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The map label for this gene is prs [H]

Identifier: 78224044

GI number: 78224044

Start: 3225810

End: 3226754

Strand: Reverse

Name: prs [H]

Synonym: Gmet_2848

Alternate gene names: 78224044

Gene position: 3226754-3225810 (Counterclockwise)

Preceding gene: 78224045

Following gene: 78224043

Centisome position: 80.72

GC content: 55.66

Gene sequence:

>945_bases
ATGAACGACAAGATCAAGGTGTTCAGCGGCAATTCCAATCGGCAGCTTGCGGAGAAGATCTGCGAAAATCTTGGTCTCCC
CCTCGGGAAGGCCAATGTCAAGAATTTCTCCGATGGCGAGATCATGGTTGAGATTGCCGAAAACGTGCGCGGACGTGATA
TCTACGTGGTTCAGTCCACCTGTGCGCCAACCAACAATAATTTGATGGAGCTGCTCATTATGAATGACGCCCTGAAGCGA
GCGTCGGCGGCCACCATCACTGCGGTTATCCCCTACTACGGCTATGCACGTCAGGATCGCAAGGCTGCCCCCCGGACCCC
CATCACCTCGAAGCTCGTAGCCGACCTTGTTACGACCTCCGGCGCTGATCGGGTGGTGACGGTCGACCTTCATGCCGGTC
AAATTCAAGGATTCTTTAATATCCCGGTCGACAACCTCTATGCCGCGCCGGTAATCCTGGAGAATCTCAAGCAGCGTTTT
CCCGAGAATGGCATTGTCATGGTTTCTCCCGATGCCGGCGGCACCGAGCGGGCCAGGGCCTTTGCCAAGCGCTTGGGTTG
TACCCTGGCGGTTATCGACAAGCGCCGTACCGGCCCCAACGTGGCCGAAGTCATGCACCTGATTGGCGATGTGAAGGACA
AGACTGCCATTATACTTGACGACATGATTGACACAGCCGGCACCCTTACCCAGGCTGCCAAGGCGCTGAAAGAACATGGG
GCGAAAGCTATCTATGCCTGTGCCACCCATGGGGTTCTCTCGGGGCCTGCCATTGATCGGATCAATGGTTCCGACATCGA
GGCGGTCGTTATTACCGATACCGTGCCTCTTGGGGACAAGGCCGAGAGAACCAATAAGATTAAAGTGCTGACCGTTGCGG
ACCTCCTTGCCGAGGCCATTCGTCGTATCCATTCTGACGAGTCGGTAAGTTCACTCTTCGTTTGA

Upstream 100 bases:

>100_bases
ATTCCGGCATTCCAAGGTTCGAATCCTTGCACCCCAGCCACTTATTCCAGTATCATCTGCGGGTCGCCGCAGGAAAATAA
ATTTGCGGGCAAGGCAGCGT

Downstream 100 bases:

>100_bases
TTTCGTGCGGCTCTGTCCGCAGTGGAATAGAATCTGAATCGCTGGTAGCGGAGGAAATCATGCAACAGAAAACCATAAGC
ATAGAGCAGAGGGAAAAGGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNDKIKVFSGNSNRQLAEKICENLGLPLGKANVKNFSDGEIMVEIAENVRGRDIYVVQSTCAPTNNNLMELLIMNDALKR
ASAATITAVIPYYGYARQDRKAAPRTPITSKLVADLVTTSGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILENLKQRF
PENGIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVKDKTAIILDDMIDTAGTLTQAAKALKEHG
AKAIYACATHGVLSGPAIDRINGSDIEAVVITDTVPLGDKAERTNKIKVLTVADLLAEAIRRIHSDESVSSLFV

Sequences:

>Translated_314_residues
MNDKIKVFSGNSNRQLAEKICENLGLPLGKANVKNFSDGEIMVEIAENVRGRDIYVVQSTCAPTNNNLMELLIMNDALKR
ASAATITAVIPYYGYARQDRKAAPRTPITSKLVADLVTTSGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILENLKQRF
PENGIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVKDKTAIILDDMIDTAGTLTQAAKALKEHG
AKAIYACATHGVLSGPAIDRINGSDIEAVVITDTVPLGDKAERTNKIKVLTVADLLAEAIRRIHSDESVSSLFV
>Mature_314_residues
MNDKIKVFSGNSNRQLAEKICENLGLPLGKANVKNFSDGEIMVEIAENVRGRDIYVVQSTCAPTNNNLMELLIMNDALKR
ASAATITAVIPYYGYARQDRKAAPRTPITSKLVADLVTTSGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILENLKQRF
PENGIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVKDKTAIILDDMIDTAGTLTQAAKALKEHG
AKAIYACATHGVLSGPAIDRINGSDIEAVVITDTVPLGDKAERTNKIKVLTVADLLAEAIRRIHSDESVSSLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=53.2258064516129, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=51.6129032258064, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=51.6129032258064, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=51.1182108626198, Blast_Score=325, Evalue=2e-89,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=39.1812865497076, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=40.1162790697674, Blast_Score=211, Evalue=5e-55,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=34.0136054421769, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=34.0136054421769, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=34.0136054421769, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=34.0136054421769, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=55.6270096463022, Blast_Score=350, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=50.9677419354839, Blast_Score=320, Evalue=9e-88,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=50.9677419354839, Blast_Score=319, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=50.9677419354839, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=50.6493506493506, Blast_Score=317, Evalue=7e-87,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=37.3134328358209, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=47.7564102564103, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=46.4968152866242, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=45.0479233226837, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=41.1167512690355, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=46.7889908256881, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=52.9032258064516, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=49.2492492492492, Blast_Score=310, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=37.9603399433428, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=37.9603399433428, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=37.9603399433428, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=37.9603399433428, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=36.0215053763441, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=36.0215053763441, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI45552010, Length=372, Percent_Identity=36.0215053763441, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33777; Mature: 33777

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKIKVFSGNSNRQLAEKICENLGLPLGKANVKNFSDGEIMVEIAENVRGRDIYVVQST
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEECC
CAPTNNNLMELLIMNDALKRASAATITAVIPYYGYARQDRKAAPRTPITSKLVADLVTTS
CCCCCCCCEEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILENLKQRFPENGIVMVSPDAGGTERARA
CCCEEEEEEEECCEECEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
FAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVKDKTAIILDDMIDTAGTLTQAAKALKEHG
HHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
AKAIYACATHGVLSGPAIDRINGSDIEAVVITDTVPLGDKAERTNKIKVLTVADLLAEAI
CCEEEEEHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHH
RRIHSDESVSSLFV
HHHCCCCCHHHHCC
>Mature Secondary Structure
MNDKIKVFSGNSNRQLAEKICENLGLPLGKANVKNFSDGEIMVEIAENVRGRDIYVVQST
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEECC
CAPTNNNLMELLIMNDALKRASAATITAVIPYYGYARQDRKAAPRTPITSKLVADLVTTS
CCCCCCCCEEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILENLKQRFPENGIVMVSPDAGGTERARA
CCCEEEEEEEECCEECEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
FAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVKDKTAIILDDMIDTAGTLTQAAKALKEHG
HHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
AKAIYACATHGVLSGPAIDRINGSDIEAVVITDTVPLGDKAERTNKIKVLTVADLLAEAI
CCEEEEEHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHH
RRIHSDESVSSLFV
HHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA