
RALYRDEVVAYGGPERTAYYYIEKLKLGGITTVGTPLRVTDVFYAVNREEPELLKLINDG
HHHHHHCEEEECCCCCEEEEEEEEEEECCEEECCCCEEEEHEEEEECCCCHHHHHHHHHH
MLEVMRNGEYDRIYRKWFVPELLPEERAELIKQATAAAINAYAPYSRVPVGAAVLTRSGK
HHHHHHCCCHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
IFTGCNVENPMLNLTGTALRTATLKAVSEGDIGIRAVVSVGPDGRLLSPSASDRQFLYEF
EEECCCCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCCCHHHHHHHH
GRGILALIEPEKGVYEERMLSELLPEPYVQRPEWQE
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PKSVIAAIPRPSHMVRFCALFCTVWLFCWLFAFPLQAAPLKVIYGFDREFPPFSFEEAQ
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHC
GIPTGFDVDLLKAVLRDKPVKLIMRPLSWDQVLVELSAGNITVTSGMAKTAQRELLYRFT
CCCCCCCHHHHHHHHCCCCCEEHCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHH
ERPTLPARVMLFTKNHNRVGNVRLLRGQTVSVEKGSFQQRVLEGFGGLNVKLFNTKVDAL
CCCCCCEEEEEEECCCCCCCCEEEEECCEEEECCCHHHHHHHHHCCCCEEEEECCHHHHH
RALYRDEVVAYGGPERTAYYYIEKLKLGGITTVGTPLRVTDVFYAVNREEPELLKLINDG
HHHHHHCEEEECCCCCEEEEEEEEEEECCEEECCCCEEEEHEEEEECCCCHHHHHHHHHH
MLEVMRNGEYDRIYRKWFVPELLPEERAELIKQATAAAINAYAPYSRVPVGAAVLTRSGK
HHHHHHCCCHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
IFTGCNVENPMLNLTGTALRTATLKAVSEGDIGIRAVVSVGPDGRLLSPSASDRQFLYEF
EEECCCCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCCCHHHHHHHH
GRGILALIEPEKGVYEERMLSELLPEPYVQRPEWQE
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2526291; 8969508; 9384377 [H]