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The map label for this gene is cheA [H]

Identifier: 78223514

GI number: 78223514

Start: 2618698

End: 2620770

Strand: Reverse

Name: cheA [H]

Synonym: Gmet_2311

Alternate gene names: 78223514

Gene position: 2620770-2618698 (Counterclockwise)

Preceding gene: 78223515

Following gene: 78223513

Centisome position: 65.56

GC content: 61.07

Gene sequence:

>2073_bases
ATGGCAAATTCAAATGATACGTCCGGCAGGGCCGTGGAAGACTTCCTGGCCGAAGCCGAAGAGATTGTCGATCGACTGAG
CACCGACTTGGGAACCCTCGGCGACTGCGCCGACAGCGGGGAGTGTGATCCGGACCTGCTCAATGCCATTTTCCGCGGCG
CCCACTCCCTCAAGGGGCTCGCCGGCATGTTCGGTTTCGCCGACATCCAGCAGCTCTCCCATAACCTGGAAAACCTTCTC
GATTCACTTCGCCTCGGCAAAATACCCCTCACCAATGCCACCATGAACATCCTCTTCGATGCCATGGAACTTCTCGGTTC
CGTGGTGCGGGGGCTCGGCACCGGAGAAAACTTCTCTTCCGCCATTGCCGACGCGATTCAGCGGCTCAATGACTGCGCCA
CAGCCCAGGAGAGTGGCGGCGAGTCACCCCTCCAGAAGCTCGGCCTGCCGGAGAAGGTCCTCAACTCCCTCACCGAATAC
GAGGAACACCGGCTGCTGGAGAATGTGAAGAAGGGGCGGACCATTTACTCCATCCATGCCTCCTTCAACCTCATGTCCTT
CGATCAGGATCTGGGGGAGATCACGGAAGTCCTGAAGAAGTCTGGAGAGGTGGTGAGTACTCTCCCCAGTGCCAGTGCCA
CTCCCGAGTCGATGATCGACTTCGAGATCCTCTACGGCACCGACCTCGCGCTTGATGATGTTACCGGACTCATTGACCGG
GATAATGTCGAGGTCACCCGGATCGGTGCGGCTGCCTCTCCACCCTCGGCCATCGCGGCCGGTGTTGCCGTGGCAATCCC
CGCTACAGCGCAGGCGTCGGTTCCGACTTCGGCTCCGGCAGAGGTCTCCGCTCCTGTCGGCCAGGGCGACGACATGACCG
CCAAGAGCATGAGCCGGACGGTGCGGGTCGACATCGGCAAGCTGGACGATCTCATGAACATCGTGGGCGAGCTGGTCCTC
TCCCATTCCATCATCTCGATGCTGGCGACACGCATGAGACTCGAAGGGTTCTCGTCCCTGGCCATCGAGCTGGGCAAGGC
GGCCAAGGGGCTCGACCGCAAGCTCACGGAACTGCAGAAGGGGGTCATGGAGATCCGGATGATCCCGGTTGGGCAACTTT
TCGAGAAGATGGCCCGCATTGTCCGGAAGGTCTCCCGGGAACAGGGGAAAAAGGTCGACCTCAAGACCTTTGGCGCGGAC
ACTGAGCTGGACAAGCTCATCATCGAGGATATCGCCGACCCCATGGTTCACATCATCCGCAACGCCATCGACCATGGACT
GGAGACCACGGAAGAGCGGGTGGCCGCCGGCAAGCCCGAGCGGGGAACCATCCGTCTCTCCTCCTACCAGAAGGGAAACC
ACGTCGTCATCGAAGTGTCGGACGACGGGCACGGGTTCAATATCGAAAAGGTGAAGAAGAAGGCCCTGGAAAAGGGGCTC
ATCAAGACCTTGGAAGGGGTATCCGACCGGGAGGCCCTCGATTTCATCTTTCTCCCCGGCTTTTCCACCGCCGACAAGGT
GAGCGAGCTGTCGGGCCGCGGCGTCGGCATGGATGTGGTGAAAAACAACATCGCCGCCGTCTCGGGGATGGTGGACATCG
AGAGCATCTTCGGCCAGGGGAGCAAGGTCATCATCACCCTTCCCATCACCCTGGCCATCATCAAGGCGCTGCTGGTTTCC
ACCGCCGGGCGCACCTACGCCCTCCCGATCACGTCGGTGCTTGAAACGATCATCGTCACCGAGAATGACATCGATACCGT
GGAGCGCAAGGAGGTCTACCAGCTCAGGCAAACGACCCTGCCGCTCGTGCGGCTGGAGCGCTTTTTCGGCGTCCCGCGCA
CAAAACCGGATTCCGCCGAGTTCTACGTGGTGGTGGTGGGGGTGGCGGAGAAACGGCTCGGGGTCATTGTCGACGATCTC
ATGGGGCAGCAGGATATTGTCATCAAATCCCTGGGGGACATGTTCAAGGGGTACCGGGGGATCACCGGAGCGGCGGACCT
GGGGGACCAGCGGACGATCCTCGTGCTCGACGTGGGGGGGATCATCGGCGAGGCGTTCCGGAGCGGAGGGTAG

Upstream 100 bases:

>100_bases
AAAGGGGCTCGCTCTCGGTGCCAACGAATATCTGGTGAAGCCGTTCGATCCGGCGCGTTTGCAGGAGTTGATCAAACAGT
ACACGGCCTGAGGGTTATCC

Downstream 100 bases:

>100_bases
ATGTACAGGGAGTTCTACGGTCTGACCGAAAAGCCGTTCTCGAAGACCCCGGACCCGCGCTACCTCTTTCTGTCGCGGGG
ACACCGGGAAGCCCTGGCAC

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MANSNDTSGRAVEDFLAEAEEIVDRLSTDLGTLGDCADSGECDPDLLNAIFRGAHSLKGLAGMFGFADIQQLSHNLENLL
DSLRLGKIPLTNATMNILFDAMELLGSVVRGLGTGENFSSAIADAIQRLNDCATAQESGGESPLQKLGLPEKVLNSLTEY
EEHRLLENVKKGRTIYSIHASFNLMSFDQDLGEITEVLKKSGEVVSTLPSASATPESMIDFEILYGTDLALDDVTGLIDR
DNVEVTRIGAAASPPSAIAAGVAVAIPATAQASVPTSAPAEVSAPVGQGDDMTAKSMSRTVRVDIGKLDDLMNIVGELVL
SHSIISMLATRMRLEGFSSLAIELGKAAKGLDRKLTELQKGVMEIRMIPVGQLFEKMARIVRKVSREQGKKVDLKTFGAD
TELDKLIIEDIADPMVHIIRNAIDHGLETTEERVAAGKPERGTIRLSSYQKGNHVVIEVSDDGHGFNIEKVKKKALEKGL
IKTLEGVSDREALDFIFLPGFSTADKVSELSGRGVGMDVVKNNIAAVSGMVDIESIFGQGSKVIITLPITLAIIKALLVS
TAGRTYALPITSVLETIIVTENDIDTVERKEVYQLRQTTLPLVRLERFFGVPRTKPDSAEFYVVVVGVAEKRLGVIVDDL
MGQQDIVIKSLGDMFKGYRGITGAADLGDQRTILVLDVGGIIGEAFRSGG

Sequences:

>Translated_690_residues
MANSNDTSGRAVEDFLAEAEEIVDRLSTDLGTLGDCADSGECDPDLLNAIFRGAHSLKGLAGMFGFADIQQLSHNLENLL
DSLRLGKIPLTNATMNILFDAMELLGSVVRGLGTGENFSSAIADAIQRLNDCATAQESGGESPLQKLGLPEKVLNSLTEY
EEHRLLENVKKGRTIYSIHASFNLMSFDQDLGEITEVLKKSGEVVSTLPSASATPESMIDFEILYGTDLALDDVTGLIDR
DNVEVTRIGAAASPPSAIAAGVAVAIPATAQASVPTSAPAEVSAPVGQGDDMTAKSMSRTVRVDIGKLDDLMNIVGELVL
SHSIISMLATRMRLEGFSSLAIELGKAAKGLDRKLTELQKGVMEIRMIPVGQLFEKMARIVRKVSREQGKKVDLKTFGAD
TELDKLIIEDIADPMVHIIRNAIDHGLETTEERVAAGKPERGTIRLSSYQKGNHVVIEVSDDGHGFNIEKVKKKALEKGL
IKTLEGVSDREALDFIFLPGFSTADKVSELSGRGVGMDVVKNNIAAVSGMVDIESIFGQGSKVIITLPITLAIIKALLVS
TAGRTYALPITSVLETIIVTENDIDTVERKEVYQLRQTTLPLVRLERFFGVPRTKPDSAEFYVVVVGVAEKRLGVIVDDL
MGQQDIVIKSLGDMFKGYRGITGAADLGDQRTILVLDVGGIIGEAFRSGG
>Mature_689_residues
ANSNDTSGRAVEDFLAEAEEIVDRLSTDLGTLGDCADSGECDPDLLNAIFRGAHSLKGLAGMFGFADIQQLSHNLENLLD
SLRLGKIPLTNATMNILFDAMELLGSVVRGLGTGENFSSAIADAIQRLNDCATAQESGGESPLQKLGLPEKVLNSLTEYE
EHRLLENVKKGRTIYSIHASFNLMSFDQDLGEITEVLKKSGEVVSTLPSASATPESMIDFEILYGTDLALDDVTGLIDRD
NVEVTRIGAAASPPSAIAAGVAVAIPATAQASVPTSAPAEVSAPVGQGDDMTAKSMSRTVRVDIGKLDDLMNIVGELVLS
HSIISMLATRMRLEGFSSLAIELGKAAKGLDRKLTELQKGVMEIRMIPVGQLFEKMARIVRKVSREQGKKVDLKTFGADT
ELDKLIIEDIADPMVHIIRNAIDHGLETTEERVAAGKPERGTIRLSSYQKGNHVVIEVSDDGHGFNIEKVKKKALEKGLI
KTLEGVSDREALDFIFLPGFSTADKVSELSGRGVGMDVVKNNIAAVSGMVDIESIFGQGSKVIITLPITLAIIKALLVST
AGRTYALPITSVLETIIVTENDIDTVERKEVYQLRQTTLPLVRLERFFGVPRTKPDSAEFYVVVVGVAEKRLGVIVDDLM
GQQDIVIKSLGDMFKGYRGITGAADLGDQRTILVLDVGGIIGEAFRSGG

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=681, Percent_Identity=33.7738619676946, Blast_Score=332, Evalue=4e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74038; Mature: 73907

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSNDTSGRAVEDFLAEAEEIVDRLSTDLGTLGDCADSGECDPDLLNAIFRGAHSLKGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGMFGFADIQQLSHNLENLLDSLRLGKIPLTNATMNILFDAMELLGSVVRGLGTGENFSS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AIADAIQRLNDCATAQESGGESPLQKLGLPEKVLNSLTEYEEHRLLENVKKGRTIYSIHA
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
SFNLMSFDQDLGEITEVLKKSGEVVSTLPSASATPESMIDFEILYGTDLALDDVTGLIDR
CCEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHEEEEEECCCCCHHHHHHCCCC
DNVEVTRIGAAASPPSAIAAGVAVAIPATAQASVPTSAPAEVSAPVGQGDDMTAKSMSRT
CCEEEEEECCCCCCHHHHHCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCE
VRVDIGKLDDLMNIVGELVLSHSIISMLATRMRLEGFSSLAIELGKAAKGLDRKLTELQK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
GVMEIRMIPVGQLFEKMARIVRKVSREQGKKVDLKTFGADTELDKLIIEDIADPMVHIIR
HHHHEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
NAIDHGLETTEERVAAGKPERGTIRLSSYQKGNHVVIEVSDDGHGFNIEKVKKKALEKGL
HHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
IKTLEGVSDREALDFIFLPGFSTADKVSELSGRGVGMDVVKNNIAAVSGMVDIESIFGQG
HHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SKVIITLPITLAIIKALLVSTAGRTYALPITSVLETIIVTENDIDTVERKEVYQLRQTTL
CEEEEEECHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
PLVRLERFFGVPRTKPDSAEFYVVVVGVAEKRLGVIVDDLMGQQDIVIKSLGDMFKGYRG
HHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
ITGAADLGDQRTILVLDVGGIIGEAFRSGG
CCCCCCCCCCCEEEEEECCHHHHHHHHCCC
>Mature Secondary Structure 
ANSNDTSGRAVEDFLAEAEEIVDRLSTDLGTLGDCADSGECDPDLLNAIFRGAHSLKGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGMFGFADIQQLSHNLENLLDSLRLGKIPLTNATMNILFDAMELLGSVVRGLGTGENFSS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AIADAIQRLNDCATAQESGGESPLQKLGLPEKVLNSLTEYEEHRLLENVKKGRTIYSIHA
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
SFNLMSFDQDLGEITEVLKKSGEVVSTLPSASATPESMIDFEILYGTDLALDDVTGLIDR
CCEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHEEEEEECCCCCHHHHHHCCCC
DNVEVTRIGAAASPPSAIAAGVAVAIPATAQASVPTSAPAEVSAPVGQGDDMTAKSMSRT
CCEEEEEECCCCCCHHHHHCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCE
VRVDIGKLDDLMNIVGELVLSHSIISMLATRMRLEGFSSLAIELGKAAKGLDRKLTELQK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
GVMEIRMIPVGQLFEKMARIVRKVSREQGKKVDLKTFGADTELDKLIIEDIADPMVHIIR
HHHHEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
NAIDHGLETTEERVAAGKPERGTIRLSSYQKGNHVVIEVSDDGHGFNIEKVKKKALEKGL
HHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
IKTLEGVSDREALDFIFLPGFSTADKVSELSGRGVGMDVVKNNIAAVSGMVDIESIFGQG
HHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SKVIITLPITLAIIKALLVSTAGRTYALPITSVLETIIVTENDIDTVERKEVYQLRQTTL
CEEEEEECHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
PLVRLERFFGVPRTKPDSAEFYVVVVGVAEKRLGVIVDDLMGQQDIVIKSLGDMFKGYRG
HHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
ITGAADLGDQRTILVLDVGGIIGEAFRSGG
CCCCCCCCCCCEEEEEECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377 [H]