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The map label for this gene is degP [H]

Identifier: 78224627

GI number: 78224627

Start: 3857970

End: 3859388

Strand: Reverse

Name: degP [H]

Synonym: Gmet_3437

Alternate gene names: 78224627

Gene position: 3859388-3857970 (Counterclockwise)

Preceding gene: 78224629

Following gene: 78224626

Centisome position: 96.55

GC content: 64.41

Gene sequence:

>1419_bases
ATGCGTATCTGTCGCCTGTTCATTGTCATCATTGCGCTCTTTACCGTTGTGCCCGCCTGCTCGAAGAAGGAAGATAAGCT
CTTCTACGAGACGGGGCGGGCCGAAGCGCCGGTAAAGGACGTTCCCAAGGACATCATGGCTACCCAGCAGGCCTTCGTGG
AGTTGGTGAAGAAGGTGACGCCGTCGGTGGTCAACATCTCCACCATCAGCAGGAAGAAGGTCGAGCAGCCCTTTTTCGAA
TTTTCTCCCTTATTCGGCGACTTGTTCGGCGACGGCAGGCCCCGCTACCGCCGCGACAAGAGCCTCGGCTCCGGATTCAT
CATCAACAAGAGCGGCTACATCGTCACCAATGACCACGTGGTGCGGGACGCCGAGACCATCAAGGTCAGGCTCTCCAACG
AAAATGTCTATGACGGCAGGGTTGTCGGCAGTGATCCCAAGACCGACATCGCCGTCATCAAGATCGACGCCAAGGAGGAT
CTCCCCGTGGCGGTCCTGGCCGATTCCGACAAGCTCCAGGTGGGGCAGTGGGCCATCGCCATCGGCAATCCTTTCGGCCT
CGACCGGACCGTGACCGTGGGGGTAGTGTCGGCCACCGGCCGCTCCAACATGGGGATCGAGACCTACGAGGACTTCATCC
AGACCGACGCCTCCATCAACCCCGGCAACTCGGGGGGGCCGCTCCTGAACGTCCACGGGGAGGTGATCGGCATCAACACC
GCCATCGTGGCCGCCGGCCAGGGGATCGGCTTTGCCATCCCCGTCAACATGGCCAAGCAGATCGTCACCCAGCTCGTCAC
CAAGGGGAGTGTGAGCCGTGGGTGGCTCGGCGTATCAATCCAGCCGGTGACCGACGAGATTGCCCGGGAGTTCGGCCTCA
AGAAGGCCCGGGGGGTGCTGGTGGCCGACGTCGTGGAGGGGAGCCCCGCTGCCAAGGGGGGGATCAAGCAGGGAGACATT
ATCCTCGACTTCGCCGGCACCGAGATCAAGGACGCCCAGCACCTCCAGCGGGTCGTGGCCGCAACGGCACCGGGGAAGAC
CGTCCAGGTCACGGTGTTCCGTGGGGGGCGCGAGGTGAAGCTTTCCCTCACCTCGGCCAGCGCCGACAGCGCCGGGGCCC
GGCAGGCCCGACCCCAGGGGGAGGAGCCCGACCTCCTCGGTCTGATGGTCGAGGAAATTCCTTCCGACCTGCGCCGCCGT
GGCGTATCCGGCGTGGTCGTGGCCGAGGTTGACGAGGAGGGGATTGCCGCCGAGGCGGGGATCCAGCGTGGCGACATCAT
CGTTTCGGTGAACCGCAAGGGGGTCGCGACCCGGGCCGAATATGAACGCGCCATGGCGGAAGCCGGACGCCGGGGCACGG
CGATCCTGCTAGTGCGCCGGGGCAACGCCAGCATTTTCTTCTCGCTCAGGCTGCGCTAA

Upstream 100 bases:

>100_bases
GTGAGTTTGACAGCCGAAAGGACGTTGACATCGCAGGGTAATTTGGCTACTCTTTCAACGGTTTAAGGTCATCTCCTCCG
TTGCTGCCGAGGCATTTCCG

Downstream 100 bases:

>100_bases
CTCCTTCTTCCGGGGCTGTTGCCGGGAGTCTGCAATGAATTCACAGGAGAGGATATCTCATGAGTCTTATCGATAACCCC
GACCAGGCAAAGCGTCTCGC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRICRLFIVIIALFTVVPACSKKEDKLFYETGRAEAPVKDVPKDIMATQQAFVELVKKVTPSVVNISTISRKKVEQPFFE
FSPLFGDLFGDGRPRYRRDKSLGSGFIINKSGYIVTNDHVVRDAETIKVRLSNENVYDGRVVGSDPKTDIAVIKIDAKED
LPVAVLADSDKLQVGQWAIAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNVHGEVIGINT
AIVAAGQGIGFAIPVNMAKQIVTQLVTKGSVSRGWLGVSIQPVTDEIAREFGLKKARGVLVADVVEGSPAAKGGIKQGDI
ILDFAGTEIKDAQHLQRVVAATAPGKTVQVTVFRGGREVKLSLTSASADSAGARQARPQGEEPDLLGLMVEEIPSDLRRR
GVSGVVVAEVDEEGIAAEAGIQRGDIIVSVNRKGVATRAEYERAMAEAGRRGTAILLVRRGNASIFFSLRLR

Sequences:

>Translated_472_residues
MRICRLFIVIIALFTVVPACSKKEDKLFYETGRAEAPVKDVPKDIMATQQAFVELVKKVTPSVVNISTISRKKVEQPFFE
FSPLFGDLFGDGRPRYRRDKSLGSGFIINKSGYIVTNDHVVRDAETIKVRLSNENVYDGRVVGSDPKTDIAVIKIDAKED
LPVAVLADSDKLQVGQWAIAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNVHGEVIGINT
AIVAAGQGIGFAIPVNMAKQIVTQLVTKGSVSRGWLGVSIQPVTDEIAREFGLKKARGVLVADVVEGSPAAKGGIKQGDI
ILDFAGTEIKDAQHLQRVVAATAPGKTVQVTVFRGGREVKLSLTSASADSAGARQARPQGEEPDLLGLMVEEIPSDLRRR
GVSGVVVAEVDEEGIAAEAGIQRGDIIVSVNRKGVATRAEYERAMAEAGRRGTAILLVRRGNASIFFSLRLR
>Mature_472_residues
MRICRLFIVIIALFTVVPACSKKEDKLFYETGRAEAPVKDVPKDIMATQQAFVELVKKVTPSVVNISTISRKKVEQPFFE
FSPLFGDLFGDGRPRYRRDKSLGSGFIINKSGYIVTNDHVVRDAETIKVRLSNENVYDGRVVGSDPKTDIAVIKIDAKED
LPVAVLADSDKLQVGQWAIAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNVHGEVIGINT
AIVAAGQGIGFAIPVNMAKQIVTQLVTKGSVSRGWLGVSIQPVTDEIAREFGLKKARGVLVADVVEGSPAAKGGIKQGDI
ILDFAGTEIKDAQHLQRVVAATAPGKTVQVTVFRGGREVKLSLTSASADSAGARQARPQGEEPDLLGLMVEEIPSDLRRR
GVSGVVVAEVDEEGIAAEAGIQRGDIIVSVNRKGVATRAEYERAMAEAGRRGTAILLVRRGNASIFFSLRLR

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=344, Percent_Identity=34.3023255813954, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI22129776, Length=329, Percent_Identity=36.1702127659575, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI24308541, Length=325, Percent_Identity=33.5384615384615, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI7019477, Length=332, Percent_Identity=34.9397590361446, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1789629, Length=430, Percent_Identity=39.5348837209302, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1786356, Length=447, Percent_Identity=36.6890380313199, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789630, Length=271, Percent_Identity=38.3763837638376, Blast_Score=182, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=34.3859649122807, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50546; Mature: 50546

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRICRLFIVIIALFTVVPACSKKEDKLFYETGRAEAPVKDVPKDIMATQQAFVELVKKVT
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHC
PSVVNISTISRKKVEQPFFEFSPLFGDLFGDGRPRYRRDKSLGSGFIINKSGYIVTNDHV
CCEEEEEHHHHHHHHCCHHHHCCHHHHHHCCCCCCCHHCCCCCCCEEECCCCEEEECCCE
VRDAETIKVRLSNENVYDGRVVGSDPKTDIAVIKIDAKEDLPVAVLADSDKLQVGQWAIA
EECCEEEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCCCEEEEECCCCEEECEEEEE
IGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNVHGEVIGINT
ECCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEEE
AIVAAGQGIGFAIPVNMAKQIVTQLVTKGSVSRGWLGVSIQPVTDEIAREFGLKKARGVL
EEEEECCCCEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHCCHHHCCEE
VADVVEGSPAAKGGIKQGDIILDFAGTEIKDAQHLQRVVAATAPGKTVQVTVFRGGREVK
EEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCEEE
LSLTSASADSAGARQARPQGEEPDLLGLMVEEIPSDLRRRGVSGVVVAEVDEEGIAAEAG
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCC
IQRGDIIVSVNRKGVATRAEYERAMAEAGRRGTAILLVRRGNASIFFSLRLR
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEEEC
>Mature Secondary Structure
MRICRLFIVIIALFTVVPACSKKEDKLFYETGRAEAPVKDVPKDIMATQQAFVELVKKVT
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHC
PSVVNISTISRKKVEQPFFEFSPLFGDLFGDGRPRYRRDKSLGSGFIINKSGYIVTNDHV
CCEEEEEHHHHHHHHCCHHHHCCHHHHHHCCCCCCCHHCCCCCCCEEECCCCEEEECCCE
VRDAETIKVRLSNENVYDGRVVGSDPKTDIAVIKIDAKEDLPVAVLADSDKLQVGQWAIA
EECCEEEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCCCEEEEECCCCEEECEEEEE
IGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNVHGEVIGINT
ECCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEEE
AIVAAGQGIGFAIPVNMAKQIVTQLVTKGSVSRGWLGVSIQPVTDEIAREFGLKKARGVL
EEEEECCCCEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHCCHHHCCEE
VADVVEGSPAAKGGIKQGDIILDFAGTEIKDAQHLQRVVAATAPGKTVQVTVFRGGREVK
EEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCEEE
LSLTSASADSAGARQARPQGEEPDLLGLMVEEIPSDLRRRGVSGVVVAEVDEEGIAAEAG
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCC
IQRGDIIVSVNRKGVATRAEYERAMAEAGRRGTAILLVRRGNASIFFSLRLR
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]