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The map label for this gene is glmS [H]

Identifier: 78355549

GI number: 78355549

Start: 508581

End: 510404

Strand: Reverse

Name: glmS [H]

Synonym: Dde_0502

Alternate gene names: 78355549

Gene position: 510404-508581 (Counterclockwise)

Preceding gene: 78355550

Following gene: 78355548

Centisome position: 13.68

GC content: 59.27

Gene sequence:

>1824_bases
ATGTGTGGCATAATCGGCTACGCGGGGCACCGCCCCGCCGTTCCCGTCATCATTGAAGGCCTGCGCAGGCTGGAATATCG
TGGTTACGACTCCGCAGGGGTCGCCTTTGTACAGAACAAAGAGCTGAACATCGTCCGCGCCGAAGGCAAACTGGCCAATC
TGGAAACAAAGCTGGAAAGCATAAACGTAACCATGGCGACCAGCGGCATCGGTCATACCCGCTGGGCAACACACGGGGTG
CCCGTAGAACGCAACGCACACCCGCATTGTTGTCAGGACGGTTCGCTGGCCATCATTCACAACGGCATCATCGAAAACTA
CCAGCAGCTCAAGGCTGAACTGCTGGAAAAAGGGTATGAGTTCCGGTCTGAAACCGACACGGAAGTCTGTGCCAACCTCA
TTGCCGAATGTCTGCGCAGCACAGGCTCGCTGGATACGGCCATATCCATGGCGCTGCAGCGGGCCGAAGGCGCATACGCC
ATTGTGGTATGCGATTCGCGCAACCCCGGCACGCTGTACGCCGCACGGCAGTCCAGCCCGCTGGTCATGGGCATAGGGCA
GGGCGAAAATTTCCTTGCTTCCGACATTCCCGCATTTCTGCCCTACACGCGTGACGTGGTCTTTCTAGAAGACGGAGAAA
TGGTCCGCATCGACGCCAACAGCTGGAGCGTCATGAATGTAAAAGACCTTTCTCCGGTTGAAAAACAGGTTCACCACATC
ACGTGGGACGTTCAGGCCGCACAGAAAGGCGGCTACAAGCACTTCATGCTCAAGGAAATCTTTGAGCAGCCCCGTGTGAT
CAGCGACTGCCTGACCGGACGCATGGACTGGAAACAGCGCACCGTCACCCTGCCGGAACTGGAACAGGCTGCCATTCCCT
CGCGGCTGCATATCGTGGCCTGCGGCACCAGTTTTCACGCCGGTCTGTGGGGCAAACAGCTGCTGGAACAATGGGCCGGT
GTGCCGGTGAGCGTTGAAATAGCCTCTGAATTCCGCTACCGCCAGCCCATCATGCAACAGGGCGAAGCCGTACTGGTTAT
CAGCCAGTCCGGTGAAACCGCAGACACACTGGCAGGGCTGAGGCTGGCCAAAGAGCAGGGCCTGCCGGTCATCGGCCTGT
GCAACGTTGTCGGCTCATCCATCGCGCGAGAAGCGGACACGGTGGTCTACACGCAGGCAGGGCCGGAAATCAGTGTGGCT
TCCACCAAGGCCATGACCAGCCAGATGACTGCGCTGGCACTGCTGGCGCTTTACTGGGGCATTCGCAAAGGCGTGCTGCC
CGATGAAACCCGCAGAGCCGCGGTGGACGGGCTGGAAAAACTGCCCGGCCAGCTTGAATCGGAACTGCCCAGAATGCGGG
AAGAAGCCAAACGTCTTGCCCGCGAATACTCTTCGGCACGCAGTTTCTTTTTTCTGGGGCGCGGGCTCAGCTATCCGCTG
GCACTGGAAGGCGCACTCAAGCTCAAGGAAATTTCCTACATCCATGCCGAAGGCTATGCCGCCGGTGAAATGAAGCACGG
CCCCATAGCGCTTATCGATCCGGAATTCCCCACGTTTGCCGTGGCGCCCGCCGACGATCTGTACCCCAAAGTCAAATCAA
ACCTGCAGGAAGTACAGGCACGCTCCGGCCGCATCATCGCACTGGTGCATCCGGGGGCCGACCTTGCCGTGGACAGCCCG
TGGGTCATGGCCGAGGCATGGGGCCCGCTCTCATCGTTTCTGGCCCTGCCCGCTCTGCAGCTCTTCAGCTATGAAGCCGC
AGACTATCTGGGCAAAGACGTTGACCAGCCCAGAAACCTGGCAAAAAGCGTCACCGTGGAATAG

Upstream 100 bases:

>100_bases
CTCATACTCTTGCGCTGATGCCCCCGACAACGTACTATGCCCGACTGTTACTTCCCGTCCGGAATCGCAAGTCTCCGGCA
CATCCCGCAAGGAGAACCCT

Downstream 100 bases:

>100_bases
CCTAGCTATGAAAAATTATTCAAGAATTATGATGTAAATTCAAAGCAATAGTGAGCGCCAGGTCATTTTCGATCAACAGT
ATCTCAGACGAACGTGGTCA

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIIGYAGHRPAVPVIIEGLRRLEYRGYDSAGVAFVQNKELNIVRAEGKLANLETKLESINVTMATSGIGHTRWATHGV
PVERNAHPHCCQDGSLAIIHNGIIENYQQLKAELLEKGYEFRSETDTEVCANLIAECLRSTGSLDTAISMALQRAEGAYA
IVVCDSRNPGTLYAARQSSPLVMGIGQGENFLASDIPAFLPYTRDVVFLEDGEMVRIDANSWSVMNVKDLSPVEKQVHHI
TWDVQAAQKGGYKHFMLKEIFEQPRVISDCLTGRMDWKQRTVTLPELEQAAIPSRLHIVACGTSFHAGLWGKQLLEQWAG
VPVSVEIASEFRYRQPIMQQGEAVLVISQSGETADTLAGLRLAKEQGLPVIGLCNVVGSSIAREADTVVYTQAGPEISVA
STKAMTSQMTALALLALYWGIRKGVLPDETRRAAVDGLEKLPGQLESELPRMREEAKRLAREYSSARSFFFLGRGLSYPL
ALEGALKLKEISYIHAEGYAAGEMKHGPIALIDPEFPTFAVAPADDLYPKVKSNLQEVQARSGRIIALVHPGADLAVDSP
WVMAEAWGPLSSFLALPALQLFSYEAADYLGKDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIIGYAGHRPAVPVIIEGLRRLEYRGYDSAGVAFVQNKELNIVRAEGKLANLETKLESINVTMATSGIGHTRWATHGV
PVERNAHPHCCQDGSLAIIHNGIIENYQQLKAELLEKGYEFRSETDTEVCANLIAECLRSTGSLDTAISMALQRAEGAYA
IVVCDSRNPGTLYAARQSSPLVMGIGQGENFLASDIPAFLPYTRDVVFLEDGEMVRIDANSWSVMNVKDLSPVEKQVHHI
TWDVQAAQKGGYKHFMLKEIFEQPRVISDCLTGRMDWKQRTVTLPELEQAAIPSRLHIVACGTSFHAGLWGKQLLEQWAG
VPVSVEIASEFRYRQPIMQQGEAVLVISQSGETADTLAGLRLAKEQGLPVIGLCNVVGSSIAREADTVVYTQAGPEISVA
STKAMTSQMTALALLALYWGIRKGVLPDETRRAAVDGLEKLPGQLESELPRMREEAKRLAREYSSARSFFFLGRGLSYPL
ALEGALKLKEISYIHAEGYAAGEMKHGPIALIDPEFPTFAVAPADDLYPKVKSNLQEVQARSGRIIALVHPGADLAVDSP
WVMAEAWGPLSSFLALPALQLFSYEAADYLGKDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIIGYAGHRPAVPVIIEGLRRLEYRGYDSAGVAFVQNKELNIVRAEGKLANLETKLESINVTMATSGIGHTRWATHGV
PVERNAHPHCCQDGSLAIIHNGIIENYQQLKAELLEKGYEFRSETDTEVCANLIAECLRSTGSLDTAISMALQRAEGAYA
IVVCDSRNPGTLYAARQSSPLVMGIGQGENFLASDIPAFLPYTRDVVFLEDGEMVRIDANSWSVMNVKDLSPVEKQVHHI
TWDVQAAQKGGYKHFMLKEIFEQPRVISDCLTGRMDWKQRTVTLPELEQAAIPSRLHIVACGTSFHAGLWGKQLLEQWAG
VPVSVEIASEFRYRQPIMQQGEAVLVISQSGETADTLAGLRLAKEQGLPVIGLCNVVGSSIAREADTVVYTQAGPEISVA
STKAMTSQMTALALLALYWGIRKGVLPDETRRAAVDGLEKLPGQLESELPRMREEAKRLAREYSSARSFFFLGRGLSYPL
ALEGALKLKEISYIHAEGYAAGEMKHGPIALIDPEFPTFAVAPADDLYPKVKSNLQEVQARSGRIIALVHPGADLAVDSP
WVMAEAWGPLSSFLALPALQLFSYEAADYLGKDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=37.9360465116279, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=36.4568081991215, Blast_Score=405, Evalue=1e-113,
Organism=Escherichia coli, GI1790167, Length=624, Percent_Identity=47.7564102564103, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI87082251, Length=307, Percent_Identity=20.1954397394137, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1788651, Length=172, Percent_Identity=27.906976744186, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=39.2609699769053, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17532899, Length=473, Percent_Identity=36.5750528541226, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17532897, Length=473, Percent_Identity=36.5750528541226, Blast_Score=279, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=38.302752293578, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6323731, Length=441, Percent_Identity=31.2925170068027, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=35.9223300970874, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=36.3372093023256, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66373; Mature: 66373

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGYAGHRPAVPVIIEGLRRLEYRGYDSAGVAFVQNKELNIVRAEGKLANLETKLES
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHH
INVTMATSGIGHTRWATHGVPVERNAHPHCCQDGSLAIIHNGIIENYQQLKAELLEKGYE
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCC
FRSETDTEVCANLIAECLRSTGSLDTAISMALQRAEGAYAIVVCDSRNPGTLYAARQSSP
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCC
LVMGIGQGENFLASDIPAFLPYTRDVVFLEDGEMVRIDANSWSVMNVKDLSPVEKQVHHI
EEEEECCCCCCHHHCCHHHCCCCCCEEEEECCCEEEEECCCEEEEEECCCCHHHHHHHHE
TWDVQAAQKGGYKHFMLKEIFEQPRVISDCLTGRMDWKQRTVTLPELEQAAIPSRLHIVA
EEEEEHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHEECCCCHHHHCCCCEEEEEE
CGTSFHAGLWGKQLLEQWAGVPVSVEIASEFRYRQPIMQQGEAVLVISQSGETADTLAGL
ECCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
RLAKEQGLPVIGLCNVVGSSIAREADTVVYTQAGPEISVASTKAMTSQMTALALLALYWG
HHHHHCCCCEEEHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHH
IRKGVLPDETRRAAVDGLEKLPGQLESELPRMREEAKRLAREYSSARSFFFLGRGLSYPL
HHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCE
ALEGALKLKEISYIHAEGYAAGEMKHGPIALIDPEFPTFAVAPADDLYPKVKSNLQEVQA
EECCCEEEEHEEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHH
RSGRIIALVHPGADLAVDSPWVMAEAWGPLSSFLALPALQLFSYEAADYLGKDVDQPRNL
CCCCEEEEECCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIIGYAGHRPAVPVIIEGLRRLEYRGYDSAGVAFVQNKELNIVRAEGKLANLETKLES
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHH
INVTMATSGIGHTRWATHGVPVERNAHPHCCQDGSLAIIHNGIIENYQQLKAELLEKGYE
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCC
FRSETDTEVCANLIAECLRSTGSLDTAISMALQRAEGAYAIVVCDSRNPGTLYAARQSSP
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCC
LVMGIGQGENFLASDIPAFLPYTRDVVFLEDGEMVRIDANSWSVMNVKDLSPVEKQVHHI
EEEEECCCCCCHHHCCHHHCCCCCCEEEEECCCEEEEECCCEEEEEECCCCHHHHHHHHE
TWDVQAAQKGGYKHFMLKEIFEQPRVISDCLTGRMDWKQRTVTLPELEQAAIPSRLHIVA
EEEEEHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHEECCCCHHHHCCCCEEEEEE
CGTSFHAGLWGKQLLEQWAGVPVSVEIASEFRYRQPIMQQGEAVLVISQSGETADTLAGL
ECCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
RLAKEQGLPVIGLCNVVGSSIAREADTVVYTQAGPEISVASTKAMTSQMTALALLALYWG
HHHHHCCCCEEEHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHH
IRKGVLPDETRRAAVDGLEKLPGQLESELPRMREEAKRLAREYSSARSFFFLGRGLSYPL
HHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCE
ALEGALKLKEISYIHAEGYAAGEMKHGPIALIDPEFPTFAVAPADDLYPKVKSNLQEVQA
EECCCEEEEHEEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHH
RSGRIIALVHPGADLAVDSPWVMAEAWGPLSSFLALPALQLFSYEAADYLGKDVDQPRNL
CCCCEEEEECCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA