Click here to switch to the map view.

The map label for this gene is yrhP [H]

Identifier: 78356433

GI number: 78356433

Start: 1406379

End: 1407065

Strand: Direct

Name: yrhP [H]

Synonym: Dde_1388

Alternate gene names: 78356433

Gene position: 1406379-1407065 (Clockwise)

Preceding gene: 78356432

Following gene: 78356434

Centisome position: 37.7

GC content: 64.19

Gene sequence:

>687_bases
ATGCCCGCTGAATCATTATGGAGCCTGCTTGCTGCCGCAGGGCCGGAACTGGCCATGCTGGCAGGCATAGCGGTGGTGCT
TACCGTTACTCCGGGGCCGGATACTTTTCTGGTGCTGCGCAATGCTCTGACAGGTGGCTCGCGGTGCGGTTTCATGACTG
CCTGCGGCATTGCCAGCGGGCTGCTGTTTCACGCTTTGCTGGCCGGTCTGGGGTTGTCCGCCGTGCTGGTGCATTCCGCG
CAGGCATATGCTGTTGTGCGCTGGTGCGGCGCGGCGTACCTGATATGGCTGGGCGTAAAAGCGCTGGCCGGTGTCCGGCG
CGCCGGCGGACTGCGTGCAGGCCCTGCAGACGAGGCAGCCCCGGCCCCTGCGCTGCAGGCGGAAGCGCCGGGCAGGCGCA
AAGCCTATTGTGAGGGGTTGGTGACAAATGTACTCAACCCCAAGGTTGCTGTTTTTTATCTTGCAGTGCTGCCCCAGATA
ATGGGTGCCCGTCCGGAAATCTGGCGTGCGGTATGGTTCGCCGCCGCGCATCTGGCGGCCACCGTGTTGTGGTTTGCGTT
GCTCAGCAAAGGGTGCGGCAGAGCGGGCAGGCTGCTGCGTCCGGTGGTCATGCGTCGTCTTGACGCTGCTGCAGGCGGTC
TTATGCTGCTTTTCGGCGTGCGGCTGGCACTGGAACAGGGGCGCTAG

Upstream 100 bases:

>100_bases
ACTTCCGGCACTTTGCAGTGTGATCACGGACGGAAAAGCCGGACACAAAGCAGACAGTAACCGGATGAACGTTTTTTGAG
CTTCGCAGACAGGAGAATAC

Downstream 100 bases:

>100_bases
TCCGGTATTTCTTGCAGGCAGGGCGCAGCCGTGGCACTTTTCTGCGGACGGAGTTGCACATGACGAGTCGTTTTTTCCTG
ATGCTGGGTCTCGGTTTACT

Product: amino acid transporter LysE

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MPAESLWSLLAAAGPELAMLAGIAVVLTVTPGPDTFLVLRNALTGGSRCGFMTACGIASGLLFHALLAGLGLSAVLVHSA
QAYAVVRWCGAAYLIWLGVKALAGVRRAGGLRAGPADEAAPAPALQAEAPGRRKAYCEGLVTNVLNPKVAVFYLAVLPQI
MGARPEIWRAVWFAAAHLAATVLWFALLSKGCGRAGRLLRPVVMRRLDAAAGGLMLLFGVRLALEQGR

Sequences:

>Translated_228_residues
MPAESLWSLLAAAGPELAMLAGIAVVLTVTPGPDTFLVLRNALTGGSRCGFMTACGIASGLLFHALLAGLGLSAVLVHSA
QAYAVVRWCGAAYLIWLGVKALAGVRRAGGLRAGPADEAAPAPALQAEAPGRRKAYCEGLVTNVLNPKVAVFYLAVLPQI
MGARPEIWRAVWFAAAHLAATVLWFALLSKGCGRAGRLLRPVVMRRLDAAAGGLMLLFGVRLALEQGR
>Mature_227_residues
PAESLWSLLAAAGPELAMLAGIAVVLTVTPGPDTFLVLRNALTGGSRCGFMTACGIASGLLFHALLAGLGLSAVLVHSAQ
AYAVVRWCGAAYLIWLGVKALAGVRRAGGLRAGPADEAAPAPALQAEAPGRRKAYCEGLVTNVLNPKVAVFYLAVLPQIM
GARPEIWRAVWFAAAHLAATVLWFALLSKGCGRAGRLLRPVVMRRLDAAAGGLMLLFGVRLALEQGR

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=202, Percent_Identity=28.2178217821782, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786522, Length=209, Percent_Identity=24.8803827751196, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI48994978, Length=216, Percent_Identity=27.3148148148148, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788099, Length=141, Percent_Identity=26.9503546099291, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 23705; Mature: 23573

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAESLWSLLAAAGPELAMLAGIAVVLTVTPGPDTFLVLRNALTGGSRCGFMTACGIASG
CCHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LLFHALLAGLGLSAVLVHSAQAYAVVRWCGAAYLIWLGVKALAGVRRAGGLRAGPADEAA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PAPALQAEAPGRRKAYCEGLVTNVLNPKVAVFYLAVLPQIMGARPEIWRAVWFAAAHLAA
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TVLWFALLSKGCGRAGRLLRPVVMRRLDAAAGGLMLLFGVRLALEQGR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAESLWSLLAAAGPELAMLAGIAVVLTVTPGPDTFLVLRNALTGGSRCGFMTACGIASG
CHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LLFHALLAGLGLSAVLVHSAQAYAVVRWCGAAYLIWLGVKALAGVRRAGGLRAGPADEAA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PAPALQAEAPGRRKAYCEGLVTNVLNPKVAVFYLAVLPQIMGARPEIWRAVWFAAAHLAA
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TVLWFALLSKGCGRAGRLLRPVVMRRLDAAAGGLMLLFGVRLALEQGR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]