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The map label for this gene is ycgM [H]

Identifier: 78224133

GI number: 78224133

Start: 3322424

End: 3323080

Strand: Direct

Name: ycgM [H]

Synonym: Gmet_2937

Alternate gene names: 78224133

Gene position: 3322424-3323080 (Clockwise)

Preceding gene: 78224132

Following gene: 78224134

Centisome position: 83.11

GC content: 61.34

Gene sequence:

>657_bases
ATGACGTTTGCCACCCTGGCAGGAAGCGCCACGGAATACCCCATCGGCAAGATCCTCTGCATTGGCCGCAACTATGCGGA
ACACATCAAGGAACTGGGGAACGAAACCCCGGATGCGCCGGTCATTTTCACCAAACCCGCCACGTCGGTCATCGGTGATG
GCGACGCCATTGTGATTCCCCCTTACTCCAGAGACTGCCACCACGAAGCGGAACTGGCGGTCCTCATCGGGACAGCGGGA
AAAGATATCCCCGTTGAACGCGCCCTGGAACACGTGGCCGGCTACGGTGTCGCCATCGACCTGACGCTACGGGACGTGCA
GGCCGAGCTCAAGAAGAAAGGGCTCCCCTGGGACATCGCCAAGGGGTTCGACACCGCCTGCCCCCTCTCTCCTTTTGTGC
CTGCCGACCGGGTCGCCGATCCGCAAGACCTGCGGATTATCCTGACCGTCAACGGCGAAACGCGCCAGGACGGCTCAACC
TCCCTCATGATCCACACGGTCCGCGAGATCATCAGCCATATGTCGGGGATATTCACCCTGGAACCGGGGGACGTGATCCT
CACCGGAACCCCCGCCGGCGTCAGCCCCATTGTTTCGGGAGATCGTCTCGTGGCTGAGATACCGGGTGTTGCCCGGCTCC
AGGTCTCCGTTAAATAA

Upstream 100 bases:

>100_bases
CCGCGGCACCTGGCAGGGATGCCGACTTACCGACTCATGCCTCAAGGCGGGTAACTTGTAGGGCGGGTCTCAAACCCGCC
CTTTTTTCAGGAGGAACATC

Downstream 100 bases:

>100_bases
TTTAAATACTCAAATTATTGATTTTATTTTCCGCACCGGGTTATTCTGGCCGAAATCGGTATTGTCAGCAAATTACAGGA
GGTGGGCAATGGAAACCCAG

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTFATLAGSATEYPIGKILCIGRNYAEHIKELGNETPDAPVIFTKPATSVIGDGDAIVIPPYSRDCHHEAELAVLIGTAG
KDIPVERALEHVAGYGVAIDLTLRDVQAELKKKGLPWDIAKGFDTACPLSPFVPADRVADPQDLRIILTVNGETRQDGST
SLMIHTVREIISHMSGIFTLEPGDVILTGTPAGVSPIVSGDRLVAEIPGVARLQVSVK

Sequences:

>Translated_218_residues
MTFATLAGSATEYPIGKILCIGRNYAEHIKELGNETPDAPVIFTKPATSVIGDGDAIVIPPYSRDCHHEAELAVLIGTAG
KDIPVERALEHVAGYGVAIDLTLRDVQAELKKKGLPWDIAKGFDTACPLSPFVPADRVADPQDLRIILTVNGETRQDGST
SLMIHTVREIISHMSGIFTLEPGDVILTGTPAGVSPIVSGDRLVAEIPGVARLQVSVK
>Mature_217_residues
TFATLAGSATEYPIGKILCIGRNYAEHIKELGNETPDAPVIFTKPATSVIGDGDAIVIPPYSRDCHHEAELAVLIGTAGK
DIPVERALEHVAGYGVAIDLTLRDVQAELKKKGLPWDIAKGFDTACPLSPFVPADRVADPQDLRIILTVNGETRQDGSTS
LMIHTVREIISHMSGIFTLEPGDVILTGTPAGVSPIVSGDRLVAEIPGVARLQVSVK

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI13654274, Length=202, Percent_Identity=46.5346534653465, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI215422413, Length=198, Percent_Identity=46.969696969697, Blast_Score=207, Evalue=5e-54,
Organism=Homo sapiens, GI66348062, Length=194, Percent_Identity=47.9381443298969, Blast_Score=207, Evalue=7e-54,
Organism=Homo sapiens, GI156231349, Length=179, Percent_Identity=46.3687150837989, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI40786394, Length=179, Percent_Identity=45.2513966480447, Blast_Score=159, Evalue=1e-39,
Organism=Escherichia coli, GI1787428, Length=203, Percent_Identity=49.7536945812808, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17557057, Length=185, Percent_Identity=43.7837837837838, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324161, Length=223, Percent_Identity=40.8071748878924, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571789, Length=202, Percent_Identity=37.6237623762376, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28572127, Length=206, Percent_Identity=35.9223300970874, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24663695, Length=182, Percent_Identity=34.0659340659341, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 23154; Mature: 23023

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFATLAGSATEYPIGKILCIGRNYAEHIKELGNETPDAPVIFTKPATSVIGDGDAIVIP
CEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEECCCCHHCCCCCEEEEC
PYSRDCHHEAELAVLIGTAGKDIPVERALEHVAGYGVAIDLTLRDVQAELKKKGLPWDIA
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCCCHHH
KGFDTACPLSPFVPADRVADPQDLRIILTVNGETRQDGSTSLMIHTVREIISHMSGIFTL
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEE
EPGDVILTGTPAGVSPIVSGDRLVAEIPGVARLQVSVK
CCCCEEEECCCCCCCCCCCCCEEEEECCCEEEEEEEEC
>Mature Secondary Structure 
TFATLAGSATEYPIGKILCIGRNYAEHIKELGNETPDAPVIFTKPATSVIGDGDAIVIP
EEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEECCCCHHCCCCCEEEEC
PYSRDCHHEAELAVLIGTAGKDIPVERALEHVAGYGVAIDLTLRDVQAELKKKGLPWDIA
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCCCHHH
KGFDTACPLSPFVPADRVADPQDLRIILTVNGETRQDGSTSLMIHTVREIISHMSGIFTL
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEE
EPGDVILTGTPAGVSPIVSGDRLVAEIPGVARLQVSVK
CCCCEEEECCCCCCCCCCCCCEEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10806384 [H]