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The map label for this gene is yqjC [H]

Identifier: 78224444

GI number: 78224444

Start: 3662111

End: 3662515

Strand: Direct

Name: yqjC [H]

Synonym: Gmet_3253

Alternate gene names: 78224444

Gene position: 3662111-3662515 (Clockwise)

Preceding gene: 78224443

Following gene: 78224445

Centisome position: 91.61

GC content: 62.47

Gene sequence:

>405_bases
ATGCTCACCAAAATCAACCATATCGGCATCGCCGTCCAATCCCTCGCCGACGCCGTTCCCTTCTACCGCGACAACCTCGG
CATGGCCTTCATGGGCACCGAGGAAGTTCCGGAGCAGAAGGTCACCGTGGCCTTTTTCCAGATCGGTGAATCGAAGATCG
AGCTCCTGGAGCCCACATCCGACGACAGCCCGGTGGCGAAGTTCATCGAGAAGAACGGCGCCGGCATCCACCACATCGCC
TACGAGGTGGAGGACATCGAAGCGGCCATCGCCAGGCTCGTGGCCGACGGCGCCCGGATGATCGACAGCGTGCCGCGAAA
CGGCGCCCACGGCGCCCGCATCGCGTTCATCCACCCTAAAACAAGTCGTGGGGTCCTGACCGAACTCTGCCAGATGGGGC
ACTGA

Upstream 100 bases:

>100_bases
GAACTTTTATACGAAATACCTGAAAGAGGGAATCAAACGGATAATATTCTGATTTTCTCCGTGCTCTCCGTATCTCCGTG
TTATTCAGAAAGGTTTTCCC

Downstream 100 bases:

>100_bases
CTGCATAAAGCCTCCCCAGGCCTTGATTTATCGGGATTTTTTTCTTGACATTGCTTTTAATCTCTTTATAGTGTCCCTGA
ATTTTAGAACGCTATTTTGC

Product: methylmalonyl-CoA epimerase

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTSDDSPVAKFIEKNGAGIHHIA
YEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPKTSRGVLTELCQMGH

Sequences:

>Translated_134_residues
MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTSDDSPVAKFIEKNGAGIHHIA
YEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPKTSRGVLTELCQMGH
>Mature_134_residues
MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTSDDSPVAKFIEKNGAGIHHIA
YEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPKTSRGVLTELCQMGH

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI188035928, Length=131, Percent_Identity=42.7480916030534, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17506387, Length=132, Percent_Identity=40.1515151515151, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR018146
- InterPro:   IPR017515 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 14555; Mature: 14555

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00934 GLYOXALASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTS
CCCCCHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCEEHEEEECCCCCEEEECCCC
DDSPVAKFIEKNGAGIHHIAYEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPK
CCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
TSRGVLTELCQMGH
CCCCHHHHHHHCCC
>Mature Secondary Structure
MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTS
CCCCCHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCEEHEEEECCCCCEEEECCCC
DDSPVAKFIEKNGAGIHHIAYEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPK
CCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
TSRGVLTELCQMGH
CCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]