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The map label for this gene is mrdA [H]

Identifier: 78356040

GI number: 78356040

Start: 1018107

End: 1019915

Strand: Reverse

Name: mrdA [H]

Synonym: Dde_0993

Alternate gene names: 78356040

Gene position: 1019915-1018107 (Counterclockwise)

Preceding gene: 78356041

Following gene: 78356039

Centisome position: 27.34

GC content: 58.93

Gene sequence:

>1809_bases
ATGAAAGTCCAGCTTGATTCGGAAGGCTTCCAGCCCCCGCGTTCAGGGCTCATGCTGCTTCAGGGGCTTGTGGCGCTTAT
CTTTCTGGTTTTTGCGCTGCGCTTCTGGTATCTGCAGATACACAAAGGTGAAGATTACGCACGTCTGGCCAGTGACAACC
GTCTGCGGCAGGAGCAGATGTACGCGCCGCGCGGATTGCTGCGTGACAGATACGGCATGCTGCTGGCAGAAAACCGTCCG
GCCTACGGTCTGGGACTGGTGCGTGAAGACTGCCACGACATTCCCTCCACACTGGCCCAGATAAGCCAGTGGACCGGTAT
TGACCTGACGGAGATAACCCAGCGCTACGAACGCGACAAACGCAAGGTTAAATCCTTCGAGCCGCTCATCCTTGTTCCGG
ATATTTCCTTTGAGCTGCTGGCCGCGGTAGAGGCCAACATAAACCGCTGGCCCGGTCTGGAGATAATTGTCCGACCGCGG
CGCTATTATCCTTCGGGGCCGGAACTGGCACACCTGCTGGGCTATGTGAGCGAAGCAGACGAAAAACAGTTGCAGCAGCG
TCCCGAACTGGCGCTGGGCGACACTGTGGGCAAACAGGGACTGGAACTGGTTTTAGAAGACCGGCTGCGCGGTCAGAAGG
GTCTGCGTCAGATGGAAGTGGATGTGGTGGGCCGCGACCTGACTCACCACATACTGCGGGCCCCTCAGGCCGGTGAAAAC
ATCAACCTGACCATTGATCTGGCCCTGCAGCACAAGGCGTTTGAAATGCTTGAAGGCCAGTCGGGCTGCATTGTGGTGCT
TGATCCCGACACAGGTCAGCTGCATGCGCTGGTCACCGCGCCGGCCTTTGACAACAACGCCTTCGCCCGTGGTCTGACCG
GCAAGGAATGGGCAGAACTGCGCGACAACCCGCGCCACCCCATGCAGAACAGAGTCATCCAGTCCGTATATCCGCCCGCC
TCCATCTGGAAGCTGCTCATGGCCGGTCTGGTGCTGGAAGACAAAGTGGTCGACCCCAAGGAGACTGTTTTCTGCAACGG
ACGCTATCCCATGGGCAACCGCGTGTTCCGCTGCTGGAAAAAATGGGGACACGGGCACACCGACCTGCACAAGGCGCTTG
TGGAATCGTGCGATGTCTATTTTTACGATGTGGCCGACAAAATCGGCATCGACCGCATTGCGGAATTTGCCAAGGCTTCC
GGATTCGGCGAACTGACCGGCATAGACCTGCCCCATGAGCGTTCGGGGCTGGTACCTTCGCGGGAATGGAAACGTAAACG
CTTCGGCGAGGTATGGCACCGCGGCGAAACGCTCAATATTTCGATCGGTCAGGGGTTCACTCTGGTCACTCCTCTGCAGA
TAGCACGCTTTATCGGCGCCCTGCTCAACGGCGGCAAATTGCTCAAACCCCAGATTCTCGTGGACGAAAAGCCGCTGGTG
CAGCATGAAATTCCCATCGGGGCCGATGCGCGCAAAGTCATCCTGAAAGCCATGGTCGATACCGTTGACGCTCCGCGGGG
CACGGCGCGCAGGCTTCGCAGACCCGACGCCGTCATCGGCGGCAAGACGGGCACGGCGCAGGTGGTGCGCATTGTGGGCG
AAGAGCGCCGCAAAAAAGAAGAAATGGAATACTGGGAACGCGACCACGCATGGATGGCCGCATGGGGCCAGAAAGACGAT
AAACGCTACGTGATTGTGGTCATGGTGGAACACGGCGGCGGTGGCAGCAGCACCGCAGGCCCCATTGTGAAAGGACTTTT
CGACTACCTCTTCGGCGTGCCCGGAGAAGCGGGAGCTGACAGCCAATGA

Upstream 100 bases:

>100_bases
CTCATCCAGAGTCGCCTTATGCACGAAAGCATTATACAGGCTCTTGTCATCCCGCCCTGCTGGCTGCTGGTCATGCAGGC
CAGAAAAAGGTTCGCCCCCG

Downstream 100 bases:

>100_bases
GCCCCATAGACAGACGCATTCTGACTCATATGAACTGGGGGCTCATCGCCATGACGCTGCTGCTTTTCGGCGTGGGCGTG
GCCAACCTGTATTCGGCATC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MKVQLDSEGFQPPRSGLMLLQGLVALIFLVFALRFWYLQIHKGEDYARLASDNRLRQEQMYAPRGLLRDRYGMLLAENRP
AYGLGLVREDCHDIPSTLAQISQWTGIDLTEITQRYERDKRKVKSFEPLILVPDISFELLAAVEANINRWPGLEIIVRPR
RYYPSGPELAHLLGYVSEADEKQLQQRPELALGDTVGKQGLELVLEDRLRGQKGLRQMEVDVVGRDLTHHILRAPQAGEN
INLTIDLALQHKAFEMLEGQSGCIVVLDPDTGQLHALVTAPAFDNNAFARGLTGKEWAELRDNPRHPMQNRVIQSVYPPA
SIWKLLMAGLVLEDKVVDPKETVFCNGRYPMGNRVFRCWKKWGHGHTDLHKALVESCDVYFYDVADKIGIDRIAEFAKAS
GFGELTGIDLPHERSGLVPSREWKRKRFGEVWHRGETLNISIGQGFTLVTPLQIARFIGALLNGGKLLKPQILVDEKPLV
QHEIPIGADARKVILKAMVDTVDAPRGTARRLRRPDAVIGGKTGTAQVVRIVGEERRKKEEMEYWERDHAWMAAWGQKDD
KRYVIVVMVEHGGGGSSTAGPIVKGLFDYLFGVPGEAGADSQ

Sequences:

>Translated_602_residues
MKVQLDSEGFQPPRSGLMLLQGLVALIFLVFALRFWYLQIHKGEDYARLASDNRLRQEQMYAPRGLLRDRYGMLLAENRP
AYGLGLVREDCHDIPSTLAQISQWTGIDLTEITQRYERDKRKVKSFEPLILVPDISFELLAAVEANINRWPGLEIIVRPR
RYYPSGPELAHLLGYVSEADEKQLQQRPELALGDTVGKQGLELVLEDRLRGQKGLRQMEVDVVGRDLTHHILRAPQAGEN
INLTIDLALQHKAFEMLEGQSGCIVVLDPDTGQLHALVTAPAFDNNAFARGLTGKEWAELRDNPRHPMQNRVIQSVYPPA
SIWKLLMAGLVLEDKVVDPKETVFCNGRYPMGNRVFRCWKKWGHGHTDLHKALVESCDVYFYDVADKIGIDRIAEFAKAS
GFGELTGIDLPHERSGLVPSREWKRKRFGEVWHRGETLNISIGQGFTLVTPLQIARFIGALLNGGKLLKPQILVDEKPLV
QHEIPIGADARKVILKAMVDTVDAPRGTARRLRRPDAVIGGKTGTAQVVRIVGEERRKKEEMEYWERDHAWMAAWGQKDD
KRYVIVVMVEHGGGGSSTAGPIVKGLFDYLFGVPGEAGADSQ
>Mature_602_residues
MKVQLDSEGFQPPRSGLMLLQGLVALIFLVFALRFWYLQIHKGEDYARLASDNRLRQEQMYAPRGLLRDRYGMLLAENRP
AYGLGLVREDCHDIPSTLAQISQWTGIDLTEITQRYERDKRKVKSFEPLILVPDISFELLAAVEANINRWPGLEIIVRPR
RYYPSGPELAHLLGYVSEADEKQLQQRPELALGDTVGKQGLELVLEDRLRGQKGLRQMEVDVVGRDLTHHILRAPQAGEN
INLTIDLALQHKAFEMLEGQSGCIVVLDPDTGQLHALVTAPAFDNNAFARGLTGKEWAELRDNPRHPMQNRVIQSVYPPA
SIWKLLMAGLVLEDKVVDPKETVFCNGRYPMGNRVFRCWKKWGHGHTDLHKALVESCDVYFYDVADKIGIDRIAEFAKAS
GFGELTGIDLPHERSGLVPSREWKRKRFGEVWHRGETLNISIGQGFTLVTPLQIARFIGALLNGGKLLKPQILVDEKPLV
QHEIPIGADARKVILKAMVDTVDAPRGTARRLRRPDAVIGGKTGTAQVVRIVGEERRKKEEMEYWERDHAWMAAWGQKDD
KRYVIVVMVEHGGGGSSTAGPIVKGLFDYLFGVPGEAGADSQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=602, Percent_Identity=32.890365448505, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786272, Length=588, Percent_Identity=23.469387755102, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67700; Mature: 67700

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVQLDSEGFQPPRSGLMLLQGLVALIFLVFALRFWYLQIHKGEDYARLASDNRLRQEQM
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCCHHHHHHH
YAPRGLLRDRYGMLLAENRPAYGLGLVREDCHDIPSTLAQISQWTGIDLTEITQRYERDK
HCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RKVKSFEPLILVPDISFELLAAVEANINRWPGLEIIVRPRRYYPSGPELAHLLGYVSEAD
HHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
EKQLQQRPELALGDTVGKQGLELVLEDRLRGQKGLRQMEVDVVGRDLTHHILRAPQAGEN
HHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
INLTIDLALQHKAFEMLEGQSGCIVVLDPDTGQLHALVTAPAFDNNAFARGLTGKEWAEL
EEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCHHCCCCCHHHHHH
RDNPRHPMQNRVIQSVYPPASIWKLLMAGLVLEDKVVDPKETVFCNGRYPMGNRVFRCWK
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHH
KWGHGHTDLHKALVESCDVYFYDVADKIGIDRIAEFAKASGFGELTGIDLPHERSGLVPS
HHCCCHHHHHHHHHHHCCEEEEECHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
REWKRKRFGEVWHRGETLNISIGQGFTLVTPLQIARFIGALLNGGKLLKPQILVDEKPLV
HHHHHHHHHHHHHCCCEEEEECCCCCEEECHHHHHHHHHHHHCCCCEECCEEEECCCCCH
QHEIPIGADARKVILKAMVDTVDAPRGTARRLRRPDAVIGGKTGTAQVVRIVGEERRKKE
HCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHH
EMEYWERDHAWMAAWGQKDDKRYVIVVMVEHGGGGSSTAGPIVKGLFDYLFGVPGEAGAD
HHHHHHHCCHHEEECCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SQ
CC
>Mature Secondary Structure
MKVQLDSEGFQPPRSGLMLLQGLVALIFLVFALRFWYLQIHKGEDYARLASDNRLRQEQM
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCCHHHHHHH
YAPRGLLRDRYGMLLAENRPAYGLGLVREDCHDIPSTLAQISQWTGIDLTEITQRYERDK
HCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RKVKSFEPLILVPDISFELLAAVEANINRWPGLEIIVRPRRYYPSGPELAHLLGYVSEAD
HHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
EKQLQQRPELALGDTVGKQGLELVLEDRLRGQKGLRQMEVDVVGRDLTHHILRAPQAGEN
HHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
INLTIDLALQHKAFEMLEGQSGCIVVLDPDTGQLHALVTAPAFDNNAFARGLTGKEWAEL
EEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCHHCCCCCHHHHHH
RDNPRHPMQNRVIQSVYPPASIWKLLMAGLVLEDKVVDPKETVFCNGRYPMGNRVFRCWK
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHH
KWGHGHTDLHKALVESCDVYFYDVADKIGIDRIAEFAKASGFGELTGIDLPHERSGLVPS
HHCCCHHHHHHHHHHHCCEEEEECHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
REWKRKRFGEVWHRGETLNISIGQGFTLVTPLQIARFIGALLNGGKLLKPQILVDEKPLV
HHHHHHHHHHHHHCCCEEEEECCCCCEEECHHHHHHHHHHHHCCCCEECCEEEECCCCCH
QHEIPIGADARKVILKAMVDTVDAPRGTARRLRRPDAVIGGKTGTAQVVRIVGEERRKKE
HCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHH
EMEYWERDHAWMAAWGQKDDKRYVIVVMVEHGGGGSSTAGPIVKGLFDYLFGVPGEAGAD
HHHHHHHCCHHEEECCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]