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The map label for this gene is mip [H]

Identifier: 78223368

GI number: 78223368

Start: 2435407

End: 2437182

Strand: Direct

Name: mip [H]

Synonym: Gmet_2161

Alternate gene names: 78223368

Gene position: 2435407-2437182 (Clockwise)

Preceding gene: 78223351

Following gene: 78223369

Centisome position: 60.92

GC content: 59.35

Gene sequence:

>1776_bases
ATGAGACTCGTCATCCCCTGCATCACGTCATTTCTTATTACGGCCGTTCTCACCCCCTTCGTCATCCGCATCGCGACCGC
CTGCAGGTGCGTGGATGTGCCAGGCGAGCGACGCCTGCACCGGAGGCCGACTCCCCGGTGGGGAGGGGCGGCGTTTTTCG
CCGGGGTGCTCCCCTTTCTGTTTGTCGAGAGCCATGGCGGAGCATTGGCGTCGTTCATTGCCGCGTCGTTCATTCTGGTC
GGCATGGGGATGGTGGATGACCTTTCCTCCCTTGACTGGAAAATGAAATTTGCCGTCATGGCGGCCGCGGCCACAATCGT
CATATTCGGCGGCAACGTCACCATCAACCACATCGGGGTCTTTGGCTCACTGGGGCGGTTGGACCTGGGGATGTTAAGCA
TCCCCTTCACCTACATCGGCATCATTGGCATTACCAACGCCATCAACCTCCTCGACGGCCTCGACGGCCTGGCAGGCGGC
GTATCGCTTCTGGGATTCCTGTTCATGGGGATTGCGGCCCTCCTTACGGGCAACGTACCGGTAGCGGTCATCTGCTTCGC
CTATGTGGGGGCGCTGGGAGCCTTTCTCCTCTTCAACTTCCCCAACGCCAGAATCTTCATGGGGGACACGGGAAGCCTCT
TTCTCGGGTTCTCTCTTGCCTTCGTGGCCGTGCTCCTCACGCAGGGCGTACAAGACTCGGTGGACTCCATGTTCCCGGTG
CTCGTGCTCCTCATCCCCATCTTCGACACGCTCCGGGTCCTGCTGGTACGACTGCTGAAAAAGAAAAACCCGTTCCGGGC
AGACAACCTTCATCTCCACTACCTGATGGTGCGCAGGAATATTCCCCCGGCACACGTGACGCTCCTCTTCTGGGGGGGCA
CGGCCCTCTTCGGCTCCATTGCGCTGCTCCTCACAAACCGGCCATCGGTCTCGTATCTTTCCGTCGTGCTGTATGCCGCG
TCATTCCTGGGCCTGACCGCCGCAAGCCTGACACCGGGAGTGGAGGCCGGCAGGGAAGCGAAACCGGTTGAAACCAGTTC
CTACAATACGGCCAGACAGCCGTACAGGCCCAAGGAAGGGACGATTACCGTCAGGCTGATGTTTGTCCTTGGCGTCGTTT
TCCTGGCAACCCAGGTCTTTGCCGAGGAACCGGCCGTTCTCAAGACCCAGCGGGACAAGGTCAATTACGCCATTGGCGTC
AACATGGTGAGGAACTTTACGCAGCAGTCGGTCGAAATCGACCTGGATATGCTGATGCAGGGCATGAGGGACGCCCGTTC
AGGCGGCAAGCTTCTCATGACTGAGGAAGAGATCCGCAGAACCACCCTTGCCGTTCAGGAAGAGGTGCGGAAGAGACAGA
AGATGGCCCCCATAATAGCGGCCAAGGAGGGGCAGGCATTCCTGGCTGAAAACAAAACGAAAGAGGGAGTGGTAACCCTG
CCGAGCGGCCTCCAGTACAAGATACTGAAGGCAGGTAACGGCAGGACCCCCACGGATGTTGACCATGTTCTCTGCGACTA
CCGCGGGACCCTTCTGAACGGAGCTGAATTCGACCGCTCCTATCCCGGCCGTCCGGTGACGTTCAGTGTCGCCGAAGGAG
GAGGAATCCCCGGCCTGAGCGAAGCTTTGAAAATGATGCCGGTGAACTCAAAGTGGCAACTTTTCATTCCCTCCCAACTG
GCCTACGGAGAGCGGGGGCGGACAAGTCTCATCGGATCGCCGGTCGGGCCCAATGAGACGATCATCGTGGAGGTTGAGCT
CCTCGCGATCAAGTGA

Upstream 100 bases:

>100_bases
AAAATTGGGCCGCCGGAACAGACAGTGCGCAGCCCTGCATCAAACATCTCCCGCAAAGTTAGCCTAGGCATATTGACATA
TTCTAAGAGGAATTCCACCT

Downstream 100 bases:

>100_bases
GCACTGAACGAGCATTGTGCAGAGTACACAGGGCGGAAAGGAGGTAAGAATCATGAGAAAGCTGCCGGCATTAGCATCCG
CGATTATCCTCTCGGGTTTG

Product: glycosyl transferase family protein

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MRLVIPCITSFLITAVLTPFVIRIATACRCVDVPGERRLHRRPTPRWGGAAFFAGVLPFLFVESHGGALASFIAASFILV
GMGMVDDLSSLDWKMKFAVMAAAATIVIFGGNVTINHIGVFGSLGRLDLGMLSIPFTYIGIIGITNAINLLDGLDGLAGG
VSLLGFLFMGIAALLTGNVPVAVICFAYVGALGAFLLFNFPNARIFMGDTGSLFLGFSLAFVAVLLTQGVQDSVDSMFPV
LVLLIPIFDTLRVLLVRLLKKKNPFRADNLHLHYLMVRRNIPPAHVTLLFWGGTALFGSIALLLTNRPSVSYLSVVLYAA
SFLGLTAASLTPGVEAGREAKPVETSSYNTARQPYRPKEGTITVRLMFVLGVVFLATQVFAEEPAVLKTQRDKVNYAIGV
NMVRNFTQQSVEIDLDMLMQGMRDARSGGKLLMTEEEIRRTTLAVQEEVRKRQKMAPIIAAKEGQAFLAENKTKEGVVTL
PSGLQYKILKAGNGRTPTDVDHVLCDYRGTLLNGAEFDRSYPGRPVTFSVAEGGGIPGLSEALKMMPVNSKWQLFIPSQL
AYGERGRTSLIGSPVGPNETIIVEVELLAIK

Sequences:

>Translated_591_residues
MRLVIPCITSFLITAVLTPFVIRIATACRCVDVPGERRLHRRPTPRWGGAAFFAGVLPFLFVESHGGALASFIAASFILV
GMGMVDDLSSLDWKMKFAVMAAAATIVIFGGNVTINHIGVFGSLGRLDLGMLSIPFTYIGIIGITNAINLLDGLDGLAGG
VSLLGFLFMGIAALLTGNVPVAVICFAYVGALGAFLLFNFPNARIFMGDTGSLFLGFSLAFVAVLLTQGVQDSVDSMFPV
LVLLIPIFDTLRVLLVRLLKKKNPFRADNLHLHYLMVRRNIPPAHVTLLFWGGTALFGSIALLLTNRPSVSYLSVVLYAA
SFLGLTAASLTPGVEAGREAKPVETSSYNTARQPYRPKEGTITVRLMFVLGVVFLATQVFAEEPAVLKTQRDKVNYAIGV
NMVRNFTQQSVEIDLDMLMQGMRDARSGGKLLMTEEEIRRTTLAVQEEVRKRQKMAPIIAAKEGQAFLAENKTKEGVVTL
PSGLQYKILKAGNGRTPTDVDHVLCDYRGTLLNGAEFDRSYPGRPVTFSVAEGGGIPGLSEALKMMPVNSKWQLFIPSQL
AYGERGRTSLIGSPVGPNETIIVEVELLAIK
>Mature_591_residues
MRLVIPCITSFLITAVLTPFVIRIATACRCVDVPGERRLHRRPTPRWGGAAFFAGVLPFLFVESHGGALASFIAASFILV
GMGMVDDLSSLDWKMKFAVMAAAATIVIFGGNVTINHIGVFGSLGRLDLGMLSIPFTYIGIIGITNAINLLDGLDGLAGG
VSLLGFLFMGIAALLTGNVPVAVICFAYVGALGAFLLFNFPNARIFMGDTGSLFLGFSLAFVAVLLTQGVQDSVDSMFPV
LVLLIPIFDTLRVLLVRLLKKKNPFRADNLHLHYLMVRRNIPPAHVTLLFWGGTALFGSIALLLTNRPSVSYLSVVLYAA
SFLGLTAASLTPGVEAGREAKPVETSSYNTARQPYRPKEGTITVRLMFVLGVVFLATQVFAEEPAVLKTQRDKVNYAIGV
NMVRNFTQQSVEIDLDMLMQGMRDARSGGKLLMTEEEIRRTTLAVQEEVRKRQKMAPIIAAKEGQAFLAENKTKEGVVTL
PSGLQYKILKAGNGRTPTDVDHVLCDYRGTLLNGAEFDRSYPGRPVTFSVAEGGGIPGLSEALKMMPVNSKWQLFIPSQL
AYGERGRTSLIGSPVGPNETIIVEVELLAIK

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=262, Percent_Identity=28.2442748091603, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87082390, Length=202, Percent_Identity=37.6237623762376, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789745, Length=219, Percent_Identity=35.1598173515982, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786275, Length=186, Percent_Identity=35.4838709677419, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 63921; Mature: 63921

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVIPCITSFLITAVLTPFVIRIATACRCVDVPGERRLHRRPTPRWGGAAFFAGVLPFL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCHHHHHHHHHHHH
FVESHGGALASFIAASFILVGMGMVDDLSSLDWKMKFAVMAAAATIVIFGGNVTINHIGV
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHEEEEEEECCCEEEEEEEE
FGSLGRLDLGMLSIPFTYIGIIGITNAINLLDGLDGLAGGVSLLGFLFMGIAALLTGNVP
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCH
VAVICFAYVGALGAFLLFNFPNARIFMGDTGSLFLGFSLAFVAVLLTQGVQDSVDSMFPV
HHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LVLLIPIFDTLRVLLVRLLKKKNPFRADNLHLHYLMVRRNIPPAHVTLLFWGGTALFGSI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEEECCHHHHHHH
ALLLTNRPSVSYLSVVLYAASFLGLTAASLTPGVEAGREAKPVETSSYNTARQPYRPKEG
HHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TITVRLMFVLGVVFLATQVFAEEPAVLKTQRDKVNYAIGVNMVRNFTQQSVEIDLDMLMQ
CEEEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEHHHHHHHHHHHHEECHHHHHH
GMRDARSGGKLLMTEEEIRRTTLAVQEEVRKRQKMAPIIAAKEGQAFLAENKTKEGVVTL
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCEEEC
PSGLQYKILKAGNGRTPTDVDHVLCDYRGTLLNGAEFDRSYPGRPVTFSVAEGGGIPGLS
CCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
EALKMMPVNSKWQLFIPSQLAYGERGRTSLIGSPVGPNETIIVEVELLAIK
HHHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure
MRLVIPCITSFLITAVLTPFVIRIATACRCVDVPGERRLHRRPTPRWGGAAFFAGVLPFL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCCCHHHHHHHHHHHH
FVESHGGALASFIAASFILVGMGMVDDLSSLDWKMKFAVMAAAATIVIFGGNVTINHIGV
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHEEEEEEECCCEEEEEEEE
FGSLGRLDLGMLSIPFTYIGIIGITNAINLLDGLDGLAGGVSLLGFLFMGIAALLTGNVP
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCH
VAVICFAYVGALGAFLLFNFPNARIFMGDTGSLFLGFSLAFVAVLLTQGVQDSVDSMFPV
HHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LVLLIPIFDTLRVLLVRLLKKKNPFRADNLHLHYLMVRRNIPPAHVTLLFWGGTALFGSI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEEECCHHHHHHH
ALLLTNRPSVSYLSVVLYAASFLGLTAASLTPGVEAGREAKPVETSSYNTARQPYRPKEG
HHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TITVRLMFVLGVVFLATQVFAEEPAVLKTQRDKVNYAIGVNMVRNFTQQSVEIDLDMLMQ
CEEEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEHHHHHHHHHHHHEECHHHHHH
GMRDARSGGKLLMTEEEIRRTTLAVQEEVRKRQKMAPIIAAKEGQAFLAENKTKEGVVTL
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCEEEC
PSGLQYKILKAGNGRTPTDVDHVLCDYRGTLLNGAEFDRSYPGRPVTFSVAEGGGIPGLS
CCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
EALKMMPVNSKWQLFIPSQLAYGERGRTSLIGSPVGPNETIIVEVELLAIK
HHHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA