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The map label for this gene is ydgK [H]

Identifier: 78355715

GI number: 78355715

Start: 683006

End: 684172

Strand: Reverse

Name: ydgK [H]

Synonym: Dde_0668

Alternate gene names: 78355715

Gene position: 684172-683006 (Counterclockwise)

Preceding gene: 78355716

Following gene: 78355708

Centisome position: 18.34

GC content: 59.13

Gene sequence:

>1167_bases
ATGCCCGATTTCATCCTTATACTGCTTCTGGCGGCTTTTCCCGCCCTGTCCACAGACATGTACCTTCCTGCCATCCCGAC
GCTGTGCACGCTGTGGAACATTCCGCTGGCTCAGGCCAACCTTTCTCTGGTGGTCTTTTTTGTCACGTTCAGCAGCTTTC
TGCTTATCCACGGTCCGCTTTCCGACAGGTTCGGCAGGCGCCCCGTGCTGCTGTGGGGCATTCTGCTGTTCATTGCGGGC
AGCCTGTTGTGCGCCGCGTCGCAGTCCATAACCACGCTGGTGGCCGCCCGTGCGGTTCAGGCCGTGGGGGCCGCCGCGGC
ATCGGCACTCAGCTTTGCGCTGGCCAAAGACATGTACACCGGTGAGCAACGCAAAAAGCTGCTGGCGTACATCGGTGTCA
TTGTTCCGCTGTGTCCCATGGCTGCCCCCACCATCGGGGCGTTCATGCTGCAGCATGTTTCGTGGCGGGGCATCTTTGTG
CTGCAGGGAGCGCTTGCCCTTTTTGCCCTGTACGGGGCATTCCGCCTGCGCGAACCGTTGACCAGCAAAGCAAGCGGAGG
AGCGGCCGCGGCGCTTAAACGCTATGTCACCCTGTTCAGCAACGCGCCTTTCATGGTGTACGCGGTGGCCTTTGCCCTTC
CCGGGCTGGCGTTTTTCGCCTTCATCGCCGGTTCTTCAAATATTTACATCAGCGGGTTCGGCAGTTCCGAGCAGCAATAC
GGCCTGTATTTCGCTTTCAACGCCTTCTCACTCATGCTCGGTTCTTTTCTCTGCTCACGGTTATGCGTCGGGCTTGCTTC
ACGCACCATACTGTTTGTCTCGTTCGTCGGCATGCTGCTTTCTGTGCTGGCCATGTTTGTCTTCGGAAACGAAACCCCGG
TCAGCTTTGCGGTGACCATGTTCTGCTACACCATGTTTCTGGGCATGAGCCGCCCCATCAGCAATCATATGATTCTGGAA
CAGGTGGACCGCAACGCCGGCGCCGCCGCCTCGCTGGTCACGTTCTTCTTTTTTCTGTGCGGCGCCGTGGCCATGGAAAC
CATTTCGCTGCAATGGGACTCCAAACCCTTTGTCATTGCCGTACTGGGCGGTGCCGGCACCGCCGCTGCACTGGGTGTCA
CACTGATGCTGCGCGGTCGCAGTGCCGAAAAACCTGCCACCTCCTGA

Upstream 100 bases:

>100_bases
TTCGGCCCGAGAACGCCGCCTGCTGCTGCGTCTGCTGCATATTCTGGAAGACAACACGCAGGCGTTCTCCACCCTGTAAC
CATCTACCCCTGCAGGCCCC

Downstream 100 bases:

>100_bases
TACGGCAGTTCAGCTGCTCCGTTCATCCTGCAACACAAAGGCTGCCCCGGAACAACGTCCCGGAGCAGCCTTTTATTCAT
ACCCGCAGCGGCGCCGCGGC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPDFILILLLAAFPALSTDMYLPAIPTLCTLWNIPLAQANLSLVVFFVTFSSFLLIHGPLSDRFGRRPVLLWGILLFIAG
SLLCAASQSITTLVAARAVQAVGAAAASALSFALAKDMYTGEQRKKLLAYIGVIVPLCPMAAPTIGAFMLQHVSWRGIFV
LQGALALFALYGAFRLREPLTSKASGGAAAALKRYVTLFSNAPFMVYAVAFALPGLAFFAFIAGSSNIYISGFGSSEQQY
GLYFAFNAFSLMLGSFLCSRLCVGLASRTILFVSFVGMLLSVLAMFVFGNETPVSFAVTMFCYTMFLGMSRPISNHMILE
QVDRNAGAAASLVTFFFFLCGAVAMETISLQWDSKPFVIAVLGGAGTAAALGVTLMLRGRSAEKPATS

Sequences:

>Translated_388_residues
MPDFILILLLAAFPALSTDMYLPAIPTLCTLWNIPLAQANLSLVVFFVTFSSFLLIHGPLSDRFGRRPVLLWGILLFIAG
SLLCAASQSITTLVAARAVQAVGAAAASALSFALAKDMYTGEQRKKLLAYIGVIVPLCPMAAPTIGAFMLQHVSWRGIFV
LQGALALFALYGAFRLREPLTSKASGGAAAALKRYVTLFSNAPFMVYAVAFALPGLAFFAFIAGSSNIYISGFGSSEQQY
GLYFAFNAFSLMLGSFLCSRLCVGLASRTILFVSFVGMLLSVLAMFVFGNETPVSFAVTMFCYTMFLGMSRPISNHMILE
QVDRNAGAAASLVTFFFFLCGAVAMETISLQWDSKPFVIAVLGGAGTAAALGVTLMLRGRSAEKPATS
>Mature_387_residues
PDFILILLLAAFPALSTDMYLPAIPTLCTLWNIPLAQANLSLVVFFVTFSSFLLIHGPLSDRFGRRPVLLWGILLFIAGS
LLCAASQSITTLVAARAVQAVGAAAASALSFALAKDMYTGEQRKKLLAYIGVIVPLCPMAAPTIGAFMLQHVSWRGIFVL
QGALALFALYGAFRLREPLTSKASGGAAAALKRYVTLFSNAPFMVYAVAFALPGLAFFAFIAGSSNIYISGFGSSEQQYG
LYFAFNAFSLMLGSFLCSRLCVGLASRTILFVSFVGMLLSVLAMFVFGNETPVSFAVTMFCYTMFLGMSRPISNHMILEQ
VDRNAGAAASLVTFFFFLCGAVAMETISLQWDSKPFVIAVLGGAGTAAALGVTLMLRGRSAEKPATS

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=360, Percent_Identity=30, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI48994889, Length=289, Percent_Identity=31.4878892733564, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790146, Length=302, Percent_Identity=25.8278145695364, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787065, Length=224, Percent_Identity=29.4642857142857, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082312, Length=211, Percent_Identity=27.0142180094787, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790794, Length=244, Percent_Identity=27.4590163934426, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87081983, Length=174, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081738, Length=114, Percent_Identity=35.9649122807018, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322071, Length=150, Percent_Identity=28, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=156, Percent_Identity=26.9230769230769, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41380; Mature: 41248

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFILILLLAAFPALSTDMYLPAIPTLCTLWNIPLAQANLSLVVFFVTFSSFLLIHGPL
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHEEECCH
SDRFGRRPVLLWGILLFIAGSLLCAASQSITTLVAARAVQAVGAAAASALSFALAKDMYT
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEQRKKLLAYIGVIVPLCPMAAPTIGAFMLQHVSWRGIFVLQGALALFALYGAFRLREPL
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
TSKASGGAAAALKRYVTLFSNAPFMVYAVAFALPGLAFFAFIAGSSNIYISGFGSSEQQY
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
GLYFAFNAFSLMLGSFLCSRLCVGLASRTILFVSFVGMLLSVLAMFVFGNETPVSFAVTM
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FCYTMFLGMSRPISNHMILEQVDRNAGAAASLVTFFFFLCGAVAMETISLQWDSKPFVIA
HHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VLGGAGTAAALGVTLMLRGRSAEKPATS
EECCCCHHHHHHHHHEEECCCCCCCCCC
>Mature Secondary Structure 
PDFILILLLAAFPALSTDMYLPAIPTLCTLWNIPLAQANLSLVVFFVTFSSFLLIHGPL
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHEEECCH
SDRFGRRPVLLWGILLFIAGSLLCAASQSITTLVAARAVQAVGAAAASALSFALAKDMYT
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEQRKKLLAYIGVIVPLCPMAAPTIGAFMLQHVSWRGIFVLQGALALFALYGAFRLREPL
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
TSKASGGAAAALKRYVTLFSNAPFMVYAVAFALPGLAFFAFIAGSSNIYISGFGSSEQQY
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
GLYFAFNAFSLMLGSFLCSRLCVGLASRTILFVSFVGMLLSVLAMFVFGNETPVSFAVTM
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FCYTMFLGMSRPISNHMILEQVDRNAGAAASLVTFFFFLCGAVAMETISLQWDSKPFVIA
HHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VLGGAGTAAALGVTLMLRGRSAEKPATS
EECCCCHHHHHHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]