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The map label for this gene is thrC [H]

Identifier: 78355218

GI number: 78355218

Start: 153942

End: 155396

Strand: Reverse

Name: thrC [H]

Synonym: Dde_0171

Alternate gene names: 78355218

Gene position: 155396-153942 (Counterclockwise)

Preceding gene: 78355219

Following gene: 78355217

Centisome position: 4.17

GC content: 60.21

Gene sequence:

>1455_bases
ATGACGGCAGCGCATGATTTTCCCGCTTACCGCGGGCAAATGGAATATTTCTGTCTGGGCTGCGGCAGCCGCTACAATGT
GGATGAACTGCACTACACCTGTCCCGACTGCGGCGGTGTGTTTCTGCTGGATAACACGGATTTCGACGCGCTGAGCGCCC
GTTCCGGCAAAGAATGGCAGGACATATTCGATGCCCGCGCAGCCACGCGCACAACCCCGTTGCGCGGTATTTTCCGTTTT
TACGAGCTGATGGCTCCCCTACTGGAACCCGAAGACATCATCTATCTGGGTGAAGGCAACACCCCCGTCATCGAAGCCTC
GCCCGCCATGAGCGACATGGCCGGCATTCCTTTCGCCTTTAAAAACGACGGACAGAACCCTTCCGCATCGTTCAAGGACA
GGGGCATGGCCTGCGCATTCAGCTTTCTCAAATCGCTGGTGCGCAAACACGGATGGGATGAAGTCCTGACCGTCTGCGCC
TCCACAGGTGACACATCTGCCGCCGCCGCCCTGTACGCCTCGTATGTGGGCGCACCGCTCAAATCCGTGGTGCTGCTGCC
TCACGGCAAGGTAACCCCGCAGCAGCTTTCGCAGCCGCTGGGCAGCGGTGCCACTGTGCTTGAAGTGCCCGGCGTGTTCG
ATGACTGCATGAAGGTGGTTGAACACCTGGCCGAAAACTACCGGGTGGCGCTGCTCAATTCTAAAAACAGCTGGCGCATT
CTGGGGCAGGAGTCGTATGCATTTGAAGTTGCCCAGTGGTACGGCTGGGACATGCAGAACAAATGCATCTTTGTGCCCAT
CGGCAACGCGGGCAACATAACCGCTGTCATGAGCGGGTTCCTCAAGCTGCACCGGCTGGGCATCATCAGCTGCCTGCCCC
GCGTTTTCGGTGTGCAGTCACACCATGCCGACCCCGTATACCGCTATTACAGCGTGCAGGACCCGGCCAGCAGAGTATTT
ACCCCCGTCACCGTACAGCCCAGTGTGGCGCAGGCAGCCATGATCGGCAATCCTGTCTCGTTCCCGCGCGTACGGCACTT
TGCCGGCCAGTTCGAAGCCATCGGCGGACAGGGAGCTTTTCAGGTGGTGCAGGTGACCGAGCAGGCCATCATGGATGCCA
TGATCATTGCCAACCGCCACGGACACATCGCCTGCACGCAGGGCGGAGAATGTCTGGCCGGACTCATGCGTGCCCGCGAA
CTGGGCATCATCGCACCGCACGAAACAGCAGTGCTCGACGCCACGGCGCACGCTCTCAAATTCTCCGGCTTTCAGGACAT
GTATTTTTCCGGCACGTTGCCCGCTGAATACGGCGTCACCCCCGATGCCGGACTTTCCAATGCTCCGGAACTGCTCATGG
ACGAAGCCGCGCGCAACGCTCTTGCGCCGGAAGAGTTCACCCTTGCAGCAGCCCGCGCCGTTGCCGGCAGACTGGGGCTG
GCCCCCAAAAGCTGA

Upstream 100 bases:

>100_bases
ATGACTCTGGTTTTCTGGAGCCACCGCGAAAACATAGGCCGCCTTGCCCGGGGCGAAGAAAAACCGTGGCAGAAAAAAAA
GCACAAGGAACATGAATAAC

Downstream 100 bases:

>100_bases
AGCGCACCCCGCGTGTGATAATACAATCCGCAGGCGCCCCTGTACTATGTGCAGGGGCGTCTTTTTGTGTACCCCCGCCA
TGCGGCACCCCGCAAAGGCT

Product: L-threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTAAHDFPAYRGQMEYFCLGCGSRYNVDELHYTCPDCGGVFLLDNTDFDALSARSGKEWQDIFDARAATRTTPLRGIFRF
YELMAPLLEPEDIIYLGEGNTPVIEASPAMSDMAGIPFAFKNDGQNPSASFKDRGMACAFSFLKSLVRKHGWDEVLTVCA
STGDTSAAAALYASYVGAPLKSVVLLPHGKVTPQQLSQPLGSGATVLEVPGVFDDCMKVVEHLAENYRVALLNSKNSWRI
LGQESYAFEVAQWYGWDMQNKCIFVPIGNAGNITAVMSGFLKLHRLGIISCLPRVFGVQSHHADPVYRYYSVQDPASRVF
TPVTVQPSVAQAAMIGNPVSFPRVRHFAGQFEAIGGQGAFQVVQVTEQAIMDAMIIANRHGHIACTQGGECLAGLMRARE
LGIIAPHETAVLDATAHALKFSGFQDMYFSGTLPAEYGVTPDAGLSNAPELLMDEAARNALAPEEFTLAAARAVAGRLGL
APKS

Sequences:

>Translated_484_residues
MTAAHDFPAYRGQMEYFCLGCGSRYNVDELHYTCPDCGGVFLLDNTDFDALSARSGKEWQDIFDARAATRTTPLRGIFRF
YELMAPLLEPEDIIYLGEGNTPVIEASPAMSDMAGIPFAFKNDGQNPSASFKDRGMACAFSFLKSLVRKHGWDEVLTVCA
STGDTSAAAALYASYVGAPLKSVVLLPHGKVTPQQLSQPLGSGATVLEVPGVFDDCMKVVEHLAENYRVALLNSKNSWRI
LGQESYAFEVAQWYGWDMQNKCIFVPIGNAGNITAVMSGFLKLHRLGIISCLPRVFGVQSHHADPVYRYYSVQDPASRVF
TPVTVQPSVAQAAMIGNPVSFPRVRHFAGQFEAIGGQGAFQVVQVTEQAIMDAMIIANRHGHIACTQGGECLAGLMRARE
LGIIAPHETAVLDATAHALKFSGFQDMYFSGTLPAEYGVTPDAGLSNAPELLMDEAARNALAPEEFTLAAARAVAGRLGL
APKS
>Mature_483_residues
TAAHDFPAYRGQMEYFCLGCGSRYNVDELHYTCPDCGGVFLLDNTDFDALSARSGKEWQDIFDARAATRTTPLRGIFRFY
ELMAPLLEPEDIIYLGEGNTPVIEASPAMSDMAGIPFAFKNDGQNPSASFKDRGMACAFSFLKSLVRKHGWDEVLTVCAS
TGDTSAAAALYASYVGAPLKSVVLLPHGKVTPQQLSQPLGSGATVLEVPGVFDDCMKVVEHLAENYRVALLNSKNSWRIL
GQESYAFEVAQWYGWDMQNKCIFVPIGNAGNITAVMSGFLKLHRLGIISCLPRVFGVQSHHADPVYRYYSVQDPASRVFT
PVTVQPSVAQAAMIGNPVSFPRVRHFAGQFEAIGGQGAFQVVQVTEQAIMDAMIIANRHGHIACTQGGECLAGLMRAREL
GIIAPHETAVLDATAHALKFSGFQDMYFSGTLPAEYGVTPDAGLSNAPELLMDEAARNALAPEEFTLAAARAVAGRLGLA
PKS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786185, Length=239, Percent_Identity=29.2887029288703, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52310; Mature: 52179

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAHDFPAYRGQMEYFCLGCGSRYNVDELHYTCPDCGGVFLLDNTDFDALSARSGKEWQ
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHEEECCCCCCEEEEECCCCCHHCCCCCCHHH
DIFDARAATRTTPLRGIFRFYELMAPLLEPEDIIYLGEGNTPVIEASPAMSDMAGIPFAF
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCHHHHCCCCEEE
KNDGQNPSASFKDRGMACAFSFLKSLVRKHGWDEVLTVCASTGDTSAAAALYASYVGAPL
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
KSVVLLPHGKVTPQQLSQPLGSGATVLEVPGVFDDCMKVVEHLAENYRVALLNSKNSWRI
HHEEEECCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCEEE
LGQESYAFEVAQWYGWDMQNKCIFVPIGNAGNITAVMSGFLKLHRLGIISCLPRVFGVQS
ECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HHADPVYRYYSVQDPASRVFTPVTVQPSVAQAAMIGNPVSFPRVRHFAGQFEAIGGQGAF
CCCCCEEEEEECCCCHHHCCCCEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHH
QVVQVTEQAIMDAMIIANRHGHIACTQGGECLAGLMRARELGIIAPHETAVLDATAHALK
HHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCEECCCCCCEEHHHHHHHC
FSGFQDMYFSGTLPAEYGVTPDAGLSNAPELLMDEAARNALAPEEFTLAAARAVAGRLGL
CCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
APKS
CCCC
>Mature Secondary Structure 
TAAHDFPAYRGQMEYFCLGCGSRYNVDELHYTCPDCGGVFLLDNTDFDALSARSGKEWQ
CCCCCCCCCCCCCEEEEEECCCCCCHHHHEEECCCCCCEEEEECCCCCHHCCCCCCHHH
DIFDARAATRTTPLRGIFRFYELMAPLLEPEDIIYLGEGNTPVIEASPAMSDMAGIPFAF
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCHHHHCCCCEEE
KNDGQNPSASFKDRGMACAFSFLKSLVRKHGWDEVLTVCASTGDTSAAAALYASYVGAPL
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
KSVVLLPHGKVTPQQLSQPLGSGATVLEVPGVFDDCMKVVEHLAENYRVALLNSKNSWRI
HHEEEECCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCEEE
LGQESYAFEVAQWYGWDMQNKCIFVPIGNAGNITAVMSGFLKLHRLGIISCLPRVFGVQS
ECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HHADPVYRYYSVQDPASRVFTPVTVQPSVAQAAMIGNPVSFPRVRHFAGQFEAIGGQGAF
CCCCCEEEEEECCCCHHHCCCCEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHH
QVVQVTEQAIMDAMIIANRHGHIACTQGGECLAGLMRARELGIIAPHETAVLDATAHALK
HHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCEECCCCCCEEHHHHHHHC
FSGFQDMYFSGTLPAEYGVTPDAGLSNAPELLMDEAARNALAPEEFTLAAARAVAGRLGL
CCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
APKS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]