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The map label for this gene is atoC [H]

Identifier: 78356063

GI number: 78356063

Start: 1039276

End: 1040748

Strand: Direct

Name: atoC [H]

Synonym: Dde_1016

Alternate gene names: 78356063

Gene position: 1039276-1040748 (Clockwise)

Preceding gene: 78356062

Following gene: 78356064

Centisome position: 27.86

GC content: 61.03

Gene sequence:

>1473_bases
ATGGCCCGTGTGCTGATAATAGATGATGATGACCTGTTTTGCGAAATGGTCGCGGCTGCGCTGGAGCTGAGCGGCCATGA
AGTGCGCAGTGCGGGAACGGCCGCCGACGGACAGGCCCTGTGCCGATCTGCCGGTTTTGATGTGATTTTTCTTGATATCC
GTCTTCCTGACGGTAACGGGCTGGAGCTTATACCCGCATTCAGCGCCTGTCCCTCAGAGCCGGAAATAATCATTATAACA
GCCGCGGGCGACCCGCATGGTGCCGAAATGGCTATCGGCAGCGGTGCTTGGGATTACCTGAGCAAGCCTTCGCCGCTGGA
CGAGCTGCAGCTTACACTTACGCGGGCGCTGCGTTACCGCAAGCGCAAAGCGGCTTTCATCAGACCCGCTGCGGACAGAC
AGGGTATTGTGGGCAGCAGCCCGCGCATGCAGGCGTGCATTGATCTTATGGCAGAGTTTGCCCCGTCCGACACTCCCGTG
CTTGTGACCGGAGAAACAGGAACAGGCAAGGAGCTGTTTGCCCGCGCTCTGCACCGCAACAGCCGCCGGACAGCCGGACC
CTTTGTGGCCGTGGACTGTGCGTCTATCCCGAAAAATCTGATTGAAAGCGAATTGTTCGGGCACGAAAAAGGGGCGTTTA
CCGGTGCCGTGGCAGAGCGCGACGGCGTGTTTGCACAGGCGCATGGCGGCACATTGTTTCTTGACGAAGTAGGTGAGCTG
CCGCTGTCGCAGCAGAAGGCTTTTCTGCGCGTACTTCAGGAAAGAACCTTCCGCAGGGTGGGAGGTAAAAAAGAACTGTA
CAGCGACTTCCGGCTGGTGGCGGCAACCAACAAAGATCTTCCTGCTCTGGCGGAGCGGGGCGAATTCCGTGCCGATCTGC
TTTTCCGGCTGCAGGCGGTGCTGCTGCACCTGCCGCCCCTGCGCGACAGGGGACGTGATATTTACGAGCTGGCGCTATAC
CATGTGGAAAAACTGTGTCTGCGCTACAAGCTGGGGCACAAGGAACTGACCCGCGAGGCGGCTGCTTTTCTGGAAGACTA
TCCGTGGCCCGGCAACGTGCGCGAACTGGTGCATGTGGTGGAACAGGCTGTGGTGGCAGCCCGCAGTGACGAACTTGTCC
AGCCGGAGCATCTGCCCCGCAATGTGCGGGCGGTGGCCATGCGGCACAGAATGCAGCGCAACGGCACCGGCGGGGCGGCA
GTTGTGCCCGCCGCTGTGTCCATGGCGGTTTCTGCCGGCGGCGAAGCGGCATTACCCACATGGAAAGCATACCGCGAACG
GGTGATGGCCGAGATGGAGCGGCAGTATCTGCTGCGCCTGCTGACCGAATCCGGCGGCAGCATCACACAGGCGGGCCGGC
TGTCGGGGCTTTCGCGGCAGCGGCTGTATGCTCTGCTCAAGCGTAACGGCATCAGCCGCTCGTGGCCGGCCGGCAACAGT
CCGGCAGAAGAGACACAGGATTCCGATGTATAG

Upstream 100 bases:

>100_bases
GCCGCTGGCCGGATGCCGGGTTTCGTTCCGTCTGCCTGCTGCGTGCGAGGGCTGAGGCTGGTCCGCCGGCGGTACGTGGT
CTTTTTTTTGAGGAGGGGAC

Downstream 100 bases:

>100_bases
TATTGGAAGGATAAATCTCTTATTAGGAGAATGTGTAAACTATTTGTTTACATATTGTGCTGAAAATAATAGCGGTACTT
CTGATTAAGTAAATAATGCA

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MARVLIIDDDDLFCEMVAAALELSGHEVRSAGTAADGQALCRSAGFDVIFLDIRLPDGNGLELIPAFSACPSEPEIIIIT
AAGDPHGAEMAIGSGAWDYLSKPSPLDELQLTLTRALRYRKRKAAFIRPAADRQGIVGSSPRMQACIDLMAEFAPSDTPV
LVTGETGTGKELFARALHRNSRRTAGPFVAVDCASIPKNLIESELFGHEKGAFTGAVAERDGVFAQAHGGTLFLDEVGEL
PLSQQKAFLRVLQERTFRRVGGKKELYSDFRLVAATNKDLPALAERGEFRADLLFRLQAVLLHLPPLRDRGRDIYELALY
HVEKLCLRYKLGHKELTREAAAFLEDYPWPGNVRELVHVVEQAVVAARSDELVQPEHLPRNVRAVAMRHRMQRNGTGGAA
VVPAAVSMAVSAGGEAALPTWKAYRERVMAEMERQYLLRLLTESGGSITQAGRLSGLSRQRLYALLKRNGISRSWPAGNS
PAEETQDSDV

Sequences:

>Translated_490_residues
MARVLIIDDDDLFCEMVAAALELSGHEVRSAGTAADGQALCRSAGFDVIFLDIRLPDGNGLELIPAFSACPSEPEIIIIT
AAGDPHGAEMAIGSGAWDYLSKPSPLDELQLTLTRALRYRKRKAAFIRPAADRQGIVGSSPRMQACIDLMAEFAPSDTPV
LVTGETGTGKELFARALHRNSRRTAGPFVAVDCASIPKNLIESELFGHEKGAFTGAVAERDGVFAQAHGGTLFLDEVGEL
PLSQQKAFLRVLQERTFRRVGGKKELYSDFRLVAATNKDLPALAERGEFRADLLFRLQAVLLHLPPLRDRGRDIYELALY
HVEKLCLRYKLGHKELTREAAAFLEDYPWPGNVRELVHVVEQAVVAARSDELVQPEHLPRNVRAVAMRHRMQRNGTGGAA
VVPAAVSMAVSAGGEAALPTWKAYRERVMAEMERQYLLRLLTESGGSITQAGRLSGLSRQRLYALLKRNGISRSWPAGNS
PAEETQDSDV
>Mature_489_residues
ARVLIIDDDDLFCEMVAAALELSGHEVRSAGTAADGQALCRSAGFDVIFLDIRLPDGNGLELIPAFSACPSEPEIIIITA
AGDPHGAEMAIGSGAWDYLSKPSPLDELQLTLTRALRYRKRKAAFIRPAADRQGIVGSSPRMQACIDLMAEFAPSDTPVL
VTGETGTGKELFARALHRNSRRTAGPFVAVDCASIPKNLIESELFGHEKGAFTGAVAERDGVFAQAHGGTLFLDEVGELP
LSQQKAFLRVLQERTFRRVGGKKELYSDFRLVAATNKDLPALAERGEFRADLLFRLQAVLLHLPPLRDRGRDIYELALYH
VEKLCLRYKLGHKELTREAAAFLEDYPWPGNVRELVHVVEQAVVAARSDELVQPEHLPRNVRAVAMRHRMQRNGTGGAAV
VPAAVSMAVSAGGEAALPTWKAYRERVMAEMERQYLLRLLTESGGSITQAGRLSGLSRQRLYALLKRNGISRSWPAGNSP
AEETQDSDV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=477, Percent_Identity=36.8972746331237, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1790437, Length=467, Percent_Identity=36.6167023554604, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1788905, Length=471, Percent_Identity=35.244161358811, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=36.1522198731501, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=40.4692082111437, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789087, Length=350, Percent_Identity=39.1428571428571, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI87082152, Length=240, Percent_Identity=48.3333333333333, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI87081872, Length=354, Percent_Identity=36.7231638418079, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789233, Length=337, Percent_Identity=35.6083086053413, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787583, Length=237, Percent_Identity=40.9282700421941, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786524, Length=240, Percent_Identity=42.0833333333333, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1789828, Length=254, Percent_Identity=35.8267716535433, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081858, Length=331, Percent_Identity=27.4924471299094, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=118, Percent_Identity=36.4406779661017, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53585; Mature: 53454

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVLIIDDDDLFCEMVAAALELSGHEVRSAGTAADGQALCRSAGFDVIFLDIRLPDGNG
CEEEEEECCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCCCCC
LELIPAFSACPSEPEIIIITAAGDPHGAEMAIGSGAWDYLSKPSPLDELQLTLTRALRYR
CEEEECCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHH
KRKAAFIRPAADRQGIVGSSPRMQACIDLMAEFAPSDTPVLVTGETGTGKELFARALHRN
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCC
SRRTAGPFVAVDCASIPKNLIESELFGHEKGAFTGAVAERDGVFAQAHGGTLFLDEVGEL
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCHHHCCCCEEEECCCEEEECCCCCC
PLSQQKAFLRVLQERTFRRVGGKKELYSDFRLVAATNKDLPALAERGEFRADLLFRLQAV
CCHHHHHHHHHHHHHHHHHCCCHHHHHHCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHH
LLHLPPLRDRGRDIYELALYHVEKLCLRYKLGHKELTREAAAFLEDYPWPGNVRELVHVV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
EQAVVAARSDELVQPEHLPRNVRAVAMRHRMQRNGTGGAAVVPAAVSMAVSAGGEAALPT
HHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCH
WKAYRERVMAEMERQYLLRLLTESGGSITQAGRLSGLSRQRLYALLKRNGISRSWPAGNS
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC
PAEETQDSDV
CHHCCCCCCC
>Mature Secondary Structure 
ARVLIIDDDDLFCEMVAAALELSGHEVRSAGTAADGQALCRSAGFDVIFLDIRLPDGNG
EEEEEECCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCCCCC
LELIPAFSACPSEPEIIIITAAGDPHGAEMAIGSGAWDYLSKPSPLDELQLTLTRALRYR
CEEEECCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHH
KRKAAFIRPAADRQGIVGSSPRMQACIDLMAEFAPSDTPVLVTGETGTGKELFARALHRN
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCC
SRRTAGPFVAVDCASIPKNLIESELFGHEKGAFTGAVAERDGVFAQAHGGTLFLDEVGEL
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCHHHCCCCEEEECCCEEEECCCCCC
PLSQQKAFLRVLQERTFRRVGGKKELYSDFRLVAATNKDLPALAERGEFRADLLFRLQAV
CCHHHHHHHHHHHHHHHHHCCCHHHHHHCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHH
LLHLPPLRDRGRDIYELALYHVEKLCLRYKLGHKELTREAAAFLEDYPWPGNVRELVHVV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
EQAVVAARSDELVQPEHLPRNVRAVAMRHRMQRNGTGGAAVVPAAVSMAVSAGGEAALPT
HHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCH
WKAYRERVMAEMERQYLLRLLTESGGSITQAGRLSGLSRQRLYALLKRNGISRSWPAGNS
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC
PAEETQDSDV
CHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]