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The map label for this gene is ffh [H]

Identifier: 78356147

GI number: 78356147

Start: 1127597

End: 1129135

Strand: Reverse

Name: ffh [H]

Synonym: Dde_1100

Alternate gene names: 78356147

Gene position: 1129135-1127597 (Counterclockwise)

Preceding gene: 78356148

Following gene: 78356146

Centisome position: 30.27

GC content: 57.12

Gene sequence:

>1539_bases
ATGTTCGATACGCTTTCCGACCGGTTGTCGTCGGTATTCAAGAAGTTCAGCGGCCAGAAACGGTTAACTGAAGAAAACGT
GCAGGAAGGCCTGCGCGAAGTCCGACTTGCGCTGCTGGAGGCCGACGTCAATTTCAAGGTCGTCAAGCAGTTCATCGACC
GTGTGCGCGATAAATGCCTTGGTCAGGACGTGCTCAAGGGCCTGAATCCCGCGCAGCAGGTTATCAAAATCGTCAATGAC
GAAATGATTGAACTGCTGGGCGGCGAAACCACGGGCCTCGACCTGCGCGGCCAGCAGCCTTATGTCATCATGATGGTGGG
TCTGCAGGGGTCTGGTAAAACCACCTCTACCGGCAAACTGGCCAACCATCTGCGTAAAAGCAAAATGCGGCCGTACCTTG
CACCGGCCGACGTCTACCGCCCGGCAGCCATCGACCAGCTGAAAACACTGGCGGCGCAGCTTGACCTGCCCGTGTATGAT
TCCACGGTGCAGATGAACCCCGTGGACATTGCCAGAAATGCGGTGGCCGCAGCCAGAGAACAGCAGTGCAACGTTGTCAT
TCTTGACACCGCCGGCCGGCTGCACATTGACGAAACGCTCATGCAGGAGCTTGTGGCCATTAAAGAGGCCGTGGCTCCGC
AGGAAATTCTGTTCGTGGCCGACGCCATGACGGGTCAGGACGCCGTGACGGTGGCAGATGCGTTCAACAACGCGCTGGAC
ATCACCGGCGTGGTGCTGACCAAAATGGACGGCGATGCCCGCGGCGGCGCGGCCCTGTCCATCAAGACTGTCACCGGAAA
ATCGGTGAAATTCGTCGGCATGGGCGAAAAGCTCTCCGACCTTGAAGTGTTCCACCCTGACAGAATTGCCAGCCGCATTC
TGGGCATGGGTGACGTACTGACGCTGATAGAAAAGGCGCAGACCACCATCAAGGAAGAAGAAGCTGAAGAACTGGGCCGC
AAAATGCAGCGGGCCGAGTTCGACTTTGAAGATTTCCGGACTCAGATGCGCCGCATGCGCAAACTGGGTTCGCTCGAAAG
TATCATGAAGCTGATTCCCGGCATGGGTGCCCTGCGCGAAAAGCTGGGCGACATGCAGGTTCCTGAAAAGGAAATGGTCC
GCATAGAGGCCATCATCAACTCCATGACGCGGCAGGAAAGGCGCCAGCCCATCCTGATGAACACCAGCCGCAAGGAACGT
ATAGCCAGAGGTGCCGGCACCACCGTGAAAGAGGTGGATAAACTGCTGAGCAACTTTGAAGGCATGCGGCAGATGATGAA
GCAGGTCATGGGCGGCGGAAAAAAGAAAAAAGGCAAAATGCCCCAGCTGCCCGGCATGGGCGGCAAAGGCATGCCCGATC
CTTCGGCCATGAGCGGTATGGGCGGACTGCCCGGTATGGGCGGCTTTCCCGGTATGCCCGGCATGCCCGGCATGGACGGC
ATGCAGCCTTCCGGTCCCAGCAAATCGGACCAGAAGAAAAAACGCGACCAGCGTAAAAAAGACAAACAGAAAAAGAAACA
GGGCAAGAAAAAAAGGTAA

Upstream 100 bases:

>100_bases
TGCCGACACGGGGCGCGGCGGCCAGCGGCAACTCTGCCCTTGACTTCCTGCGCGAAGTCACTTAACGAATCGCCTCTTAC
GTTGTTAACTTGGGGTTACC

Downstream 100 bases:

>100_bases
GATTGCGGCCAGCACAGGGGTGTCCCCTTGCGATTTCCCGCAAATACCATATTATGCCATAAAATAATGGGAGAGTGTCA
TTATGGCCGTTAAACTCAGA

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MFDTLSDRLSSVFKKFSGQKRLTEENVQEGLREVRLALLEADVNFKVVKQFIDRVRDKCLGQDVLKGLNPAQQVIKIVND
EMIELLGGETTGLDLRGQQPYVIMMVGLQGSGKTTSTGKLANHLRKSKMRPYLAPADVYRPAAIDQLKTLAAQLDLPVYD
STVQMNPVDIARNAVAAAREQQCNVVILDTAGRLHIDETLMQELVAIKEAVAPQEILFVADAMTGQDAVTVADAFNNALD
ITGVVLTKMDGDARGGAALSIKTVTGKSVKFVGMGEKLSDLEVFHPDRIASRILGMGDVLTLIEKAQTTIKEEEAEELGR
KMQRAEFDFEDFRTQMRRMRKLGSLESIMKLIPGMGALREKLGDMQVPEKEMVRIEAIINSMTRQERRQPILMNTSRKER
IARGAGTTVKEVDKLLSNFEGMRQMMKQVMGGGKKKKGKMPQLPGMGGKGMPDPSAMSGMGGLPGMGGFPGMPGMPGMDG
MQPSGPSKSDQKKKRDQRKKDKQKKKQGKKKR

Sequences:

>Translated_512_residues
MFDTLSDRLSSVFKKFSGQKRLTEENVQEGLREVRLALLEADVNFKVVKQFIDRVRDKCLGQDVLKGLNPAQQVIKIVND
EMIELLGGETTGLDLRGQQPYVIMMVGLQGSGKTTSTGKLANHLRKSKMRPYLAPADVYRPAAIDQLKTLAAQLDLPVYD
STVQMNPVDIARNAVAAAREQQCNVVILDTAGRLHIDETLMQELVAIKEAVAPQEILFVADAMTGQDAVTVADAFNNALD
ITGVVLTKMDGDARGGAALSIKTVTGKSVKFVGMGEKLSDLEVFHPDRIASRILGMGDVLTLIEKAQTTIKEEEAEELGR
KMQRAEFDFEDFRTQMRRMRKLGSLESIMKLIPGMGALREKLGDMQVPEKEMVRIEAIINSMTRQERRQPILMNTSRKER
IARGAGTTVKEVDKLLSNFEGMRQMMKQVMGGGKKKKGKMPQLPGMGGKGMPDPSAMSGMGGLPGMGGFPGMPGMPGMDG
MQPSGPSKSDQKKKRDQRKKDKQKKKQGKKKR
>Mature_512_residues
MFDTLSDRLSSVFKKFSGQKRLTEENVQEGLREVRLALLEADVNFKVVKQFIDRVRDKCLGQDVLKGLNPAQQVIKIVND
EMIELLGGETTGLDLRGQQPYVIMMVGLQGSGKTTSTGKLANHLRKSKMRPYLAPADVYRPAAIDQLKTLAAQLDLPVYD
STVQMNPVDIARNAVAAAREQQCNVVILDTAGRLHIDETLMQELVAIKEAVAPQEILFVADAMTGQDAVTVADAFNNALD
ITGVVLTKMDGDARGGAALSIKTVTGKSVKFVGMGEKLSDLEVFHPDRIASRILGMGDVLTLIEKAQTTIKEEEAEELGR
KMQRAEFDFEDFRTQMRRMRKLGSLESIMKLIPGMGALREKLGDMQVPEKEMVRIEAIINSMTRQERRQPILMNTSRKER
IARGAGTTVKEVDKLLSNFEGMRQMMKQVMGGGKKKKGKMPQLPGMGGKGMPDPSAMSGMGGLPGMGGFPGMPGMPGMDG
MQPSGPSKSDQKKKRDQRKKDKQKKKQGKKKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=507, Percent_Identity=32.9388560157791, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI226371618, Length=450, Percent_Identity=32.4444444444444, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=27.2151898734177, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI23308697, Length=316, Percent_Identity=27.2151898734177, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=35.3658536585366, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=51.6431924882629, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789874, Length=239, Percent_Identity=34.7280334728033, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=454, Percent_Identity=31.9383259911894, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=31.6498316498317, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6325345, Length=477, Percent_Identity=34.3815513626834, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=28.9099526066351, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17647949, Length=487, Percent_Identity=32.2381930184805, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24641198, Length=318, Percent_Identity=26.7295597484277, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 56396; Mature: 56396

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTLSDRLSSVFKKFSGQKRLTEENVQEGLREVRLALLEADVNFKVVKQFIDRVRDKCL
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GQDVLKGLNPAQQVIKIVNDEMIELLGGETTGLDLRGQQPYVIMMVGLQGSGKTTSTGKL
CHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHH
ANHLRKSKMRPYLAPADVYRPAAIDQLKTLAAQLDLPVYDSTVQMNPVDIARNAVAAARE
HHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHH
QQCNVVILDTAGRLHIDETLMQELVAIKEAVAPQEILFVADAMTGQDAVTVADAFNNALD
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHEEHHCCCCCCHHHHHHHHCCHHH
ITGVVLTKMDGDARGGAALSIKTVTGKSVKFVGMGEKLSDLEVFHPDRIASRILGMGDVL
HHEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHH
TLIEKAQTTIKEEEAEELGRKMQRAEFDFEDFRTQMRRMRKLGSLESIMKLIPGMGALRE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
KLGDMQVPEKEMVRIEAIINSMTRQERRQPILMNTSRKERIARGAGTTVKEVDKLLSNFE
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCCHHHHHHHHHHHH
GMRQMMKQVMGGGKKKKGKMPQLPGMGGKGMPDPSAMSGMGGLPGMGGFPGMPGMPGMDG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
MQPSGPSKSDQKKKRDQRKKDKQKKKQGKKKR
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFDTLSDRLSSVFKKFSGQKRLTEENVQEGLREVRLALLEADVNFKVVKQFIDRVRDKCL
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GQDVLKGLNPAQQVIKIVNDEMIELLGGETTGLDLRGQQPYVIMMVGLQGSGKTTSTGKL
CHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHH
ANHLRKSKMRPYLAPADVYRPAAIDQLKTLAAQLDLPVYDSTVQMNPVDIARNAVAAARE
HHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHH
QQCNVVILDTAGRLHIDETLMQELVAIKEAVAPQEILFVADAMTGQDAVTVADAFNNALD
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHEEHHCCCCCCHHHHHHHHCCHHH
ITGVVLTKMDGDARGGAALSIKTVTGKSVKFVGMGEKLSDLEVFHPDRIASRILGMGDVL
HHEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHH
TLIEKAQTTIKEEEAEELGRKMQRAEFDFEDFRTQMRRMRKLGSLESIMKLIPGMGALRE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHH
KLGDMQVPEKEMVRIEAIINSMTRQERRQPILMNTSRKERIARGAGTTVKEVDKLLSNFE
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCCHHHHHHHHHHHH
GMRQMMKQVMGGGKKKKGKMPQLPGMGGKGMPDPSAMSGMGGLPGMGGFPGMPGMPGMDG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
MQPSGPSKSDQKKKRDQRKKDKQKKKQGKKKR
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]