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The map label for this gene is lpxD

Identifier: 78223558

GI number: 78223558

Start: 2662074

End: 2663111

Strand: Reverse

Name: lpxD

Synonym: Gmet_2355

Alternate gene names: 78223558

Gene position: 2663111-2662074 (Counterclockwise)

Preceding gene: 78223559

Following gene: 78223557

Centisome position: 66.62

GC content: 62.43

Gene sequence:

>1038_bases
ATGGCGGTCTCGCGAACCCTCAGGGAACTTGCCGAATACCTCGGCGGCACCGTTGCCGGTGACGAGTCCAAGACGATATC
CGGCGTTGCAAGCCTTGACGATGCCGCCGATCACCAGATTACCTTCCTCGCCAATCCCCGCTACGCGCCAAAGGTTGCCA
CAACCGGAGCCGGCGCAGTGGTGCTGCCGCCGGGGGGCGAGCGCCACGGCAGAAACGCGATCCACGTGGCGAACCCCTAC
CTGGCCTTTGCCAAGCTGCTCACGTTGTTCCATGTCGCGCCACGGAAGCCCCAAGGGGTTATGGAGGGGGCGCTGGTGGG
CCACAACGTCGCCATGGGGAGCGACGTCACCATCTATCCCGGAGCCTTCGTGGGAGACGGCGTAACGCTCGGGGACCGGG
TGACGATCTTTCCGGGTGTTGTCATCTATGAAGGGGTCACCCTGGGCAGCGATGTGACGCTCCACTCCAACGTTGTCGTC
TACCAGGGGTGCCGCATCGGGAACCGGGTTACAATCCATGCCGGTACCATCATCGGTTCCGATGGTTTCGGTTACGCCCC
GGACGGCGATGGTTTCTACAAGATCCCTCAACTGGGGATCGTTGTCATTGAGGATGATGTGGAGGTCGGCGCCAACACCA
CCATCGACCGGGCGGCCCTTGCCGCTACCCGCATCGGGCGGGGGACCAAGATCGACAACCTCGTCATGATAGCCCATAAC
TGTGTGATCGGCGAAAACTGTACAATCGTCTCCCAGGTGGGGATTTCCGGCAGTACAAAGCTCGGCAGGCGCGTGACCCT
CGCCGGCCAGGTGGGGGTTGCGGGACACCTGGAAATCGGCGACAACTCCATGGTGGGGGCCAAGTCGGGCATTCCCGGCA
ATATCCCCGCCGGTTCCATGGTGAGCGGCATCCCTGCCTTCAACCACCGGGATTGGCTCCGAGCGTCTGCGGTGGTGCCG
AAACTCCCTGAACTGAGGAAGACGATCGCCGAACTGGAGAAGCGGGTCAGGGAACTGGAAGAGAAACAAGGAGCCTGA

Upstream 100 bases:

>100_bases
CATCTTTATTCGGAATGAAGGGATGATCTATGTGGATGACAAGGCTGACGTGACCGACGAAATCCTCAAGCTCTTCAACG
CGTCGCGGAAGAAGTAGCCC

Downstream 100 bases:

>100_bases
TAATGGAAACTGTCTTTGATATCAATGAAATCATGAAAATCCTTCCCCACCGTTACCCCTTTCTCCTGGTGGACCGGATC
GTGGAGCACGTGCCGGGAGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAVSRTLRELAEYLGGTVAGDESKTISGVASLDDAADHQITFLANPRYAPKVATTGAGAVVLPPGGERHGRNAIHVANPY
LAFAKLLTLFHVAPRKPQGVMEGALVGHNVAMGSDVTIYPGAFVGDGVTLGDRVTIFPGVVIYEGVTLGSDVTLHSNVVV
YQGCRIGNRVTIHAGTIIGSDGFGYAPDGDGFYKIPQLGIVVIEDDVEVGANTTIDRAALAATRIGRGTKIDNLVMIAHN
CVIGENCTIVSQVGISGSTKLGRRVTLAGQVGVAGHLEIGDNSMVGAKSGIPGNIPAGSMVSGIPAFNHRDWLRASAVVP
KLPELRKTIAELEKRVRELEEKQGA

Sequences:

>Translated_345_residues
MAVSRTLRELAEYLGGTVAGDESKTISGVASLDDAADHQITFLANPRYAPKVATTGAGAVVLPPGGERHGRNAIHVANPY
LAFAKLLTLFHVAPRKPQGVMEGALVGHNVAMGSDVTIYPGAFVGDGVTLGDRVTIFPGVVIYEGVTLGSDVTLHSNVVV
YQGCRIGNRVTIHAGTIIGSDGFGYAPDGDGFYKIPQLGIVVIEDDVEVGANTTIDRAALAATRIGRGTKIDNLVMIAHN
CVIGENCTIVSQVGISGSTKLGRRVTLAGQVGVAGHLEIGDNSMVGAKSGIPGNIPAGSMVSGIPAFNHRDWLRASAVVP
KLPELRKTIAELEKRVRELEEKQGA
>Mature_344_residues
AVSRTLRELAEYLGGTVAGDESKTISGVASLDDAADHQITFLANPRYAPKVATTGAGAVVLPPGGERHGRNAIHVANPYL
AFAKLLTLFHVAPRKPQGVMEGALVGHNVAMGSDVTIYPGAFVGDGVTLGDRVTIFPGVVIYEGVTLGSDVTLHSNVVVY
QGCRIGNRVTIHAGTIIGSDGFGYAPDGDGFYKIPQLGIVVIEDDVEVGANTTIDRAALAATRIGRGTKIDNLVMIAHNC
VIGENCTIVSQVGISGSTKLGRRVTLAGQVGVAGHLEIGDNSMVGAKSGIPGNIPAGSMVSGIPAFNHRDWLRASAVVPK
LPELRKTIAELEKRVRELEEKQGA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=36.3095238095238, Blast_Score=209, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_GEOMG (Q39T44)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385305.1
- ProteinModelPortal:   Q39T44
- SMR:   Q39T44
- STRING:   Q39T44
- GeneID:   3738815
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2355
- NMPDR:   fig|269799.3.peg.2599
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- PhylomeDB:   Q39T44
- ProtClustDB:   PRK00892
- BioCyc:   GMET269799:GMET_2355-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35943; Mature: 35811

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSRTLRELAEYLGGTVAGDESKTISGVASLDDAADHQITFLANPRYAPKVATTGAGAV
CCHHHHHHHHHHHHCCEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCEEECCCCEE
VLPPGGERHGRNAIHVANPYLAFAKLLTLFHVAPRKPQGVMEGALVGHNVAMGSDVTIYP
EECCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCEECCCCEEEEC
GAFVGDGVTLGDRVTIFPGVVIYEGVTLGSDVTLHSNVVVYQGCRIGNRVTIHAGTIIGS
CCEECCCEEECCEEEEECCEEEEECEECCCCEEEECCEEEEECCCCCCEEEEEEEEEECC
DGFGYAPDGDGFYKIPQLGIVVIEDDVEVGANTTIDRAALAATRIGRGTKIDNLVMIAHN
CCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEE
CVIGENCTIVSQVGISGSTKLGRRVTLAGQVGVAGHLEIGDNSMVGAKSGIPGNIPAGSM
EEECCCCEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCH
VSGIPAFNHRDWLRASAVVPKLPELRKTIAELEKRVRELEEKQGA
HHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVSRTLRELAEYLGGTVAGDESKTISGVASLDDAADHQITFLANPRYAPKVATTGAGAV
CHHHHHHHHHHHHCCEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCEEECCCCEE
VLPPGGERHGRNAIHVANPYLAFAKLLTLFHVAPRKPQGVMEGALVGHNVAMGSDVTIYP
EECCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCEECCCCEEEEC
GAFVGDGVTLGDRVTIFPGVVIYEGVTLGSDVTLHSNVVVYQGCRIGNRVTIHAGTIIGS
CCEECCCEEECCEEEEECCEEEEECEECCCCEEEECCEEEEECCCCCCEEEEEEEEEECC
DGFGYAPDGDGFYKIPQLGIVVIEDDVEVGANTTIDRAALAATRIGRGTKIDNLVMIAHN
CCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEE
CVIGENCTIVSQVGISGSTKLGRRVTLAGQVGVAGHLEIGDNSMVGAKSGIPGNIPAGSM
EEECCCCEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCH
VSGIPAFNHRDWLRASAVVPKLPELRKTIAELEKRVRELEEKQGA
HHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA