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The map label for this gene is lctP [H]

Identifier: 78356121

GI number: 78356121

Start: 1100912

End: 1102432

Strand: Reverse

Name: lctP [H]

Synonym: Dde_1074

Alternate gene names: 78356121

Gene position: 1102432-1100912 (Counterclockwise)

Preceding gene: 78356122

Following gene: 161485610

Centisome position: 29.55

GC content: 58.32

Gene sequence:

>1521_bases
ATGGAAGCAGTACAACTTTTCGCGGCATTCGCGCCGATTCTCTGGCTCATCTTTTCTCTCGTCATTTTAAAGCTGCCTGC
TTACAAGACCTGCAGCGCCACGCTGGTGCTCACTCTGGCGCTGGCAATTTTCGGATGGTGGGAGATGCCGGTCACCGACG
CGCTGGCTGCGGCTCTGGAGGGGGCTGCGCTGGCACTGTGGCCCATCATGATTGTCATCATTGCAGCAGTGTTCACGTAC
AATCTTGCCCGTAAAACAGGCAGCATGGATATCATCACCCGCATGCTGTCCGGCATAACCACCGACAAACGTCTGCTGGT
GCTTATTGTGGCATGGGGATTCGGGGGATTTCTGGAAGGTGTGGCAGGGTACGGCACGGCGGTTGCCATTCCGGCCAGCA
TTCTGGCAGCCATGGGCTTTCAGCCCATGTTCGCGGCCATTATCTGTCTGGTGGCCAACACCGTGCCCACGGCGTTCGGC
GCCATCGGCATTCCCATCATCACCATGGCCGGTGTCACGGGGCTGCCTGTCGAAACCATCAGCTACTACACCGCACTGCA
GCTGTCCGTCTTCATCATTCTCATTACATTTCTGCTGGTCATCCTCACCGCCGGTTTCAAGGGACTGCGCGGGGTAGTAG
GCGCCACGTTTGTATCGGGTGTGGCTTTTGCCCTGCCCCAGCTGTATACGGCCAAATACATGGGTGCCGAGCTGCCCTGC
CTCATCGGCAGCATATGCAGCATGCTGGCCACCATAATCTGGGCGCGTATTTTCCACCGCGACACCGCAGCACCCGAAAC
AGAACCACTGCCTGCCAGCGTGAAAATAAAGGCATGGCTGCCCTACATGCTGGTATTCGGCTTCATCATTCTGTGCAGCA
ACCTGTTCCCGCTTATCAAAGACACGCTGGGACTGGTAAAGACCACCGTCACCATTTACGGCGACAATGAATTCACCTTT
AAATGGCTGGCCACACCCGGCACGCTCATCATTCTGGCCACATACATCGGCGGCCGCATTCAGGGTGAAAGTCTGCGCTC
CATCACAGGCGTGCTCGCTTCCACGGCAGGCAAGCTCACTTACTCCGCCGTCACCGTGGTCAGCATCGTGGCGCTGGCAA
AGGTCATGGCCTACAGCGGCATGATCAACACCATAGCCGTGGCCGTGGCAGACACCACAGCATCATACTTCCCGCTCATT
TCGCCCCTGCTGGGCGCGCTGGGCACCTTTGTGACCGGCAGCGACACTTCGTCCAACGTGCTTTTCGGCCAGCTGCAGAT
GGAAGTGGCAGGCCGCATCAGCATTGATCAGGCATGGATAGTCGCCGCATCGGCAGCCGGTGCCACCGCGGGCAAGATGA
TTTCGCCCCAGTCCATTGCCGTGGCCACCGCTGCCACCGGCCTTGTAGGCTCGGAAGGACGCATAATGAACCGCACTCTG
GCCGTATGCGCGGCCTATGTCCTGATTCTGGGCACACTGGTGTACGCCACCATTCCGTACATCAAGTACTTTGCCGTGTA
G

Upstream 100 bases:

>100_bases
ATCCCCTTGAGATTGTTTGACTAACCAAACAAAACACCACGCAAGGAGAGCGGGTAACCCGCCGTTATTGATTCACTTCA
ACTTTCCGGAAAGGAAGACC

Downstream 100 bases:

>100_bases
CACAGGCAGACAAACCGCCCCGCGGGGCTGCATATAAAAAAAGCGGGAAGGCTGACAGCCTTCCCGCTTTACTATTGTCC
GCAGTGCCGCAGTTACGGGC

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MEAVQLFAAFAPILWLIFSLVILKLPAYKTCSATLVLTLALAIFGWWEMPVTDALAAALEGAALALWPIMIVIIAAVFTY
NLARKTGSMDIITRMLSGITTDKRLLVLIVAWGFGGFLEGVAGYGTAVAIPASILAAMGFQPMFAAIICLVANTVPTAFG
AIGIPIITMAGVTGLPVETISYYTALQLSVFIILITFLLVILTAGFKGLRGVVGATFVSGVAFALPQLYTAKYMGAELPC
LIGSICSMLATIIWARIFHRDTAAPETEPLPASVKIKAWLPYMLVFGFIILCSNLFPLIKDTLGLVKTTVTIYGDNEFTF
KWLATPGTLIILATYIGGRIQGESLRSITGVLASTAGKLTYSAVTVVSIVALAKVMAYSGMINTIAVAVADTTASYFPLI
SPLLGALGTFVTGSDTSSNVLFGQLQMEVAGRISIDQAWIVAASAAGATAGKMISPQSIAVATAATGLVGSEGRIMNRTL
AVCAAYVLILGTLVYATIPYIKYFAV

Sequences:

>Translated_506_residues
MEAVQLFAAFAPILWLIFSLVILKLPAYKTCSATLVLTLALAIFGWWEMPVTDALAAALEGAALALWPIMIVIIAAVFTY
NLARKTGSMDIITRMLSGITTDKRLLVLIVAWGFGGFLEGVAGYGTAVAIPASILAAMGFQPMFAAIICLVANTVPTAFG
AIGIPIITMAGVTGLPVETISYYTALQLSVFIILITFLLVILTAGFKGLRGVVGATFVSGVAFALPQLYTAKYMGAELPC
LIGSICSMLATIIWARIFHRDTAAPETEPLPASVKIKAWLPYMLVFGFIILCSNLFPLIKDTLGLVKTTVTIYGDNEFTF
KWLATPGTLIILATYIGGRIQGESLRSITGVLASTAGKLTYSAVTVVSIVALAKVMAYSGMINTIAVAVADTTASYFPLI
SPLLGALGTFVTGSDTSSNVLFGQLQMEVAGRISIDQAWIVAASAAGATAGKMISPQSIAVATAATGLVGSEGRIMNRTL
AVCAAYVLILGTLVYATIPYIKYFAV
>Mature_506_residues
MEAVQLFAAFAPILWLIFSLVILKLPAYKTCSATLVLTLALAIFGWWEMPVTDALAAALEGAALALWPIMIVIIAAVFTY
NLARKTGSMDIITRMLSGITTDKRLLVLIVAWGFGGFLEGVAGYGTAVAIPASILAAMGFQPMFAAIICLVANTVPTAFG
AIGIPIITMAGVTGLPVETISYYTALQLSVFIILITFLLVILTAGFKGLRGVVGATFVSGVAFALPQLYTAKYMGAELPC
LIGSICSMLATIIWARIFHRDTAAPETEPLPASVKIKAWLPYMLVFGFIILCSNLFPLIKDTLGLVKTTVTIYGDNEFTF
KWLATPGTLIILATYIGGRIQGESLRSITGVLASTAGKLTYSAVTVVSIVALAKVMAYSGMINTIAVAVADTTASYFPLI
SPLLGALGTFVTGSDTSSNVLFGQLQMEVAGRISIDQAWIVAASAAGATAGKMISPQSIAVATAATGLVGSEGRIMNRTL
AVCAAYVLILGTLVYATIPYIKYFAV

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=530, Percent_Identity=35.6603773584906, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1790031, Length=519, Percent_Identity=35.8381502890173, Blast_Score=256, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 53187; Mature: 53187

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVQLFAAFAPILWLIFSLVILKLPAYKTCSATLVLTLALAIFGWWEMPVTDALAAALE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
GAALALWPIMIVIIAAVFTYNLARKTGSMDIITRMLSGITTDKRLLVLIVAWGFGGFLEG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEHHCCHHHHHH
VAGYGTAVAIPASILAAMGFQPMFAAIICLVANTVPTAFGAIGIPIITMAGVTGLPVETI
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
SYYTALQLSVFIILITFLLVILTAGFKGLRGVVGATFVSGVAFALPQLYTAKYMGAELPC
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LIGSICSMLATIIWARIFHRDTAAPETEPLPASVKIKAWLPYMLVFGFIILCSNLFPLIK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
DTLGLVKTTVTIYGDNEFTFKWLATPGTLIILATYIGGRIQGESLRSITGVLASTAGKLT
HHHHHHHEEEEEEECCCEEEEEECCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHCCHHH
YSAVTVVSIVALAKVMAYSGMINTIAVAVADTTASYFPLISPLLGALGTFVTGSDTSSNV
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
LFGQLQMEVAGRISIDQAWIVAASAAGATAGKMISPQSIAVATAATGLVGSEGRIMNRTL
EEEEEEEHHHCCEEECHHHEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHH
AVCAAYVLILGTLVYATIPYIKYFAV
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEAVQLFAAFAPILWLIFSLVILKLPAYKTCSATLVLTLALAIFGWWEMPVTDALAAALE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
GAALALWPIMIVIIAAVFTYNLARKTGSMDIITRMLSGITTDKRLLVLIVAWGFGGFLEG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEHHCCHHHHHH
VAGYGTAVAIPASILAAMGFQPMFAAIICLVANTVPTAFGAIGIPIITMAGVTGLPVETI
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
SYYTALQLSVFIILITFLLVILTAGFKGLRGVVGATFVSGVAFALPQLYTAKYMGAELPC
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LIGSICSMLATIIWARIFHRDTAAPETEPLPASVKIKAWLPYMLVFGFIILCSNLFPLIK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
DTLGLVKTTVTIYGDNEFTFKWLATPGTLIILATYIGGRIQGESLRSITGVLASTAGKLT
HHHHHHHEEEEEEECCCEEEEEECCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHCCHHH
YSAVTVVSIVALAKVMAYSGMINTIAVAVADTTASYFPLISPLLGALGTFVTGSDTSSNV
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
LFGQLQMEVAGRISIDQAWIVAASAAGATAGKMISPQSIAVATAATGLVGSEGRIMNRTL
EEEEEEEHHHCCEEECHHHEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHH
AVCAAYVLILGTLVYATIPYIKYFAV
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]