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The map label for this gene is ffh [H]

Identifier: 78224068

GI number: 78224068

Start: 3252941

End: 3254299

Strand: Reverse

Name: ffh [H]

Synonym: Gmet_2872

Alternate gene names: 78224068

Gene position: 3254299-3252941 (Counterclockwise)

Preceding gene: 78224069

Following gene: 78224067

Centisome position: 81.41

GC content: 60.12

Gene sequence:

>1359_bases
ATGTTCGAAAACCTTTCCGACAAACTTGACCTCCTCTTTAAAAAGCTCCGCGGCCAAGGGGTGATGACCGAGGAGAACAT
CAAGGAGGCGCTCCGTGAGGTGCGGCTTGTCCTTCTTGAGGCAGACGTCAATTTCAAGGTTGTCAAGGATTTCGTCGAGA
AGGTCCGCGAGCGGGCTGTCGGCACCCAGGTTCTCCAGAGTCTCTCGCCGGGGCAGCAGGTCATCAAGATTGTGCAGGAA
GAGCTCGTGGCCCTCATGGGGGGCGGCGAGGACAATAGTCTCGATCTTGCCGCGAAGCCCCCGGTCGCCCTCATGATGGT
CGGTCTCCAGGGCTCCGGCAAGACCACCACCTGCGGCAAGCTGGCGCGGCTCCTCAAAGGGCAGCGGCGGCGTCCGCTTC
TCGTGCCCGCTGACGTCTACCGCCCTGCCGCCATTGAGCAGCTCAGGACCCTTGGTCGTCAGCTTTCGGTGGAAACGTTT
GATTCGCGGGCCGACCAGGACCCGGTTGATATCTGCCGCGAGGCGCTCCGTTACGCCACGCTCAATGGCTTCGATACGGT
GATTCTCGATACCGCCGGTCGTCTCCAGATCGACGAGTATCTCATGAATGAGCTCGTCCGTATCAAGGAGGCGGTACAGC
CCCGGGAGATTCTCTTTGTGGCCGACGCCATGACCGGCCAGGAGGCGGTTAACGTCGCCACCGGCTTTAACGAGAGGCTC
GACATCACCGGCGTGGTCCTTACCAAGCTGGACGGCGATGCCAAGGGGGGCGCTGCCCTCTCTATCCGTGCGGTCACCGG
CAAGCCGGTGAAGCTCGTGGGGCTCGGCGAAAAGCTTGATGCCTTGGAGGTCTTCTACCCGGACCGCCTCGTTTCCCGCA
TTCTTGGCATGGGTGATATTCTCACTCTGGTCGAGAAGGCCCAGGCCACGTTCGATGCTACGGAAACGGAGCGGCTTCAG
CAGAAGCTCAAGAAGAGCCAGTTCGATCTGGAGGATTTCAGGAGCCAGCTCCAGCAGATCAAGAAGATGGGGTCCCTTGA
ATCGATTCTCGGCATGATTCCCGGCGTGGGCAAGGCCATGAAGCAGATGCAGGGAGCCCAGCCGTCGGAGAAGGAGCTCA
AGCGGATCGAGGCGATTATCGATTCCATGACTCCCGGCGAGCGGGCGAACCATCAGATCATCAACGGCAGCCGTCGTTTG
AGGATCGCCAAAGGGAGCGGCACAACGGTCCAGGAGGTCAATCAGCTCCTGAAGCGGTTCACCGAGGCACAAAAGGTGAT
GAAGCAGCTTCAGAAGATGGGCCCCAAGGGGCTGATGCGGGGGATGAAAGGGATGGGAAAGGGAATGTTCCCCTTCTGA

Upstream 100 bases:

>100_bases
TGACACTGGCTTGTGGCCTCATCTATAGTTAACCTCTTTCTCAATGGATACGTGCGCCCTGTGTGGCGCTTTCCGCCGCT
TGTACGGCATTGTGGAATAG

Downstream 100 bases:

>100_bases
GAGGATGCAGCAGGCAACGCTCGATTCGTCACCAATGTGACGTACAACATACACACGAAAACTCTCGCCGGTCAGCGGCC
GGGAGAACACCAGGAGGAAG

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFENLSDKLDLLFKKLRGQGVMTEENIKEALREVRLVLLEADVNFKVVKDFVEKVRERAVGTQVLQSLSPGQQVIKIVQE
ELVALMGGGEDNSLDLAAKPPVALMMVGLQGSGKTTTCGKLARLLKGQRRRPLLVPADVYRPAAIEQLRTLGRQLSVETF
DSRADQDPVDICREALRYATLNGFDTVILDTAGRLQIDEYLMNELVRIKEAVQPREILFVADAMTGQEAVNVATGFNERL
DITGVVLTKLDGDAKGGAALSIRAVTGKPVKLVGLGEKLDALEVFYPDRLVSRILGMGDILTLVEKAQATFDATETERLQ
QKLKKSQFDLEDFRSQLQQIKKMGSLESILGMIPGVGKAMKQMQGAQPSEKELKRIEAIIDSMTPGERANHQIINGSRRL
RIAKGSGTTVQEVNQLLKRFTEAQKVMKQLQKMGPKGLMRGMKGMGKGMFPF

Sequences:

>Translated_452_residues
MFENLSDKLDLLFKKLRGQGVMTEENIKEALREVRLVLLEADVNFKVVKDFVEKVRERAVGTQVLQSLSPGQQVIKIVQE
ELVALMGGGEDNSLDLAAKPPVALMMVGLQGSGKTTTCGKLARLLKGQRRRPLLVPADVYRPAAIEQLRTLGRQLSVETF
DSRADQDPVDICREALRYATLNGFDTVILDTAGRLQIDEYLMNELVRIKEAVQPREILFVADAMTGQEAVNVATGFNERL
DITGVVLTKLDGDAKGGAALSIRAVTGKPVKLVGLGEKLDALEVFYPDRLVSRILGMGDILTLVEKAQATFDATETERLQ
QKLKKSQFDLEDFRSQLQQIKKMGSLESILGMIPGVGKAMKQMQGAQPSEKELKRIEAIIDSMTPGERANHQIINGSRRL
RIAKGSGTTVQEVNQLLKRFTEAQKVMKQLQKMGPKGLMRGMKGMGKGMFPF
>Mature_452_residues
MFENLSDKLDLLFKKLRGQGVMTEENIKEALREVRLVLLEADVNFKVVKDFVEKVRERAVGTQVLQSLSPGQQVIKIVQE
ELVALMGGGEDNSLDLAAKPPVALMMVGLQGSGKTTTCGKLARLLKGQRRRPLLVPADVYRPAAIEQLRTLGRQLSVETF
DSRADQDPVDICREALRYATLNGFDTVILDTAGRLQIDEYLMNELVRIKEAVQPREILFVADAMTGQEAVNVATGFNERL
DITGVVLTKLDGDAKGGAALSIRAVTGKPVKLVGLGEKLDALEVFYPDRLVSRILGMGDILTLVEKAQATFDATETERLQ
QKLKKSQFDLEDFRSQLQQIKKMGSLESILGMIPGVGKAMKQMQGAQPSEKELKRIEAIIDSMTPGERANHQIINGSRRL
RIAKGSGTTVQEVNQLLKRFTEAQKVMKQLQKMGPKGLMRGMKGMGKGMFPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=446, Percent_Identity=35.2017937219731, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=35.73264781491, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=37.8048780487805, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295424842, Length=299, Percent_Identity=30.1003344481605, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI23308697, Length=297, Percent_Identity=30.6397306397306, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=52.317880794702, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789874, Length=215, Percent_Identity=36.7441860465116, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=34.9425287356322, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI193206261, Length=257, Percent_Identity=33.852140077821, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=396, Percent_Identity=33.5858585858586, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=24.0506329113924, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=34.841628959276, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24641198, Length=316, Percent_Identity=28.1645569620253, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49921; Mature: 49921

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDKLDLLFKKLRGQGVMTEENIKEALREVRLVLLEADVNFKVVKDFVEKVRERAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GTQVLQSLSPGQQVIKIVQEELVALMGGGEDNSLDLAAKPPVALMMVGLQGSGKTTTCGK
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHH
LARLLKGQRRRPLLVPADVYRPAAIEQLRTLGRQLSVETFDSRADQDPVDICREALRYAT
HHHHHCCCCCCCEECCHHHCCHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHH
LNGFDTVILDTAGRLQIDEYLMNELVRIKEAVQPREILFVADAMTGQEAVNVATGFNERL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCC
DITGVVLTKLDGDAKGGAALSIRAVTGKPVKLVGLGEKLDALEVFYPDRLVSRILGMGDI
EEEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHCHHHHHHHHHCCHHH
LTLVEKAQATFDATETERLQQKLKKSQFDLEDFRSQLQQIKKMGSLESILGMIPGVGKAM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
KQMQGAQPSEKELKRIEAIIDSMTPGERANHQIINGSRRLRIAKGSGTTVQEVNQLLKRF
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHHHHH
TEAQKVMKQLQKMGPKGLMRGMKGMGKGMFPF
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFENLSDKLDLLFKKLRGQGVMTEENIKEALREVRLVLLEADVNFKVVKDFVEKVRERAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GTQVLQSLSPGQQVIKIVQEELVALMGGGEDNSLDLAAKPPVALMMVGLQGSGKTTTCGK
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHH
LARLLKGQRRRPLLVPADVYRPAAIEQLRTLGRQLSVETFDSRADQDPVDICREALRYAT
HHHHHCCCCCCCEECCHHHCCHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHH
LNGFDTVILDTAGRLQIDEYLMNELVRIKEAVQPREILFVADAMTGQEAVNVATGFNERL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCC
DITGVVLTKLDGDAKGGAALSIRAVTGKPVKLVGLGEKLDALEVFYPDRLVSRILGMGDI
EEEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHCHHHHHHHHHCCHHH
LTLVEKAQATFDATETERLQQKLKKSQFDLEDFRSQLQQIKKMGSLESILGMIPGVGKAM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
KQMQGAQPSEKELKRIEAIIDSMTPGERANHQIINGSRRLRIAKGSGTTVQEVNQLLKRF
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHHHHH
TEAQKVMKQLQKMGPKGLMRGMKGMGKGMFPF
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]