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The map label for this gene is serS

Identifier: 78355243

GI number: 78355243

Start: 179923

End: 181206

Strand: Reverse

Name: serS

Synonym: Dde_0196

Alternate gene names: 78355243

Gene position: 181206-179923 (Counterclockwise)

Preceding gene: 78355244

Following gene: 78355240

Centisome position: 4.86

GC content: 56.93

Gene sequence:

>1284_bases
ATGCTTGACCTTAAACTGCTGCAGAACAATCCCGAAGTGGTTGCCGAGGCCCTTGCCAAACGCAATTCGGGCATTGATAT
CACCCTGTTTACCGCACTTGACCAGCGCCGCAGAGAACTGCTGCTGGAAGTGGAAGCGCTGAAAAGCGAACGCAACAAGG
CTTCCGGCGATGTCGCCCGCATGAAGCGCGCCGGAGAAAACGCCGACGCACTCATCGAAAAACTGGGCGCTCTGTCAGAC
CGCATCAAAACACTGGACGCTGAAACCGAAACGGTAAAAGCCGAAGTGCACCAGTGGCTCATTTCTCTGCCCAATATCCC
GCACGAAAGCGTTCCCGCCGGAGCAGACGAAAACGACAACGTATTTCTGCATGCATGGGGAGAAAAGCCTTCTTTTGACT
TCACTCCCAAAGAGCACTGGGAAATCGGCCCTGCACTGGGGCTTGATTTTGAACGCGGCAGCCGTCTGACGGGCAGCCGT
TTCACCGTGCTGTGGCACTGGGCGGCAAAGCTGGAACGCGCCCTGACGGCATTCTTTCTGGACGTGCACACCCGCGAACA
CGGGTACATGGAAGTCTACCCGCCCGCCATGGTCAACGCCCAGACCATGACCGGCACCGGACAGCTGCCCAAGTTCGAGG
AAGACCTCTTCAAGCTGCGCGATTCCGAGTACTATCTTATTCCCACGGCAGAAGTACCGCTGACAAACCTGCACAGCGGC
GAAGTGGTGCCGGAAGAAAAACTGCCCATAGCCTATACCGCGCAGACACAGTGCTTCCGCTCCGAAGCGGGCAGCTACGG
CAAGGATACCAAAGGCTTCATACGCCAGCATCAGTTCACCAAAGTGGAAATGGTGCGGTTTGCCCACCCTGAAAAATCGT
TTGAAGAGCTGGAAAAACTGCGCAGTCACGCCGAAGTGCTGTTGCAGAAGCTGGGCCTGCATTACAGGGTTGTCACCCTG
TGCAGCGGGGATATGGGCTTTTCTGCGGCAAAAACATACGATCTGGAAGTGTGGCTGCCCGGACAGGATAAATACCGCGA
GATATCCTCGTGTTCCAACTGCACCGATTTTCAGGCCCGCAGAGCCAATATCCGCACCAGACTGGCCGATGCTAAAAAAC
CTGTGTTCCTGCACACGCTCAACGGTTCGGGGCTGGCTGTGGGCCGTACGCTGGTGGCCATACTGGAAAACTACCAGCAG
GCTGACGGCAGTGTGGTGGTGCCCGAAGTTCTGCGTCCCTACATGGGCGGCGTGGCACTGCTGACTCCCGACGGACCTTT
CTAG

Upstream 100 bases:

>100_bases
TACCCGTGCAGACGGTTTTACCGTCTGCTGAGCGGCAGGTTGACCCGTCAGTGCCTTGGGGCTATTCTCCCCCACTGCAT
TTCGCCCAAGGAGAATCCCC

Downstream 100 bases:

>100_bases
GCGCGGCCGGCAGACTGTCGACGATTTTTTTCATTTTTCCGCTTGACAGTTTTGCCCTCGCACCGTACAACGCATTCCTC
ACTTCGGGGGCGTTAACTCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDLKLLQNNPEVVAEALAKRNSGIDITLFTALDQRRRELLLEVEALKSERNKASGDVARMKRAGENADALIEKLGALSD
RIKTLDAETETVKAEVHQWLISLPNIPHESVPAGADENDNVFLHAWGEKPSFDFTPKEHWEIGPALGLDFERGSRLTGSR
FTVLWHWAAKLERALTAFFLDVHTREHGYMEVYPPAMVNAQTMTGTGQLPKFEEDLFKLRDSEYYLIPTAEVPLTNLHSG
EVVPEEKLPIAYTAQTQCFRSEAGSYGKDTKGFIRQHQFTKVEMVRFAHPEKSFEELEKLRSHAEVLLQKLGLHYRVVTL
CSGDMGFSAAKTYDLEVWLPGQDKYREISSCSNCTDFQARRANIRTRLADAKKPVFLHTLNGSGLAVGRTLVAILENYQQ
ADGSVVVPEVLRPYMGGVALLTPDGPF

Sequences:

>Translated_427_residues
MLDLKLLQNNPEVVAEALAKRNSGIDITLFTALDQRRRELLLEVEALKSERNKASGDVARMKRAGENADALIEKLGALSD
RIKTLDAETETVKAEVHQWLISLPNIPHESVPAGADENDNVFLHAWGEKPSFDFTPKEHWEIGPALGLDFERGSRLTGSR
FTVLWHWAAKLERALTAFFLDVHTREHGYMEVYPPAMVNAQTMTGTGQLPKFEEDLFKLRDSEYYLIPTAEVPLTNLHSG
EVVPEEKLPIAYTAQTQCFRSEAGSYGKDTKGFIRQHQFTKVEMVRFAHPEKSFEELEKLRSHAEVLLQKLGLHYRVVTL
CSGDMGFSAAKTYDLEVWLPGQDKYREISSCSNCTDFQARRANIRTRLADAKKPVFLHTLNGSGLAVGRTLVAILENYQQ
ADGSVVVPEVLRPYMGGVALLTPDGPF
>Mature_427_residues
MLDLKLLQNNPEVVAEALAKRNSGIDITLFTALDQRRRELLLEVEALKSERNKASGDVARMKRAGENADALIEKLGALSD
RIKTLDAETETVKAEVHQWLISLPNIPHESVPAGADENDNVFLHAWGEKPSFDFTPKEHWEIGPALGLDFERGSRLTGSR
FTVLWHWAAKLERALTAFFLDVHTREHGYMEVYPPAMVNAQTMTGTGQLPKFEEDLFKLRDSEYYLIPTAEVPLTNLHSG
EVVPEEKLPIAYTAQTQCFRSEAGSYGKDTKGFIRQHQFTKVEMVRFAHPEKSFEELEKLRSHAEVLLQKLGLHYRVVTL
CSGDMGFSAAKTYDLEVWLPGQDKYREISSCSNCTDFQARRANIRTRLADAKKPVFLHTLNGSGLAVGRTLVAILENYQQ
ADGSVVVPEVLRPYMGGVALLTPDGPF

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=387, Percent_Identity=37.4677002583979, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI8923421, Length=442, Percent_Identity=31.447963800905, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI225579074, Length=447, Percent_Identity=30.8724832214765, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=53.0516431924883, Blast_Score=455, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17539260, Length=339, Percent_Identity=34.2182890855457, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=328, Percent_Identity=31.0975609756098, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=433, Percent_Identity=36.2586605080831, Blast_Score=255, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6321799, Length=352, Percent_Identity=33.5227272727273, Blast_Score=206, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24581334, Length=466, Percent_Identity=32.4034334763949, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI17737985, Length=354, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_DESDG (Q316Z9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386692.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q316Z9
- SMR:   Q316Z9
- STRING:   Q316Z9
- GeneID:   3756608
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0196
- NMPDR:   fig|207559.3.peg.852
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   DDES207559:DDE_0196-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47896; Mature: 47896

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKLLQNNPEVVAEALAKRNSGIDITLFTALDQRRRELLLEVEALKSERNKASGDVAR
CCEEEEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
MKRAGENADALIEKLGALSDRIKTLDAETETVKAEVHQWLISLPNIPHESVPAGADENDN
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VFLHAWGEKPSFDFTPKEHWEIGPALGLDFERGSRLTGSRFTVLWHWAAKLERALTAFFL
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
DVHTREHGYMEVYPPAMVNAQTMTGTGQLPKFEEDLFKLRDSEYYLIPTAEVPLTNLHSG
HHEECCCCCEEECCCCCCCCEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCC
EVVPEEKLPIAYTAQTQCFRSEAGSYGKDTKGFIRQHQFTKVEMVRFAHPEKSFEELEKL
CCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHHHCCCCHHHHHHHHH
RSHAEVLLQKLGLHYRVVTLCSGDMGFSAAKTYDLEVWLPGQDKYREISSCSNCTDFQAR
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCHHHHH
RANIRTRLADAKKPVFLHTLNGSGLAVGRTLVAILENYQQADGSVVVPEVLRPYMGGVAL
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHCCEEE
LTPDGPF
ECCCCCC
>Mature Secondary Structure
MLDLKLLQNNPEVVAEALAKRNSGIDITLFTALDQRRRELLLEVEALKSERNKASGDVAR
CCEEEEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
MKRAGENADALIEKLGALSDRIKTLDAETETVKAEVHQWLISLPNIPHESVPAGADENDN
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VFLHAWGEKPSFDFTPKEHWEIGPALGLDFERGSRLTGSRFTVLWHWAAKLERALTAFFL
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
DVHTREHGYMEVYPPAMVNAQTMTGTGQLPKFEEDLFKLRDSEYYLIPTAEVPLTNLHSG
HHEECCCCCEEECCCCCCCCEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCC
EVVPEEKLPIAYTAQTQCFRSEAGSYGKDTKGFIRQHQFTKVEMVRFAHPEKSFEELEKL
CCCCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHHHCCCCHHHHHHHHH
RSHAEVLLQKLGLHYRVVTLCSGDMGFSAAKTYDLEVWLPGQDKYREISSCSNCTDFQAR
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCHHHHH
RANIRTRLADAKKPVFLHTLNGSGLAVGRTLVAILENYQQADGSVVVPEVLRPYMGGVAL
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHCCEEE
LTPDGPF
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA