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The map label for this gene is cobD [H]

Identifier: 78356446

GI number: 78356446

Start: 1416825

End: 1417958

Strand: Reverse

Name: cobD [H]

Synonym: Dde_1401

Alternate gene names: 78356446

Gene position: 1417958-1416825 (Counterclockwise)

Preceding gene: 78356447

Following gene: 78356444

Centisome position: 38.01

GC content: 57.76

Gene sequence:

>1134_bases
ATGAATAGCGGACCGGTTTCTGTGGCATGCGCACAGGGCAGCCACGGCGGTGATGTTGTACGGCTGGCCGCCAGGCTGGG
CATATCGCCGACGGATATTCTTGATTTCAGCAGCAACGCCAACTCTCTCTGTGACGACCTGACCCGTCAGGTGCTTGCAC
AGACAGGCTATGCGCACAGCCACTACCCCGACAGTGAATGTACCGGCCTGCGCCACCGCATAGCCGGCTTTGAAGAGACA
CAGCCGGAACGCATTCTTGCCGGCAACGGCTCGTCAGAACTCATCTATCTGGCCATGCACAGCCTGAAACCGCGCAGAGT
GCTGCTCATCGCTCCTGTTTTTTCGGAATATGTCCGGGCCTGTCAGGCCTGCGGTGCAGATTACCGCCTGTTCGAAACCG
ACCCGTATGACGGCTTCGACATTCCGGAACGCCACATCTGCCGCCTGCACGATGCGGTGACGGCATACCGCCCCGACATG
GCGGTCATCTGTGCGCCCAGCAATCCGGCATGTACTGATTACAGCCGGATGGACGATATTCTGTATGCGCTGGACTGCCC
CCATGTACTTGTGGACAACAGCTATCTGGATTTTCTGTGGGGCACTCCGGCCTACAGCCGTCACGGCATGGCTGCCTACG
CCGGATGCACGCGCACGGAAACGAAAGTTATCTCTCTGCGCAGCATGACCAAGTTCTTTTACTGCACCGGCGTCAGGCTG
GGGTACTGCCATGCAGATGAACAGACCATCGAACGGATGAACAGATGCAAAACGCCGTGGTCTGTCTGGCATGCCGCCCA
GCAGGCAGGGATGGCTTTTCTTGACCGCATGGATGAATACCGCCTGCGTCTGCCGGCCATGCGTGCCGAAAAAACAGCTT
TTGCAGGGGCACTCCGGAATACAGGGATATTTGACAACAACCTTGTGCTGGAAGGGGCCAACTTTGTCACCGCGCGTCTG
CAGCGTCCTGCAAAGGCCGCGACCGTTTACACGGAGTTGCTGCAGCACGGCATACTGGTCCGGCTATGTGATAATATTCC
CGGTATGCCGCAAGGCTTCATACGGATGCAGGTACGCGAAAAAAAAGCATGGAGCAGGCTGACCGCGATATTGGGCACTC
TGGACGCGGAATAA

Upstream 100 bases:

>100_bases
GGTCTCGAACGCCGCGTGGAACGCATTGAAGGGATATACAGAGGCTTGCTGCGCAGACGCGGTCTGCGTCAGGACTGAGC
ATGCCGGAGGAAAGCAGAGC

Downstream 100 bases:

>100_bases
CCGGCCTGCCCCGCTGTCACCCGCGCGGACGTCTGTCAAAATCAGCAGCACGGAAAACCGGCAGCAGCCGGCGCAGAACC
TATGTATCTGCCGTGCATGG

Product: L-threonine O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNSGPVSVACAQGSHGGDVVRLAARLGISPTDILDFSSNANSLCDDLTRQVLAQTGYAHSHYPDSECTGLRHRIAGFEET
QPERILAGNGSSELIYLAMHSLKPRRVLLIAPVFSEYVRACQACGADYRLFETDPYDGFDIPERHICRLHDAVTAYRPDM
AVICAPSNPACTDYSRMDDILYALDCPHVLVDNSYLDFLWGTPAYSRHGMAAYAGCTRTETKVISLRSMTKFFYCTGVRL
GYCHADEQTIERMNRCKTPWSVWHAAQQAGMAFLDRMDEYRLRLPAMRAEKTAFAGALRNTGIFDNNLVLEGANFVTARL
QRPAKAATVYTELLQHGILVRLCDNIPGMPQGFIRMQVREKKAWSRLTAILGTLDAE

Sequences:

>Translated_377_residues
MNSGPVSVACAQGSHGGDVVRLAARLGISPTDILDFSSNANSLCDDLTRQVLAQTGYAHSHYPDSECTGLRHRIAGFEET
QPERILAGNGSSELIYLAMHSLKPRRVLLIAPVFSEYVRACQACGADYRLFETDPYDGFDIPERHICRLHDAVTAYRPDM
AVICAPSNPACTDYSRMDDILYALDCPHVLVDNSYLDFLWGTPAYSRHGMAAYAGCTRTETKVISLRSMTKFFYCTGVRL
GYCHADEQTIERMNRCKTPWSVWHAAQQAGMAFLDRMDEYRLRLPAMRAEKTAFAGALRNTGIFDNNLVLEGANFVTARL
QRPAKAATVYTELLQHGILVRLCDNIPGMPQGFIRMQVREKKAWSRLTAILGTLDAE
>Mature_377_residues
MNSGPVSVACAQGSHGGDVVRLAARLGISPTDILDFSSNANSLCDDLTRQVLAQTGYAHSHYPDSECTGLRHRIAGFEET
QPERILAGNGSSELIYLAMHSLKPRRVLLIAPVFSEYVRACQACGADYRLFETDPYDGFDIPERHICRLHDAVTAYRPDM
AVICAPSNPACTDYSRMDDILYALDCPHVLVDNSYLDFLWGTPAYSRHGMAAYAGCTRTETKVISLRSMTKFFYCTGVRL
GYCHADEQTIERMNRCKTPWSVWHAAQQAGMAFLDRMDEYRLRLPAMRAEKTAFAGALRNTGIFDNNLVLEGANFVTARL
QRPAKAATVYTELLQHGILVRLCDNIPGMPQGFIRMQVREKKAWSRLTAILGTLDAE

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41976; Mature: 41976

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGPVSVACAQGSHGGDVVRLAARLGISPTDILDFSSNANSLCDDLTRQVLAQTGYAHS
CCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHEECCCCHHHHHHHHHHHHHHHCCCCCC
HYPDSECTGLRHRIAGFEETQPERILAGNGSSELIYLAMHSLKPRRVLLIAPVFSEYVRA
CCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCCCCCEEEEECHHHHHHHHH
CQACGADYRLFETDPYDGFDIPERHICRLHDAVTAYRPDMAVICAPSNPACTDYSRMDDI
HHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
LYALDCPHVLVDNSYLDFLWGTPAYSRHGMAAYAGCTRTETKVISLRSMTKFFYCTGVRL
HHHCCCCEEEECCCCEEHEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHEECCCEE
GYCHADEQTIERMNRCKTPWSVWHAAQQAGMAFLDRMDEYRLRLPAMRAEKTAFAGALRN
EEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
TGIFDNNLVLEGANFVTARLQRPAKAATVYTELLQHGILVRLCDNIPGMPQGFIRMQVRE
CCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHH
KKAWSRLTAILGTLDAE
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSGPVSVACAQGSHGGDVVRLAARLGISPTDILDFSSNANSLCDDLTRQVLAQTGYAHS
CCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHEECCCCHHHHHHHHHHHHHHHCCCCCC
HYPDSECTGLRHRIAGFEETQPERILAGNGSSELIYLAMHSLKPRRVLLIAPVFSEYVRA
CCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCCCCCEEEEECHHHHHHHHH
CQACGADYRLFETDPYDGFDIPERHICRLHDAVTAYRPDMAVICAPSNPACTDYSRMDDI
HHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
LYALDCPHVLVDNSYLDFLWGTPAYSRHGMAAYAGCTRTETKVISLRSMTKFFYCTGVRL
HHHCCCCEEEECCCCEEHEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHEECCCEE
GYCHADEQTIERMNRCKTPWSVWHAAQQAGMAFLDRMDEYRLRLPAMRAEKTAFAGALRN
EEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
TGIFDNNLVLEGANFVTARLQRPAKAATVYTELLQHGILVRLCDNIPGMPQGFIRMQVRE
CCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHH
KKAWSRLTAILGTLDAE
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]