Click here to switch to the map view.

The map label for this gene is glcD [H]

Identifier: 78224436

GI number: 78224436

Start: 3650590

End: 3651969

Strand: Direct

Name: glcD [H]

Synonym: Gmet_3245

Alternate gene names: 78224436

Gene position: 3650590-3651969 (Clockwise)

Preceding gene: 78224435

Following gene: 78224437

Centisome position: 91.32

GC content: 63.55

Gene sequence:

>1380_bases
ATGCTCGACAACCGCATCATCGATGAACTGAAAACCATCGTCGGCGCCGACAACGTGGCCACCGACCGCCAGGACCTGAT
CTGCTACGGCTACGACGCCACCCAGATGGAATTCCTCCCCGACGCCGTGGTTCACCCCGGCAGCCCCGACGAGGTTTCCG
CGGTGCTGAAGCTGGCCAACCGAGAGCAGTTCCCGGTCTATCCCCGGGGGGCCGGCAGCGGCTTCACCGGCGGGGCGCTC
CCCAAGGGGGGCGGTATTGTCCTCGTCGTCACGCGGCTTAACCGCATCCTCCGCATCGACACCGAGAACCTCATCGCCGA
GGTGGAGCCCGGCGTAGTCACCGAGCAGTTCCAACTGGAGGTGGAAAAGCTGGGGCTCTTCTACCCGCCGGACCCCGCAT
CCCTCAAGTTCTCCACCCTGGGGGGAAACGTGGCCGAGAACGCCGGCGGTCCCCGCTGCGTGAAGTACGGTGTCACCCGG
GACTTCGTCATGGGGCTCGAAGTGGTCCTTCCCTCCGGCGAGATCATCCGCACCGGGGGCGAGACCTACAAGGGGGTGGT
GGGGTACGACCTAACCCGGCTCCTCTGCGGCTCCGAGGGGACCCTCGGCGTCATCACCAAGATCATCTTCAAGCTCCTGC
CGTTGCCAGAGGCGAAGAAGACCATGATGACCATCTTCGACTCCATCGACGGCGCCGCCAAGGCGGTCTCCACCATCATC
GGCAACAAGATCATCCCCACGACCCTGGAGTTCATGGATCACGCCACACTCCAGTGCGTGGAGAAGCGCTTCAACCTGGG
GATTCCGGCCAGCGGCCGAGCCGTCCTCATTATCGAAGTGGACGGCGACCGGGACCTGATCGAGAAACAGGCGGCCCGCA
TCCAGGAATTGATCAAACCGCTGGGATTGGTTGAGTGCAAGATCGCCAAGGACGCCGCCGAATCCGAGGCCCTCTGGAAG
GTGCGGCGGCTGGTGTCGCCGTCCCTTCGGGACGTGAACCCGGACAAGTTCAACGAAGACATCGTGGTCCCCCGCTCGAA
GGTGCCCGACGTTATCCGGGTGATCGAGAAGATTCAGCAGAAGTACGCGATCCCCATCGTCAACTTCGGCCATGCCGGCG
ACGGCAACATCCACGTCAACATCATGATCGACAAGTCCGTGGCCGGACAGGAAGAGAAGGCCCACGAGGCCATCGCCGAG
GTGTTCCAGGCGGCCCTTGACCTGAACGGCACCATGTCCGGCGAGCACGGCGTGGGGCTCGCCAAGCAGCCCTACATCCA
CCTGGAGCTGAAACCGGCCCAGGTGGCGACCATGCAGGCCATCAAGAAGGCCCTGGACCCCAACAACATCCTCAATCCGG
GGAAGATGTTCCCGGTGTAA

Upstream 100 bases:

>100_bases
GAGTTGAAAATCACAAGACAAGTTCTTTGAACGTTTTGTATTTTAGCTTTTGATTTCTCAGTTGCTCTGTTGCTCTGTGT
TATTCAAGAACAGAGGTAAC

Downstream 100 bases:

>100_bases
GTAGCTGCAAGACCAACTTCATTAATAACACGGAGAGACGGAGAGCACGGAGTTCCAGTACTATCAGGAAATTAGATTCA
CAAATGATTTCCTCATAATT

Product: FAD linked oxidase-like

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MLDNRIIDELKTIVGADNVATDRQDLICYGYDATQMEFLPDAVVHPGSPDEVSAVLKLANREQFPVYPRGAGSGFTGGAL
PKGGGIVLVVTRLNRILRIDTENLIAEVEPGVVTEQFQLEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTR
DFVMGLEVVLPSGEIIRTGGETYKGVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMMTIFDSIDGAAKAVSTII
GNKIIPTTLEFMDHATLQCVEKRFNLGIPASGRAVLIIEVDGDRDLIEKQAARIQELIKPLGLVECKIAKDAAESEALWK
VRRLVSPSLRDVNPDKFNEDIVVPRSKVPDVIRVIEKIQQKYAIPIVNFGHAGDGNIHVNIMIDKSVAGQEEKAHEAIAE
VFQAALDLNGTMSGEHGVGLAKQPYIHLELKPAQVATMQAIKKALDPNNILNPGKMFPV

Sequences:

>Translated_459_residues
MLDNRIIDELKTIVGADNVATDRQDLICYGYDATQMEFLPDAVVHPGSPDEVSAVLKLANREQFPVYPRGAGSGFTGGAL
PKGGGIVLVVTRLNRILRIDTENLIAEVEPGVVTEQFQLEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTR
DFVMGLEVVLPSGEIIRTGGETYKGVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMMTIFDSIDGAAKAVSTII
GNKIIPTTLEFMDHATLQCVEKRFNLGIPASGRAVLIIEVDGDRDLIEKQAARIQELIKPLGLVECKIAKDAAESEALWK
VRRLVSPSLRDVNPDKFNEDIVVPRSKVPDVIRVIEKIQQKYAIPIVNFGHAGDGNIHVNIMIDKSVAGQEEKAHEAIAE
VFQAALDLNGTMSGEHGVGLAKQPYIHLELKPAQVATMQAIKKALDPNNILNPGKMFPV
>Mature_459_residues
MLDNRIIDELKTIVGADNVATDRQDLICYGYDATQMEFLPDAVVHPGSPDEVSAVLKLANREQFPVYPRGAGSGFTGGAL
PKGGGIVLVVTRLNRILRIDTENLIAEVEPGVVTEQFQLEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTR
DFVMGLEVVLPSGEIIRTGGETYKGVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMMTIFDSIDGAAKAVSTII
GNKIIPTTLEFMDHATLQCVEKRFNLGIPASGRAVLIIEVDGDRDLIEKQAARIQELIKPLGLVECKIAKDAAESEALWK
VRRLVSPSLRDVNPDKFNEDIVVPRSKVPDVIRVIEKIQQKYAIPIVNFGHAGDGNIHVNIMIDKSVAGQEEKAHEAIAE
VFQAALDLNGTMSGEHGVGLAKQPYIHLELKPAQVATMQAIKKALDPNNILNPGKMFPV

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=458, Percent_Identity=31.0043668122271, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI37595754, Length=481, Percent_Identity=29.5218295218295, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI119964728, Length=428, Percent_Identity=30.3738317757009, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI4501993, Length=457, Percent_Identity=23.4135667396061, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1789351, Length=431, Percent_Identity=35.9628770301624, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1787977, Length=529, Percent_Identity=26.6540642722117, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI48994907, Length=496, Percent_Identity=25.4032258064516, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI48994914, Length=133, Percent_Identity=37.593984962406, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71992373, Length=460, Percent_Identity=31.0869565217391, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17534361, Length=455, Percent_Identity=28.1318681318681, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71992381, Length=460, Percent_Identity=30, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=30.46875, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17556096, Length=464, Percent_Identity=25, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320027, Length=488, Percent_Identity=28.8934426229508, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6320023, Length=470, Percent_Identity=28.2978723404255, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320764, Length=473, Percent_Identity=28.3298097251586, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI18921117, Length=424, Percent_Identity=31.8396226415094, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24639277, Length=424, Percent_Identity=31.8396226415094, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24639275, Length=424, Percent_Identity=31.8396226415094, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24653753, Length=514, Percent_Identity=23.9299610894942, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 49731; Mature: 49731

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNRIIDELKTIVGADNVATDRQDLICYGYDATQMEFLPDAVVHPGSPDEVSAVLKLAN
CCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHCCHHHCCCCCCHHHHHHHHHHC
REQFPVYPRGAGSGFTGGALPKGGGIVLVVTRLNRILRIDTENLIAEVEPGVVTEQFQLE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHEEECHHHHHHHCCCCCCCHHHHHH
VEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTRDFVMGLEVVLPSGEIIRTGG
HHHCCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEECCCHHHHHCEEEEECCCCEEECCC
ETYKGVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMMTIFDSIDGAAKAVSTII
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHH
GNKIIPTTLEFMDHATLQCVEKRFNLGIPASGRAVLIIEVDGDRDLIEKQAARIQELIKP
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
LGLVECKIAKDAAESEALWKVRRLVSPSLRDVNPDKFNEDIVVPRSKVPDVIRVIEKIQQ
CCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
KYAIPIVNFGHAGDGNIHVNIMIDKSVAGQEEKAHEAIAEVFQAALDLNGTMSGEHGVGL
HHCCCEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AKQPYIHLELKPAQVATMQAIKKALDPNNILNPGKMFPV
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDNRIIDELKTIVGADNVATDRQDLICYGYDATQMEFLPDAVVHPGSPDEVSAVLKLAN
CCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHCCHHHCCCCCCHHHHHHHHHHC
REQFPVYPRGAGSGFTGGALPKGGGIVLVVTRLNRILRIDTENLIAEVEPGVVTEQFQLE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHEEECHHHHHHHCCCCCCCHHHHHH
VEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTRDFVMGLEVVLPSGEIIRTGG
HHHCCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEECCCHHHHHCEEEEECCCCEEECCC
ETYKGVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMMTIFDSIDGAAKAVSTII
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHH
GNKIIPTTLEFMDHATLQCVEKRFNLGIPASGRAVLIIEVDGDRDLIEKQAARIQELIKP
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
LGLVECKIAKDAAESEALWKVRRLVSPSLRDVNPDKFNEDIVVPRSKVPDVIRVIEKIQQ
CCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
KYAIPIVNFGHAGDGNIHVNIMIDKSVAGQEEKAHEAIAEVFQAALDLNGTMSGEHGVGL
HHCCCEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AKQPYIHLELKPAQVATMQAIKKALDPNNILNPGKMFPV
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]