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The map label for this gene is atoC [H]

Identifier: 78356307

GI number: 78356307

Start: 1274131

End: 1275552

Strand: Reverse

Name: atoC [H]

Synonym: Dde_1260

Alternate gene names: 78356307

Gene position: 1275552-1274131 (Counterclockwise)

Preceding gene: 78356308

Following gene: 78356306

Centisome position: 34.19

GC content: 61.04

Gene sequence:

>1422_bases
ATGCGCGTTCTGATCATTGACGACGACGAACATATGCGCCACGCGCTGGGACGCACAGTCAGACGTCTGGGATGTGAACC
GGTCATGGCCGGCATGGGCGGCGAAGGCCTGCAACATGCGGAAAAAGGCGATATCGATGCCGTGTTTCTGGATGTGCGGC
TGCCGGACGGCAACGGGCTTTCCTTTCTGCCCCGGCTGGCGGAAGCCCCCTCACGCCCGGAGGTCATAATCATCACCGGC
GCCGGAGACCCTGACGGTGCAGAACTGGCCATTACCAACGGCGCGTGGGACTACATAGAAAAGACAGCTTCCATTCAGGA
TATCACGCTTACCCTCAGACGTGCGCTGGATTTCCGCCGCGAACGCATGGAATCGCGCAAGGACTGCCCCGTACGCGCCC
TGCGCCGCAAAGGCATAGTGGGTGACAGCCCCGCCCTGATGCGCTGTCTTGATCTGGTTGCACAGTCGGCCCAGACCCGC
GCCAACGTCCTCATCTGCGGCGAAACAGGTACCGGCAAGGAACTGTTCGCCCGCGCCATACACGAAAACAGCATGCGCTC
CGACGGCCCCTTTGTGGTGGTGGACTGCGCCGGTCTGCCGGAAAATCTGGTGGAAAGTATTCTTTTCGGCCACAACAAAG
GATCATTCACCGGTGCAGAAAAAGACCGCACAGGACTGGTGCAGCGTGCCCACGGCGGAACGCTCTTTCTGGACGAGGTA
GGCGAACTGCCACTGCTCATGCAGAAAAGCTTCCTGCGGGTTCTGCAGGAGCGCACCGTCCGCCCGCTGGGGTCGGCAGA
GGAAGTGCCCTGCGACTTCCGGCTGGTGGCGGCGACAAACCGCGATCTGGAAGCCATGGTGCAGGCGGGAGAATTCCGCA
ATGATCTTCTGTTCCGCCTGCGTTCCATACTTATCGATCTGCCGCCGCTGCGCGATCGCAAAGATGATATCCCCGCCATC
AGCAACAATTATCTGGACAGGGAATGCGCAAGGGCCGGCATGGACCGCAAAGGGTGCTACGCTGATTTTTTTGATGTGCT
CACGCACTACAGCTGGCCGGGCAACGTGCGCGAACTGCTGCATGCGCTTGACCACGCACTGGCTGCAGCCATTACCGAAC
CGTACCTTTTTGCATGGCATCTGCCGCCCGCACTGCGTGCCAAAGTAGCCCGGGCCCGTGTGGCTGCCGGTCCCGGCAGC
ACGCCGCCGCAAGCATCGCCCCCCATGGCTGAAAACGCCGGCGCCGGGCTGCCGCTGCTGCAGGATTACCGTGAAGCGGT
GCTGCAGCAGGCCGAATCAGGATACCTGCGGCGCCTCATGGCAGAAAGCGGCAACTGCGTGCGCAAAGCAGTCAGCACGT
CAGGTCTTTCCCAGTCGCGGCTGTATGCCCTGTTAAAAAAACACAACATAACCACCTCATGA

Upstream 100 bases:

>100_bases
GGGGTGGCGGCCTTTTTCTACAAACCGTTTGATACCGCGGCTCTGAGCGCGGAAATACGCACCCAGCTGGACAAGCATAA
AAAGCACAGGAGCACCGCAC

Downstream 100 bases:

>100_bases
TGTACCGGCGGCCACGCGCATATGCAGCAAACCAACGCCGCAGAAGCCTGCTGACAGCAGGCTGTGCGCCTGCGCCGCCG
CCTGTTCCGCCTCCATGCCG

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRVLIIDDDEHMRHALGRTVRRLGCEPVMAGMGGEGLQHAEKGDIDAVFLDVRLPDGNGLSFLPRLAEAPSRPEVIIITG
AGDPDGAELAITNGAWDYIEKTASIQDITLTLRRALDFRRERMESRKDCPVRALRRKGIVGDSPALMRCLDLVAQSAQTR
ANVLICGETGTGKELFARAIHENSMRSDGPFVVVDCAGLPENLVESILFGHNKGSFTGAEKDRTGLVQRAHGGTLFLDEV
GELPLLMQKSFLRVLQERTVRPLGSAEEVPCDFRLVAATNRDLEAMVQAGEFRNDLLFRLRSILIDLPPLRDRKDDIPAI
SNNYLDRECARAGMDRKGCYADFFDVLTHYSWPGNVRELLHALDHALAAAITEPYLFAWHLPPALRAKVARARVAAGPGS
TPPQASPPMAENAGAGLPLLQDYREAVLQQAESGYLRRLMAESGNCVRKAVSTSGLSQSRLYALLKKHNITTS

Sequences:

>Translated_473_residues
MRVLIIDDDEHMRHALGRTVRRLGCEPVMAGMGGEGLQHAEKGDIDAVFLDVRLPDGNGLSFLPRLAEAPSRPEVIIITG
AGDPDGAELAITNGAWDYIEKTASIQDITLTLRRALDFRRERMESRKDCPVRALRRKGIVGDSPALMRCLDLVAQSAQTR
ANVLICGETGTGKELFARAIHENSMRSDGPFVVVDCAGLPENLVESILFGHNKGSFTGAEKDRTGLVQRAHGGTLFLDEV
GELPLLMQKSFLRVLQERTVRPLGSAEEVPCDFRLVAATNRDLEAMVQAGEFRNDLLFRLRSILIDLPPLRDRKDDIPAI
SNNYLDRECARAGMDRKGCYADFFDVLTHYSWPGNVRELLHALDHALAAAITEPYLFAWHLPPALRAKVARARVAAGPGS
TPPQASPPMAENAGAGLPLLQDYREAVLQQAESGYLRRLMAESGNCVRKAVSTSGLSQSRLYALLKKHNITTS
>Mature_473_residues
MRVLIIDDDEHMRHALGRTVRRLGCEPVMAGMGGEGLQHAEKGDIDAVFLDVRLPDGNGLSFLPRLAEAPSRPEVIIITG
AGDPDGAELAITNGAWDYIEKTASIQDITLTLRRALDFRRERMESRKDCPVRALRRKGIVGDSPALMRCLDLVAQSAQTR
ANVLICGETGTGKELFARAIHENSMRSDGPFVVVDCAGLPENLVESILFGHNKGSFTGAEKDRTGLVQRAHGGTLFLDEV
GELPLLMQKSFLRVLQERTVRPLGSAEEVPCDFRLVAATNRDLEAMVQAGEFRNDLLFRLRSILIDLPPLRDRKDDIPAI
SNNYLDRECARAGMDRKGCYADFFDVLTHYSWPGNVRELLHALDHALAAAITEPYLFAWHLPPALRAKVARARVAAGPGS
TPPQASPPMAENAGAGLPLLQDYREAVLQQAESGYLRRLMAESGNCVRKAVSTSGLSQSRLYALLKKHNITTS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=393, Percent_Identity=40.4580152671756, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1790437, Length=384, Percent_Identity=40.3645833333333, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1788905, Length=473, Percent_Identity=33.4038054968288, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1790299, Length=360, Percent_Identity=36.9444444444444, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI87082117, Length=222, Percent_Identity=47.2972972972973, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=33.9285714285714, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87082152, Length=255, Percent_Identity=44.3137254901961, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789087, Length=229, Percent_Identity=46.7248908296943, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786524, Length=317, Percent_Identity=39.4321766561514, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87081872, Length=336, Percent_Identity=35.1190476190476, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1787583, Length=230, Percent_Identity=40.8695652173913, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789828, Length=235, Percent_Identity=38.2978723404255, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081858, Length=334, Percent_Identity=28.4431137724551, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51904; Mature: 51904

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIIDDDEHMRHALGRTVRRLGCEPVMAGMGGEGLQHAEKGDIDAVFLDVRLPDGNGL
CEEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCH
SFLPRLAEAPSRPEVIIITGAGDPDGAELAITNGAWDYIEKTASIQDITLTLRRALDFRR
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHH
ERMESRKDCPVRALRRKGIVGDSPALMRCLDLVAQSAQTRANVLICGETGTGKELFARAI
HHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHH
HENSMRSDGPFVVVDCAGLPENLVESILFGHNKGSFTGAEKDRTGLVQRAHGGTLFLDEV
HHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEECCCC
GELPLLMQKSFLRVLQERTVRPLGSAEEVPCDFRLVAATNRDLEAMVQAGEFRNDLLFRL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
RSILIDLPPLRDRKDDIPAISNNYLDRECARAGMDRKGCYADFFDVLTHYSWPGNVRELL
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
HALDHALAAAITEPYLFAWHLPPALRAKVARARVAAGPGSTPPQASPPMAENAGAGLPLL
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
QDYREAVLQQAESGYLRRLMAESGNCVRKAVSTSGLSQSRLYALLKKHNITTS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRVLIIDDDEHMRHALGRTVRRLGCEPVMAGMGGEGLQHAEKGDIDAVFLDVRLPDGNGL
CEEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCH
SFLPRLAEAPSRPEVIIITGAGDPDGAELAITNGAWDYIEKTASIQDITLTLRRALDFRR
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHH
ERMESRKDCPVRALRRKGIVGDSPALMRCLDLVAQSAQTRANVLICGETGTGKELFARAI
HHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHH
HENSMRSDGPFVVVDCAGLPENLVESILFGHNKGSFTGAEKDRTGLVQRAHGGTLFLDEV
HHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEECCCC
GELPLLMQKSFLRVLQERTVRPLGSAEEVPCDFRLVAATNRDLEAMVQAGEFRNDLLFRL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
RSILIDLPPLRDRKDDIPAISNNYLDRECARAGMDRKGCYADFFDVLTHYSWPGNVRELL
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
HALDHALAAAITEPYLFAWHLPPALRAKVARARVAAGPGSTPPQASPPMAENAGAGLPLL
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
QDYREAVLQQAESGYLRRLMAESGNCVRKAVSTSGLSQSRLYALLKKHNITTS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]