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The map label for this gene is lpxB

Identifier: 78223553

GI number: 78223553

Start: 2657588

End: 2658742

Strand: Reverse

Name: lpxB

Synonym: Gmet_2350

Alternate gene names: 78223553

Gene position: 2658742-2657588 (Counterclockwise)

Preceding gene: 78223554

Following gene: 78223552

Centisome position: 66.51

GC content: 63.64

Gene sequence:

>1155_bases
ATGGGTACCGCTCCGAACAAACGCGTGATGATCGTGGCCGGCGAGGCTTCCGGCGACCTCCATGGCTCGAACCTGGTGAA
AGAGGCTCTGCGCCTCGATCCGACCCTCTCATTTTTCGGCATTGGCGGCCCGCACATGCGGGCGGCGGGGGTGGAGACCG
TTGTCGATTCTTCGGAAATGGCGGTGGTGGGGCTCGTGGAGGTGCTTGCCCACTTCGGCGTCATCTACAAGGCATACGCT
ACCCTCAAGCGTCTCATCACGACCAATCCGCCGGACCTTCTGATCCTCATCGACTACCCGGATTTCAACATGCTCGTGGC
AAAGGTGGCGAAGCGGGCCGGGGTCAAGGTGCTCTACTACATCAGTCCCCAGGTCTGGGCCTGGCGGACGGGGCGGGTGA
AAAAGATCGCCCGGCTCGTGGACCGGATGGCGGTGGTCTTTCCCTTTGAGGTCCCCTTTTACGAGAAGGCGGGTGTACCG
GTATCCTTCGTGGGGCATCCCCTGGCGGATCGCGTCTCCCCGTCAATGAGCCGCAGCGAGGCCCTGGCTGCCTTCGGGCT
CGATCCTTCCCGGCGGGTGGTGGGGCTCTTCCCGGGGAGCCGCCGGGGGGAAATCGCCCGACTCTTCCCGGTTATCCTGG
AGAGCGCGAAACTTTTACGGGACCGTTACCCCGGCATCCAGTTCATCCTTCCCCTGGCATCGAGCCTGACCGATGCCGAC
ATCGCTCCCCATCTGGCGGCGTCGGGGCTGGAGGTTGTCGTGGCCCGGGACAAGGTCTACGACGTGATGCAGGTCTGCGA
TGCCATCGCGACGGTATCGGGGACGGTTACCCTTGAAATCGCCCTCATGGGGGTGCCGATGGTGATCATCTACACGGTAT
CCCCCCTGACCTACGAGGTGGGCAAGCGCCTCATCCGGGTCGATCACATCGGCATCTGCAACATCGTGGCGGGAGAGCGG
GTGGTGCCGGAACTGATCCAGGACGAGGCCACCGCCGAGCGGATCGCCGCGGAGATCGGCCGTTATCTGGATGACCCTGT
CCACACGGAGAAAACCCGGGCCGGGCTTGCCAGGGTCAGGGAAAAGCTCGGTTCCGGGGGCTGCTCGGAACGGGTGGCGG
GAATCGTCCTCGAGATGCTCGGAAAGAAGAGATAA

Upstream 100 bases:

>100_bases
TCGTGGACGTGGTGAAATCGGCCCTCAAGGCATAGCCGGAAGCAACGCTTTCGTGCATGAAAGGGAGAGACGCCCCCCGT
GGGCGTCTCTTTGTATTCGT

Downstream 100 bases:

>100_bases
TGGAAACCTTCAAACGCCTCTTACGCTACAGCAAACCCTACGGGTGGCGCATTGCCATTTCCATGGTGGCCTCCCTGTGT
GTCGGCGGAACCGACGCGGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MGTAPNKRVMIVAGEASGDLHGSNLVKEALRLDPTLSFFGIGGPHMRAAGVETVVDSSEMAVVGLVEVLAHFGVIYKAYA
TLKRLITTNPPDLLILIDYPDFNMLVAKVAKRAGVKVLYYISPQVWAWRTGRVKKIARLVDRMAVVFPFEVPFYEKAGVP
VSFVGHPLADRVSPSMSRSEALAAFGLDPSRRVVGLFPGSRRGEIARLFPVILESAKLLRDRYPGIQFILPLASSLTDAD
IAPHLAASGLEVVVARDKVYDVMQVCDAIATVSGTVTLEIALMGVPMVIIYTVSPLTYEVGKRLIRVDHIGICNIVAGER
VVPELIQDEATAERIAAEIGRYLDDPVHTEKTRAGLARVREKLGSGGCSERVAGIVLEMLGKKR

Sequences:

>Translated_384_residues
MGTAPNKRVMIVAGEASGDLHGSNLVKEALRLDPTLSFFGIGGPHMRAAGVETVVDSSEMAVVGLVEVLAHFGVIYKAYA
TLKRLITTNPPDLLILIDYPDFNMLVAKVAKRAGVKVLYYISPQVWAWRTGRVKKIARLVDRMAVVFPFEVPFYEKAGVP
VSFVGHPLADRVSPSMSRSEALAAFGLDPSRRVVGLFPGSRRGEIARLFPVILESAKLLRDRYPGIQFILPLASSLTDAD
IAPHLAASGLEVVVARDKVYDVMQVCDAIATVSGTVTLEIALMGVPMVIIYTVSPLTYEVGKRLIRVDHIGICNIVAGER
VVPELIQDEATAERIAAEIGRYLDDPVHTEKTRAGLARVREKLGSGGCSERVAGIVLEMLGKKR
>Mature_383_residues
GTAPNKRVMIVAGEASGDLHGSNLVKEALRLDPTLSFFGIGGPHMRAAGVETVVDSSEMAVVGLVEVLAHFGVIYKAYAT
LKRLITTNPPDLLILIDYPDFNMLVAKVAKRAGVKVLYYISPQVWAWRTGRVKKIARLVDRMAVVFPFEVPFYEKAGVPV
SFVGHPLADRVSPSMSRSEALAAFGLDPSRRVVGLFPGSRRGEIARLFPVILESAKLLRDRYPGIQFILPLASSLTDADI
APHLAASGLEVVVARDKVYDVMQVCDAIATVSGTVTLEIALMGVPMVIIYTVSPLTYEVGKRLIRVDHIGICNIVAGERV
VPELIQDEATAERIAAEIGRYLDDPVHTEKTRAGLARVREKLGSGGCSERVAGIVLEMLGKKR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=333, Percent_Identity=34.8348348348348, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_GEOMG (Q39T49)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385300.1
- ProteinModelPortal:   Q39T49
- STRING:   Q39T49
- GeneID:   3738810
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2350
- NMPDR:   fig|269799.3.peg.2594
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   EFAFICS
- PhylomeDB:   Q39T49
- ProtClustDB:   PRK00025
- BioCyc:   GMET269799:GMET_2350-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41622; Mature: 41491

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTAPNKRVMIVAGEASGDLHGSNLVKEALRLDPTLSFFGIGGPHMRAAGVETVVDSSEM
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHCCCCH
AVVGLVEVLAHFGVIYKAYATLKRLITTNPPDLLILIDYPDFNMLVAKVAKRAGVKVLYY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEE
ISPQVWAWRTGRVKKIARLVDRMAVVFPFEVPFYEKAGVPVSFVGHPLADRVSPSMSRSE
ECCCEEEECCCHHHHHHHHHHHHHHEEECCCCCHHCCCCCEEECCCCHHHHCCCCCHHHH
ALAAFGLDPSRRVVGLFPGSRRGEIARLFPVILESAKLLRDRYPGIQFILPLASSLTDAD
HHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCH
IAPHLAASGLEVVVARDKVYDVMQVCDAIATVSGTVTLEIALMGVPMVIIYTVSPLTYEV
HCHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCHHHHH
GKRLIRVDHIGICNIVAGERVVPELIQDEATAERIAAEIGRYLDDPVHTEKTRAGLARVR
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EKLGSGGCSERVAGIVLEMLGKKR
HHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GTAPNKRVMIVAGEASGDLHGSNLVKEALRLDPTLSFFGIGGPHMRAAGVETVVDSSEM
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHCCCCH
AVVGLVEVLAHFGVIYKAYATLKRLITTNPPDLLILIDYPDFNMLVAKVAKRAGVKVLYY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEE
ISPQVWAWRTGRVKKIARLVDRMAVVFPFEVPFYEKAGVPVSFVGHPLADRVSPSMSRSE
ECCCEEEECCCHHHHHHHHHHHHHHEEECCCCCHHCCCCCEEECCCCHHHHCCCCCHHHH
ALAAFGLDPSRRVVGLFPGSRRGEIARLFPVILESAKLLRDRYPGIQFILPLASSLTDAD
HHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCH
IAPHLAASGLEVVVARDKVYDVMQVCDAIATVSGTVTLEIALMGVPMVIIYTVSPLTYEV
HCHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCHHHHH
GKRLIRVDHIGICNIVAGERVVPELIQDEATAERIAAEIGRYLDDPVHTEKTRAGLARVR
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EKLGSGGCSERVAGIVLEMLGKKR
HHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA