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The map label for this gene is gph [C]

Identifier: 78223493

GI number: 78223493

Start: 2596353

End: 2597024

Strand: Reverse

Name: gph [C]

Synonym: Gmet_2290

Alternate gene names: 78223493

Gene position: 2597024-2596353 (Counterclockwise)

Preceding gene: 78223494

Following gene: 78223492

Centisome position: 64.97

GC content: 58.18

Gene sequence:

>672_bases
GTGCTGTACCCTGTCAACCTCATCATTTTCGATCTGGATGGAACCCTCATCGATTCCCTTCCTGACCTCGCCGACGCCAC
AAACCACATGCTGTCCAGTCTCGGTAGGCCTTCCATCGGCCAGAATGCCGTGCGCAGACTCGTGGGGCAGGGGGCGCGCC
GTCTTGTCGAACGGGCCCTTGCCGGTGCTTCTGAGGACGAAATCAATCAGGGGCTTGATCTCTTCCTCGACTACAATCAC
CGGCATATTGCCGACCGAACCGTCCTCTATCTCGGCGTTCCGGAGACCCTCGACGCCCTGAAGGGGCGGGGGATGCGGAT
GGCGATCATCTCCAACAAGAACGTGGCCCTCTGTCGTGAGGTAGTCTCTGTCCTTGGCATAGACCGCTACTTTGACGAGG
TTCTGGGTGCCGATTCCCTGCCGTTCCGTAAACCGTCGCCCGAGCCGGTCCTGAAGCTTTTGGCCGATTTCGGGGTGCCT
CCGGAACGGGCAGCCCTGGTCGGAGACAGCATTAACGACATGGCCGCCGCCAAGGGGGCAAGGGTATCAACGGTGGGATG
CACCTGGGGGTATGGCGAACTGACGGAGCTTGCCGATGCTGATTATCTTGTTGAAAGCTTCGGTGAACTTTTTGGAATAC
CGTTGTTTTGTGGTGGCGAGGTAAGTATATAA

Upstream 100 bases:

>100_bases
GCCCGCGCGTAAAAGCCCGCCCAGAGACGGGCTTTTTTATTGCGGCCAAGCCGTGAAACGCTCTATAGTTATTAGGTTGC
TTCAGTTTCAGGAGTCTGCT

Downstream 100 bases:

>100_bases
TGGTTGGGGTTGCGGTGCAGGGATGGACCGGGCGCATGCTGTGTGTCGATCTGGCGACAAGGGAGAGTCGGCGCGAGACG
ATTCCGGCGGAATTTCTCCA

Product: HAD family hydrolase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MLYPVNLIIFDLDGTLIDSLPDLADATNHMLSSLGRPSIGQNAVRRLVGQGARRLVERALAGASEDEINQGLDLFLDYNH
RHIADRTVLYLGVPETLDALKGRGMRMAIISNKNVALCREVVSVLGIDRYFDEVLGADSLPFRKPSPEPVLKLLADFGVP
PERAALVGDSINDMAAAKGARVSTVGCTWGYGELTELADADYLVESFGELFGIPLFCGGEVSI

Sequences:

>Translated_223_residues
MLYPVNLIIFDLDGTLIDSLPDLADATNHMLSSLGRPSIGQNAVRRLVGQGARRLVERALAGASEDEINQGLDLFLDYNH
RHIADRTVLYLGVPETLDALKGRGMRMAIISNKNVALCREVVSVLGIDRYFDEVLGADSLPFRKPSPEPVLKLLADFGVP
PERAALVGDSINDMAAAKGARVSTVGCTWGYGELTELADADYLVESFGELFGIPLFCGGEVSI
>Mature_223_residues
MLYPVNLIIFDLDGTLIDSLPDLADATNHMLSSLGRPSIGQNAVRRLVGQGARRLVERALAGASEDEINQGLDLFLDYNH
RHIADRTVLYLGVPETLDALKGRGMRMAIISNKNVALCREVVSVLGIDRYFDEVLGADSLPFRKPSPEPVLKLLADFGVP
PERAALVGDSINDMAAAKGARVSTVGCTWGYGELTELADADYLVESFGELFGIPLFCGGEVSI

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=233, Percent_Identity=33.4763948497854, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788021, Length=182, Percent_Identity=27.4725274725275, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 24075; Mature: 24075

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPVNLIIFDLDGTLIDSLPDLADATNHMLSSLGRPSIGQNAVRRLVGQGARRLVERAL
CCCEEEEEEECCCCHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
AGASEDEINQGLDLFLDYNHRHIADRTVLYLGVPETLDALKGRGMRMAIISNKNVALCRE
CCCCHHHHHCCCEEEEECCCCCCCCCEEEEEECHHHHHHHCCCCEEEEEECCCCHHHHHH
VVSVLGIDRYFDEVLGADSLPFRKPSPEPVLKLLADFGVPPERAALVGDSINDMAAAKGA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCCC
RVSTVGCTWGYGELTELADADYLVESFGELFGIPLFCGGEVSI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MLYPVNLIIFDLDGTLIDSLPDLADATNHMLSSLGRPSIGQNAVRRLVGQGARRLVERAL
CCCEEEEEEECCCCHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
AGASEDEINQGLDLFLDYNHRHIADRTVLYLGVPETLDALKGRGMRMAIISNKNVALCRE
CCCCHHHHHCCCEEEEECCCCCCCCCEEEEEECHHHHHHHCCCCEEEEEECCCCHHHHHH
VVSVLGIDRYFDEVLGADSLPFRKPSPEPVLKLLADFGVPPERAALVGDSINDMAAAKGA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCCC
RVSTVGCTWGYGELTELADADYLVESFGELFGIPLFCGGEVSI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA