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The map label for this gene is pbpA [H]

Identifier: 78223974

GI number: 78223974

Start: 3141686

End: 3143053

Strand: Reverse

Name: pbpA [H]

Synonym: Gmet_2778

Alternate gene names: 78223974

Gene position: 3143053-3141686 (Counterclockwise)

Preceding gene: 78223975

Following gene: 78223973

Centisome position: 78.63

GC content: 62.21

Gene sequence:

>1368_bases
ATGCAAGATTTTAAACATCTGACGAGAAAGCGCCGTTTTTCATTTTCCGCCCTCACCGGGCGCCGGAAAGACCCTCCCCG
CAACTCCTTCAAAAGACTCGAAAGCAAGGGGCTCGAAGAATCGAAGCCCCGGAAAAAAAGTCTTCGGGTCCTCCTTCCCG
TGCTGGCGGCCCTTATCGCCGCCTATCCGGTGTTTTCTTCCGTGCTTTCGGGGCGAACGGCCGTTTCCAGCGATCAGAAG
GAGGCGCAATCTGCCGGGAAGCTTCCCCGCGATCTGGATATCTACAGCTCCTTCCGTCTCGGTGCCGGCCTCTTTCCCCA
GGCCCGGCTTGAAGGCGACCGCCTCGTTGCTCCCGTTCCCGAAGGGGGGAGAGTGGTCTTTGCCATCGACAGTACGATTC
AGGAGAGGGTCAGGGAGGTCCTGACCCAGTTCGATGTTCCCTATGGGGTCTTTGTTGCCATCGAACCCAAGAGCGGCAAG
GTCCTGGCCATGGTTTCCCACTCGTCCGTCTCTCCCGAGTGGGAGGAGCGGGCCTTTTACGGGGTCTACCCCATGGCCTC
CCTCTTCAAGATCATCACCGCCACGGCGGCCCTGGAACAGGGGAAGGTAACCCCCGATACGGTCATCCCCTTCCGGGGAG
GGCTCTATTCGGAGAGTGCCCGCTACTGGAGTTCCCTCCCGAAGCGGGGCGCCCAGGAGATGGACCTGACGACCGCCATG
GGGAAATCGGTCAACCCGGTCTTTGGCCGGGTCGCCTGCGATATCGCCGGGAGGGAGTCGGTGCTGCGCTGCGCCGAGCG
CTACGGGTTCAACCACTACCTCCTCCCCGGCACCCCGGTCCAGCCGAGCCGGGCCGAGTATCCCCGGACCGACAACGATC
TGCGCCTCATGGGTGCCGGCCTCGGCCGGGAAGTGAAGATCTCTCCCATCCATGTGGCAGTCATGATGGCAGCCATCGCC
AACGGCGGCACCATGCTCGCCCCCTCCCTCGTGGAGGAGATCAGGAACACCGGAAACAAGGTGACCTACACGCATCAGCC
CCGGACCATCCGCTCCATCGCGGCTCCCGAGGTGACTGCCCAGCTCACGCGAATGCTCTCCACCACCGTCACCAGCGGCA
CTTCCCGCCGAGCCTTCCACGACAACCATGGACGTCCCCGGATCGCCAATGTCAACATAGCCGCCAAGACCGGCTCCATC
AACGGCACTGATCCCGAGGGGCATTACAACTGGTTTGCCGCCTACGCTCCCGTTGAGAATCCGCAGATCGCCCTCGCCGC
CCTCGTCATCAATCAGGACAAGTGGAAAATCAAGGCGTCATATCTGGGTGAACAGGCCCTGGAGGCGTTTTTCGCCAAGG
GGCGGTAA

Upstream 100 bases:

>100_bases
GTTGACAAAGGGAGGGGTTTTGCATATAGTGACGGCAATGTAACCGCCATGAATTTCATGTATTCACGCCTGTTTCGGGC
AACCGGACCCTTTTCCATAT

Downstream 100 bases:

>100_bases
TCGGGGGGAGATTCATGGAGTGTCTGAAGTGCGGCACCTGCTGTATCGCTCCTGATATTACGACGCTCGGAAAGCCGGTT
GGGGAGAGGTGTCGGCATCT

Product: penicillin-binding protein, transpeptidase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MQDFKHLTRKRRFSFSALTGRRKDPPRNSFKRLESKGLEESKPRKKSLRVLLPVLAALIAAYPVFSSVLSGRTAVSSDQK
EAQSAGKLPRDLDIYSSFRLGAGLFPQARLEGDRLVAPVPEGGRVVFAIDSTIQERVREVLTQFDVPYGVFVAIEPKSGK
VLAMVSHSSVSPEWEERAFYGVYPMASLFKIITATAALEQGKVTPDTVIPFRGGLYSESARYWSSLPKRGAQEMDLTTAM
GKSVNPVFGRVACDIAGRESVLRCAERYGFNHYLLPGTPVQPSRAEYPRTDNDLRLMGAGLGREVKISPIHVAVMMAAIA
NGGTMLAPSLVEEIRNTGNKVTYTHQPRTIRSIAAPEVTAQLTRMLSTTVTSGTSRRAFHDNHGRPRIANVNIAAKTGSI
NGTDPEGHYNWFAAYAPVENPQIALAALVINQDKWKIKASYLGEQALEAFFAKGR

Sequences:

>Translated_455_residues
MQDFKHLTRKRRFSFSALTGRRKDPPRNSFKRLESKGLEESKPRKKSLRVLLPVLAALIAAYPVFSSVLSGRTAVSSDQK
EAQSAGKLPRDLDIYSSFRLGAGLFPQARLEGDRLVAPVPEGGRVVFAIDSTIQERVREVLTQFDVPYGVFVAIEPKSGK
VLAMVSHSSVSPEWEERAFYGVYPMASLFKIITATAALEQGKVTPDTVIPFRGGLYSESARYWSSLPKRGAQEMDLTTAM
GKSVNPVFGRVACDIAGRESVLRCAERYGFNHYLLPGTPVQPSRAEYPRTDNDLRLMGAGLGREVKISPIHVAVMMAAIA
NGGTMLAPSLVEEIRNTGNKVTYTHQPRTIRSIAAPEVTAQLTRMLSTTVTSGTSRRAFHDNHGRPRIANVNIAAKTGSI
NGTDPEGHYNWFAAYAPVENPQIALAALVINQDKWKIKASYLGEQALEAFFAKGR
>Mature_455_residues
MQDFKHLTRKRRFSFSALTGRRKDPPRNSFKRLESKGLEESKPRKKSLRVLLPVLAALIAAYPVFSSVLSGRTAVSSDQK
EAQSAGKLPRDLDIYSSFRLGAGLFPQARLEGDRLVAPVPEGGRVVFAIDSTIQERVREVLTQFDVPYGVFVAIEPKSGK
VLAMVSHSSVSPEWEERAFYGVYPMASLFKIITATAALEQGKVTPDTVIPFRGGLYSESARYWSSLPKRGAQEMDLTTAM
GKSVNPVFGRVACDIAGRESVLRCAERYGFNHYLLPGTPVQPSRAEYPRTDNDLRLMGAGLGREVKISPIHVAVMMAAIA
NGGTMLAPSLVEEIRNTGNKVTYTHQPRTIRSIAAPEVTAQLTRMLSTTVTSGTSRRAFHDNHGRPRIANVNIAAKTGSI
NGTDPEGHYNWFAAYAPVENPQIALAALVINQDKWKIKASYLGEQALEAFFAKGR

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 49968; Mature: 49968

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDFKHLTRKRRFSFSALTGRRKDPPRNSFKRLESKGLEESKPRKKSLRVLLPVLAALIA
CCHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AYPVFSSVLSGRTAVSSDQKEAQSAGKLPRDLDIYSSFRLGAGLFPQARLEGDRLVAPVP
HHHHHHHHHCCCHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHCCCCEEEEECC
EGGRVVFAIDSTIQERVREVLTQFDVPYGVFVAIEPKSGKVLAMVSHSSVSPEWEERAFY
CCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHCEEE
GVYPMASLFKIITATAALEQGKVTPDTVIPFRGGLYSESARYWSSLPKRGAQEMDLTTAM
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
GKSVNPVFGRVACDIAGRESVLRCAERYGFNHYLLPGTPVQPSRAEYPRTDNDLRLMGAG
CCCCCHHHHHHEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
LGREVKISPIHVAVMMAAIANGGTMLAPSLVEEIRNTGNKVTYTHQPRTIRSIAAPEVTA
CCCEEEECHHHHHHHHHHHHCCCCEECHHHHHHHHHCCCEEEEEECCCHHHHHCCCHHHH
QLTRMLSTTVTSGTSRRAFHDNHGRPRIANVNIAAKTGSINGTDPEGHYNWFAAYAPVEN
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCC
PQIALAALVINQDKWKIKASYLGEQALEAFFAKGR
CCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQDFKHLTRKRRFSFSALTGRRKDPPRNSFKRLESKGLEESKPRKKSLRVLLPVLAALIA
CCHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AYPVFSSVLSGRTAVSSDQKEAQSAGKLPRDLDIYSSFRLGAGLFPQARLEGDRLVAPVP
HHHHHHHHHCCCHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHCCCCEEEEECC
EGGRVVFAIDSTIQERVREVLTQFDVPYGVFVAIEPKSGKVLAMVSHSSVSPEWEERAFY
CCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHCEEE
GVYPMASLFKIITATAALEQGKVTPDTVIPFRGGLYSESARYWSSLPKRGAQEMDLTTAM
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
GKSVNPVFGRVACDIAGRESVLRCAERYGFNHYLLPGTPVQPSRAEYPRTDNDLRLMGAG
CCCCCHHHHHHEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
LGREVKISPIHVAVMMAAIANGGTMLAPSLVEEIRNTGNKVTYTHQPRTIRSIAAPEVTA
CCCEEEECHHHHHHHHHHHHCCCCEECHHHHHHHHHCCCEEEEEECCCHHHHHCCCHHHH
QLTRMLSTTVTSGTSRRAFHDNHGRPRIANVNIAAKTGSINGTDPEGHYNWFAAYAPVEN
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCC
PQIALAALVINQDKWKIKASYLGEQALEAFFAKGR
CCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA