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The map label for this gene is pipB2 [H]

Identifier: 78224729

GI number: 78224729

Start: 3978210

End: 3979091

Strand: Reverse

Name: pipB2 [H]

Synonym: Gmet_3546

Alternate gene names: 78224729

Gene position: 3979091-3978210 (Counterclockwise)

Preceding gene: 78224733

Following gene: 78224726

Centisome position: 99.54

GC content: 67.23

Gene sequence:

>882_bases
ATGAAGCACCTCCTGTTCCGTTGCCTGGGAATTCCGATCGTCATCACCACCTTCTTCGTCTCCGTCGGCAGTGAAACGCC
GGCCGCCGCCTCCCCGGCGGGGAAGAAAAAAACCGAGTCCACCGAAGTCGCGGCCTCTTCCCCGGCGAAGCCGGCCCTTG
CCTATGCCGAGTATGTGCGTCTCGTAAGCAGGCGGGGTGTCGCCGGGCGTGGCCACGCCAAAAAGAAGCCGGCGAAGGCG
GCAAAGGTGACCCGTACTGCAAAGAAAGCGGACCAGAAGGTGGTTTCCGCAAAAGCCGAGCCGACGCCGGTCGTTCCCGT
CCGGACCGTTGCGCCGGTCGTGGCAGTCGAGCCGAAGCGGGGAGGGGGATGGCGGCCCGGTCCGGCAGAGGTGCGCGAGG
TCCTTGGCACGACCCGCGATCTGTCGGGGGCGAACCTGCGGGGGATGAACCTGGCCGGCCTTGATCTGCGCAACGCCTCC
CTGGCCAATGCCGACCTCTACCTGGCTAATTTGGCGGGGGCGTGCCTCGACGGGGCGAACCTGCGAGGGACATCCCTCGA
AATGGCCAATCTGCGGGGGGCAAGCCTCAAGGGGGCCAAGCTCTCGGGGGCCGGCCTCTTCATGACGAACCTGGAAGGGG
CCGACCTGGAGCGGGCGGACCTGACGGGTGTCTATGCCGTGGGGGCGAACCTGCGGGGTGCAGCGCTGGCAAGCGCAAAC
CTACGGGGCGGGCTCTTCACCAATGCGGTCATGGCGCGGAGCGTGGCGGTGCTGACGGAGGATGGAGAGGGGAGGGGGGG
CGGCACGGTGACAAAGGCGACGGCACGGGACGATGCAGCTCGACCCGACCCGGCCGAACGGCTCACGTTCCTCAAATTCT
GA

Upstream 100 bases:

>100_bases
GAAGGCGAAAAATGTCCGATACGGAAAGAGGGGACAATGTCGTCTGCCTCCGGCAAGCCCGCCCCCCTGTTCGCACTACG
CCCGAGAGGAAGTACCGTCC

Downstream 100 bases:

>100_bases
CCAGTTTCCCTGCGTTGCGATAACAAAAAAGCCGGCTCCCCTCGAGGGGATGCCGGCTTTTTTGTTGGCTGCGGAGGCCG
GGTGCTATGGCGTATCGTCC

Product: pentapeptide repeat-containing protein

Products: NA

Alternate protein names: Type III effector pipB2 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKHLLFRCLGIPIVITTFFVSVGSETPAAASPAGKKKTESTEVAASSPAKPALAYAEYVRLVSRRGVAGRGHAKKKPAKA
AKVTRTAKKADQKVVSAKAEPTPVVPVRTVAPVVAVEPKRGGGWRPGPAEVREVLGTTRDLSGANLRGMNLAGLDLRNAS
LANADLYLANLAGACLDGANLRGTSLEMANLRGASLKGAKLSGAGLFMTNLEGADLERADLTGVYAVGANLRGAALASAN
LRGGLFTNAVMARSVAVLTEDGEGRGGGTVTKATARDDAARPDPAERLTFLKF

Sequences:

>Translated_293_residues
MKHLLFRCLGIPIVITTFFVSVGSETPAAASPAGKKKTESTEVAASSPAKPALAYAEYVRLVSRRGVAGRGHAKKKPAKA
AKVTRTAKKADQKVVSAKAEPTPVVPVRTVAPVVAVEPKRGGGWRPGPAEVREVLGTTRDLSGANLRGMNLAGLDLRNAS
LANADLYLANLAGACLDGANLRGTSLEMANLRGASLKGAKLSGAGLFMTNLEGADLERADLTGVYAVGANLRGAALASAN
LRGGLFTNAVMARSVAVLTEDGEGRGGGTVTKATARDDAARPDPAERLTFLKF
>Mature_293_residues
MKHLLFRCLGIPIVITTFFVSVGSETPAAASPAGKKKTESTEVAASSPAKPALAYAEYVRLVSRRGVAGRGHAKKKPAKA
AKVTRTAKKADQKVVSAKAEPTPVVPVRTVAPVVAVEPKRGGGWRPGPAEVREVLGTTRDLSGANLRGMNLAGLDLRNAS
LANADLYLANLAGACLDGANLRGTSLEMANLRGASLKGAKLSGAGLFMTNLEGADLERADLTGVYAVGANLRGAALASAN
LRGGLFTNAVMARSVAVLTEDGEGRGGGTVTKATARDDAARPDPAERLTFLKF

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the

COG id: COG1357

COG function: function code S; Uncharacterized low-complexity proteins

Gene ontology:

Cell location: Secreted. Host membrane (By similarity). Note=Secreted via the type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 pentapeptide repeat domains [H]

Homologues:

Organism=Homo sapiens, GI39753959, Length=113, Percent_Identity=38.0530973451327, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221377802, Length=113, Percent_Identity=38.9380530973451, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001646 [H]

Pfam domain/function: PF00805 Pentapeptide [H]

EC number: NA

Molecular weight: Translated: 30183; Mature: 30183

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLLFRCLGIPIVITTFFVSVGSETPAAASPAGKKKTESTEVAASSPAKPALAYAEYVR
CHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHH
LVSRRGVAGRGHAKKKPAKAAKVTRTAKKADQKVVSAKAEPTPVVPVRTVAPVVAVEPKR
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEECCCC
GGGWRPGPAEVREVLGTTRDLSGANLRGMNLAGLDLRNASLANADLYLANLAGACLDGAN
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEHHHHHHHHCCCCC
LRGTSLEMANLRGASLKGAKLSGAGLFMTNLEGADLERADLTGVYAVGANLRGAALASAN
CCCCEEEECCCCCCCCCCCEECCCEEEEECCCCCCCCHHCCCEEEEECCCCCCCEEECCC
LRGGLFTNAVMARSVAVLTEDGEGRGGGTVTKATARDDAARPDPAERLTFLKF
CCCCHHHHHHHHHEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHEEECCC
>Mature Secondary Structure
MKHLLFRCLGIPIVITTFFVSVGSETPAAASPAGKKKTESTEVAASSPAKPALAYAEYVR
CHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHH
LVSRRGVAGRGHAKKKPAKAAKVTRTAKKADQKVVSAKAEPTPVVPVRTVAPVVAVEPKR
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEECCCC
GGGWRPGPAEVREVLGTTRDLSGANLRGMNLAGLDLRNASLANADLYLANLAGACLDGAN
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEHHHHHHHHCCCCC
LRGTSLEMANLRGASLKGAKLSGAGLFMTNLEGADLERADLTGVYAVGANLRGAALASAN
CCCCEEEECCCCCCCCCCCEECCCEEEEECCCCCCCCHHCCCEEEEECCCCCCCEEECCC
LRGGLFTNAVMARSVAVLTEDGEGRGGGTVTKATARDDAARPDPAERLTFLKF
CCCCHHHHHHHHHEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA