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The map label for this gene is hprA [H]

Identifier: 78223891

GI number: 78223891

Start: 3043029

End: 3044021

Strand: Reverse

Name: hprA [H]

Synonym: Gmet_2695

Alternate gene names: 78223891

Gene position: 3044021-3043029 (Counterclockwise)

Preceding gene: 78223892

Following gene: 78223888

Centisome position: 76.15

GC content: 66.06

Gene sequence:

>993_bases
ATGGGAGAGAGGACCCGCATTGTCATTCTGGACGGCTACACCATCAACCCGGGAGACAATCCCTGGACGCCGGTGGAAGA
ATACGGCGACTGCACCATCCATGACCGTACCCCTCCCGAGCTGAAACTGGAGCGAGCCCGCGATGCGGAGATCATCCTCA
CCAGCAAGGTGAAGCTGGACGAGGCGACCATCGCGGCGCTGCCGAGGCTTCGTTACATATCGCTCCTTGCCACGGGGTAC
AACAACGTGGACGTGGCGGCCGCGGGCCGGCGCGGCATTCCGGTTTCCAACGTTCCGGCCTACTCGACCGAATCGGTGGC
CCAGACCGCCTTTGCCCTGTTGCTGGAACTCACCACGCGGGTGGGGCTCCATGACGCCGCCGTTCGAGGCGGCGAATGGA
GCCACTGCCCCGACCACTCCTTCTGGAAAACATCGATCGTGGAGCTGGACGGCCTTACCCTGGGCATTGTGGGCTACGGC
GCCATCGGCCGCGCCGTGGCCCGGATCGCCCAGGCCTTCGGGATGCGGACGATCGCCCATGCGCCCCGTATTCCCGCCGA
TCCGGGGCCGGTTCCGGTGCGTTTCGTATCCCTCGAAGAGCTCTTCGCCACCGCCGACGTGGTGACCCTCAACTGTCCGC
AGACCCCGGAAAATACCGAATTTGTCAACGAAGGGCTCCTCTCCCTCATGAAGCGGAGCGCCTACCTCATCAATGTGGCC
CGGGGAGGGTTGGTGAACGAAGCCGACCTGGCCCGGGCGCTTCGGGATGGCACCCTGGCCGGCGCGGGGCTCGACGTGGT
GGCCCATGAGCCGATGCTTCCCGACAACCCCCTCCTGGCGGCACCCAATTGCATCTTCACGCCGCACCTGGCCTGGGCGT
CGCTGGCGGCCCGCCGGAGACTCACCGGGGTCGTTGCGGCCAATGTGGCTGCGTTTCTGGCCGGTTCGCCGATCAATGTG
GTGAATGGCCCGTGGCTGGCCGGGGGACGGTGA

Upstream 100 bases:

>100_bases
GGATGGTTATGGCATGATTGCGGGGAGGGGAGGAGAAGGTTCCCTCCCCGTGGTCATCGGCGGTGTTGAAATTTGAATAT
TCTTGCAAGGAGAGGAATGA

Downstream 100 bases:

>100_bases
CGGCAGCGGACCAGCCCCGCCTCGGCATCAGGCCTTCTTGATGGTAAACCAGAATTCCGATCCCTTGCCGGGCTCGCTCT
CCACCCCCACGGCGCCGCCA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MGERTRIVILDGYTINPGDNPWTPVEEYGDCTIHDRTPPELKLERARDAEIILTSKVKLDEATIAALPRLRYISLLATGY
NNVDVAAAGRRGIPVSNVPAYSTESVAQTAFALLLELTTRVGLHDAAVRGGEWSHCPDHSFWKTSIVELDGLTLGIVGYG
AIGRAVARIAQAFGMRTIAHAPRIPADPGPVPVRFVSLEELFATADVVTLNCPQTPENTEFVNEGLLSLMKRSAYLINVA
RGGLVNEADLARALRDGTLAGAGLDVVAHEPMLPDNPLLAAPNCIFTPHLAWASLAARRRLTGVVAANVAAFLAGSPINV
VNGPWLAGGR

Sequences:

>Translated_330_residues
MGERTRIVILDGYTINPGDNPWTPVEEYGDCTIHDRTPPELKLERARDAEIILTSKVKLDEATIAALPRLRYISLLATGY
NNVDVAAAGRRGIPVSNVPAYSTESVAQTAFALLLELTTRVGLHDAAVRGGEWSHCPDHSFWKTSIVELDGLTLGIVGYG
AIGRAVARIAQAFGMRTIAHAPRIPADPGPVPVRFVSLEELFATADVVTLNCPQTPENTEFVNEGLLSLMKRSAYLINVA
RGGLVNEADLARALRDGTLAGAGLDVVAHEPMLPDNPLLAAPNCIFTPHLAWASLAARRRLTGVVAANVAAFLAGSPINV
VNGPWLAGGR
>Mature_329_residues
GERTRIVILDGYTINPGDNPWTPVEEYGDCTIHDRTPPELKLERARDAEIILTSKVKLDEATIAALPRLRYISLLATGYN
NVDVAAAGRRGIPVSNVPAYSTESVAQTAFALLLELTTRVGLHDAAVRGGEWSHCPDHSFWKTSIVELDGLTLGIVGYGA
IGRAVARIAQAFGMRTIAHAPRIPADPGPVPVRFVSLEELFATADVVTLNCPQTPENTEFVNEGLLSLMKRSAYLINVAR
GGLVNEADLARALRDGTLAGAGLDVVAHEPMLPDNPLLAAPNCIFTPHLAWASLAARRRLTGVVAANVAAFLAGSPINVV
NGPWLAGGR

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=284, Percent_Identity=34.8591549295775, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557497, Length=283, Percent_Identity=33.2155477031802, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=33.2155477031802, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=293, Percent_Identity=32.0819112627986, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4557499, Length=293, Percent_Identity=32.0819112627986, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI145580575, Length=293, Percent_Identity=32.0819112627986, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI6912396, Length=259, Percent_Identity=33.5907335907336, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1787645, Length=260, Percent_Identity=30.7692307692308, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=33.8129496402878, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789279, Length=316, Percent_Identity=32.5949367088608, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87081824, Length=193, Percent_Identity=31.6062176165803, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=293, Percent_Identity=31.740614334471, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=269, Percent_Identity=30.1115241635688, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=339, Percent_Identity=30.3834808259587, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=311, Percent_Identity=30.5466237942122, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=324, Percent_Identity=27.7777777777778, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=305, Percent_Identity=30.8196721311475, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=29.3814432989691, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=36.2595419847328, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=36.2595419847328, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=36.2595419847328, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=36.2595419847328, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI62472511, Length=264, Percent_Identity=35.9848484848485, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=30.2839116719243, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=291, Percent_Identity=31.9587628865979, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28571528, Length=269, Percent_Identity=33.0855018587361, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=30.6513409961686, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=30.6513409961686, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=30.6513409961686, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=30.6513409961686, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=30.6513409961686, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI19921140, Length=299, Percent_Identity=28.0936454849498, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 35203; Mature: 35071

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGERTRIVILDGYTINPGDNPWTPVEEYGDCTIHDRTPPELKLERARDAEIILTSKVKLD
CCCCEEEEEEECEEECCCCCCCCCHHHCCCEEECCCCCCCHHHHCCCCCEEEEEECEEEC
EATIAALPRLRYISLLATGYNNVDVAAAGRRGIPVSNVPAYSTESVAQTAFALLLELTTR
HHHHHHHHHHHEEHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGLHDAAVRGGEWSHCPDHSFWKTSIVELDGLTLGIVGYGAIGRAVARIAQAFGMRTIAH
CCCHHHHHCCCCCCCCCCCCCHHEEEEEECCEEEEEECHHHHHHHHHHHHHHHCCHHHHC
APRIPADPGPVPVRFVSLEELFATADVVTLNCPQTPENTEFVNEGLLSLMKRSAYLINVA
CCCCCCCCCCCCEEEEEHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEC
RGGLVNEADLARALRDGTLAGAGLDVVAHEPMLPDNPLLAAPNCIFTPHLAWASLAARRR
CCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEECCCCEECCCHHHHHHHHHHH
LTGVVAANVAAFLAGSPINVVNGPWLAGGR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GERTRIVILDGYTINPGDNPWTPVEEYGDCTIHDRTPPELKLERARDAEIILTSKVKLD
CCCEEEEEEECEEECCCCCCCCCHHHCCCEEECCCCCCCHHHHCCCCCEEEEEECEEEC
EATIAALPRLRYISLLATGYNNVDVAAAGRRGIPVSNVPAYSTESVAQTAFALLLELTTR
HHHHHHHHHHHEEHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGLHDAAVRGGEWSHCPDHSFWKTSIVELDGLTLGIVGYGAIGRAVARIAQAFGMRTIAH
CCCHHHHHCCCCCCCCCCCCCHHEEEEEECCEEEEEECHHHHHHHHHHHHHHHCCHHHHC
APRIPADPGPVPVRFVSLEELFATADVVTLNCPQTPENTEFVNEGLLSLMKRSAYLINVA
CCCCCCCCCCCCEEEEEHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEC
RGGLVNEADLARALRDGTLAGAGLDVVAHEPMLPDNPLLAAPNCIFTPHLAWASLAARRR
CCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEECCCCEECCCHHHHHHHHHHH
LTGVVAANVAAFLAGSPINVVNGPWLAGGR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]