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The map label for this gene is rspB [H]

Identifier: 78223440

GI number: 78223440

Start: 2528207

End: 2529229

Strand: Reverse

Name: rspB [H]

Synonym: Gmet_2235

Alternate gene names: 78223440

Gene position: 2529229-2528207 (Counterclockwise)

Preceding gene: 78223441

Following gene: 78223439

Centisome position: 63.27

GC content: 54.25

Gene sequence:

>1023_bases
ATGAGAGCGGCTGTCTTTCACCAAATCGGAAAGCCTCTTGCCATTGAATCACTAAATGATCCGATACCTTTAGATGGTGA
GGTAATCGTTAACGTAAAGGCATGCGGAATTTGTGGCACCGATATTCATGCAACGGCGGACAAGGAAATGCGCCTTGCCG
ACGGTACAGTCCTGGGACACGAGTTTGCAGGTGAAATTGTCGAGGTCGGGCCACAGGTAGCCGTGGGCTGGGCGCAAGGT
GACCGACTCTGTACACTGCCGTACATCGGCTGCGGCCACTGTCTTGCCTGCCTCACCGGTATGCCGTGGCAATGCAAGCT
GAAAAAAGTCATTGGAATTCAAACTGCTGGCGGCTTTGCAGAATACGCCCGTGTGCATGTCAATGAGGCGGTCAGGTTGC
CGGTCTCGGTCAGTTGGCAGGAAGGTGCCTTGGTGGAGCCGCTTGCAATCGGTCTTCATGCAGTGCGTCTTTCTCGCGGT
GTCGCGGGGAAAAGTGTCCTGGTTACTGGTGCGGGCCCTATCGGTCTAGCTGTCGCGCTCTGGTGCCGATTTTTCGGCGC
CAGACAGGTGGTCGTAAGCGAATTTGATCCTGAACGCTCGAAGATGGCTCTTGCCATGGGGGCGACCCACGCCGTCGATG
CAAAAGCTGATGTGGGTGCCCAGTACCAGGAGATAACCGGGGAGTTGCCGGAACTGATTTTCGAATGTGTGGGAATTCCC
GGCCTTATCGCCCAATGCGTTGACAGGGCAGCATTCGGAGCAGAGATTGTCGTAGTCGGCTTTTGCATGCGTCCGGATAC
CTTTGTCCCGGCTCTAGCGATGCTGAAGGAGATTACGGTCAAATTTTCCATCGGTAACAACAAGTCCGATTTCCAGTTCA
TTGTTGACATGCTCTCATCTGGCCGTATCTCGGTAAAACCAATGATTACCGCCGCCGTTTCTTTAGACGATTTACCAAAG
ACATTCGAGTCTCTCAGAACCCCCGGGGAGCATTGCAAGGTAGTGGTGGAACCGGGACGTTGA

Upstream 100 bases:

>100_bases
GCTGGTTTAACCCTGCTAAAGAGGCTGTTTATCTTAAAACTTTGCATAGGTGTTTAGGATATACATGGTTTAAGCTCGAA
AAATTTATGGAGTGTGTCTT

Downstream 100 bases:

>100_bases
CACCAGCATCTATTGAATACTTCAGGAGCGGCAATTACATGACCCAGTCTGACCCTCGTCTTGCAGAATACCGGAAATGG
GAAGGGGTCGATCCCTGGGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRAAVFHQIGKPLAIESLNDPIPLDGEVIVNVKACGICGTDIHATADKEMRLADGTVLGHEFAGEIVEVGPQVAVGWAQG
DRLCTLPYIGCGHCLACLTGMPWQCKLKKVIGIQTAGGFAEYARVHVNEAVRLPVSVSWQEGALVEPLAIGLHAVRLSRG
VAGKSVLVTGAGPIGLAVALWCRFFGARQVVVSEFDPERSKMALAMGATHAVDAKADVGAQYQEITGELPELIFECVGIP
GLIAQCVDRAAFGAEIVVVGFCMRPDTFVPALAMLKEITVKFSIGNNKSDFQFIVDMLSSGRISVKPMITAAVSLDDLPK
TFESLRTPGEHCKVVVEPGR

Sequences:

>Translated_340_residues
MRAAVFHQIGKPLAIESLNDPIPLDGEVIVNVKACGICGTDIHATADKEMRLADGTVLGHEFAGEIVEVGPQVAVGWAQG
DRLCTLPYIGCGHCLACLTGMPWQCKLKKVIGIQTAGGFAEYARVHVNEAVRLPVSVSWQEGALVEPLAIGLHAVRLSRG
VAGKSVLVTGAGPIGLAVALWCRFFGARQVVVSEFDPERSKMALAMGATHAVDAKADVGAQYQEITGELPELIFECVGIP
GLIAQCVDRAAFGAEIVVVGFCMRPDTFVPALAMLKEITVKFSIGNNKSDFQFIVDMLSSGRISVKPMITAAVSLDDLPK
TFESLRTPGEHCKVVVEPGR
>Mature_340_residues
MRAAVFHQIGKPLAIESLNDPIPLDGEVIVNVKACGICGTDIHATADKEMRLADGTVLGHEFAGEIVEVGPQVAVGWAQG
DRLCTLPYIGCGHCLACLTGMPWQCKLKKVIGIQTAGGFAEYARVHVNEAVRLPVSVSWQEGALVEPLAIGLHAVRLSRG
VAGKSVLVTGAGPIGLAVALWCRFFGARQVVVSEFDPERSKMALAMGATHAVDAKADVGAQYQEITGELPELIFECVGIP
GLIAQCVDRAAFGAEIVVVGFCMRPDTFVPALAMLKEITVKFSIGNNKSDFQFIVDMLSSGRISVKPMITAAVSLDDLPK
TFESLRTPGEHCKVVVEPGR

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=328, Percent_Identity=29.2682926829268, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=22.8412256267409, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=22.8412256267409, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501929, Length=267, Percent_Identity=25.4681647940075, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI34577061, Length=264, Percent_Identity=24.6212121212121, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=24.0641711229947, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787863, Length=328, Percent_Identity=32.0121951219512, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=33.5403726708075, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=30.6990881458967, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1790045, Length=323, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788407, Length=349, Percent_Identity=29.2263610315186, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788075, Length=325, Percent_Identity=28.3076923076923, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790718, Length=312, Percent_Identity=26.6025641025641, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87082125, Length=227, Percent_Identity=32.15859030837, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1786825, Length=229, Percent_Identity=29.6943231441048, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=293, Percent_Identity=27.6450511945392, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=320, Percent_Identity=27.8125, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=225, Percent_Identity=30.2222222222222, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=346, Percent_Identity=26.3005780346821, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=26.1627906976744, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=344, Percent_Identity=25.2906976744186, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=338, Percent_Identity=29.2899408284024, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=29.6610169491525, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=29.6610169491525, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6319257, Length=355, Percent_Identity=28.169014084507, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=380, Percent_Identity=28.6842105263158, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=348, Percent_Identity=26.7241379310345, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=24.251497005988, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=218, Percent_Identity=30.2752293577982, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=25.7225433526012, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=24.7761194029851, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737897, Length=339, Percent_Identity=28.6135693215339, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=28.1437125748503, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17737895, Length=268, Percent_Identity=27.2388059701493, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221457811, Length=192, Percent_Identity=26.5625, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551930, Length=192, Percent_Identity=26.5625, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45550770, Length=192, Percent_Identity=26.5625, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 36117; Mature: 36117

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVFHQIGKPLAIESLNDPIPLDGEVIVNVKACGICGTDIHATADKEMRLADGTVLGH
CCCHHHHHCCCCEEECCCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCEEEECCEEECH
EFAGEIVEVGPQVAVGWAQGDRLCTLPYIGCGHCLACLTGMPWQCKLKKVIGIQTAGGFA
HHHHHHHHCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEEEEEECCCCHH
EYARVHVNEAVRLPVSVSWQEGALVEPLAIGLHAVRLSRGVAGKSVLVTGAGPIGLAVAL
HHHHHHHCCEEECCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
WCRFFGARQVVVSEFDPERSKMALAMGATHAVDAKADVGAQYQEITGELPELIFECVGIP
HHHHHCCCEEEEECCCCCHHHEEEEECCCCCCCCCHHCCCHHHHHHCHHHHHHHHHHCCH
GLIAQCVDRAAFGAEIVVVGFCMRPDTFVPALAMLKEITVKFSIGNNKSDFQFIVDMLSS
HHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHC
GRISVKPMITAAVSLDDLPKTFESLRTPGEHCKVVVEPGR
CCEEEEEHEEEEECHHHHHHHHHHHCCCCCCCEEEECCCC
>Mature Secondary Structure
MRAAVFHQIGKPLAIESLNDPIPLDGEVIVNVKACGICGTDIHATADKEMRLADGTVLGH
CCCHHHHHCCCCEEECCCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCEEEECCEEECH
EFAGEIVEVGPQVAVGWAQGDRLCTLPYIGCGHCLACLTGMPWQCKLKKVIGIQTAGGFA
HHHHHHHHCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEEEEEECCCCHH
EYARVHVNEAVRLPVSVSWQEGALVEPLAIGLHAVRLSRGVAGKSVLVTGAGPIGLAVAL
HHHHHHHCCEEECCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
WCRFFGARQVVVSEFDPERSKMALAMGATHAVDAKADVGAQYQEITGELPELIFECVGIP
HHHHHCCCEEEEECCCCCHHHEEEEECCCCCCCCCHHCCCHHHHHHCHHHHHHHHHHCCH
GLIAQCVDRAAFGAEIVVVGFCMRPDTFVPALAMLKEITVKFSIGNNKSDFQFIVDMLSS
HHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHC
GRISVKPMITAAVSLDDLPKTFESLRTPGEHCKVVVEPGR
CCEEEEEHEEEEECHHHHHHHHHHHCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]