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The map label for this gene is adhB [H]

Identifier: 78356211

GI number: 78356211

Start: 1186693

End: 1187859

Strand: Direct

Name: adhB [H]

Synonym: Dde_1164

Alternate gene names: 78356211

Gene position: 1186693-1187859 (Clockwise)

Preceding gene: 78356207

Following gene: 78356212

Centisome position: 31.81

GC content: 59.55

Gene sequence:

>1167_bases
ATGGTGGATGATTCTTTGTATGCTTTGCGCAAGCTGATTGTGCCCGAAGTGGTCTTCGGTGCCGGAGCGCTCCGTCTGGT
GGGTCAGTATGCCGTCAACTTCAACCTGACGCACTGCCTTGTGGTTACCGATGCCGGTGTGGCGTCGGCGGGATGGAGCG
GCAGCGTAGTGGATGCTTTGCAGGCTCACGGAGTCAGCTCCACTGTATTCAGCGATATTTCCGCCAATCCCCGCGATACC
GAGGTGCGCCAAGGGGTTGCCGTGTACCGCGCGGCAGGGTGTGACGGCATTGTGGCTGTGGGCGGCGGCAGCCCCATGGA
CTGCGCCAAAGGGATAGGACTGATGGTTTCCGGCGGCAGAGACGTGCTGGAATACGAAGGCGTGGATAAAGTTGAGGTGC
CCGCGCCGCCGCTCATCTGTATTCCCACCACGGCGGGCACCAGTGCCGATGTATCTCAGTTCGCCATTATCAATGACGCA
CGACGCAGGTTGAAAATAGCCATTGTCAGCAAATCCGCTGTGCCTGATCTGGCGCTTGTCGATCCTTCCACCACTCTTTC
CATGCCGCCGCGGCTCACCGCATCCACCGGCCTTGATGCCTTGTGCCATGCGGTGGAGGCCTATTGTTCCACGGTAAGCT
CGCCCATGACTGATCTTTTTGCATTGCGCGCCATGCGGCTTATCGGTGCCAATCTGCAGAAGGTGCTCGACAACCCGCAG
GACATGGCCGCGCGGGAAAATATGATGCTGGCATCCATGTATGCGGGGTTTGCATTTTCCAATGCCATACTTGGGGCGGT
TCACGCCATGGCGCACGGTCTGGGGGGGCTGCTGGACATGCCGCACGGAGAGTGCAATGCCATTCTGATGCCCCATGTGG
TGCGGGCAAACTGTCAGGTTGTTCCCGCCCGCTGCGCCGATATTGCGCAGGAACTGGGGTTTGCCGGTGCGCCGTCCGGT
GCGGATGCACTGGGTGATTTTTTACATGACAGGCTGCTCGATATGCGGCGCAGGGCCGGAGTGACGGCAACGCTGGGCAC
CATGGGCATGAAGCGTGAAGATATCCCCCCGCTGGCACGTAATGCCATGCACGATGCCTGCATGCTGACCAACCCCCGCA
GGTTTACGCTGCAGGAAGTGGAAGCATTGTATCTGGAAGCGTTTTGA

Upstream 100 bases:

>100_bases
TTGCGGATGTGCTGAACCTGCTTGTATTTGTCTCTGCGATGCGTAATAGTGGAAGAAGTATATTTTTACGTCTCCACTGC
TAACCTCGGGGAGCCTTCGG

Downstream 100 bases:

>100_bases
AAATGAAATCAAGGGTGCGGCATGATGCAGGATTCCAGAAAAAAACAGCCCGATCTTCCGCCGGACAGTCAGGGGGGTGA
GCACCCGCTCCGTGCCGGAC

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MVDDSLYALRKLIVPEVVFGAGALRLVGQYAVNFNLTHCLVVTDAGVASAGWSGSVVDALQAHGVSSTVFSDISANPRDT
EVRQGVAVYRAAGCDGIVAVGGGSPMDCAKGIGLMVSGGRDVLEYEGVDKVEVPAPPLICIPTTAGTSADVSQFAIINDA
RRRLKIAIVSKSAVPDLALVDPSTTLSMPPRLTASTGLDALCHAVEAYCSTVSSPMTDLFALRAMRLIGANLQKVLDNPQ
DMAARENMMLASMYAGFAFSNAILGAVHAMAHGLGGLLDMPHGECNAILMPHVVRANCQVVPARCADIAQELGFAGAPSG
ADALGDFLHDRLLDMRRRAGVTATLGTMGMKREDIPPLARNAMHDACMLTNPRRFTLQEVEALYLEAF

Sequences:

>Translated_388_residues
MVDDSLYALRKLIVPEVVFGAGALRLVGQYAVNFNLTHCLVVTDAGVASAGWSGSVVDALQAHGVSSTVFSDISANPRDT
EVRQGVAVYRAAGCDGIVAVGGGSPMDCAKGIGLMVSGGRDVLEYEGVDKVEVPAPPLICIPTTAGTSADVSQFAIINDA
RRRLKIAIVSKSAVPDLALVDPSTTLSMPPRLTASTGLDALCHAVEAYCSTVSSPMTDLFALRAMRLIGANLQKVLDNPQ
DMAARENMMLASMYAGFAFSNAILGAVHAMAHGLGGLLDMPHGECNAILMPHVVRANCQVVPARCADIAQELGFAGAPSG
ADALGDFLHDRLLDMRRRAGVTATLGTMGMKREDIPPLARNAMHDACMLTNPRRFTLQEVEALYLEAF
>Mature_388_residues
MVDDSLYALRKLIVPEVVFGAGALRLVGQYAVNFNLTHCLVVTDAGVASAGWSGSVVDALQAHGVSSTVFSDISANPRDT
EVRQGVAVYRAAGCDGIVAVGGGSPMDCAKGIGLMVSGGRDVLEYEGVDKVEVPAPPLICIPTTAGTSADVSQFAIINDA
RRRLKIAIVSKSAVPDLALVDPSTTLSMPPRLTASTGLDALCHAVEAYCSTVSSPMTDLFALRAMRLIGANLQKVLDNPQ
DMAARENMMLASMYAGFAFSNAILGAVHAMAHGLGGLLDMPHGECNAILMPHVVRANCQVVPARCADIAQELGFAGAPSG
ADALGDFLHDRLLDMRRRAGVTATLGTMGMKREDIPPLARNAMHDACMLTNPRRFTLQEVEALYLEAF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=395, Percent_Identity=29.620253164557, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=40.1055408970976, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI1789163, Length=385, Percent_Identity=34.025974025974, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=35.6770833333333, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787493, Length=403, Percent_Identity=29.7766749379653, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789386, Length=266, Percent_Identity=26.6917293233083, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=427, Percent_Identity=28.1030444964871, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=39.9470899470899, Blast_Score=282, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24657991, Length=408, Percent_Identity=28.4313725490196, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40782; Mature: 40782

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDDSLYALRKLIVPEVVFGAGALRLVGQYAVNFNLTHCLVVTDAGVASAGWSGSVVDAL
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCEEEEEEECCCCCCCCCCCHHHHHH
QAHGVSSTVFSDISANPRDTEVRQGVAVYRAAGCDGIVAVGGGSPMDCAKGIGLMVSGGR
HHCCCCHHHHHHCCCCCCCHHHHHHHHHHEECCCCCEEEECCCCCHHHHCCCCEEEECCC
DVLEYEGVDKVEVPAPPLICIPTTAGTSADVSQFAIINDARRRLKIAIVSKSAVPDLALV
CEEECCCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCCEEEE
DPSTTLSMPPRLTASTGLDALCHAVEAYCSTVSSPMTDLFALRAMRLIGANLQKVLDNPQ
CCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHH
DMAARENMMLASMYAGFAFSNAILGAVHAMAHGLGGLLDMPHGECNAILMPHVVRANCQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCEE
VPARCADIAQELGFAGAPSGADALGDFLHDRLLDMRRRAGVTATLGTMGMKREDIPPLAR
EHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCHHHH
NAMHDACMLTNPRRFTLQEVEALYLEAF
HHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDDSLYALRKLIVPEVVFGAGALRLVGQYAVNFNLTHCLVVTDAGVASAGWSGSVVDAL
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCEEEEEEECCCCCCCCCCCHHHHHH
QAHGVSSTVFSDISANPRDTEVRQGVAVYRAAGCDGIVAVGGGSPMDCAKGIGLMVSGGR
HHCCCCHHHHHHCCCCCCCHHHHHHHHHHEECCCCCEEEECCCCCHHHHCCCCEEEECCC
DVLEYEGVDKVEVPAPPLICIPTTAGTSADVSQFAIINDARRRLKIAIVSKSAVPDLALV
CEEECCCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCCEEEE
DPSTTLSMPPRLTASTGLDALCHAVEAYCSTVSSPMTDLFALRAMRLIGANLQKVLDNPQ
CCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHH
DMAARENMMLASMYAGFAFSNAILGAVHAMAHGLGGLLDMPHGECNAILMPHVVRANCQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCEE
VPARCADIAQELGFAGAPSGADALGDFLHDRLLDMRRRAGVTATLGTMGMKREDIPPLAR
EHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCHHHH
NAMHDACMLTNPRRFTLQEVEALYLEAF
HHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]