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The map label for this gene is atoS [H]

Identifier: 78224348

GI number: 78224348

Start: 3552237

End: 3553691

Strand: Direct

Name: atoS [H]

Synonym: Gmet_3157

Alternate gene names: 78224348

Gene position: 3552237-3553691 (Clockwise)

Preceding gene: 78224336

Following gene: 78224349

Centisome position: 88.86

GC content: 61.72

Gene sequence:

>1455_bases
ATGACCCTCAATACCAGGCTGGTTATGATCATGCTGACGCTCCTGGTCATCGCCATCCTCACGCTCTTCTTCCTGAACCA
GTACAGCCAGAACGAGATGGTGCAGGAAATCCAGGAAAGCTCCACCATGGTGACCAAGGCCCTCCAGATGAGCATCGAGG
ACCTCACCTCCGAGTACGAGCCCGACCGGGGCCGCCTCACGGAGTACCTGAAGGAGGCGAAGGTCAAGGGGGTCAAGGAG
ATCAACATCTTCAGCAACGAGGGGGAGATTATCGACTCTTCGAACCCGGCGAAGATCGGGAAAAAGCGCGAGATCAAGAA
GCTTGAGAAGGGTCTCAAGGTTTCCCCGGGGACGAAGACCGATGCCGGGTCGTCGCGGGCCTACGACCTGGTCGTTCCGG
TCATCGTCGGCGACGAGCAGCTGGGCTATGTGCAGATTAACCTCCTCCTCGACAACATCCGCACCATCCAGCACGAGAAC
TTCGTCAACCGGGTGGTGGCCACCTCCCTGGTCTTTCTCCTGGGCATATCCCTTACCATCTTCCTGGCAAAGCGCTACAC
CGCACCCATCAACCACCTGGCGGACGGGGTGCGGCGGGTGGCCGTCGGGGACCTATCCGTCACGTTCCCGGTAACAACCG
GTGATGAAATCGGTGAACTGGCCAAGAACTTCAACGAGATGGTGGAGAAGCTCCGGGAGAGGGAGATCCTCGAAAAGCGC
CTCTACGAGGCCGAGCACCTCTCCCGGGTGGGGCAGCTCGCCTCGGGCATTGCCCACGAGATCCGAAACCCCCTCAACTA
CATCAGCCTCGCCATCGACCACCTGAAGAGCGAGTTTACGGCCGCCTGCCCGGACAAGACGGAGCGGGTCGTCCCCGTGG
CCGACAAGATCAAGGAAGAGGTGCGGCGGGCCAACTACATGGTGGTCAACTTCATGAACTTCGGCCGCCCCCTGAAGTTG
AGGATAACGGAGATTTCCTACCGAGAGCTTATCGAAAAGGCGTTGCCGCTCCTTGAGGAAAAGCTCGCGGAACAGCGGGT
AACGGTGCGCACCGCCATCCCCACCGACCTTCCCGCCATGCGAGTCGACGGGGAGATGCTCCGCAACTGCCTCTTCAACT
TCGTCACCAACGCCGCCCAGGCCATGCCCGACGGCGGCACCGTCACCCTCGGCGCCACGTTCGACCGGGAGCAGAATCGC
TTCCTCCTCACCTTCAGCGACGAGGGGTGCGGCATTCGGGAGGAGGACCTGGCGAAGGTATTCCAGCCCTGGTACACTAC
CCGCGAGGCCGGCATCGGCCTGGGCCTTGCCATCACCGAGCGGATCGTCCGGGAGCATGGGGGAGAAATCAGGGTGGCAA
GCAGTGCCGGCAAGGGGACGACGTTTACGGTGCTTCTCCCCGGAGGGGAGAAGCCGGGACCGGGGACCAGGGACCGGGGA
CCAGGAAAAGACTAG

Upstream 100 bases:

>100_bases
CGAGGAAAGAAAGGGATATACTTCCTTACTTCCTTGTCTCCACCGGCATGGGTAAGGTATACTTCCGCGGTATTTCACGC
CGTTCTCCCCGAGGTTATCC

Downstream 100 bases:

>100_bases
AAACAAACGACAGGGATCTAGCATGGGAAGAGGGATTGGGAGCAAAATCAGGTTTTACGTTACTGGTCCCCGGTCCCGGC
CTTTGCCGGTCCCTGTCTCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTLNTRLVMIMLTLLVIAILTLFFLNQYSQNEMVQEIQESSTMVTKALQMSIEDLTSEYEPDRGRLTEYLKEAKVKGVKE
INIFSNEGEIIDSSNPAKIGKKREIKKLEKGLKVSPGTKTDAGSSRAYDLVVPVIVGDEQLGYVQINLLLDNIRTIQHEN
FVNRVVATSLVFLLGISLTIFLAKRYTAPINHLADGVRRVAVGDLSVTFPVTTGDEIGELAKNFNEMVEKLREREILEKR
LYEAEHLSRVGQLASGIAHEIRNPLNYISLAIDHLKSEFTAACPDKTERVVPVADKIKEEVRRANYMVVNFMNFGRPLKL
RITEISYRELIEKALPLLEEKLAEQRVTVRTAIPTDLPAMRVDGEMLRNCLFNFVTNAAQAMPDGGTVTLGATFDREQNR
FLLTFSDEGCGIREEDLAKVFQPWYTTREAGIGLGLAITERIVREHGGEIRVASSAGKGTTFTVLLPGGEKPGPGTRDRG
PGKD

Sequences:

>Translated_484_residues
MTLNTRLVMIMLTLLVIAILTLFFLNQYSQNEMVQEIQESSTMVTKALQMSIEDLTSEYEPDRGRLTEYLKEAKVKGVKE
INIFSNEGEIIDSSNPAKIGKKREIKKLEKGLKVSPGTKTDAGSSRAYDLVVPVIVGDEQLGYVQINLLLDNIRTIQHEN
FVNRVVATSLVFLLGISLTIFLAKRYTAPINHLADGVRRVAVGDLSVTFPVTTGDEIGELAKNFNEMVEKLREREILEKR
LYEAEHLSRVGQLASGIAHEIRNPLNYISLAIDHLKSEFTAACPDKTERVVPVADKIKEEVRRANYMVVNFMNFGRPLKL
RITEISYRELIEKALPLLEEKLAEQRVTVRTAIPTDLPAMRVDGEMLRNCLFNFVTNAAQAMPDGGTVTLGATFDREQNR
FLLTFSDEGCGIREEDLAKVFQPWYTTREAGIGLGLAITERIVREHGGEIRVASSAGKGTTFTVLLPGGEKPGPGTRDRG
PGKD
>Mature_483_residues
TLNTRLVMIMLTLLVIAILTLFFLNQYSQNEMVQEIQESSTMVTKALQMSIEDLTSEYEPDRGRLTEYLKEAKVKGVKEI
NIFSNEGEIIDSSNPAKIGKKREIKKLEKGLKVSPGTKTDAGSSRAYDLVVPVIVGDEQLGYVQINLLLDNIRTIQHENF
VNRVVATSLVFLLGISLTIFLAKRYTAPINHLADGVRRVAVGDLSVTFPVTTGDEIGELAKNFNEMVEKLREREILEKRL
YEAEHLSRVGQLASGIAHEIRNPLNYISLAIDHLKSEFTAACPDKTERVVPVADKIKEEVRRANYMVVNFMNFGRPLKLR
ITEISYRELIEKALPLLEEKLAEQRVTVRTAIPTDLPAMRVDGEMLRNCLFNFVTNAAQAMPDGGTVTLGATFDREQNRF
LLTFSDEGCGIREEDLAKVFQPWYTTREAGIGLGLAITERIVREHGGEIRVASSAGKGTTFTVLLPGGEKPGPGTRDRGP
GKD

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=298, Percent_Identity=30.5369127516779, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=297, Percent_Identity=25.5892255892256, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789149, Length=535, Percent_Identity=22.803738317757, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=29.296875, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=28.8461538461538, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786783, Length=436, Percent_Identity=24.5412844036697, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=265, Percent_Identity=25.2830188679245, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789808, Length=340, Percent_Identity=23.2352941176471, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=25.3333333333333, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53969; Mature: 53838

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNTRLVMIMLTLLVIAILTLFFLNQYSQNEMVQEIQESSTMVTKALQMSIEDLTSEYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDRGRLTEYLKEAKVKGVKEINIFSNEGEIIDSSNPAKIGKKREIKKLEKGLKVSPGTKT
CCHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCHHCCHHHHHHHHHCCCCCCCCCCC
DAGSSRAYDLVVPVIVGDEQLGYVQINLLLDNIRTIQHENFVNRVVATSLVFLLGISLTI
CCCCCCCEEEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLAKRYTAPINHLADGVRRVAVGDLSVTFPVTTGDEIGELAKNFNEMVEKLREREILEKR
HHHHHHCCCHHHHHHHHHHHEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYEAEHLSRVGQLASGIAHEIRNPLNYISLAIDHLKSEFTAACPDKTERVVPVADKIKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VRRANYMVVNFMNFGRPLKLRITEISYRELIEKALPLLEEKLAEQRVTVRTAIPTDLPAM
HHHCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
RVDGEMLRNCLFNFVTNAAQAMPDGGTVTLGATFDREQNRFLLTFSDEGCGIREEDLAKV
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
FQPWYTTREAGIGLGLAITERIVREHGGEIRVASSAGKGTTFTVLLPGGEKPGPGTRDRG
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCC
PGKD
CCCC
>Mature Secondary Structure 
TLNTRLVMIMLTLLVIAILTLFFLNQYSQNEMVQEIQESSTMVTKALQMSIEDLTSEYE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDRGRLTEYLKEAKVKGVKEINIFSNEGEIIDSSNPAKIGKKREIKKLEKGLKVSPGTKT
CCHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCHHCCHHHHHHHHHCCCCCCCCCCC
DAGSSRAYDLVVPVIVGDEQLGYVQINLLLDNIRTIQHENFVNRVVATSLVFLLGISLTI
CCCCCCCEEEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLAKRYTAPINHLADGVRRVAVGDLSVTFPVTTGDEIGELAKNFNEMVEKLREREILEKR
HHHHHHCCCHHHHHHHHHHHEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYEAEHLSRVGQLASGIAHEIRNPLNYISLAIDHLKSEFTAACPDKTERVVPVADKIKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VRRANYMVVNFMNFGRPLKLRITEISYRELIEKALPLLEEKLAEQRVTVRTAIPTDLPAM
HHHCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
RVDGEMLRNCLFNFVTNAAQAMPDGGTVTLGATFDREQNRFLLTFSDEGCGIREEDLAKV
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
FQPWYTTREAGIGLGLAITERIVREHGGEIRVASSAGKGTTFTVLLPGGEKPGPGTRDRG
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCC
PGKD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]