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The map label for this gene is uvrC

Identifier: 78356061

GI number: 78356061

Start: 1036022

End: 1038124

Strand: Direct

Name: uvrC

Synonym: Dde_1014

Alternate gene names: 78356061

Gene position: 1036022-1038124 (Clockwise)

Preceding gene: 78356059

Following gene: 78356062

Centisome position: 27.77

GC content: 61.91

Gene sequence:

>2103_bases
ATGGATCAGATCGACATCTCATGTATTCCCACCACACCGGGAGTATATCTATATAAAGACCCCGCTGGGAAAGTTGTCTA
CGTGGGCAAGGCTAAACACCTGCGCCGTCGCGTGGCATCGTATTTTCGCGATATACAGCGGCATACGCCTAAAACCCGTG
CCATGCTGCGCAGTGCCGCCACGGTGGAAACGCTGTCTACCACCACGGAAAAAGAGGCTCTGCTGCTTGAAGCAAGCCTG
ATCAAAAAGCACCGCCCGCGTTACAACATCCTGCTGCGTGACGACAAACAGTATGTGCTTTTTCAACTGACCAGAAAGCA
CCACTGGCCCAGACTGGTGCTTACGCGCAAAGTCCGTAAAGACGGCTCCGCCTATTTCGGGCCGTTCACCTCCGGTCAGG
CCGCGCGGCAGACATGGAAGGTAATACACAAGGTGTTTCCGCTGCGCAGATGCTCGGATAAGGCTTTTCGTAACCGGGTG
CGCCCCTGCCTGTATCATTTTATGAACCAGTGCCCCGGCCCCTGCGTGCTGGATGTGGACCGCGACGGATATATGCAGAT
GGTCCGCAAGGTGGAGATGCTGCTCGCCGGCCGTTCCACGGAACTGATCGACATGTTGCGTGCCGACATGCAGGCAGCCA
GCGATGCGCTGGAATTTGAAGAGGCCGCCCTCTTGCGTGATCAGTTACAGGCTGTGGAACGGACAGTGGAGCGTCAGGCC
GCTGTGCTGCCGGGCGTGCACGATATGGATGCCGTGGGGCTGGCGGAGGCCGGAGGCGGTCTGGCCTTGAGCGTGCTGTT
TATCCGGCGGTCGGTATTGCTGGATAAGCGTAATTTTTTCTGGTCGGGTCTCACGCTGGAAGAAGGCCCCGAAGTTCTGC
TGAGTTTTCTGACCCAGTACTACGGACCGGGCAGCTTTATTCCTCCCCGCATTCTTGTGCCGTGGGATATCCGTACAGAA
GACCGTGAAGGGGCGGAGCTGGCGCCTGCCGCGGTATGCACCGATGCCGGTCTGCTGCCCGATACGCCTTTGCTGCCGGA
TTGTCCGGAAGCTGCCCCCCTGCCCGCCGCGCCGGTATTCGCGGTGTCGGCGGGTGACGTCATGCCGTCGGGACACGATG
CGGACCCTGCCGGTACAGCCGATGCTCCCGTTGTACGGGGTGACTCCGCCCCGGAACAGCCCTTGCCGGCGGCGGTGCCG
CCGCTGTGTGCGGAAGAGAGCGCTTCCGGTTCGGCCCTGCGGGCCGTGGCGGAGATGCTGACCGAACTGCGCGGCGGGCC
TGTGCGGGTGCTGCCGCCGCGGAATGCCACGGACAACCAGCTGGTGACCATGGCCACCGAAAATGCCCGGGAAGATGCCC
GTGCCGAAAAGCGTCCCGACGTGGCGGGTGTCATTGCGGCAAAGCTTGGCATGAGCGCACCGCCGGTGCGCATTGAGGCC
GTGGATGTTTCGCATACCGGCGGAAGCAACACCCGTGTGGGCGTTGTGGTGTTTGAAAACGGCACTCCGGCCAGGGACCA
GTACCGTACCTATGCGTTTGCGGATGATGAGGCCGGAGGGGACGATACGGGTGTGCTGGCGTTGTGGGCTGTGCGGCGGG
TGCATTCCGGACCGCCGTGGCCGGACCTGCTGTTGGTGGACGGCGGGCGCGGGCAGCTTGCGGCGGTAATGACCGCACTG
GAATCGGCCGGTGCGGGCGGTCTGTTTGCCGTGGCTTCCATAGCCAAGGCCCGTAATGAAGAAACCGGCAGGGCAGACCG
GCGTGCAGGAAATCTGGCCGACAGAATCTTTCTGCCCGGCCGCTCCAATCCGGTGAATTTCAAATCCGGATCGCCGGAAC
TGCTTTTTTTGCAGCATGTGCGTGATACCGTGCATGACTATGCCATCGGACGTCACCGCCGCGCGCGGAGCGGGGCTGCG
CTTTCCGGCGAGTTGCAGCGCATGCAGGGCATCGGTCCGGCAACGGCCCGTCTGCTGTGGGAACATTTTTCCAGCCTGCA
GGAAATGGTGGACGCAGGGGAAAAGGGGCTGGCTGCTCTTCCGGGTATCGGCAAAGCCAAGGCAGCCGTCATCCACGAGG
GGCTTAAAAGGCTTGTGGGTTGA

Upstream 100 bases:

>100_bases
CCCTGGTATGCGCAGCGCCGCCTGCGGCACGGGTGATGAAGGTCCGCCGCTCTTTGCCCATGACGTTGCATTCAGCGGTT
ATTAAGGCGATAACCACCGC

Downstream 100 bases:

>100_bases
GTCCGCCGGCGGGTGTCTGTTCCTGCCGGAAACAGGGGAAAGGTATGACAGAGCTTTTGCATCACCGGCAGCCGCGGCGC
TGCAATGCCGGCCCGCTGTA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
MDQIDISCIPTTPGVYLYKDPAGKVVYVGKAKHLRRRVASYFRDIQRHTPKTRAMLRSAATVETLSTTTEKEALLLEASL
IKKHRPRYNILLRDDKQYVLFQLTRKHHWPRLVLTRKVRKDGSAYFGPFTSGQAARQTWKVIHKVFPLRRCSDKAFRNRV
RPCLYHFMNQCPGPCVLDVDRDGYMQMVRKVEMLLAGRSTELIDMLRADMQAASDALEFEEAALLRDQLQAVERTVERQA
AVLPGVHDMDAVGLAEAGGGLALSVLFIRRSVLLDKRNFFWSGLTLEEGPEVLLSFLTQYYGPGSFIPPRILVPWDIRTE
DREGAELAPAAVCTDAGLLPDTPLLPDCPEAAPLPAAPVFAVSAGDVMPSGHDADPAGTADAPVVRGDSAPEQPLPAAVP
PLCAEESASGSALRAVAEMLTELRGGPVRVLPPRNATDNQLVTMATENAREDARAEKRPDVAGVIAAKLGMSAPPVRIEA
VDVSHTGGSNTRVGVVVFENGTPARDQYRTYAFADDEAGGDDTGVLALWAVRRVHSGPPWPDLLLVDGGRGQLAAVMTAL
ESAGAGGLFAVASIAKARNEETGRADRRAGNLADRIFLPGRSNPVNFKSGSPELLFLQHVRDTVHDYAIGRHRRARSGAA
LSGELQRMQGIGPATARLLWEHFSSLQEMVDAGEKGLAALPGIGKAKAAVIHEGLKRLVG

Sequences:

>Translated_700_residues
MDQIDISCIPTTPGVYLYKDPAGKVVYVGKAKHLRRRVASYFRDIQRHTPKTRAMLRSAATVETLSTTTEKEALLLEASL
IKKHRPRYNILLRDDKQYVLFQLTRKHHWPRLVLTRKVRKDGSAYFGPFTSGQAARQTWKVIHKVFPLRRCSDKAFRNRV
RPCLYHFMNQCPGPCVLDVDRDGYMQMVRKVEMLLAGRSTELIDMLRADMQAASDALEFEEAALLRDQLQAVERTVERQA
AVLPGVHDMDAVGLAEAGGGLALSVLFIRRSVLLDKRNFFWSGLTLEEGPEVLLSFLTQYYGPGSFIPPRILVPWDIRTE
DREGAELAPAAVCTDAGLLPDTPLLPDCPEAAPLPAAPVFAVSAGDVMPSGHDADPAGTADAPVVRGDSAPEQPLPAAVP
PLCAEESASGSALRAVAEMLTELRGGPVRVLPPRNATDNQLVTMATENAREDARAEKRPDVAGVIAAKLGMSAPPVRIEA
VDVSHTGGSNTRVGVVVFENGTPARDQYRTYAFADDEAGGDDTGVLALWAVRRVHSGPPWPDLLLVDGGRGQLAAVMTAL
ESAGAGGLFAVASIAKARNEETGRADRRAGNLADRIFLPGRSNPVNFKSGSPELLFLQHVRDTVHDYAIGRHRRARSGAA
LSGELQRMQGIGPATARLLWEHFSSLQEMVDAGEKGLAALPGIGKAKAAVIHEGLKRLVG
>Mature_700_residues
MDQIDISCIPTTPGVYLYKDPAGKVVYVGKAKHLRRRVASYFRDIQRHTPKTRAMLRSAATVETLSTTTEKEALLLEASL
IKKHRPRYNILLRDDKQYVLFQLTRKHHWPRLVLTRKVRKDGSAYFGPFTSGQAARQTWKVIHKVFPLRRCSDKAFRNRV
RPCLYHFMNQCPGPCVLDVDRDGYMQMVRKVEMLLAGRSTELIDMLRADMQAASDALEFEEAALLRDQLQAVERTVERQA
AVLPGVHDMDAVGLAEAGGGLALSVLFIRRSVLLDKRNFFWSGLTLEEGPEVLLSFLTQYYGPGSFIPPRILVPWDIRTE
DREGAELAPAAVCTDAGLLPDTPLLPDCPEAAPLPAAPVFAVSAGDVMPSGHDADPAGTADAPVVRGDSAPEQPLPAAVP
PLCAEESASGSALRAVAEMLTELRGGPVRVLPPRNATDNQLVTMATENAREDARAEKRPDVAGVIAAKLGMSAPPVRIEA
VDVSHTGGSNTRVGVVVFENGTPARDQYRTYAFADDEAGGDDTGVLALWAVRRVHSGPPWPDLLLVDGGRGQLAAVMTAL
ESAGAGGLFAVASIAKARNEETGRADRRAGNLADRIFLPGRSNPVNFKSGSPELLFLQHVRDTVHDYAIGRHRRARSGAA
LSGELQRMQGIGPATARLLWEHFSSLQEMVDAGEKGLAALPGIGKAKAAVIHEGLKRLVG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=324, Percent_Identity=40.4320987654321, Blast_Score=238, Evalue=1e-63,
Organism=Escherichia coli, GI1788037, Length=177, Percent_Identity=32.2033898305085, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_DESDG (Q313T1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387510.1
- ProteinModelPortal:   Q313T1
- STRING:   Q313T1
- GeneID:   3755516
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1014
- NMPDR:   fig|207559.3.peg.33
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   RVRPCLY
- ProtClustDB:   PRK14666
- BioCyc:   DDES207559:DDE_1014-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 75960; Mature: 75960

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQIDISCIPTTPGVYLYKDPAGKVVYVGKAKHLRRRVASYFRDIQRHTPKTRAMLRSAA
CCCCEEEEECCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVETLSTTTEKEALLLEASLIKKHRPRYNILLRDDKQYVLFQLTRKHHWPRLVLTRKVRK
HHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEHEEHHHCCCCHHHHHHHHHH
DGSAYFGPFTSGQAARQTWKVIHKVFPLRRCSDKAFRNRVRPCLYHFMNQCPGPCVLDVD
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
RDGYMQMVRKVEMLLAGRSTELIDMLRADMQAASDALEFEEAALLRDQLQAVERTVERQA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLPGVHDMDAVGLAEAGGGLALSVLFIRRSVLLDKRNFFWSGLTLEEGPEVLLSFLTQY
HHCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHCCHHHHHHHHHHH
YGPGSFIPPRILVPWDIRTEDREGAELAPAAVCTDAGLLPDTPLLPDCPEAAPLPAAPVF
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
AVSAGDVMPSGHDADPAGTADAPVVRGDSAPEQPLPAAVPPLCAEESASGSALRAVAEML
EEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TELRGGPVRVLPPRNATDNQLVTMATENAREDARAEKRPDVAGVIAAKLGMSAPPVRIEA
HHHCCCCEEEECCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEE
VDVSHTGGSNTRVGVVVFENGTPARDQYRTYAFADDEAGGDDTGVLALWAVRRVHSGPPW
EEEECCCCCCCEEEEEEECCCCCCHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCC
PDLLLVDGGRGQLAAVMTALESAGAGGLFAVASIAKARNEETGRADRRAGNLADRIFLPG
CCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHEEEECC
RSNPVNFKSGSPELLFLQHVRDTVHDYAIGRHRRARSGAALSGELQRMQGIGPATARLLW
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHH
EHFSSLQEMVDAGEKGLAALPGIGKAKAAVIHEGLKRLVG
HHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQIDISCIPTTPGVYLYKDPAGKVVYVGKAKHLRRRVASYFRDIQRHTPKTRAMLRSAA
CCCCEEEEECCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVETLSTTTEKEALLLEASLIKKHRPRYNILLRDDKQYVLFQLTRKHHWPRLVLTRKVRK
HHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEHEEHHHCCCCHHHHHHHHHH
DGSAYFGPFTSGQAARQTWKVIHKVFPLRRCSDKAFRNRVRPCLYHFMNQCPGPCVLDVD
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
RDGYMQMVRKVEMLLAGRSTELIDMLRADMQAASDALEFEEAALLRDQLQAVERTVERQA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLPGVHDMDAVGLAEAGGGLALSVLFIRRSVLLDKRNFFWSGLTLEEGPEVLLSFLTQY
HHCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHCCHHHHHHHHHHH
YGPGSFIPPRILVPWDIRTEDREGAELAPAAVCTDAGLLPDTPLLPDCPEAAPLPAAPVF
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
AVSAGDVMPSGHDADPAGTADAPVVRGDSAPEQPLPAAVPPLCAEESASGSALRAVAEML
EEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TELRGGPVRVLPPRNATDNQLVTMATENAREDARAEKRPDVAGVIAAKLGMSAPPVRIEA
HHHCCCCEEEECCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEE
VDVSHTGGSNTRVGVVVFENGTPARDQYRTYAFADDEAGGDDTGVLALWAVRRVHSGPPW
EEEECCCCCCCEEEEEEECCCCCCHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCC
PDLLLVDGGRGQLAAVMTALESAGAGGLFAVASIAKARNEETGRADRRAGNLADRIFLPG
CCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCHHEEEECC
RSNPVNFKSGSPELLFLQHVRDTVHDYAIGRHRRARSGAALSGELQRMQGIGPATARLLW
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHH
EHFSSLQEMVDAGEKGLAALPGIGKAKAAVIHEGLKRLVG
HHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA