| Definition | Desulfovibrio desulfuricans subsp. desulfuricans str. G20 chromosome, complete genome. |
|---|---|
| Accession | NC_007519 |
| Length | 3,730,232 |
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The map label for this gene is topB [H]
Identifier: 78356365
GI number: 78356365
Start: 1336747
End: 1339164
Strand: Direct
Name: topB [H]
Synonym: Dde_1318
Alternate gene names: 78356365
Gene position: 1336747-1339164 (Clockwise)
Preceding gene: 78356363
Following gene: 78356366
Centisome position: 35.84
GC content: 58.93
Gene sequence:
>2418_bases ATGTCTAAAATACTTATTATTGCAGAAAAACCATCCGTAGCGCGGGAAATTGCACCGCTGGTCGGTGCCGTTTCCAGACG TGACGGCTTTCTGGAAGGCCCGACGCATATCGTCAGCTGGGCGGTGGGGCATCTGGTTAACATAGCCGAGCCGGAAGAAC AGGACGAAGCATGGGGCGGACGCTGGGCGCTGGAACAGCTGCCCATGATTCCCCGGCAGTTTCGACTGACCGTGCTGCCC GAAGCCCGCAGACAGTATGAAACCGTGCGGCAGCTCATGCATCGCGATGATGTGGCGCATGTGGTTAACGCCACCGACGC CGGACGGGAGGGTGAACTTATTTTCCGGCGCATCCAGCTGCACGCCGGCTGCACAAAGCCTGTGCAGCGCATGTGGGCCA ACGATATGACGGAAGAAGGGCTGCGCCGCAGTCTGGGCAATCTGCTGGAGGATGCCGCCAAGCGTAATCTGGGGCTTGCG GCCTTTGCACGGGCCGAGGCGGACTGGCTTATCGGTATGAATCTTTCGCGCCTGTTCACGCTGAAGGCCGGTTCACTTAT TTCTGTCGGCCGTGTGCAGACGCCGGTGCTCAAGCTTATCTGTGACCGGCGTGCGGAAATAGAACATTTTGTTCCTTCTG ATTTCTGGACGGTGGAGGCCCGTTTCGGCCGCAGCGCACCCTGTAATGCCGGTGGTGCCGCAGCTGCAGCCGGTTCCGCC GCGCCGGTGTGTTTGTCTGCCGGGGCGGCGGACGCGCAAGGAGCGGAAAAACACCCCCCGCAGGCCGCTGCGGCAACTGC CGGTCAGGCATCATGCCCGCCGGATGAGAACGCGGATGCCCGAGGCACGGGAACGGAGACACCGGCTGATGATGTGTTCA GTGCCGTGTGGCACCTGCCGCCCGACTTCAAGGAAACACGTCTGGAGCGGCAGGATGATGCCGAAGCAGTCATCGGTCGT TGTCAGGGCGGTACAGGCGTGGTGGACGCCACGGAAAACCGCAAGGGCTCTCAGAAACCTCCGCTTCCCTTCGACCTGAC TACCCTGCAGCGCGAAGCGAACTCGCGTTTCGGCTATTCAGCCAAGGAAACACTCGCCATAGCGCAGGCTCTGTACGAAC AGCGCAAGCTCATCACTTATCCCAGAACTGATTCGCGATACCTTACCCGTGATTTGTTCAAGGAAATTTTAAAGCATTTC AGAGCGGTATATCATCTGTACCCGCAGGAGACGGTTCCGGCAGTGGAGCGTGTCAAAGCGGGGTGCAAGTTTGACTGTGT CAATGACAAAAAAGTCACCGATCACCACGCCATCATTCCCACAGCTGCCAAAGGCAGGCCTGATGCGCTTTCTGCCGAAG AACGTAATGTTTACGACATGGTCTGCCGCCGTTTTGTGGCCGCGTTCAGCGCTCCGGCCAGTTTCATGTCATCCACGGTA CGGGTGCTCTCCGGTGAAGATGTTTTTGTAGCGCGGGGAAAAGTATTCAAGGATATCGGCTGGCTGGCTGTGGAACCGTG GCGCACGGCCGAGGACAACCCGTTGCCCGCACTGCGCAAGGGGACACGGCTGCATGTGCATGAAGTTTCGGCTGTCAGAC GGCAGACAAAAGCTCCGGCGCATTTTACCGATGCTTCGCTGCTTGCCGCCATGGAAACCGCGGGGCGGCTGGTGGATGAC GAAGAGCTGCGCAATGCCATGAAGGAGCGCGGGCTGGGCACTCCGGCCACAAGGGCACAGATTATTGAAACCCTGCTGGC GCGGGGGTATGTGGAAAAGAAAGGCAAAAGGCTGATTGCCACCGATTCCGGCATGCAGGCCGCGGCGCTGGTCTCTTCCA TGCTGCCTGATATGGCCTCGGCGGAACTGACTGGTCTCTGGGAAAAAAAGCTCAAAGATATCGAAGCGGGAAATAATACA TACCCTTTGTTCATGCAGGAAATCAGAACCATGCTGGCGCAGAGTGTCGAAAGCATAAAGCCCCGCAATGTCAAAAACAT ACTGGTAGAAACCGCTGCGCGTCTGGCCTCGCGCGAGCTGGACGGTAAATGTCCGTTGTGCGGGGCAGAGGTGGAAGAGC GGGACAAAGGGTTCGGGTGCAGCCGCTGGAAACGCGCTGACGGCGGGTGTCCCTTTATGATCTGGCGGACATTTATGGGT ACGCAGATTGATGCGGGTATGGTACGCGAGCTGCTGGAGACGGGCTGCACCAGTCAGGAACTGCAGCTTACTTCCCGCGG CGGCAATACTTTTTCGGCACGGCTCAGACTGGAGCAGGGAAGAGTGCGCCCCGACCTGCCGGAAAAACATGCCCGTGCGT CCGGCGGCGCTGCACCGTCTGCCGGTGTGGACATGCACGACCCTGCCGAAAATCCTTTTTTCGCGGATGAAAATCCGTTT CCGCCGGAAATGCCCTGA
Upstream 100 bases:
>100_bases GGGGTCAAGATGCGCGCCAGCTGTCATTTGACGCCCGCCTTTCAAGCGGGTAGGTAGCGGCTCAGACTGGCTCAGAGCCT GTCAGGCGGAATCATATATT
Downstream 100 bases:
>100_bases TTGACCTGCGTGCTTGATGCCTGCCCGTTTTTGCGCAGCTCAGGCTGACCTGTATGGCTCGACCGGAAAAAGCAGACTTG CTCCGCTTTTTCCGGTCTGT
Product: DNA topoisomerase III
Products: NA
Alternate protein names: DNA topoisomerase III [H]
Number of amino acids: Translated: 805; Mature: 804
Protein sequence:
>805_residues MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLP EARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLA AFARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSA APVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGR CQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHF RAVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTV RVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDD EELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNT YPLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMG TQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPF PPEMP
Sequences:
>Translated_805_residues MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLP EARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLA AFARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSA APVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGR CQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHF RAVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTV RVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDD EELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNT YPLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMG TQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPF PPEMP >Mature_804_residues SKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLPE ARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAA FARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSAA PVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGRC QGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFR AVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTVR VLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDDE ELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTY PLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMGT QIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPFP PEMP
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. TOP3 is a potent decatenase [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=373, Percent_Identity=26.8096514745308, Blast_Score=100, Evalue=8e-21, Organism=Homo sapiens, GI4507635, Length=341, Percent_Identity=24.0469208211144, Blast_Score=93, Evalue=1e-18, Organism=Escherichia coli, GI1788061, Length=389, Percent_Identity=38.0462724935733, Blast_Score=223, Evalue=4e-59, Organism=Escherichia coli, GI1787529, Length=381, Percent_Identity=26.509186351706, Blast_Score=125, Evalue=1e-29, Organism=Caenorhabditis elegans, GI32563869, Length=365, Percent_Identity=24.9315068493151, Blast_Score=91, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17555378, Length=343, Percent_Identity=24.7813411078717, Blast_Score=78, Evalue=2e-14, Organism=Drosophila melanogaster, GI24640096, Length=339, Percent_Identity=23.3038348082596, Blast_Score=86, Evalue=9e-17, Organism=Drosophila melanogaster, GI24585251, Length=323, Percent_Identity=25.6965944272446, Blast_Score=82, Evalue=1e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR005738 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 88353; Mature: 88222
Theoretical pI: Translated: 7.37; Mature: 7.37
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGG CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCC RWALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQL CHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH HAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRLFT HCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCHHHHEE LKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSA ECCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHCCCCC APVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLP CCCEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC PDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYS CCHHHHHCCCCCCHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC AKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETVPAVERVKA HHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC GCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTV CCEEECCCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH RVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPA HHHCCCCEEEECCHHHHHCCCEEECCCCCCCCCCCCHHHCCCEEEHHHHHHHHHHHCCCC HFTDASLLAAMETAGRLVDDEELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIA CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE TDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQEIRTMLAQSVESIK ECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC PRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMG CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHC TQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPS CCCCHHHHHHHHHCCCCCHHEEEECCCCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCCC AGVDMHDPAENPFFADENPFPPEMP CCCCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure SKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGG CCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCC RWALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQL CHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH HAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRLFT HCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCHHHHEE LKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSA ECCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHCCCCC APVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLP CCCEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC PDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYS CCHHHHHCCCCCCHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC AKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETVPAVERVKA HHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC GCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTV CCEEECCCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH RVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPA HHHCCCCEEEECCHHHHHCCCEEECCCCCCCCCCCCHHHCCCEEEHHHHHHHHHHHCCCC HFTDASLLAAMETAGRLVDDEELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIA CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE TDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQEIRTMLAQSVESIK ECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC PRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMG CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHC TQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPS CCCCHHHHHHHHHCCCCCHHEEEECCCCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCCC AGVDMHDPAENPFFADENPFPPEMP CCCCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7542800 [H]